Treatment FAQ

which treatment has the best utility for huntington?s disease?

by Magdalen Morissette Published 3 years ago Updated 3 years ago

There is no treatment to stop or reverse Huntington's disease, however there are some medications that can help keep symptoms under control. Treatment for HD includes the drug tetrabenazine, antipsychotic drugs, antidepressants, and tranquilizers. Patients who exercise tend to do better than those who do not.

Drugs like haloperidol, tetrabenazine, and amantadine are especially helpful for controlling the unusual movements caused by Huntington disease. Haloperidol and tetrabenazine can also help offset hallucinations and delusional thoughts.

Full Answer

How is Huntington's disease treated?

Dec 24, 2013 · Huntington’s disease (HD) is a hereditary, progressive neurodegenerative disease clinically characterized by abnormal involuntary movements, behavioral disturbance, cognitive dysfunction, and psychiatric disease. The disease is caused by a CAG (glutamine) trinucleotide expansion in exon 1 of the huntingtin ( htt) gene at the location 4p16.9 ...

Can Huntington’s disease be reversed?

Medications to lessen the mental and physical effects of the disease. Therapy for depression and anxiety that often accompany Huntington’s disease. Exercise therapies to help movement problems. Access to support services in your community. Studies of new therapies for Huntington’s disease are also in progress.

What is Huntington’s disease (HD)?

Feb 10, 2019 · Speech and language therapy is one of the best treatment options for Huntington’s disease a nd you should consider enrolling them in a program. It’s very important for a Huntington’s disease patient to be able to speak some basic sentences (greetings, make an emergency call, talk about their feelings, etc) clearly.

Which medications are used in the treatment of severe aggressiveness in Huntington's disease?

a. Which treatment has the best utility for Huntington's disease? i. deep brain stimulation of the caudate ii. implantation of fetal caudate and putamen cells iii. lesioning the putamen iv. There is no current treatment for Huntington's disease.

How to help someone with Huntington's disease?

These strategies include: Using calendars and schedules to help keep a regular routine. Initiating tasks with reminders or assistance.

What is the preliminary diagnosis of Huntington's disease?

A preliminary diagnosis of Huntington's disease is based primarily on your answers to questions, a general physical exam, a review of your family medical history, and neurological and psychiatric examinations.

Why is it important to plan for end of life care?

Planning for residential and end-of-life care. Because Huntington's disease causes the progressive loss of function and death, it's important to anticipate care that will be needed in the advanced stages of the disease and near the end of life.

What tests do neurologists do?

The neurologist will ask you questions and conduct relatively simple tests of your: Motor symptoms, such as reflexes, muscle strength and balance. Sensory symptoms, including sense of touch, vision and hearing. Psychiatric symptoms, such as mood and mental status.

Can Huntington's disease cause movement disorders?

Family history of Huntington's disease or other disorders that may cause movement disorders or psychiatric conditions. You may want a family member or friend to accompany you to your appointment. This person can provide support and offer a different perspective on the effect of symptoms on your functional abilities.

What tests are done to determine the function of the brain?

Your doctor may order brain-imaging tests for assessing the structure or function of the brain. The imaging technologies may include MRI or CT scans that show detailed images of the brain. These images may reveal changes in the brain in areas affected by Huntington's disease. These changes may not show up early in the course of the disease.

What is genetic testing?

A genetic test can be given if you have a family history of the disease but don't have symptoms. This is called predictive testing. The test can't tell you when the disease will begin or what symptoms will appear first.

What is the name of the drug that is used to treat Huntington's disease?

Austedo. Austedo (deutetrabenazine) was approved by the FDA in 2017. It is also prescribed to treat the involuntary movements (chorea) in Huntington's disease. Austedo is chemically similar to Xenazine but its effectiveness lasts longer.

What are the symptoms of Huntington's disease?

As a neurological condition, Huntington's causes symptoms that typically fall into one of three categories: physical/movement changes, cognitive changes, and emotional/behavioral changes. HD is also one of several conditions that cause dementia to develop.

Who is Claudia Chaves?

