Precautions
Inlyta is used to treat advanced kidney cancer (advanced renal cell carcinoma). Inlyta is sometimes given after at least one other cancer treatment did not work or has stopped working. It is not known if Inlyta is safe and effective in children. Do not use Inlyta if you are pregnant.
What is Inlyta used to treat?
The median duration of treatment was 6.4 months (range 0.03 to 22.0) for patients who received INLYTA and 5.0 months (range 0.03 to 20.1) for patients who received sorafenib.
What is the typical duration of treatment for Inlyta?
If INLYTA is interrupted, patients receiving anti-hypertensive medications should be monitored for hypotension [see DOSAGE AND ADMINISTRATION ]. In clinical trials, arterial thromboembolic events have been reported, including deaths.
What happens if Inlyta is interrupted during treatment?
Is Inlyta chemotherapy or immunotherapy?
Inlyta is considered a targeted treatment, not an immunotherapy drug. It is a tyrosine kinase inhibitor and vascular endothelial growth factor receptor inhibitor (VEGF/VEGFR inhibitor).
Is Inlyta a chemotherapy drug?
No, Inlyta isn't a chemotherapy drug. Chemotherapy drugs work on your whole body to kill any cells that grow quickly. Although this helps kill cancer cells, it also kills many healthy cells in your body.
Is Inlyta targeted therapy?
Inlyta is a targeted therapy that targets and binds to the vascular endothelial growth factor receptors (VEGFR) on the inside of cancer cells. VEGFR is found on the surface of many normal and cancer cells.
Is axitinib an immunotherapy?
Axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Does Inlyta shrink tumors?
Goals of therapy: Axitinib is taken to shrink kidney tumors and decrease symptoms of Renal Cell Carcinoma (RCC).
Is Keytruda a chemotherapy?
KEYTRUDA is not chemotherapy or radiation therapy—it is an immunotherapy and it works with your immune system to help fight cancer. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work.
Does immunotherapy work for renal cell carcinoma?
D. Immunotherapy for kidney cancer—also called renal cell cancer—has tremendously changed the treatment landscape and overall survival of patients with metastatic kidney cancer. The kidneys, located on each side of the body toward the back of the abdominal cavity, filter blood, clear waste, and make urine.
Does Inlyta cause hair loss?
Nausea, vomiting, loss of appetite, dizziness, tiredness/weakness, weight loss, temporary hair loss, cough, headache, altered sense of taste, hoarseness, constipation, or upset stomach may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What is immunotherapy treatments?
Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. The immune system helps your body fight infections and other diseases. It is made up of white blood cells and organs and tissues of the lymph system. Immunotherapy is a type of biological therapy.
Is Inlyta a checkpoint inhibitor?
Keytruda checkpoint inhibitor Inlyta combo FDA approved - new standard treatment for renal cell cancer.
How effective is Keytruda for renal cell carcinoma?
At 24 months median follow-up, patients receiving Keytruda had a 32% reduction in the risk of disease recurrence or death. The 24-month estimated cancer free survival was 77.3% with the addition of Keytruda, compared to 68.1% with placebo. Overall benefit was consistent across all subgroups.
Can Keytruda affect the kidneys?
Inflammation of the kidneys (nephritis) Nephritis, a potentially life-threatening disease which may lead to kidney failure, has uncommonly been reported in patients taking Keytruda (may affect between 1 and 10 in 1,000 patients).
Is Inlyta bad for kidneys?
Inlyta is not usually bad for the kidneys, in fact, research has found no difference with regards to kidney toxicity between patients with advanced...
Can you drink alcohol with Inlyta?
You may drink a small to moderate amount of alcohol with Inlyta if you wish, because there is no direct interaction between alcohol and Inlyta. How...
Why are Bavencio and Inlyta used together?
Bavencio and Inlyta are used together because the combination is more effective than single therapy, reducing the overall risk of disease progressi...
Is Inlyta a chemotherapy drug?
Inlyta is considered a targeted treatment rather than a chemotherapy drug. Inlyta works by targeting specific receptors that exist on the surface o...
How does Inlyta work?
Inlyta is an oral medicine that is an angiogenesis inhibitor and VEGF/VEGFR inhibitor. It works by blocking proteins and signals to help slow down...
How are Inlyta and Keytruda used in kidney cancer?
Inlyta and Keytruda are given as a combination therapy for first-line treatment of kidney cancer (advanced renal cell carcinoma) in adults. Inlyta...
How long does Inlyta last?
