The main contraindications to testosterone therapy (T therapy) are:1 Prostate cancer (locally advanced or metastatic) Male breast cancer An active desire to father children Haematocrit >54% Severe chronic heart failure (NYHA class IV)
Full Answer
What is the clinical pharmacology of testosterone?
Testosterone - Clinical Pharmacology. Testosterone in plasma is 98 percent bound to a specific Testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of Testosterone between free and bound forms,...
Is testosterone cypionate injection a controlled substance?
Testosterone Cypionate Injection contains Testosterone, a Schedule III controlled substance in the Controlled Substances Act. Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects.
What are the precautions for testosterone injections in mice?
Precautions. There is suggestive evidence that injection of Testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.
What is the purpose of testosterone injection?
Indications and Usage for Testosterone. Testosterone cypionate injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous Testosterone.
Which conditions are contraindications for treatment with testosterone?
The following conditions are contraindicated with this drug....Conditions:breast cancer in a male patient.cancer of the prostate gland.polycythemia vera.increased calcium in the blood from cancer.diabetes.high cholesterol.overweight.high blood pressure.More items...
Which condition is an indication for a primary healthcare provider to prescribe Danazol for a female patient?
Danazol is used to treat endometriosis.
Which condition is an indication for a primary health care provider to prescribe Danazol?
This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease).
Which location would be used for placing a transdermal patch of testosterone on a patient for the treatment?
Apply the patch to a clean, dry area of the skin on your back, abdomen or stomach, thighs, or upper arm. Do not put the patch over burns, cuts, or irritated skin. Avoid putting the patch on oily or sweaty skin, or on areas covered with hair, since the patch may not stick tightly to these areas.
What class of drug is testosterone?
Testosterone is in a class of medications called androgenic hormones.
Which drug will be prescribed for a patient who presents with erectile dysfunction?
Sildenafil. Sildenafil (Viagra), whose labeling was approved by the U.S. Food and Drug Administration (FDA) in March 1998, is the first oral medication to be marketed for the treatment of erectile dysfunction.
Is danazol safe during pregnancy?
Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to have a negative pregnancy test before you begin taking this medication. Start taking this medication during your menstrual cycle to be sure you are not pregnant.
What is indication of danazol?
Danazol capsules are indicated for the prevention of attacks of angioedema of all types (cutaneous, abdominal, laryngeal) in males and females.
What are the side effects of danazol?
Weight gain, acne, flushing, sweating, voice changes (hoarseness, change in pitch), abnormal growth of body hair (in women), vaginal dryness/irritation, or decreased breast size may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Which condition in a patient's history is a contraindication for the administration of estrogens?
Estrogens are contraindicated in patients with an active or past history of stroke, thrombophlebitis, thromboembolism, thromboembolic disease, or myocardial infarction (MI). An increased risk of cerebrovascular disease (stroke) and deep venous thrombosis (DVT) has been reported with unopposed estrogen therapy.
What is testosterone used to treat?
Testosterone is used primarily to treat symptoms of sexual dysfunction in men and women and hot flashes in women. Potential benefits include improved libido, increased bone mass, and increased sense of well-being.
What are the side effects of testosterone patches?
Itching, irritation, and discomfort at the application site may occur during the first few days as your body adjusts to the patch. Other side effects may include acne, headache, hair loss, anxiety, and a change in sexual desire. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
INDICATIONS AND USAGE
DEPO-Testosterone Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.
DOSAGE AND ADMINISTRATION
Prior to initiating DEPO-Testosterone (testosterone cypionate), confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least...
WARNINGS
Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.
ADVERSE REACTIONS
Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur...
DRUG ABUSE AND DEPENDENCE
DEPO-Testosterone Injection contains testosterone, a Schedule III controlled substance in the Controlled Substances Act...
DESCRIPTION
DEPO-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone.
CLINICAL PHARMACOLOGY
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the...
What happens if you get a testosterone injection?
Testosterone undecanoate injection (Aveed) may cause serious breathing problems and allergic reactions, during or immediately after the injection. The injection should be given by a doctor or nurse in a healthcare setting where these problems or reactions can be treated. You will need to remain in the healthcare setting for at least 30 minutes after you receive your injection. Tell your doctor or nurse immediately if you experience any of the following symptoms during or after your injection: tightening of your throat, difficulty breathing, difficulty swallowing, shortness of breath, cough or urge to cough, chest pain, dizziness, fainting, sweating, rash, hives, or itching.
Why is testosterone low at night?
Testosterone levels can temporarily lower due to too much exercise, poor nutrition, severe illness, and with certain medications.
Conditions
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Are you currently using testosterone intramuscular?
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What is the USP for testosterone?
Testosterone Cypionate Injection, USP, for intramuscular injection, contains Testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone Testosterone. Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air.
When should androgen therapy be used?
Premature and low-birth weight infants may be more likely to develop toxicity. Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months.
How to confirm hypogonadism before cypionate injection?
Prior to initiating Testosterone cypionate injection, confirm the diagnosis of hypogonadism by ensuring that serum Testosterone concentrations have been measured in the morning on at least two separate days and that these serum Testosterone concentrations are below the normal range.
How long does it take to get testosterone cypionate?
Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone cypionate can be given at intervals of two to four weeks.
What determines the half life of testosterone?
Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of Testosterone between free and bound forms, and the free Testosterone concentration will determine its half-life.
Is testosterone cypionate a controlled substance?
Controlled Substance. Testosterone cypionate injection contains Testosterone, a Schedule III controlled substance in the Controlled Substances Act. Abuse. Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects.
Can you use testosterone cypionate with testosterone propionate?
If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized. Testosterone cypionate should not be used interchangeably with Testosterone propionate because of differences in duration of action. Testosterone cypionate is not for intravenous use.