Precautions
Drug type: Lupron is a hormone therapy. It is classified as an "LHRH agonist." (For more detail, see "How this drug works" section below). Also used in non-cancerous conditions such as endometriosis, infertility, benign prostatic hypertrophy (BPH).
What is Lupron used to treat?
Generic Name: leuprolide (LOO proe lide) Brand Names: Eligard, Lupron Depot, Lupron Depot-Ped, Lupron, Lupron Depot-Gyn, Viadur. Medically reviewed on Apr 4, 2018. Lupron (leuprolide) overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.
What is the generic name for Lupron (leuprolide)?
Hormone therapies, such as Lupron, are often effective in combination with other treatments for people with late-stage prostate cancer. Many doctors do not recommend hormone therapy during the early stages of this disease.
Is Lupron an effective treatment for prostate cancer?
Doctors often prescribe hormone therapies in combination with radiation therapy or following surgery. They administer Lupron by injecting it under a person’s skin, which they will do between once a month and once every 6 months. Because Lupron lowers testosterone levels, it can cause a range of side effects.
How is Lupron administered for hormone replacement therapy?
Is Lupron considered chemotherapy?
Official answer. Lupron Depot (leuprolide acetate) injection is not a chemotherapy treatment, but a prescription hormone medicine used in the palliative treatment of advanced prostate cancer. Palliative treatment is used to relieve pain or other symptoms and improve the quality of your life.
What type of therapy is Lupron?
LHRH is a naturally occurring hormone that stimulates the production of testosterone in the testes. Lupron effectively blocks LHRH, so it reduces the amount of testosterone in your body. Lupron is a type of hormone therapy used to treat prostate cancer, which is powered by testosterone.
What is the drug flutamide used for?
USES: This medication is used to treat men with prostate cancer. Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone). Testosterone, a natural hormone, helps prostate cancer to grow and spread.
Is flutamide a steroid?
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer.
Is Lupron a biologic?
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty, to perform chemical castration of violent sex offenders, or as part of transgender hormone therapy....Leuprorelin.Clinical dataExcretionKidneyIdentifiers33 more rows
Is Lupron ADT therapy?
LUPRON DEPOT, an androgen deprivation therapy (ADT), has been a pioneer in the treatment of advanced prostate cancer.
Is flutamide a chemotherapy?
Phase II study of flutamide as second line chemotherapy in patients with advanced pancreatic cancer. Invest New Drugs.
What kind of drug is flutamide?
Flutamide is in a class of medications called nonsteroidal antiandrogens. It works by blocking the effects of androgen (a male hormone) to stop the growth and spread of cancer cells.
What are the side effects of flutamide?
Common flutamide side effects may include: breast swelling or tenderness; hot flashes; vomiting, nausea, diarrhea; or....Flutamide side effectsnausea, upper stomach pain, loss of appetite;itching, tiredness, flu-like symptoms;dark urine, clay-colored stools; or.jaundice (yellowing of the skin or eyes).
Does flutamide cause hair loss?
Results: Both groups showed a marked decrease in alopecia scores after 12 months of flutamide therapy, compared with baseline values. The maximum drug effect occurred after 2 years and was maintained during the following 2 years of treatment. Androgens were strongly suppressed.
Does flutamide cause hair growth?
Flutamide and finasteride had a significantly higher effect (P<0.05) than the placebo in all the tested parameters, but flutamide demonstrated more hair per graft and longer hair shafts than finasteride (P<0.05).
Does flutamide increase testosterone?
Flutamide is a nonsteroidal antiandrogen that blocks androgen receptors, with a consequent increase in serum immunoreactive LH (I-LH) in the presence of high testosterone concentrations.
Is leuprolide an immunosuppressant?
Thus, the investigations revealed that leuprolide prevented stress-induced immunosuppression through a peripheral mechanism, which is independent of systemic sex steroids.
Is Lupron A estrogen hormone?
What is the mechanism of action? Lupron is classified as a luteinizing hormone releasing hormone (LHRH) agonist. LHRH is a naturally occurring hormone in the body that is involved in stimulating the production of female and male hormones such as estrogen and testosterone.
Is Lupron a progesterone?
