Treatment FAQ

which of the following is not part of the recommended treatment for myxedema coma?

by Paula Wiegand Published 3 years ago Updated 2 years ago

Medication

Myxedema coma is an extreme complication of hypothyroidism (low thyroid hormone). It’s rare and potentially fatal. The condition is also called myxedema crisis.

Procedures

Friends or family members should not give the person in myxedema coma any thyroid medication before taking him or her to the emergency department. If adrenal insufficiency is present, then administration of thyroxin (in the thyroid medication) will provoke an adrenal crisis.

Therapy

Myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition. Patients with hypothyroidism may exhibit a number of physiologic alterations to compensate for the lack of thyroid hormone. If these homeostatic mechanisms are overwhelmed by factors such as …

Nutrition

Myxedema is a serious condition. Any person displaying symptoms of myxedema or severe hypothyroidism must receive medical attention urgently. A person with myxedema may notice swelling in their face, legs, or tongue. Their skin may also become dry and pale.

What is myxedema coma and how is it treated?

What medications should not be given to a person in myxedema coma?

Is myxedema coma a form of hypothyroidism?

Is myxedema a serious condition?

What is the treatment for myxedema coma?

Patients with suspected myxedema coma should be admitted to an intensive care unit for vigorous pulmonary and cardiovascular support. Most authorities recommend treatment with intravenous levothyroxine (T4) as opposed to intravenous liothyronine (T3).

Which drug is used to treat myxedema coma where a rapid response is required?

This report is also unique in the literature to describe the specific benefits of using loading dose levothyroxine for myxedema psychosis, because traditionally, loading doses were mainly used in the setting of myxedema coma3 when there is a need for a rapid response within days.

Why T4 is preferred over T3 in treatment of myxedema coma?

Because the rate of conversion of T4 to the active hormone T3 can be reduced in these patients, the addition of T3 along with T4 has been recommended. T3 has a quicker onset of action than T4, as increases in body temperature and oxygen consumption has been reported to be faster with T3 therapy compared to T4.

Which of the following medications should be administered with levothyroxine for the treatment of myxedema coma?

Most authorities recommend treatment with intravenous levothyroxine (T4) as opposed to intravenous liothyronine (T3). Hydrocortisone should be administered until coexisting adrenal insufficiency is ruled out.

Why are steroids used in myxedema coma?

Hydrocortisone (Solu-Cortef, Hydrocortone) Patients presenting with myxedema coma/crisis may have adrenal insufficiency, and stress doses of IV steroids must be administered along with initial thyroid replacement until adrenal function has been determined to be normal.

What is this for levothyroxine?

Levothyroxine is a medicine used to treat an underactive thyroid gland (hypothyroidism). The thyroid gland makes thyroid hormones which help to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone thyroxine. Levothyroxine is only available on prescription.

What is the first line treatment of hypothyroidism?

American Thyroid Association Continues to Recommend Levothyroxine as First-Line Therapy for Hypothyroidism.

What is the latest treatment for hypothyroidism?

Standard treatment for hypothyroidism involves daily use of the synthetic thyroid hormone levothyroxine (Levo-T, Synthroid, others). This oral medication restores adequate hormone levels, reversing the signs and symptoms of hypothyroidism.

How is high T3 treated?

Antithyroid Medications: Antithyroid medications (sometimes written anti-thyroid) prevent the thyroid from producing excess amounts of T4 and T3 hormones. There are 2 types of antithyroid medications used in the US—propylthiouracil (PTU) and methimazole (also known as Tapazole).

What is myxedema hypothyroidism?

Myxedema is another term for severely advanced hypothyroidism. It's a condition that occurs when your body doesn't produce enough thyroid hormone. The thyroid is a small gland that sits right at the front of your neck. It releases hormones that help your body regulate energy and control a wide variety of functions.

What are the symptoms of myxedema coma?

Symptoms of myxedema coma include a severe drop in body temperature, reduced breathing, and central nervous system failure, alongside other symptoms of hypothyroidism.

What is the treatment for myxedema?

Treatment involves administering thyroid hormone replacement medication into a vein. Antibiotics, steroid treatment, and breathing support may be necessary also.

What is myxedema in medical terms?

Outlook. Myxedema refers to a severe form of hypothyroidism than can occur when the condition is left untreated or is not treated sufficiently. The term also applies to the effects that hypothyroidism can have on the skin, making it appear swollen and puffy. When thyroid hormone levels become extremely low, a person may experience symptoms such as ...

Why does myxedema occur?

