
Treatment of advanced NSCLC may begin with treating metastases (tumors that have spread to distant locations). Surgery and radiation therapy, followed by chemotherapy, may be able to treat or cure one or a few distant metastases. Most people with stage 4 NSCLC have cancer that has spread widely throughout the body.
Full Answer
What is the life expectancy of someone with Stage 4 lung cancer?
The median stage 4 non-small cell lung cancer life expectancy—the time at which 50 percent of patients are alive and 50 percent have passed away—is only around eight months. The five-year survival rate—that is, the percent of people who are expected to be alive five years after a diagnosis of stage 4 lung cancer—is sadly only 4 percent.
What is the best treatment for Stage 4 lung cancer?
- Pembrolizumab (Keytruda), atezolizumab (Tecentriq), or cemiplimab (Libtayo) alone
- Pembrolizumab or atezolizumab, along with chemo
- Nivolumab (Opdivo) and ipilimumab (Yervoy), possibly along with chemo
How bad is Stage 4 lung cancer?
Your risk for ovarian cancer may be increased if you have gone through menopause, have a gene mutation like BRCA1 or BRCA2, are obese or overweight, had your first pregnancy after age 35 or never carried a pregnancy to full-term, have a family history of cancer or used hormone replacement therapy.
What are the chances of surviving Stage 4 lung cancer?
Patients with metastatic (stage 4) non-small cell lung cancer that’s spread to distant organs or regions of the body have a five-year relative survival rate of 7 percent, according to ACS. For metastatic (stage 4) small cell lung cancer that’s widespread in the body, the five-year relative survival rate is 3 percent.

How long can you live with stage 4 non-small-cell lung cancer?
Background: Most lung cancer patients worldwide [stage IV nonsmall cell lung cancer (NSCLC)] have a poor survival: 25%–30% die <3. months. Yet, of those surviving >3 months, 10%–15% (70,000–105,000 new patients worldwide per year) survive (very) long.
How long can you live with stage 4 lung cancer that has spread?
Stage 4 lung cancer is the most advanced stage of lung cancer. In stage 4, the cancer has spread, or metastasized, to both lungs, the area around the lungs, or distant organs....What are the survival rates for stage 4 lung cancer?Stage5-year survival rateall stages combined for non-small cell lung cancer25 percent1 more row
What happens when stage 4 lung cancer progresses?
Stage 4 is advanced lung cancer and is metastatic—meaning the cancer has spread from the lung, where it originated, into other parts of the body. Metastasis occurs when cancer cells separate from the original tumor and move through the body via the blood or lymph system.
How long can you live with stage 4 lung cancer with chemo?
One study found that depending on the stage of the metastases (spread) the average survival time following diagnosis of stage 4 lung cancer ranged from 6.3 months to 11.4 months.
How do you know death is near with lung cancer?
The dying person often sweats and, even though the skin is cool, it may feel wet and clammy. They usually stop eating and drinking, and this is normal. They will not feel thirsty or hungry. As death gets closer, the person's breathing may change.
What happens in the final stages of lung cancer that's spread to the brain?
As many as 40% of people with lung cancer develop brain metastases, or brain mets. These are new tumors that form as a result of cancer spreading from the lungs. Brain mets can cause headaches, mood swings, paralysis, and other issues.
How fast can stage 4 lung cancer spread?
Overall Doubling Time On average, lung cancers double in size in four to five months.
What is the life expectancy of someone with metastatic lung cancer?
Lung cancer that spreads to the bones The location of metastasis may also affect a person's survival rate. For example, in one 2018 study , researchers looked at the survival rates for lung cancer that had spread to the bones. They found that the median survival time following diagnosis was about 148 days.
Is stage 4 lung cancer always terminal?
A diagnosis of stage 4 lung cancer indicates that the cancer has spread to the other lung or more distant parts of the body. It is the final stage of lung cancer. There is currently no cure, but certain treatments can prolong life.
Is stage 4 lung cancer a death sentence?
A Diagnosis of Advanced Lung Cancer Is Not a Death Sentence.
Does Chemo work for stage 4 lung cancer?
Chemotherapy. Chemotherapy may be offered for stage 4 non–small cell lung cancer if there are no genetic changes (mutations) that can be identified in the lung cancer tumours using cell and tissue studies. You need to be well enough to have chemotherapy.
