What is the best sialogogue drug for xerostomia?
Pilocarpine continues to be the best performing sialogogue drug for subjects with xerostomia due to radiation on head and neck cancer or diseases such as Sjogren’s Syndrome.
When are salivary substitutes used in the treatment of xerostomia?
These salivary substitutes are often used when the xerostomia has been caused by the irreversible destruction of the salivary hyposialia by parenchyma or because sialagogues can not be administered to patients because of the adverse effects (26).
What are sialogogues for the treatment of dry mouth?
Pilocarpine and cevimeline are two systemic US Food and Drug Administration-approved sialogogues for treatment of dry mouth. Their effect depends on the presence of functional glandular tissue.
Which topical products are used to treat xerostomia in polypharmacy?
Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil. 2007;34(10):724–732.
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Which drug is used to treat xerostomia?
If you have severe dry mouth, your doctor or dentist may: Prescribe medication that stimulates saliva. Your doctor may prescribe pilocarpine (Salagen) or cevimeline (Evoxac) to stimulate saliva production.
What drugs are Sialogogues?
Salivation may be promoted by using a stimulant: (sialogogue) such as; chewing gums (containing sorbitol or xylitol, not sucrose) diabetic sweets. cholinergic drugs such as pilocarpine, bethanecol, cevimeline or anetholetrithione.
What are measures given to assist a patient with xerostomia?
Saliva stimulants or sialagogues, such as sugarless candies and chewing gum, or certain pharmacologic agents may be used to stimulate saliva. These agents are effective when functional salivary glands remain.
Why pilocarpine is used in xerostomia?
Pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer of the head and neck or in patients with Sjogren's syndrome. This medicine may help you speak without having to sip liquids.
What does Sialogogue mean?
can stimulate the flow of salivaor sialogogue (ˈsaɪələˌɡɒɡ , saɪˈæləˌɡɒɡ ) noun. medicine. any drug or agent that can stimulate the flow of saliva. Derived forms.
How is hyposalivation treated?
In some cases, your doctor may prescribe a medication that works by stimulating the salivary glands to produce more saliva, such as pilocarpine (SalagenTM) or cevimeline (EvoxacTM). These medications are taken three times a day, before meals, and in many cases may take several weeks before their full benefit is felt.
What is the best artificial saliva?
What are the most popular brands of artificial saliva?Aquoral. This is a lipid-based oral spray that should be used three to four times daily. ... Biotène Oralbalance moisturizing gel. ... Mouth Kote dry mouth spray. ... NeutraSal. ... Oasis mouth moisturizing spray. ... XyliMelts.
How can you prevent xerostomia?
AdvertisementChew sugar-free gum or suck on sugar-free hard candies to stimulate the flow of saliva. ... Limit your caffeine intake because caffeine can make your mouth drier.Don't use mouthwashes that contain alcohol because they can be drying.Stop all tobacco use if you smoke or chew tobacco.Sip water regularly.More items...
What is xerostomia in dentistry?
Xerostomia is dry mouth caused by reduced or absent flow of saliva. This condition can result in discomfort, interfere with speech and swallowing, make wearing dentures difficult, cause halitosis. See also Evaluation of the Dental Patient.)
Which is better pilocarpine and cevimeline?
Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine.
What is pilocarpine nitrate used for?
This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma or other eye diseases (such as ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness, vision loss, and nerve damage.
Is pilocarpine and atropine the same?
For the good order, atropine and pilocarpine are, respectively, an antagonist and agonist of the muscarinic acetylcholine receptor: atropine causes drying of the mouth by blocking the parasympathetic-mediated secretion (cholinergic nerves) and it increases heart rate by blocking the inhibitory influence of the vagus ...
What is the treatment for xerostomia?
Although no standard treatment guidelines are available, many treatment options exist for the management of xerostomia and hyposalivation: topical agents to alleviate and/or prevent xerostomia, systemic therapy, or newer devices.
What is the subjective complaint of dry mouth?
Xerostomia, the subjective complaint of dry mouth, and hyposalivation remain a significant burden for many individuals. Diagnosis of xerostomia and salivary gland hypofunction is dependent upon a careful and detailed history and thorough oral examination. There exist many options for treatment and symptom management: salivary stimulants, ...
Does sialogogue cause enamel erosion?
These include chewing gums, saliva stimulants, and substitutes. A topical sialogogue spray containing 1% malic acid has recently shown its efficacy in managing symptoms of xerostomia in patients with antidepressant- or antihypertensive-induced dry mouth;49,50however, this has the potential to cause mild enamel erosion.
Is Anethole trithione a cholagogue?
Other sialogogues. Anethole trithione is a cholagogue that has been shown to improve oral symptoms and increase the salivary flow in patients with xerostomia and hyposalivation.47More studies are necessary to prove the efficacy of this medication.
Drugs used to treat Xerostomia
The following list of medications are in some way related to, or used in the treatment of this condition.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
