Data suggests that Firmagon improves OS, PFS and reduced incidence of musculoskeletal and urinary tract adverse events versus leuprolide (Lupron), especially in patients with prior cardiovascular risk factors. Klotz makes the case that this difference is likely due to better FSH suppression by degarelix/Firmagon.
Full Answer
Is Firmagon better for heart patients than Lupron?
I believe there is recent evidence to suggest Firmagon has a slightly lower cardiac risk profile than Lupron. Specifically DVT clot formation.
How effective is Firmagon for prostate cancer?
FIRMAGON dropped PSA levels by 95% by month 3. FIRMAGON is proven to maintain PSA suppression through 12 months of treatment. PSA level is a nonspecific measurement that may indicate cancer progression. These results should be evaluated with caution because of the broad range of patient types in the clinical study.
What is Firmagon used to treat?
FIRMAGON is the only GnRH antagonist approved to treat advanced prostate cancer (APC). By day 28 of treatment, both FIRMAGON and Lupron Depot® (leuprolide acetate) achieved equivalent testosterone levels.
What are the side effects of Firmagon?
Important Safety Information. The common side effects of FIRMAGON include: hot flashes, injection site pain, redness and swelling, weight gain, increase in some liver enzymes, decreased sex drive, and erectile function problems.
What is better firmagon vs Lupron?
Lupron Depot initially increased testosterone levels—65% by the third day, compared to a 94% reduction with FIRMAGON. Some patients may require additional medication to prevent a symptomatic flare with Lupron Depot.
Can Lupron cause heart failure?
Increased risk of developing myocardial infarction, sudden cardiac death and stroke has been reported in association with the use of GnRH agonists such as leuprolide, and triptorelin.
Does Lupron affect heart muscle?
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Does degarelix affect the heart?
This medicine can cause a change in heart rhythm called prolongation of the QT interval. This condition may change the way your heart beats (faster or slower) and can cause chest pain, dizziness, fainting, or shortness of breath. Contact your doctor right away if you have any of these symptoms or any questions.
Can Lupron cause heart palpitations?
Side effects that have been associated with the use of Lupron Depot include hot flashes and night sweats and, less frequently, palpitations, syncope, and tachycardia.
How long can you stay on Lupron?
The duration of therapy with LUPRON DEPOT is limited to 3 months. The symptoms associated with fibroids will return after stopping therapy.
What is an alternative to Lupron?
While Orgovyx offers an oral alternative to Lupron injection and has some potential therapeutic benefits some doctors have expressed concerns about compliance and convenience between the requirement to take a pill daily compared to an injection every 3-4 months.
Who should not take Lupron?
You should not take norethindrone acetate and LUPRON DEPOT 3.75 mg if you currently have or have previously had any clotting disorder, heart disease, stroke, impaired liver function or liver disease, or breast cancer.
Does Lupron cause blood clots?
Rare but significant side effects may include heart problems such as congestive heart failure (1%) or problems with blood clots (1%). Blood clots can lead to pulmonary embolus or stroke - potentially life-threatening conditions. Not all Lupron Depot side effects are listed above.
How long can you stay on Firmagon?
Degarelix (Firmagon) is effective and well tolerated beyond 3 years in patients with advanced prostate cancer, according to a recent study published in The Journal of Urology.
Does Firmagon cause shortness of breath?
shortness of breath; sudden dizziness (like you might pass out); or. severe headache, blurred vision, pounding in your neck or ears.
How long do you take Firmagon?
Firmagon is usually given once every 28 days. Follow your doctor's instructions. The first time you receive this medicine, you will be given two injections. At your monthly follow-up visits you will receive only one injection.
What is a FIRMAGON?
AN ANTAGONIST. FIRMAGON is a gonadotropin-releasing hormone (GnRH) antagonist that immediately stops testosterone production at its source, eliminating the possibility of an initial testosterone “sur ge” and any need for additional therapies to counteract surges. FIRMAGON is the only gonadotropin-releasing hormone ...
What is the only GNRH antagonist approved to treat advanced prostate cancer?
Additional medication may be required to prevent the effects of the testosterone surge. Get to T goal fast with FIRMAGON. FIRMAGON is the only GnRH antagonist approved to treat advanced prostate cancer (APC).
Is FIRMAGON an antagonist?
FIRMAGON IS AN ANTAGONIST. FIRMAGON is a gonadotropin-releasing hormone (GnRH) antagonist that immediately stops testosterone production at its source, eliminating the possibility of an initial testosterone “surge” and any need for additional therapies to counteract surges. FIRMAGON is the only gonadotropin-releasing hormone (GnRH) ...
Does luporn depot cause testosterone?
Lupron Depot triggers a receptor called the luteinizing hormone–releasing hormone (LHRH) receptor, which results in an initial surge in testosterone. This initial surge subsequently reduces over a few weeks. Additional medication may be required to prevent the effects of the testosterone surge.
Is Lupron Depot an anti-agonist?
LUPRON DEPOT IS AN AGONIST. Lupron Depot triggers a receptor called the luteinizing hormone–releasing hormone (LHRH) receptor, which results in an initial surge in testosterone. This initial surge subsequently reduces over a few weeks. Additional medication may be required to prevent the effects of the testosterone surge.
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Zero - The End of Prostate Cancer
The ZERO - The End of Prostate Cancer Support Community connects patients, families, friends and caregivers to enhance the quality of life for all those affected by prostate cancer. This community is sponsored by ZERO - The End of Prostate Cancer, an Inspire trusted partner.
About this Community
The ZERO - The End of Prostate Cancer Support Community connects patients, families, friends and caregivers to enhance the quality of life for all those affected by prostate cancer. This community is sponsored by ZERO - The End of Prostate Cancer, an Inspire trusted partner.