What are the side effects of Torisel?
low potassium level - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. Side effects such as diarrhea, swelling, and breathing problems may be more likely in older adults. Common Torisel side effects may include: abnormal blood tests.
How often should Torisel be given for cancer?
Torisel is usually given once each week unless your cancer progresses or you have serious side effects from this medicine. You may be given medication to prevent certain side effects while you are receiving this medicine. Torisel can lower blood cells that help your body fight infections and help your blood to clot.
Can I use Torisel If I am pregnant?
Do not use Torisel if you are pregnant. It could harm the unborn baby. Use an effective form of birth control while you are using this medication and for at least 3 months after your treatment ends.
What are the uses of Torisel?
Torisel is used to treat cancer of the kidneys, also called renal cell carcinoma. Torisel may also be used for purposes not listed in this medication guide. You should not use Torisel if you are allergic to temsirolimus or if you have severe liver disease. Do not use Torisel if you are pregnant. It could harm the unborn baby.
Is Torisel a chemotherapy?
Torisel is the trade name for the generic chemotherapy drug Temsirolimus . In some cases, health care professionals may use the generic name Temsirolimus when referring to the trade drug name Torisel.
How long can you take Sunitinib?
Recommended dosage for advanced renal cell carcinoma (RCC) SUTENT is taken once every day for 4 weeks (28 days), then it is stopped for 2 weeks (14 days). This is 1 cycle of treatment. This cycle is repeated for as long as your doctor tells you to.
What is Torisel used for?
Torisel is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Torisel is used to treat cancer of the kidneys, also called renal cell carcinoma. Torisel may also be used for purposes not listed in this medication guide.
Is temsirolimus a chemotherapy?
Temsirolimus is the generic name for the trade name chemotherapy drug Torisel. In some cases, health care professionals may use the trade name Torisel when referring to the generic drug name Temsirolimus.
How long can you survive Sutent?
Progression-free survival was 24.1 weeks with Sutent compared to 6.0 with placebo. Progression-free survival for patients with pancreatic neuroendocrine tumors (pNET) was 10.2 months with Sutent and 5.4 months with placebo.
Is sunitinib a chemotherapy?
Sutent is used to treat certain types of cancer, but it is considered a targeted treatment, rather than a traditional chemotherapy drug. Sutent (sunitinib) works by inhibiting receptors that exist on the surface of some cells called receptor tyrosine kinases (RTKs).
Is temsirolimus an immunotherapy?
The mTOR inhibitors are also immunosuppressants and are used clinically to prevent rejection following solid-organ transplant. Novel immunotherapies are being actively developed for immunoresponsive tumours, such as RCC and melanoma.
How do mTOR inhibitors work?
What are MTOR inhibitors? Mammalian target of rapamycin (mTOR) inhibitors block the activity of the mammalian target of rapamycin. Mammalian target of rapamycin is a protein kinase, which regulates growth factors that stimulate cell growth and angiogenesis. In certain cancers the mTOR pathway is more active.
What is Avastin made from?
Avastin contains bevacizumab, a recombinant humanised monoclonal antibody produced by DNA technology. The applicant sought a marketing authorisation for Avastin in combination with 5- fluorouracil/folinic acid containing regimens for the first-line treatment of patients with metastatic carcinoma of the colon or rectum.
What is the medication temsirolimus used for?
Temsirolimus is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the kidney). Temsirolimus is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.
What kind of drug is temsirolimus?
Temsirolimus is a type of targeted cancer drug treatment called an mTOR inhibitor. It blocks the effects of a protein called mTOR that is often over active in cancer cells.
Is temsirolimus FDA approved?
FDA Approves Temsirolimus for the Treatment of Advanced Kidney Cancer. Wyeth Pharmaceuticals recently announced that the US Food and Drug Administration (FDA) has approved temsirolimus (Torisel) for patients with advanced renal cell carcinoma (RCC).
How Torisel Is Given
Torisel is given as an injection into the vein (intravenous, IV). The amount of Torisel that you will receive will be prescribed by your doctor based on established dosing guidelines.
Precautions
Before starting Torisel treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
Self-Care Tips
Drink 2 to 3 quarts of fluid every 24 hours, unless you were told to restrict your fluid intake, and maintain good nutrition. This will decrease your chances of being constipated, and prevent dehydration.
Monitoring and Testing
You will be checked regularly by your health care professional while you are taking Torisel, to monitor side effects and check your response to therapy. Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys and liver) will also be ordered by your doctor.
How Torisel Works
Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly.
What is the best treatment for metastatic RCC?
People with metastatic RCC may benefit from cytoreductive surgery. This is a procedure that involves removing the primary cancer in the kidneys. It also removes some or all the cancer that has spread to other parts of the body.
What is clinical trial?
Clinical trials. If you’ve tried one or more of the treatment options above with limited success, you may want to consider participating in a clinical trial. Clinical trials offer you access to experimental treatments. This means they haven’t yet been approved by the FDA.
How does targeted therapy work?
Targeted therapy drugs work by attacking specific molecules within your cells and slowing the growth of tumors. There are many different targeted therapy drugs available.
Can you have cancer removed with surgery?
Surgery can remove the cancer and ease some of your symptoms. It can also improve survival, especially if you undergo surgery before beginning targeted therapy. However, there are risk factors that you should consider before choosing this treatment method. Talk to your doctor for more information.
Can you take a targeted therapy drug at a time?
Targeted therapy drugs are typically used one at a time. However, researchers. are experimenting with newer targeted therapies as well as combination therapy. So, if the drug you’re currently taking isn’t working, you may be able to try a different drug or combine with another drug under this family of chemotherapies.
How many women refused breast cancer surgery?
It compared patients who refused breast cancer with those that those that accepted surgery. Only 1.3% of women (70) refused surgery. Of that group, 37 had no treatment, 25 had hormone-therapy only, and 8 had other types of treatments.
Is treatment without risk?
No treatment is without some sort of risk. And a decision to decline treatment has its own risks. One of the challenges that I confront regularly as a pharmacist is helping patients understand a medication’s expected long-term benefits against the risks and side effects of treatment.
Is CAM a substitute for medicine?
Surveys suggest the vast majority of consumers with medical conditions use CAM in addition to, rather than as a substitute for medicine – that is, it is truly “complementary”. But there is a smaller population that uses CAM as a true “alternative” to medicine.
Can you opt out of follow up on cancer?
Most patients who decide to opt-out of cancer treatment, also opt-out of any follow-up evaluation. So tracking down patients, and their outcomes, is essential. The effects of treatment refusals and delay, and the effectiveness of CAM as a substitute, has been evaluated in several groups of patients with breast cancer.
Is it reasonable to say no to palliative care?
Saying “ no” may also be reasonable where the benefits from treatment are expected to be modest, yet the adverse effects from treatments are substantial. These scenarios are not uncommon in the palliative care setting.
Is breast cancer curable?
Breast cancer is well studied, frequently diagnosed, and if detected early, potentially curable. Conventional treatment for early (localized) breast cancer is surgical resection of the tumor, followed by radiation and chemotherapy to reduce the risk of disease recurrence, by killing any residual cancer cells that remain.
What happens if you stop taking TKIs?
You might experience symptoms of withdrawal. If you stop taking TKIs, you might develop withdrawal symptoms, such as skin rash or pain in your bones and muscles. In most cases, these symptoms can be managed with over-the-counter pain relievers. In some cases, your doctor might prescribe corticosteroids to provide relief.
How long can you stay in remission after TKI?
But some people can stop TKI therapy and stay in remission for several months or longer . According to the Leukemia & Lymphoma Society, you might be a good candidate for attempting treatment-free remission if: the cancer has never progressed past the chronic phase. you’ve been taking a TKI for at least three years.
How long does TKI therapy last?
This is known as relapse. If you obtain remission after treatment with TKIs, your doctor will likely advise you to continue TKI therapy for at least two years to lower your risk of relapse.
What is the first line of treatment for CML?
The recommended first-line treatment for the chronic phase of CML is tyrosine kinase inhibitor (TKI) therapy . This treatment can potentially bring the cancer into remission, which happens when no more than 1 in 32,000 cells in your blood are cancerous.
How long does it take for a cancer patient to relapse?
According to guidelines from the National Comprehensive Cancer Network, approximately 40 to 60 percent of people who attempt treatment-free remission experience relapse within 6 months. When those people restart treatment right away, almost all of them obtain remission again.
Does TKI help with cancer?
TKI therapy can help stop the cancer from progressing. If you decide to stop treatment before the cancer is in remission, CML can get worse. Without effective treatment, CML eventually progresses from the chronic phase to the accelerated and blast crisis phases. In the advanced phases, CML causes more severe symptoms and reduced life expectancy.
Can CML be stopped?
In the advanced phases, CML causes more severe symptoms and reduced life expectancy. Getting treatment during the chronic phase can help stop CML from progressing. It can also improve your chances of obtaining remission. If you’re in remission, you may continue to live a full life for years to come.
