Treatment FAQ

when lidocaine is used in the treatment of ventricular fibrillation, the recommended dose is:

by Elmer Kassulke Published 2 years ago Updated 2 years ago
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What is the initial dose of lidocaine given for cardiac arrest?

Doses Range from 0.5 to 0.75 mg/kg and up to 1 to 1.5mg/kg. Repeat 0.5 to 0.75 mg/kg every 5-10 minutes with maximum total dose of 3 mg/kg. Maintenance infusion: 1 to 4 mg/min (30-50 mcg/kg/min) Discontinue a lidocaine infusion immediately if signs of toxicity develop.

How is lidocaine used to treat ventricular tachycardia?

Aug 05, 2020 · Lidocaine Dosage: When used to treat cardiac arrest from VT/VF, the initial dose should be 1-1.5 mg/kg IV/IO. For refractory VF, an additional 0.5-0.75 mg/kg IV push may be given, then repeated every 5-10 minutes, with a max of 3 doses or a total of 3 mg/kg.

What is the initial dose for cardiac arrest from ventricular fibrillation?

Jun 01, 2016 · Lidocaine Dosage. Cardiac Arrest from VT / VT: 1 – 1.5 mg/kg via IV/IO. Refractory VF: Additional 0.5 – 0.75 mg/kg via IV/IO; Repeat every 5 – 10 minutes for maximum of 3 doses, or 3 mg/kg. Stable VT: 0.5 – 0.75 mg/kg up to 1.5 mg/kg; Repeat in 0.5 – 0.75 mg/kg doses to maximum of 3 mg/kg.

What is lidocaine for ACLS exam?

Adult Dosage for Lidocaine: Dosage for cardiac arrest from ventricular fibrillation or pulseless ventricular tachycardia: Initial dose is 1 to 1.5 mg/kg IV or IO. Can also be delivered via endotracheal tube. Dosage for refractory ventricular fibrillation: An additional .5 to .75 mg/kg may be given via IV push.

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The Effects of Lidocaine

Lidocaine causes negative inotropic effects and antiarrhythmic actions in the heart that weaken the force of muscular contractions. Lidocaine can calm erratic and uncoordinated electro-myocardial activity.

Lidocaine Precautions & Contraindications

Lidocaine should not be used as a prophylactic treatment in acute myocardial infarction.

Adult Dosage for Lidocaine

Dosage for cardiac arrest from ventricular fibrillation or pulseless ventricular tachycardia:

Usual Adult Dose for Ventricular Fibrillation

Initial dose: 50 to 100 mg IV bolus once over 2 to 3 minutes; may repeat after 5 minutes if necessary not to exceed up to 300 mg in a 1-hour period#N#Following bolus administration: 1 to 4 mg/min continuous IV infusion#N#Comments:#N#-Patients should be under constant ECG monitoring during administration of this drug.#N#-Sufficient time should be allowed to enable a slow circulation to carry this drug to the site of action.#N#-The rate of the IV infusion should be reassessed as soon as the patient's basic cardiac rhythm appears stable or at the earliest signs of toxicity.#N#Uses: For the acute management of ventricular arrhythmias occurring during cardiac manipulations, such as cardiac surgery; and for life-threatening arrhythmias which are ventricular in origin, such as those that occur during acute myocardial infarction#N#The American Heart Association (AHA) recommends:#N#IV:#N#-Initial dose: 1 to 1.5 mg/kg IV bolus once; may repeat if necessary at a dose of 0.5 to 0.75 mg/kg IV every 5 to 10 minutes up to a maximum cumulative dose of 3 mg/kg#N#-Following bolus administration: 1 to 4 mg/min continuous IV infusion (30 to 50 mcg/kg/min)#N#Endotracheal: May be administered endotracheally (bolus dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose diluted in 5 to 10 mL NS or distilled water#N#Uses: For the treatment of ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT) unresponsive to CPR, defibrillation, and vasopressor therapy as an alternative to amiodarone.

Usual Adult Dose for Ventricular Tachycardia

Initial dose: 50 to 100 mg IV bolus once over 2 to 3 minutes; may repeat after 5 minutes if necessary not to exceed up to 300 mg in a 1-hour period#N#Following bolus administration: 1 to 4 mg/min continuous IV infusion#N#Comments:#N#-Patients should be under constant ECG monitoring during administration of this drug.#N#-Sufficient time should be allowed to enable a slow circulation to carry this drug to the site of action.#N#-The rate of the IV infusion should be reassessed as soon as the patient's basic cardiac rhythm appears stable or at the earliest signs of toxicity.#N#Uses: For the acute management of ventricular arrhythmias occurring during cardiac manipulations, such as cardiac surgery; and for life-threatening arrhythmias which are ventricular in origin, such as those that occur during acute myocardial infarction#N#The American Heart Association (AHA) recommends:#N#IV:#N#-Initial dose: 1 to 1.5 mg/kg IV bolus once; may repeat if necessary at a dose of 0.5 to 0.75 mg/kg IV every 5 to 10 minutes up to a maximum cumulative dose of 3 mg/kg#N#-Following bolus administration: 1 to 4 mg/min continuous IV infusion (30 to 50 mcg/kg/min)#N#Endotracheal: May be administered endotracheally (bolus dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose diluted in 5 to 10 mL NS or distilled water#N#Uses: For the treatment of ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT) unresponsive to CPR, defibrillation, and vasopressor therapy as an alternative to amiodarone.

Usual Adult Dose for Cardiac Arrhythmia

Initial dose: 50 to 100 mg IV bolus once over 2 to 3 minutes; may repeat after 5 minutes if necessary not to exceed up to 300 mg in a 1-hour period#N#Following bolus administration: 1 to 4 mg/min continuous IV infusion#N#Comments:#N#-Patients should be under constant ECG monitoring during administration of this drug.#N#-Sufficient time should be allowed to enable a slow circulation to carry this drug to the site of action.#N#-The rate of the IV infusion should be reassessed as soon as the patient's basic cardiac rhythm appears stable or at the earliest signs of toxicity.#N#Uses: For the acute management of ventricular arrhythmias occurring during cardiac manipulations, such as cardiac surgery; and for life-threatening arrhythmias which are ventricular in origin, such as those that occur during acute myocardial infarction#N#The American Heart Association (AHA) recommends:#N#IV:#N#-Initial dose: 1 to 1.5 mg/kg IV bolus once; may repeat if necessary at a dose of 0.5 to 0.75 mg/kg IV every 5 to 10 minutes up to a maximum cumulative dose of 3 mg/kg#N#-Following bolus administration: 1 to 4 mg/min continuous IV infusion (30 to 50 mcg/kg/min)#N#Endotracheal: May be administered endotracheally (bolus dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose diluted in 5 to 10 mL NS or distilled water#N#Uses: For the treatment of ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT) unresponsive to CPR, defibrillation, and vasopressor therapy as an alternative to amiodarone.

Usual Adult Dose for Anesthesia

Local Injectable Anesthesia:#N#-Maximum individual dose: 4 mg/kg (IV regional anesthesia); 4.5 mg/kg (infiltration)#N#-Maximum total dose: 300 mg#N#Comments:#N#-The manufacturer product information should be consulted.#N#-Dose varies with procedure, depth of anesthesia and degree of muscle relaxation needed, duration of anesthesia required, and physical condition of patient.#N#-For continuous epidural or caudal anesthesia, the maximum recommended dose should not be administered at intervals of less than 90 minutes.#N#-The maximum recommended dose per 90-minute period for paracervical block is 200 mg total.#N#-In all cases the lowest effective dose that will produce the desired result should be used.#N#Use: For the production of local or regional anesthesia by infiltration techniques such as percutaneous injection and IV regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.

Usual Pediatric Dose for Ventricular Fibrillation

The manufacturer gives no specific dosing instructions.#N#The AHA recommends:#N#IV:#N#-Initial dose: 1 mg/kg IV or intraosseous once#N#-Maintenance infusion: 20 to 50 mcg/kg/min IV#N#Endotracheal: May be administered endotracheally (bolus dose only) if IV or intraosseous access unavailable at a dose of 2 to 3 times the dose (2 to 3 mg/kg) followed by a flush with at least 5 mL of NS and 5 consecutive positive-pressure ventilations#N#Use: For use in shock-refractory VF or pVT after resuscitation from cardiac arrest in infants and children.