When you get Inlyta from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication.
What happens if you don't take Inlyta?
If you no longer need to take Inlyta and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment.
Can I use Inlyta while pregnant?
Inlyta use is not recommended during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Inlyta.
Can you take Inlyta with grapefruit?
Inlyta may interact with grapefruit or grapefruit juice. Consuming grapefruit or grapefruit juice during your Inlyta treatment may cause Inlyta to build up in your body. This can raise your risk for serious side effects.
Does Inlyta work with St John'swort?
Inlyta may interact with an herbal supplement called St. John’s wort. Using Inlyta with this supplement can cause Inlyta to be broken down more quickly in your body. This may make Inlyta less effective.
Is Inlyta a generic?
Inlyta is a brand-name medication that’s not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.
Can I use Inlyta and Bavencio together?
Inlyta is approved for RCC when used along with Bavencio. These drugs can be used together as your first RCC treatment. If you have any questions about using Bavencio with Inlyta, talk with your doctor.
What are the conditions that can cause Inlyta to be changed?
bacterial infections. fungal infections. depression. HIV or AIDS. Ask your doctor or pharmacist if you are not sure if your medicine is one listed above. If you are taking any medicines for the conditions listed above, your doctor might need to prescribe a different medicine or your dose of Inlyta may need to be changed.
How much Inlyta is needed for kidney cancer?
Dosage: Starting dose is 5 mg taken twice a day. How supplied: 5 mg and 1 mg tablets.
Can Inlyta cause protein in urine?
Your doctor should check your urine for protein before and during your treatment with Inlyta. If you develop protein in your urine, your doctor may decrease your dose of Inlyta or stop your treatment. Change in liver function.
Can Inlyta cause bleeding?
Inlyta can cause bleeding which can be serious, and sometimes lead to death. Call your doctor or get medical help if you develop any bleeding, including: unusual bleeding from the gums. menstrual bleeding that is heavier than normal. vaginal bleeding. bleeding that is severe or you cannot control.
Does Inlyta affect other medicines?
Inlyta may affect the way other medicines work and other medicines may affect how Inlyta works.
Can you get pregnant while taking Inlyta?
Taking Inlyta during pregnancy may cause the death of an unborn baby or birth defects. You should not become pregnant while you are taking Inlyta. Talk to your doctor if you are pregnant or plan to become pregnant. are able to become pregnant. You should use effective birth control during your treatment with Inlyta.
Can Inlyta be used for high blood pressure?
High blood pressure (hypertension). Your doctor should check your blood pressure regularly during treatment with Inlyta. If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with Inlyta.
How is Inlyta given?
How Inlyta Is Given: Inlyta is given as a pill by mouth. Swallow whole with a full glass of water. Can be taken with or without food. The amount of Inlyta that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition you have.
What is Inlyta drug?
Drug Type: Inlyta is a targeted therapy and is a receptor protein-kinase inhibitor. It inhibits the actions of vascular growth factor (VEGF) and is an angiogenesis inhibitor.
What is the trade name for Inlyta?
Trade Name: Inlyta®. Axitinib is the generic name for the trade name drug Inlyta®. In some cases, health care professionals may use the trade name Inlyta® when referring to the generic drug name Axitinib. Drug Type: Inlyta is a targeted therapy and is a receptor protein-kinase inhibitor. It inhibits the actions of vascular growth factor (VEGF) ...
What are the side effects of Inlyta?
The following side effects are common (occurring in greater than 30%) for patients taking Inlyta: Diarrhea. High blood pressure (hypertension) This can be the development of high blood pressure or the worsening of pre-existing high blood pressure. Fatigue.
Can you take aspirin with Inlyta?
Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
Can Inlyta cause headaches?
This is a very rare condition that can happen while taking Inlyta. Symptoms include headache, seizure, confusion, blindness or change in vision, or problems thinking. Not all side effects are listed above. Side effects that are very rare -- occurring in less than about 10 percent of patients -- are not listed here.
Is Inlyta safe after therapy?
Inlyta side effects are often predictable in terms of their onset, duration, and severity. Inlyta side effects will improve after therapy is complete. Inlyta side effects may be quite manageable. There are many options to minimize or prevent the side effects of Inlyta.
What is Inlyta used for?
Inlyta is a prescription medicine used to treat kidney cancer that has spread or cannot be removed by surgery (advanced renal cell carcinoma or RCC): in combination with avelumab or pembrolizumab as your first treatment. alone when 1 prior drug treatment regimen for your RCC has not worked.