What are signs of end of life with cancer?
Signs that death has occurredBreathing stops.Blood pressure cannot be heard.Pulse stops.Eyes stop moving and may stay open.Pupils of the eyes stay large, even in bright light.Control of bowels or bladder may be lost as the muscles relax.
What is stage 4 lung cancer?
Stage 4 Lung Cancer: What to Expect. Stage 4 lung cancer is the most advanced stage of lung cancer. In stage 4, the cancer has spread (metastasized) to both lungs, the area around the lungs, or distant organs. The most common type of lung cancer is non-small cell lung cancer. According to the American Cancer Society, ...
When was stage 4 lung cancer last reviewed?
With preparation, you can be ready to make decisions that’ll maximize your treatment options and comfort. Last medically reviewed on February 3, 2021.
How many lung cancer cases will there be in 2020?
It represents about 12.7 percent of all new cancer cases, the NCI reports, with an estimate of about 229,000 new cases in the United States in 2020.
How much more likely are black men to get lung cancer than white men?
The ACS also indicates that while black women are 14 percent less likely to develop lung cancer than white women, black men are about 15 percent more likely to develop lung cancer than white men, which may be the result of systemic environmental and healthcare-related factors. Response to treatment.
How long do people with stage 4 lung cancer live?
For example, a 5-year survival rate of 6 percent means that people with stage 4 lung cancer are, an average, about 6 percent as likely to survive for at least 5 years as people who don’t have lung cancer. database.
What is the most advanced stage of lung cancer?
Stage 4 lung cancer is the most advanced stage of lung cancer. In stage 4 , the cancer has spread (metastasized) to both lungs, the area around the lungs, or distant organs.
Where does stage 4A cancer spread?
Stage 4a, where the cancer has spread within the lungs or to one area outside the lungs. Stage 4b, where the cancer has spread to several places in one or more organs that aren’t close to the lungs, such as the brain, liver, or bones. According to the National Cancer Institute (NCI), 57 percent. Trusted Source.
What is stage 4 lung cancer?
Coping. Stage 4 non-small cell lung cancer (NSCLC), also called metastatic lung cancer, is the most advanced stage of this disease and refers to any size and type of NSCLC (adenocarinoma, squamous cell carcinoma, large cell carcinoma) that has spread from one lung to the other lung, to another region of the body, ...
How long does it take to live with stage 4 lung cancer?
The median survival time (time at which 50% of patients are alive and 50% have died) is about eight months. 11
What is the best treatment for lung cancer?
Immunotherapy is another newer type of treatment for lung cancer that stimulates your own immune system to recognize and fight cancer cells. 7 People who have tumors that are PD-L1 positive and/or have a high number of mutations (called a high tumor mutational burden) may respond best to these medications. Those who have genomic alterations, such as EGFR mutations, tend not to respond as well.
How long does lung cancer last?
The median survival time (time at which 50% of patients are alive and 50% have died) is about eight months. 11 . Understanding Lung Cancer Survival Rates.
What are the symptoms of cancer metastasis?
As cancer metastasizes, symptoms are related to the area where the cancer has spread. For example: Abdominal pain and jaundice (a yellowing of the skin) from a tumor that has spread to the liver. Headaches, memory loss, vision problems, and weakness if a tumor spreads to the brain .
Do EGFR mutations work for everyone?
Those who have genomic alterations, such as EGFR mutations, tend not to respond as well. While they don't work for everyone, some people with advanced non-small cell lung cancer have experienced long-term control of their disease with these drugs. 8 .
Does radiation kill lung cancer?
Radiation therapy, such as stereotactic body radiotherapy (SBRT), delivers high doses of radiation directly to a tumor to kill it. This won't stop aggressive stage 4 non-small cell lung cancer that has spread, but it may be recommended as palliative therapy.
What is stage 4 lung cancer?
What Is Stage IV (4) Lung Cancer? When this disease has reached stage IV (4), it’s the most advanced. Most patients are diagnosed at stages 3 and 4. Treatment options are much fewer when cancer has advanced this far. At stage IV, tumors have metastasized (spread) from the originating lung to the second lung, to space around the heart, ...