Usual Pediatric Dose for Ventricular Tachycardia

The manufacturer gives no specific dosing instructions.#N#The AHA recommends:#N#IV:#N#-Initial dose: 1 mg/kg IV or intraosseous once#N#-Maintenance infusion: 20 to 50 mcg/kg/min IV#N#Endotracheal: May be administered endotracheally (bolus dose only) if IV or intraosseous access unavailable at a dose of 2 to 3 times the dose (2 to 3 mg/kg) followed by a flush with at least 5 mL of NS and 5 consecutive positive-pressure ventilations#N#Use: For use in shock-refractory VF or pVT after resuscitation from cardiac arrest in infants and children.

Usual Pediatric Dose for Anesthesia

3 years or older with normal lean body mass and normal body development: Maximum dose based on patient's age and weight#N#Comments:#N#-The manufacturer product information should be consulted.#N#-Dose varies with procedure, depth of anesthesia and degree of muscle relaxation needed, duration of anesthesia required, and physical condition of patient.#N#-In all cases the lowest effective dose that will produce the desired result should be used.#N#Use: For the production of local or regional anesthesia by infiltration techniques such as percutaneous injection and IV regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.

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Description

  • Lidocainealso known as Xylocaineis a medication that blocks the transmission of information along the sensory nerves. Sensory nerve cells in the body collect information from organs such as the skin, eyes, and ears. This information is then transmitted to the brain. One type of sensory information is pain.
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Treatment

  • Intra-articular infusions of local anesthetics following arthroscopic and other surgical procedures is un approved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions. The majority of reported cases of chondrolysis have involved the shoulder joint; cases of gleno-humeral chondrolysis have been described in pediatric and adult p…
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  • Other forms of topical lidocaine, such as creams, can be absorbed at various rates depending on the condition of the skin. When the skin is irritated and inflamedsuch as what happens with burns or laser hair removalthe medicine could absorb much more quickly than expected, causing an overdose. Lidocaine overdose treatment depends on which signs and symptoms the patient is e…
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Medical Uses

  • Lidocaine Hydrochloride Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these …
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  • Lidocaine is commonly used as a numbing agent during dental procedures and is increasingly being used as a pain reliever in other settings. Lidocaine is especially useful in patients for whom there is a legitimate concern about the potential for abuse of more addictive and mind-altering pain medications.
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  • 1. Lidocaine patch 5% is indicated for relief of pain associated with post-herpetic neuralgia. It should be applied only to intact skin.
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Side Effects

  • Use in the Head and Neck Area: Small doses of local anesthetics injected into the head and neck area, including retrobulbar, dental and stellate ganglion blocks, may produce adverse reactions similar to systemic toxicity seen with unintentional intravascular injections of larger doses. Confusion, convulsions, respiratory depression and/or respiratory arrest and cardiovascular stim…
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  • Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. 1. Irritation at the application site. 2. Dizziness. 3. Nervousnes…
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Interactions

  • Clinically Significant Drug Interactions: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe prolonged hypertension. Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine. Drug Laboratory Test I…
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  • Patients with suspected lidocaine overdoses should have reduced epinephrine doses of less than 1 microgram per kilogram.
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  • Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any …
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Toxicity

  • Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of lidocaine required to produce overt systemic effects. Objective adverse manifestations become increasingly apparent with increase venous plasma levels about 6.0 mcg free base per mL. In the rhesus monkey arterial blood levels of 18-21 mcg/mL have been shown to be threshold for conv…
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Contraindications

  • Lidocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type. LIDOCAINE HYDROCHLORIDE INJECTION, FOR INFILATRATION AND NERVE BLOCK SHOULD BE EMPLOYED ONLY BY CLINICIANS WHO ARE WELL VERSED IN DIAGNOSIS AND MANAGEMENT OF DOSE-RELATED TOXICITY AND OTHER ACUTE EMERGENC…
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Pharmacology

  • Mechanism of action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Pharmacokinetics and metabolism: Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral a…
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Administration

  • Pediatric Use: Dosages in pediatric patients should be reduced, commensurate with age, body weight and physical condition. See DOSAGE AND ADMINISTRATION.
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Adverse Effects

  • Drowsiness following the administration of lidocaine is usually an early sign of high blood level of the drug and may occur as a consequence of rapid absorption.
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  • Depending on the patch, a patient could inadvertently receive significant dosages of transdermal medications, including lidocaine.
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