What does it feel like to vomit on Inlyta?
cough up blood or blood clots. vomit blood or your vomit looks like “coffee grounds”. unexpected pain, swelling, or joint pain. headaches, feeling dizzy or weak. Heart failure. Your healthcare provider should check you for signs or symptoms of heart failure regularly during treatment with Inlyta.
Can Inlyta be used for high blood pressure?
Your healthcare provider should check your blood pressure regularly during treatment with INLYTA. If you develop blood pressure problems, your healthcare provider may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA.
Can Inlyta cause fetal harm?
Based on findings in animal studies, INLYTA can cause fetal harm when administered to a pregnant woman [see Use In Specific Populations ]. When INLYTA is used in combination with avelumab or pembrolizumab, refer to the full prescribing information of avelumab or pembrolizumab for contraception information.
Does Inlyta affect wound healing?
Therefore, INLYTA has the potential to adversely affect wound healing.
Is Inlyta safe with Pembrolizumab?
The safety of INLYTA in combination with pembrolizumab was investigated in KEYNOTE-426 [see Clinical Studies ]. Patients with medical conditions that required systemic corticosteroids or other immunosuppressive medications or had a history of severe autoimmune disease other than type 1 diabetes, vitiligo, Sjogren's syndrome, and hypothyroidism stable on hormone replacement were ineligible. Patients received INLYTA 5 mg orally twice daily and pembrolizumab 200 mg intravenously every 3 weeks, or sunitinib 50 mg once daily for 4 weeks and then off treatment for 2 weeks. The median duration of exposure to the combination therapy of INLYTA and pembrolizumab was 10.4 months (range: 1 day to 21.2 months).
Does Inlyta cause protein in urine?
Your healthcare provider should check your urine for protein before and during your treatment with Inlyta. If you develop protein in your urine, your healthcare provider may decrease your dose of Inlyta or stop your treatment.
What is axitinib used for?
Axitinib is taken to shrink kidney tumors and decrease symptoms of Renal Cell Carcinoma (RCC). Axitinib is not commonly given with the goal of cure.
How many patients discontinue Axitinib?
Side effects sometimes have percentage ranges [example 50 – 55%] because they differed between in clinical studies: On average, 4 - 5% of patients discontinue axitinib due to unacceptable side effects.
How to get rid of stomach acid?
Eating soda crackers every couple of hours may help to absorb some of the acid in your stomach. Your nurse may recommend ginger ale, ginger chews, peppermints, or bland foods when you are feeling nauseated. Ensure you are maintaining proper hydration since being dehydrated can make nausea worse.
Is it unethical to give no treatment?
In clinical trials with patients with cancer, it is sometimes unethical to give no treatment or a placebo. The type of treatment received by the patient is determined by the study protocol. Ask your doctor if they have any clinical trials that are enrolling patients or know if any at treatment centers nearby.
Can you prescribe medication for lab work abnormal?
This way you will have a better understanding if the treatment is working or not. Plus, doctors may prescribe medications when your lab work is abnormal.
What is advanced renal cell carcinoma?
You have two kidneys, which are bean-shaped organs located on either side of the backbone in the mid-back area. Kidney cancer starts when normal cells in the kidney change into abnormal cells. These abnormal cells then grow out of control and may spread.
Why are Inlyta and Keytruda combined?
In general, traditional chemotherapy is not very effective against advanced kidney cancer.
How well does Inlyta and Keytruda work in kidney cancer?
In a clinical trial with 861 patients with advanced renal cell carcinoma, the combination of Keytruda and Inlyta was compared with sunitinib ( Sutent) given alone, another tyrosine kinase inhibitor. Statistically significant results were shown in favor of Keytruda and Inlyta for several clinical outcomes.
Bottom Line
Inlyta (generic name: axitinib) and Keytruda (generic name: pembrolizumab) were approved by the FDA in April 2019 as a combination therapy for first-line treatment of kidney cancer (advanced renal cell carcinoma or RCC) in adults.
What Axitinib Is Used For
Treatment of advanced renal cell carcinoma after the failure of one prior systemic therapy.
Axitinib Precautions
Before starting axitinib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
Axitinib Self-Care Tips
Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
Monitoring and Testing While Taking Axitinib
You will be checked regularly by your doctor while you are taking axitinib, to monitor side effects and check your response to therapy. Periodic blood work will be obtained to monitor your complete blood count (CBC) the function of other organs (such as your kidneys and liver) as well as your thyroid function.
How Axitinib Works
Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly.