Which drug is prescribed for the treatment of idiopathic hypercalciuria?
Which drug can be prescribed for the treatment of idiopathic hypercalciuria? 1. Mannitol 2. Amiloride 3. Metolazone 4. Furosemide 3. Metolazone
Is indapamide an efficient drug for the treatment of hypercalciuria?
The results show that indapamide is an efficient drug for the treatment of idiopathic hypercalciuria. Full text Full text is available as a scanned copy of the original print version.
What is the pathophysiology of idiopathic hypercalciuria?
Idiopathic hypercalciuria is a metabolic abnormality with various causes and developmental pathways. The systematic review describes specific mutations associated with idiopathic hypercalciuria and nephrolithiasis.
How is hypercalciuria diagnosed and treated?
Hypercalciuria can be difficult to identify and manage. Diagnosis usually begins with primary care, the nurse practitioner, nephrology or urology. It can take time to identify the type of hypercalciuria and its optimal treatment. A high index of suspicion should be maintained by all members of the health care team treating the patient.
How is idiopathic hypercalciuria treated?
Proper treatment requires a high calcium intake, a low sodium intake, moderation of very high protein intakes, avoidance of refined sugar loads, and – not rarely – use of diuretic drugs which can lower urine calcium losses, prevent stones, and protect bones.
Which drug causes hypercalciuria?
Loop diuretics, such as bumetanide and furosemide, inhibit both sodium and calcium resorption in the thick ascending limb of the loop of Henle. In addition to exerting a diuretic effect, this mechanism of action produces a hypercalciuric state.
What is idiopathic hypercalciuria?
Idiopathic hypercalciuria (IH) is the commonest metabolic abnormality in patients with calcium kidney stones. It is characterized by normocalcemia, absence of diseases that cause increased urine calcium, and calcium excretion that is above 250 mg/day in women and 300 mg/day in men.
How do you manage hypercalciuria?
How is Hypercalciuria Treated?Addressing any secondary disease causing the hypercalciuria.Making changes to the diet with the help of a Registered Dietitian. ... If diet changes aren't enough, the doctor may need to add medicines to decrease calcium in the urine or prevent stone formation.More items...
How do thiazides treat hypercalciuria?
Thiazides work by increasing calcium reabsorption at the level of the distal renal tubule and, thus, lowering urinary calcium.
How is idiopathic hypercalciuria diagnosed?
Hypercalciuria is determined on 24-hour urine collection test, and is often associated with a calcium/creatinine ratio greater than 0.20 mg/mg. Kidney stones may be revealed by ultrasound and high resolution CT imaging of the urinary tract.
How common is idiopathic hypercalciuria?
Idiopathic hypercalciuria has been noted in 10% to 19% of otherwise healthy men with low bone mass, in postmenopausal women with osteoporosis,10–12 and in up to 40% of postmenopausal women with osteoporotic fractures and no history of kidney stones.
Is vitamin D good for kidney stones?
Increased vitamin D levels may prevent a wide range of diseases, according to recent studies. However, some previous studies led to a concern that vitamin D supplementation could increase an individual's risk of developing kidney stones.
Can calcium supplements cause hypercalciuria?
Hypercalciuria and hypercalcemia occurs commonly on vitamin D and calcium supplements.
Is calcitonin a hormone?
Calcitonin is a 32 amino acid hormone secreted by the C-cells of the thyroid gland. Calcitonin has been preserved during the transition from ocean-based life to land dwellers and is phylogenetically older than parathyroid hormone.
What causes calcium in urine?
A high level of urine calcium (above 300 mg/day) may be due to: Chronic kidney disease. High vitamin D level. Leaking of calcium from the kidneys into the urine, which may cause calcium kidney stones.
How do you increase calcium excretion?
Calcium excretion is increased by loop diuretics and diminished by thiazide-type diuretics and amiloride. How these effects occur is related to the mechanisms of sodium, chloride, and calcium transport in the different diuretic-sensitive segments. Ions cannot directly cross epithelial cell membranes.