Where do stage IV lung tumors spread?
At stage IV, tumors have metastasized (spread) from the originating lung to the second lung, to space around the heart, lungs (pericardium), chest, lymph nodes, or other areas. At this level, symptoms that develop vary based on the region in the body where the tumors have spread. This differs slightly for every patient.
How do you know if you have stage 4 cancer?
At this level, symptoms that develop vary based on the region in the body where the tumors have spread. This differs slightly for every patient. At stage IV, cancer could have made its way to the bones, at which point symptoms would consist of bone pain or easy breaks. If tumors have metastasized to the liver, a patient could experience nausea, fatigue, bloating, or swelling in the fingers and toes. When cancer makes its way to the brain, it could cause neurological issues like recurring headaches, difficulty with vision, trouble talking, or seizures. More common symptoms of stage 4 include: 1 Back or abdominal pain 2 Excessive coughing or coughing up blood 3 Feeling fatigued or weak 4 Growth in the neck or collarbone area 5 Issues with breathing and loss of breath 6 Lack of a desire to eat
What is the prognosis of an oncologist?
When your oncologist makes a prognosis, they’re predicting how they think the disease will develop and how you’ll react to it. This involves symptoms and side-effects you may experience while you’re sick and undergoing treatment.
What are the symptoms of stage IV cancer?
At stage IV, cancer could have made its way to the bones, at which point symptoms would consist of bone pain or easy breaks. If tumors have metastasized to the liver, a patient could experience nausea, fatigue, bloating, or swelling in the fingers and toes.
What is clinical trial?
Clinical trials are where scientists, doctors, and researchers develop and test new treatments and therapies on patients that sign up. The patient could gain access to new therapies not yet approved by the Food and Drug Administration that are otherwise unavailable.
How to tell if you have stage 4 symtoms?
More common symptoms of stage 4 include: Back or abdominal pain. Excessive coughing or coughing up blood. Feeling fatigued or weak. Growth in the neck or collarbone area. Issues with breathing and loss of breath. Lack of a desire to eat. Talk to a doctor if you have recurring symptoms for an extended period.
What is stage 4 lung cancer?
Stage 4 non-small cell lung cancer (NSCLC) is the most advanced form of the condition and can be the most challenging to treat. At stage 4, the cancer is no longer isolated in one lung. It has spread to either of the following areas:
What is the survival rate for stage 4 cancer?
For stage 4 NSCLC, the 5-year relative survival rate is about 7 percent.
What are the symptoms of stage 4 NSCLC?
It’s often the severity of symptoms that leads people to get a lung cancer screening. The symptoms for stage 4 NSCLC include those for most cases of lung cancer : nagging cough. shortness of breath.
What does it mean to live with NSCLC?
Living with NSCLC means more than treating symptoms and side effects — it also means dealing with the emotional weight of the condition. Managing the emotional aspect of a serious condition like NSCLC is important, and shouldn’t be ignored as you focus on the cancer treatment itself.
What are the symptoms of a cancer diagnosis?
conditions related to your nervous system, such as dizziness, balance problems, muscle weakness or tingling in your limbs. Moffitt Cancer Center specialists note that some symptoms may be more likely to develop based on where the cancer has spread.
What are the symptoms of cancer?
Some of them may include: headache. aches and pains, especially in your bones. jaundice (a yellowing of your skin and eyes) swollen lymph nodes, particularly those near your neck or collarbone.
Is NSCLC stage 4 dying?
In fact, the National Cancer Institute reported in 2020 that NSCLC mortality rates are falling in the United States due to remarkable advances in treatment .
What to do if you have lung cancer?
Tissue biopsy. If your doctor suspects your lung cancer has spread to other organs, you may get a biopsy to confirm or rule out cancer in those areas. Your doctor may use a hollow needle to remove a small sample of tissue from your lymph nodes or liver, for instance. A specialist called a pathologist will look at it under a microscope to see ...
How to treat a tumor in the airway?
Laser therapy. Doctors sometimes use laser procedures to treat small tumors that block your airways. You may find it easier to breathe once these tumors are removed. Radiation. This therapy, which uses high-energy beams to kill tumor cells, can shrink your tumors' size and ease pain.
Why do tumors grow so quickly?
For example, some tumor cells grow quickly because they make too much of a protein called EGFR. Drugs called EGFR inhibitors, like amivantamab-vmiw ( Rybrevant ), erlotinib ( Tarceva) and osimertinib ( Tagrisso ), block signals from this protein so the tumor cells don't grow as fast. Immunotherapy.
What is the best way to check for lung cancer?
Your doctor may use X-rays, CT scans, or PET scans to see if new tumors have formed in your body and check how large they are. High-resolution CT and PET scans are good at finding tiny tumors that might not show up on an X-ray. Tissue biopsy. If your doctor suspects your lung cancer has spread to other organs, you may get a biopsy to confirm ...
What is the best treatment for cancer?
This type of medicine activates your immune system to find and destroy cancer cells. Your doctor may suggest drugs called immune checkpoint inhibitors, like nivolumab ( Opdivo) and pembrolizumab ( Keytruda ). Laser therapy. Doctors sometimes use laser procedures to treat small tumors that block your airways.
How do you know if you have lung cancer?
Shortness of breath. Loss of appetite and weight loss. Other symptoms may appear as lung cancer spreads to different parts of your body. If it moves into the brain or spinal cord, you may feel dizzy, get headaches, or have trouble keeping your balance. If it spreads to the liver, your skin and eyes may turn yellow (jaundice).
What does stage IV mean?
If you're in stage IV of non-small-cell lung cancer, it means the disease has spread from the lungs to distant areas of your body, such as the liver, brain, or bones. Although it usually can't be cured, there are a variety of treatments that can slow the cancer's growth and help you manage its symptoms.
What is the last stage of lung cancer?
Last-Stage Lung Cancer: Sign, Treatment and Life Expectancy. Stage 4 is an advanced stage of lung cancer, where the tumor has spread to nearby organs as well as distant organs and tissues. About 40% of people diagnosed with lung cancer are diagnosed at the 4 th stage of cancer. The outlook of last-stage lung cancer is poor ...
What determines the treatment for lung cancer?
Treatment is uniquely determined for every patient based on many factors such as the size of the primary lung cancer, organs and tissues where the lung cancer has spread, age, overall health, etc.
What is endobronchial therapy?
Endobronchial therapies are often used in last-stage lung cancer patients in order to relieve the signs and symptoms caused by a blockage of the airways from the tumor. Available types of endobronchial therapies are: Laser surgery. Brachytherapy.
What are the symptoms of metastatic lung cancer?
If the tumor spreads to the liver, jaundice, a yellowing of the skin and eye whites will appear. Loss of appetite, unintended weight loss, and fatigue are common general signs and symptoms of metastatic lung cancer.
How does lung cancer affect life expectancy?
Some of these factors include: Age – the younger you are, the greater is the possibility for a better life expectancy, compared to older people.
How long does lung cancer last?
The life expectancy of patients with last-stage lung cancer is short, only around eight months. The 5-years survival rate is only 4%, meaning that only 4% of all patients diagnosed with last-stage lung cancer has survived for more than 5 years. These numbers are sadly low, but worldwide, there are many patients who have lived for more ...
How do you know if you have lung cancer?
Common signs and symptoms of last-stage lung cancer include: A persistent cough. Presence of blood in the mucus. Hemoptysis, coughing up blood. Chest pain. Pain in the arms, shoulders, and back. Difficulties breathing.
How does knowing your stage of lung cancer help you?
Knowing the stage helps your doctor choose the right treatments for you. It may also help them gau ge your chances of success with that treatment . One thing your lung cancer stage can’t tell you is how long you’ll live.
What does the letter T stand for in lung cancer?
Lung cancer staging often uses the letters T, N, and M: T stands for your tumor’s size and where it’s located in your lungs or body. N stands for node involvement. This means whether or not your cancer has spread to your lymph nodes near your lungs. M stands for metastasis.
What does it mean when a lung tumor is unresectable?
This means the tumor can’t be measured or it’s unclear how far it has spread. If your doctor says your lung cancer is “unresectable,” that means that surgeons cannot remove it.
What is the stage of NSCLC?