Claudia Chaves, MD, is board-certified in cerebrovascular disease and neurology with a subspecialty certification in vascular neurology. She is an associate professor of neurology at Tufts Medical School and medical director of the Lahey Clinic Multiple Sclerosis Center in Lexington, Massachusetts.

What are the symptoms of HD?

Physical Changes. One of the hallmark symptoms of HD is chorea . Chorea refers to the loss of ability to control physical movements. It produces brief, involuntary, non-stereotyped movements. These movements often occur in the upper body and include the upper arms, trunk, head, neck, and face. They can also occur in the legs.

How do you know if you have HD?

Other physical signs of HD include a decline in walking and talking, a lack of coordination, an impairment in swallowing food and liquids and, consequently, significant weight loss. Due to these symptoms, the risk for falling is high in people with HD, but working with specialists can help reduce risk.

Is apathy a sign of dementia?

As with other kinds of dementia, apathy is common in HD. Depression (which is similar to apathy but usually involves feelings of sadness and hopelessness) can be especially significant and is a strong predictor of thinking about or considering suicide.

What are the effects of HD?

HD is a result of changes in the brain, so it's understandable that cognitive abilities are affected. While memory can be affected, other areas of cognition are impacted as well. These include impaired executive functioning (such as the ability to plan and make decisions), poor concentration, a lack of focus, poor judgment and a lack of insight into your own behaviors. A lack of inhibitions may also develop. For example, if you have HD, you might do something that you normally wouldn't feel is appropriate because your impulse control is decreased.

What is sensory feedback?

A speech and language therapist uses sensory feedback to make the Huntington’s disease patient aware of their faulty speech and incorrect use of words. They record a sample of patients voice and play them back to them so that the patient can distinguish his faulty speech from someone else’s correct one.

Can you walk with a walker?

Studies show that with physical therapy it’s possible for them to maintain a good range of motion in their legs, also walk with the help of a walker. A study by Bellarmine University, USA highlighted how community-based yoga can make a change in the lives of people affected by Huntington’s Disease. [1 ]

Diagnosis

  • A preliminary diagnosis of Huntington's disease is based primarily on your answers to questions, a general physical exam, a review of your family medical history, and neurological and psychiatric examinations.
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Lifestyle and Home Remedies

  • Managing Huntington's disease is demanding on the person with the disorder, family members and other in-home caregivers. As the disease progresses, the person will become more dependent on caregivers. A number of issues will need to be addressed, and strategies to cope with them will evolve.
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Coping and Support

  • A number of strategies may help people with Huntington's disease and their families cope with the challenges of the disease.
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Preparing For Your Appointment

  • If you have any signs or symptoms associated with Huntington's disease, you'll likely be referred to a neurologist after an initial visit to your family doctor. A review of your symptoms, mental state, medical history and family medical history can all be important in the clinical assessment of a potential neurological disorder.
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Types of Symptoms

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As a neurological condition, Huntington's causes symptoms that typically fall into one of three categories: physical/movement changes, cognitive changes, and emotional/behavioral changes. HD is also one of several conditions that cause dementiato develop. Symptoms most often develop between 30 and 50 years old…
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Treatment Overview

  • While there is no cure available for HD at this time, there are a few medications and complementary approaches that may help relieve some symptoms for a time. Keep in mind that you should not use complementary or supplementary substances without checking with your physician, as some can have significant negative side effects or drug interactions with your othe…
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Medications

  • Xenazine
    Xenazine (tetrabenazine) was approved in 2008 by the U.S. Food and Drug Administration (FDA) to treat chorea in HD. It has been shown to help reduce involuntary movements and is generally regarded as one of the most common and effective ways to treat HD. Xenazine does, however, c…
  • Austedo
    Austedo (deutetrabenazine)was approved by the FDA in 2017. It is also prescribed to treat the involuntary movements (chorea) in Huntington's disease. Austedo is chemically similar to Xenazine but its effectiveness lasts longer. Consequently, Austedo is usually prescribed to be ta…
See more on verywellhealth.com

Non-Drug Approaches

  • Since medications are currently limited to attempting to manage specific symptoms in HD, other non-drug complementary approaches are recommended.
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