Myxedema occurs because of severe hypothyroidism that is not diagnosed or is not treated successfully. A person ceasing to take their medication can cause this complication. Hypothyroidism develops because the thyroid stops working as it should. Causes of hypothyroidism include: surgical removal of the thyroid.

What are the complications of myxedema?

hypothermia. decreased drug metabolism, leading to overdosing of medications. pregnancy complications, such as preeclampsia, miscarriage, and stillbirth. coma. death. Myxedema coma is a rare but severe complication of myxedema.

What happens if a doctor suspects hypothyroidism?

If a doctor believes that a person has hypothyroidism, they will perform more tests to measure thyroid function and to find an underlying cause. If a doctor suspects myxedema coma, they will recommend that treatment begins immediately. The sooner a person is treated, the more likely they are to recover.

How long does it take to recover from myxedema?

A person with myxedema is likely to stay in an intensive care unit with continual monitoring and treatment, and recovery may take several weeks. A myxedema coma requires immediate admission to a hospital.

When is myxedema coma most common?

Myxedema coma is most common in the winter. You’re at higher risk if:

What causes myxedema coma?

Myxedema coma results from long-term, untreated hypothyroidism plus a triggering event that strains the body’s resources. This causes multiple systems and organs to slow down, leading to lethargy, excessive sleep, and possibly loss of consciousness. The best way to prevent myxedema coma is to have your thyroid condition diagnosed and treated early.

What is the term for the loss of the ability to maintain body temperature?

Defective temperature regulation ( hypothermia): You lose the ability to maintain your body temperature. Exposure to the cold can make your body temperature drop sharply.

Can you get into a coma with hypothyroidism?

Myxedema coma is a potentially life-threatening complication of hypothyroidism. It’s more likely to happen if your thyroid condition is not managed. If you have signs of hypothyroidism, talk to your doctor about your concerns. Getting diagnosed and treated early can significantly reduce your risk of having myxedema coma. If you or someone you know is having symptoms that could point to myxedema coma, get medical help immediately. The sooner you act, the better the chance of recovery.

Can your body keep up with adaptations?

Your body can’t keep up the adaptations.

Can hypothyroidism cause a coma?

Myxedema coma is most common when severe hypothyroidism has gone untreated for a long time. It rarely leads to a coma. Instead, it causes lethargy due to slowed function of multiple systems.

Myxedema Coma Symptoms

Causes

Diagnosis

Treatment

Medically reviewed by
Dr. Rakshith Bharadwaj
Your provider will work with you to develop a care plan that may include one or more of these treatment options.
Myxedema coma is a medical emergency and requires immediate attention. Most patients require admission to the ICU.
Medication

Thyroid hormone replacement: To control the hypothyroidism.

Levothyroxine . Liothyronine


Glucocorticoids: To treat adrenal insufficiency.

Hydrocortisone


Vasopressors: To treat hypotension.

Dopamine

Procedures

Mechanical ventilation: For patients with respiratory depression.

Therapy

Intravenous therapy:Saline to correct hyponatremia and dextrose to correct hypoglycemia.

Nutrition

Foods to eat:

  • Parenteral nutrition
  • Nasogastric feeding

Foods to avoid:

  • NA

Specialist to consult

Emergency medicine specialist
Specializes in identifying and managing illnesses or injuries requiring immediate medical attention.

Prognosis

  • Myxedema coma has three major symptoms: 1. Altered mental status: You may be lethargic, sleep a lot, and have episodes of reduced consciousness for a few months, then eventually enter a coma. 2. Defective temperature regulation (hypothermia): You lose the ability to maintain your body temperature. Exposure to the cold can make your body temperature drop sharply. 3. Trigge…
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Summary

  • Your thyroid gland makes hormones that regulate homeostasis. That’s the way your body controls automatic things like temperature, digestion, and heart rate. When thyroid hormones are low, your body adapts and finds other ways to maintain homeostasis. But then, a triggering event strains the body’s resources, and as a result: 1. Your body can’t keep up the adaptations. 2. Your core te…
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A Word from Verywell

  • Doctors identify myxedema coma in several ways. A physical exam may show: 1. Low body temperature 2. Slow breathing 3. Low blood pressure 4. Slow heart rate 5. Delayed reflexes 6. Coarse, dry skin 7. Enlarged tongue Lab tests may reveal: 1. Anemia 2. Low blood sugar 3. Low sodium 4. Low cortisol (the stress hormone) 5. High cholesterol 6. High creatine kinase 7. Low t…
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