Which antibiotic inhibits mRNA synthesis?
Rifamycin inhibits bacterial DNA transcription into mRNA by inhibiting DNA-dependent RNA polymerase by binding its beta-subunit.
Which of the following antibiotics causes misreading of mRNA?
4.6 Aminoglycosides Aminoglycosides are potent bactericidal antibiotics that act by inhibiting bacterial protein synthesis, thereby binding bacterial 30S or 50S ribosomal subunit, inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site, and also causing misreading of mRNA.
Which drug for the treatment of tuberculosis inhibits RNA production?
Rifamycins inhibit RNA polymerase of most bacterial genera. Rifampicin remains part of combination therapy for treating tuberculosis (TB), and for treating Gram-positive prosthetic joint and valve infections, in which biofilms are prominent.
Which of the following antibiotics inhibits protein synthesis?
Macrolides such as azithromycin, lincosamides (clindamycin), linezolid, chloramphenicol, aminoglycosides such as tobramycin, mupirocin, and tetracycline all inhibit protein synthesis.
Which of the drugs shown would inhibit peptidoglycan synthesis?
Significant glycopeptide antibiotics include vancomycin, teicoplanin, telavancin, bleomycin, ramoplanin, and decaplanin. This class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis.Jan 3, 2021
What are antibiotics What is the mechanism of action of antibiotics?
Antibiotics commonly block biochemical pathways important for bacteria. Many bacteria make a cell wall to protect themselves. The antibiotic penicillin blocks the biochemical processes that build the cell wall. Consequently, the growing bacteria become unable to make cell walls and die easily.
What type of inhibit is rifampin?
Abstract. Rifampin specifically inhibits bacterial RNA polymerase, the enzyme responsible for DNA transcription, by forming a stable drug-enzyme complex with a binding constant of 10(-9) M at 37 C.
What class of drug is trimethoprim?
Trimethoprim is a prescription medicine used to treat the symptoms of bacterial infections. Trimethoprim may be used alone or with other medications. Trimethoprim belongs to a class of drugs called Antibiotics, Other.
Where does rifampicin bind RNA polymerase?
exit channelRifampicin binds to the exit channel of the RNA polymerase by making specific contacts that involve the β-subunit of RNA polymerase. Rifampicin blocks the exit channel thereby inhibiting transcription (Campbell et al., 2001).
Does amoxicillin inhibit protein synthesis?
0:282:20Protein Synthesis Inhibitors antibiotics animation video - YouTubeYouTubeStart of suggested clipEnd of suggested clipAnd tRNA coordinated together to produce an elongated polypeptide chain different antibiotics workMoreAnd tRNA coordinated together to produce an elongated polypeptide chain different antibiotics work through the inhibition of bacterial protein synthesis.
What antibiotics inhibit DNA synthesis?
Examples of antibiotics that inhibit DNA replication include the quinolones and coumarin. The quinolones can selectively bind to the A subunit of DNA gyrase (aka topoisomerase II) at exposed single strand ends of the cut DNA chain.