Common allopurinol side effects may include: an increase in gout attacks when you first starting taking allopurinol oral; rash; drowsiness;
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How does allopurinol work to treat gout?
· Common allopurinol side effects may include: an increase in gout attacks when you first starting taking allopurinol oral; rash; drowsiness; fever, chills; abnormal liver function tests; nausea, diarrhea; or. joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
What class of drug is allopurinol?
SIDE EFFECTS. -Anorexia, NVD, stomatitis, dizziness, HA, rash, pruritus, malaise, metallic taste, diaphoresis, edema, erectile dysfunction, peripheral neuropathy. ADVERSE EFFECTS. AR. • Cataracts, retinopathy, bradycardia, depression, LT. • Bone marrow depression, aplastic anemia, thrombocytopenia, neutropenia, agranulocytosis, leukopenia.
What should I know before taking allopurinol?
Doses of <300 mg may be given a single daily dose. IV: 200 - 400 mg / and square / day, up to 600 mg / day, as a single daily dose or in divided doses Q 8 - 24 HR. Adverse reaction. Cv: hypertension, Flushing, hypertension, bradycardia, and heart failure, reporting with iv administration. CNS: draw a penis.
What are the adverse effects of allopurinol?
Allopurinol side effectsskin rash.diarrhea.nausea.changes in your liver function test results.gout flare-up (if you have gout)
What is the most serious side effect on the use of allopurinol?
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
What adverse event is associated with allopurinol zyloprim )?
The most frequent adverse reaction to ZYLOPRIM (allopurinol) is skin rash. Skin reactions can be severe and sometimes fatal. Therefore, treatment with ZYLOPRIM (allopurinol) should be discontinued immediately if a rash develops (see WARNINGS).
Why is allopurinol contraindicated in gout?
Sometimes starting allopurinol can trigger a gout attack. This is because some of the crystals can dislodge into the joint as they get smaller which can cause an attack. You may be given another medicine to reduce the risk of these attacks.
Does gout medication have side effects?
Other side effects of NSAIDs include headaches, dizziness, rashes, aggravation of asthma, heart and kidney problems, and increased blood pressure.
Does allopurinol make gout worse?
Allopurinol Doesn't Worsen Acute Gout Attacks.
What is the contraindication of allopurinol?
Contraindications / Precautions Gout flares may occur after initiation of urate lowering therapy, such as allopurinol, due to changing serum uric acid concentrations resulting in mobilization of urate from tissue deposits. If a gout flare occurs during treatment, allopurinol does not need to be discontinued.
What is the action of allopurinol?
Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopurinol is used to prevent gout attacks, not to treat them once they occur.
Can allopurinol cause joint pain?
A rare, but serious side effect of allopurinol is that the medication can cause an allergic reaction. Symptoms include fever, chills, nausea, vomiting, joint pain, and skin rash. If you develop any of these symptoms stop the medication and contact your healthcare provider.
What should you monitor when taking allopurinol?
VI. Monitoring: Obtain 6 weeks after starting AllopurinolComplete Blood Count (CBC)Alanine Aminotransferase (ALT)Serum Creatinine.Serum Uric Acid.
What should you assess before giving allopurinol?
Assess heart rate, ECG, and heart sounds, especially during exercise (See Appendices G, H). Report an abnormally slow heart rate (bradycardia) or symptoms of other arrhythmias such as including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness.
Can allopurinol cause bleeding?
These could be symptoms of bone marrow suppression. This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily.
Before Taking This Medicine
You should not take allopurinol if you are allergic to it.To make sure you can safely take allopurinol, tell your doctor if you have any of these o...
How Should I Take Allopurinol?
Take allopurinol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directio...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Allopurinol Dosing Information
Usual Allopurinol Adult Dose for Gout:Initial: 100 mg orally once a day.Maintenance: 200 to 300 mg (mild gout) orally once a day or 400 to 600 mg/d...
What Other Drugs Will Affect Allopurinol?
Tell your doctor about all other medicines you use, especially: 1. azathioprine (Imuran); 2. chlorpropamide (Diabinese); 3. cyclosporine (Gengraf,...
What are the most common adverse reactions to gout?
Skin rash is one of the most common adverse reactions and may occur at any time during treatment. Some skin reactions can be severe and sometimes fatal. In patients with the most severe reactions, systemic symptoms such as fever, chills, arthralgia, cholestatic jaundice, eosinophilia and mild leukocytosis, or leukopenia accompany the rash. Among 55 patients with gout who received this drug for an average of 1 year (3 to 34 months), 3% developed pruritic maculopapular skin eruptions, sometimes scaly or exfoliative. The incidence of skin rash appears to be greater in patients with renal insufficiency.
What is the Associated Vasculitis and tissue responses?
Associated vasculitis and tissue responses may manifest as hepatitis, interstitial nephritis, and very rarely epilepsy. When generalized hypersensitivity reactions have occurred, renal and or/hepatic disorders have often been present, particularly when the outcome has been fatal.
How many patients have reaction to parenteral product?
Injection site reactions have been reported with the parenteral product in less than 1% of patients. [ Ref]
What is generalized hypersensitivity?
Generalized hypersensitivity including skin reactions associated with exfoliation, fever, lymphadenopathy, arthralgia, and/or eosinophilia resembling Stevens-Johnson and/or Lyell syndromes have occurred rarely. Associated vasculitis and tissue responses may manifest as hepatitis, interstitial nephritis, and very rarely epilepsy. When generalized hypersensitivity reactions have occurred, renal and or/hepatic disorders have often been present, particularly when the outcome has been fatal.
Does allopurinol need medical attention?
Side effects not requiring immediate medical attention. Some side effects of allopurinol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Does allopurinol cause pain?
Along with its needed effects, allopurinol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking allopurinol: More common. Ankle, knee, or great toe joint pain.
Does Xanthine cause crystalluria?
Xanthine crystalluria has been reported in 3 patients; 2 patients with Lesch-Nyhan syndrome and 1 patient with lymphosarcoma who produced an extremely large amount of uric acid during chemotherapy.
Why is colchicine given early in therapy?
Colchicine and NSAIDS given early in therapy to avoid precipitating factors.
What is the effect of Rasburicase on the body?
Rasburicase- enhance urica acid metabolism (think raspberries increase your metabolism).
Is allopurinol metabolized by xanthine oxidase?
Both are purine analogues also metabolized by xanthine oxidase, we need to reduce the amount so of these drugs given to patients on allopurinol.
Does hyperuricemia lead to gout?
Hyperuricemia does not always lead to gout, but gout is always preceded by hyperuricemia.
Is Aspergillus uricase recombinant?
Recombinant version of Aspergillus uricase (Rasburicase) is available in the US.
What is allopurinol used for?
What is allopurinol and how is it used? Allopurinol (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. Taken regularly, it can stop attacks of gout and help prevent damage to your joints. It can also be used for treating kidney stones.
What to do if you get a rash while taking allopurinol?
If you become dizzy or drowsy while taking allopurinol, do not drive or operate machinery , and see your doctor as soon as possible. You should also speak to your doctor if you develop any new symptoms that worry you.
Can you stop taking allopurinol if you have gout?
If you do have an acute attack of gout while on allopurinol, don ’t stop taking it. If you’re unable to continue taking allopurinol because of your side effects, you may be able to take febuxostat instead, which works in a similar way to allopurinol.
Can allopurinol cause gout?
Sometimes starting allopurinol can trigger a gout attack. This is because some of the crystals can dislodge into the joint as they get smaller which can cause an attack.
Can you restart allopurinol?
Most people who take allopurinol don’t get any side effects. But if you do have side effects, it may be possible to restart allopurinol using a special ‘desensitisation’ course. This involves beginning allopurinol at a very low dose and increasing the dose gradually.
Can you stop gout attacks?
you stop having gout attacks – stopping your treatment can cause urate crystals to form again, which will lead to more gout attacks.
Do you need to take allopurinol for the rest of your life?
It is likely that you will need to take allopurinol for the rest of your life to manage your urate levels. You should keep taking allopurinol even if:
Why is allopurinol prescribed?
Allopurinol is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body.
How long does it take to get the full effect of allopurinol?
Your doctor will probably start you on a low dose of allopurinol and gradually increase your dose, not more than once a week. It may take several months or longer before you feel the full benefit of allopurinol.
Can you get pregnant while taking allopurinol?
If you become pregnant while taking allopurinol, call your doctor. you should know that allopurinol may make you drowsy.
What to tell your doctor before taking allopurinol?
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
Does allopurinol make you drowsy?
you should know that allopurinol may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.