An important improvement in the management of ovarian cancer was introduced by the administration of chemotherapy via the intraperitoneal (IP) route. Several randomized clinical trials were able to demonstrate an improvement in survival from IP versusIV chemotherapy [Armstrong et al. 2006; Markman et al. 2001; Alberts et al. 1996].
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What is the typical course of chemo for epithelial ovarian cancer?
Chemotherapy plays a key role in the management of women with epithelial ovarian, fallopian tube and primary peritoneal cancer (EOC). Platinum- and taxane-based regimens are the standard of care for adjuvant treatment in early-stage EOC and first-line therapy for advanced stage disease. Efforts to d …
How does chemotherapy for ovarian cancer work?
An important improvement in the management of ovarian cancer was introduced by the administration of chemotherapy via the intraperitoneal (IP) route. Several randomized clinical trials were able to demonstrate an improvement in survival from IP versus IV chemotherapy [ Armstrong et al . 2006 ; Markman et al . 2001 ; Alberts et al . 1996 ].
What are some of the best references on ovarian cancer treatment?
The typical course of chemo for epithelial ovarian cancer involves 3 to 6 cycles of treatment, depending on the stage and type of ovarian cancer. A cycle is a schedule of regular doses of a drug, followed by a rest period. Different drugs have varying cycles; your doctor will let you know what schedule is planned for your chemo.
Can intraperitoneal chemotherapy and IV chemotherapy improve survival in advanced ovarian cancer?
Sep 04, 2015 · IP chemotherapy is delivered through an implanted subcutaneous port that drains into the cavity of the abdomen, allowing direct access for the drug to the peritoneal cavity, where ovarian cancer has spread. Its use, however, can cause more frequent and more severe side effects than IV chemotherapy, including abdominal pain, nausea, and vomiting.
Which route is the most common for administration of chemotherapy?
Intravenous administration of therapy medication allows for rapid entry into the body's circulation, where it is carried throughout the body in the blood stream. This is the most common method of chemotherapy administration, since most chemo drugs are easily absorbed through the blood stream.
What chemotherapy is used for ovarian cancer?
Doctors most commonly use the chemotherapy drug carboplatin to treat ovarian cancer. You might have it on its own or with another chemotherapy drug called paclitaxel (Taxol). Your doctor might use other types of chemotherapy drugs if your cancer has come back.
What is the best way to administer chemotherapy?
Chemotherapy is most often given as an infusion into a vein (intravenously). The drugs can be given by inserting a tube with a needle into a vein in your arm or into a device in a vein in your chest.
What is the best treatment for ovarian cancer?
Surgery is the main treatment for ovarian cancer, recommended primarily when the vast majority of the cancer or affected tissue can be removed successfully. Some early-stage ovarian patients may undergo minimally-invasive procedures to remove ovarian tumors and/or preserve fertility.
Is chemotherapy necessary for ovarian cancer?
Chemotherapy is usually recommended after surgery for most stages of ovarian cancer. A combination of chemotherapy medications is typically used. The primary goal of chemotherapy is to destroy cancer cells by preventing them from growing and dividing rapidly and to bring about cancer remission.Oct 16, 2021
How does chemotherapy work for cancer?
Chemotherapy is the use of drugs to destroy cancer cells. It usually works by keeping the cancer cells from growing, dividing, and making more cells. Because cancer cells usually grow and divide faster than normal cells, chemotherapy has more of an effect on cancer cells.
How is chemotherapy administered through a port?
Chemotherapy drugs and other fluids or medications can be given directly through the port. This is done with a special needle that goes into an access point within the port. The fluids or medications flow through the catheter and directly into a large vein. Blood can also be drawn this way.May 27, 2021
How is IV chemotherapy administered?
Intravenous or IV chemo is put right into your bloodstream through a tiny, soft, plastic tube called a catheter. A needle is used to put the catheter into a vein in your forearm or hand; then the needle is taken out, leaving the catheter behind.Nov 22, 2019
What is procedure of chemotherapy?
It consists of administration of a single type of medication or a combination of a few medications. As chemotherapy is usually given through the intravenous (IV) route, it reaches the whole body and affects the entire body. Chemotherapy is intended to either stop or at least slow down the growth of cancer cells.
What is first line treatment for ovarian cancer?
Intensive surgical staging and cytoreduction, followed by primary chemotherapy are considered the gold standard of treatment in the first-line setting of advanced ovarian cancer. To date, the standard first-line chemotherapy consists of a taxane (paclitaxel 175 mg/m2) with the addition of carboplatin (AUC > 5).
Why is chemo given for ovarian cancer before surgery?
However, since most women will have widespread disease, surgery alone is unlikely to cure the disease and most will also need chemotherapy. Chemotherapy for ovarian cancer uses platinum-based drugs to treat cells that cannot be removed by surgery (macroscopic disease) or are too small to be seen (microscopic disease).Jul 30, 2021
Where is the best treatment center for ovarian cancer?
Mayo Clinic in Rochester, Minn., Mayo Clinic in Phoenix/Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., are ranked among the Best Hospitals for cancer by U.S. News & World Report.Aug 31, 2021
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What is chemo for ovarian cancer?
Chemotherapy for Ovarian Cancer. Chemotherapy (chemo) is the use of drugs to treat cancer. Most often, chemo is a systemic treatment, meaning the drugs enter the bloodstream and reach almost all areas of the body. Chemo can be useful to kill very small amounts of cancer cells that may still be around after surgery, ...
What is the best treatment for ovarian cancer?
Getting a combination of drugs instead of just one drug alone seems to work better as a first treatment for ovarian cancer. Usually, the combination includes a type of chemo drug called a platinum compound (usually cisplatin or carboplatin), and another type of chemo drug called a taxane, such as paclitaxel (Taxol ®) or docetaxel (Taxotere ® ).
Where does chemo go?
Giving chemo this way gives the most concentrated dose of the drugs directly to the cancer cells in the abdominal cavity. This chemo also gets absorbed into the bloodstream and so can reach cancer cells outside the abdominal cavity.
Do side effects of cancer go away?
These side effects usually go away after treatment is finished. While you are in treatment, tell your cancer care team about any side effects you are having. There are often ways to lessen these side effects. For example, drugs can be given to help prevent or reduce nausea and vomiting.
What is intraperitoneal chemo?
Intraperitoneal (IP) chemotherapy. For women who have stage III ovarian cancer (cancer that has not spread outside the abdomen) and whose cancers were optimally debulked (no tumors larger than 1 cm after surgery), intraperitoneal (IP) chemotherapy might be given in addition to systemic chemo (paclita xel given in a vein).
Can chemo cause menopause?
Chemo can also cause early menopause and infertility (being unable to become pregnant), which may be permanent. This is rarely an issue in the treatment of epithelial ovarian cancer, since most women have both ovaries removed as a part of treatment. Rarely, some chemo drugs can permanently damage bone marrow.
What is the best chemotherapy for cancer?
High dose chemotherapy (the exact drugs used can vary depending on what cancer center is giving the treatment) TIP (paclitaxel/Taxol, ifosfamide, and cisplatin/Platinol) VeIP (vinblastine, ifosfamide, and cisplatin/Platinol) VIP (etoposide/VP-16, ifosfamide, and cisplatin/Platinol)