Doctors may also use general stages for NSCLC. Yours may use the TNM system and numbers to stage your cancer in each of these: Occult stage: Cancer cells can be picked up in the mucus you cough up. Your tumor can’t be seen on imaging scans or a biopsy. It’s also called hidden cancer. Stage 0: Your tumor is very small.
Where does lung cancer spread?
Your tumor has spread to other areas of your lungs and chest. It may have spread to the fluid around your lungs (called the pleura) or other organs like your brain. Non-small-cell lung cancer (NSCLC) is a more common type of lung cancer than small cell. One way to describe NSCLC is by its clinical or pathologic stage.
What does 0-4 mean?
This means whether or not your cancer has spread. Lung cancer can spread to your other lung or your liver, bones, brain, kidneys, adrenal glands, or other parts of your body. Your doctor can stage your tumor with these letters, and then be more specific with the numbers 0-4.
How to tell if you have cancer surgery?
If you have cancer surgery, your doctor can look at your tumor and see your cancer’s pathologic stage. This tells your doctor how far the cancer has grown or spread.
What happens if you have stage 4 lung cancer?
If you have stage 4 lung cancer and another party exposed you to the toxins that led to your diagnosis of cancer, you may be eligible to receive compensation for your medical costs, pain, and suffering.
How long can you live with stage 4 cancer?
Stage 4 cancer usually has spread to multiple places in the body, meaning you can live only a few weeks or a few months. In rare cases, some people may survive for several months or even a year with stage 4 cancer, with or without treatment. Some studies have found that attempting to aggressively treat cancer that has reached stage 4 can actually ...
How do doctors treat cancer?
At this point, a doctor may success an alternative to traditional cancer treatments, including: 1 A clinical trial: Researchers may provide experimental treatments for the cancer, all of which may present higher risks than traditional treatments. 2 Palliative care: Doctors may suggest stopping treatment and working to relieve the symptoms of the cancer for the remainder of life. 3 Entering hospice: This type of palliative care focuses on end-of-life preparation.
What is the difference between clinical trial and palliative care?
A clinical trial: Researchers may provide experimental treatments for the cancer, all of which may present higher risks than traditional treatments. Palliative care: Doctors may suggest stopping treatment and working to relieve the symptoms of the cancer for the remainder of life.
What is stage 2 cancer?
Stage 2: often consists of large tumors that are affecting nearby tissues. Stage 3: consists of large tumors that likely have spread into the lymph nodes. Stage 4: advanced or metastatic cancer that has spread to other parts of the body, including other organs. A doctor may initially diagnose cancer at any of these stages.
What is the most advanced stage of cancer?
Stage 4 is the most advanced and most serious cancer diagnosis. Stage 0: a small cancerous tumor that is easy to remove and has little to no chance of spreading. Stage 1: an early-stage cancer that has not spread to the lymph nodes, resulting in a good chance of a cure.
Can chemo affect quality of life?
In fact, for someone who likely only has weeks or months to live, aggressive treatments like chemotherapy may end up causing a significant reduction in quality of life over a period of a few weeks. This can cause the ill person to delay making end-of-life preparations or to delay entering hospice.

Staging
Stage 4 NSCLC Symptoms
- Stage 4 non-small cell lung cancer symptoms may vary based on the location of tumors and how far the cancer has spread. Problems due to the presence of a tumor in the lungs include:4 1. Persistent cough 2. Coughing up blood(hemoptysis) 3. Shortness of breath 4. Hoarseness 5. Pain the chest, back, shoulderor arms 6. Repeated episodes of pneumonia or...
Treatments
- Because stage 4 non-small cell lung cancer has spread beyond the lungs, it is considered inoperable. But stage 4 lung cancer is treatable. New medications have helped people live longer, fuller lives while managing this disease.5
Prognosis
- The overall 5-year survival rate for stage 4 non-small cell lung cancer is approximately only 4% but can be much higher in certain populations. The median survival time (time at which 50% of patients are alive and 50% have died) is about eight months.13
Coping
- Healthcare providers often say that learning what you can about your lung cancer can improve your quality of life and possibly even your outcome. Ask questions. Learn about clinical trials. Consider joining a support group. Many people hesitate to talk about end-of-life issues, but discussing these with your healthcare provider and your family is associated with fewer feeling…