What is Lupron? Lupron (Leuprolide Acetate) is an injectable medication which reduces the production of hormones (estrogen and progesterone) by the ovaries. Lupron works by blocking the effect of Gonadotropin Releasing Hormone (GnRH) on the pituitary gland in the brain.
What is the purpose of Lupron?
LUPRON DEPOT ® (leuprolide acetate for depot suspension) 3.75 mg for 1‑month and 11.25 mg for 3‑month administration are prescription medications used for the management of endometriosis, including pain relief and reduction of endometriotic lesions.
How long should you take Lupron for prostate cancer?
Patients treated with Lupron Depot (leuprolide acetate) for prostate cancer usually continue treatment upon development of castration-resistant pro...
Is Lupron Depot a chemotherapy treatment?
Lupron Depot (leuprolide acetate) injection is not a chemotherapy treatment, but a prescription hormone medicine used in the palliative treatment o...
How do you inject Lupron Depot for prostate cancer?
Lupron Depot (leuprolide acetate) is a depot suspension formulation only injected by your doctor. Lupron Depot is injected into a muscle of your up...
Does Lupron Depot need to be refrigerated?
Before reconstitution, Lupron Depot for treatment of prostate cancer can be stored in its original container at room temperature (77°F [25°C]), wit...
Will I get my period while on Lupron?
In clinical studies evaluating endometriosis, 95% of women started their periods (normal menstrual cycle) in the third month after treatment ended...
What does Lupron do for IVF?
During an vitro fertilization (IVF) protocol, your doctor may use leuprolide (Lupron) injection as part of an ovarian stimulation regimen. Leuproli...
Are Lupron Depot and Eligard the same drug?
Lupron Depot and Eligard are brand name medicines that both contain the active ingredient leuprolide acetate. Both Lupron Depot and Eligard are pre...
How often is luporn depot injected?
Lupron Depot is injected under the skin or into a muscle, once every month or once every 3 to 6 months.
How long does it take for leuprolide to get worse?
Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using Lupron Depot. You may need frequent medical tests while using Lupron Depot.
What is luporn depot used for?
Lupron Depot is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself). Lupron Depot is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.
Is Lupron Depot safe?
Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. To make sure Lupron Depot is safe for you, tell your doctor if you have ever had: depression, mental illness or psychosis; seizures or epilepsy; a blood vessel disorder; a brain tumor or spinal cord injury;
Can you take Lupron Depot if you are allergic to leuprolide?
You should not use Lupron Depot if you are allergic to leuprolide or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.
Does leuprolide cause prostate cancer?
This medicine reduces the amount of testosterone in men or estrogen in women. Lupron Depot is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself).
Can luporn cause birth defects?
Your symptoms may become temporarily worse when you first start using Lupron Depot. Tell your doctor if this continues for longer than 2 months. Call your doctor at once if you have a seizure, or unusual changes in mood or behavior. Lupron Depot can harm an unborn baby or cause birth defects.
What is the role of leuprolide in the brain?
HRH agonists work by telling the pituitary gland located in the brain to stop producing leutinizing hormone, which (in men) stimulates the testicles to release testosterone and (in women) stimulates the ovaries to release estrogen.
What are the trade names for leuprolide?
Chemocare.com uses generic names in all descriptions of drugs. Lupron, Eligard, Lupron Depot, and Viadur are trade names for Leuprolide. In some cases, health care professionals may use the trade names Lupron, Eligard, Lupron Depot, and Viadur when referring to the generic drug name Leuprolide.
What is LHRH agonist?
In treatment of prostate cancer LHRH agonists are often used together with anti-androgen medications. Anti-androgens are substances that block the effects of testosterone. Cancer of the prostate depends on the male hormone testosterone for its growth.
How does testosterone work?
How This Drug Works: Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone, made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair.
What are the side effects of a syringe?
Rare but significant side effects may include heart problems such as congestive heart failure (1%) or problems with blood clots (1%) .
What are the symptoms of a swollen arm?
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Urinary retention or inability to urinate. Weakness, numbness or tingling in arms or legs. The following symptoms require medical attention, but are not an emergency.
How to stop hot flashes?
Consult your health care provider if these worsen, or become intolerable. Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
More About Flutamide
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
Clinical Trials Accepting Patients
Find Clinical Trials for Flutamide - Check for trials from NCI's list of cancer clinical trials now accepting patients.
What is the purpose of LHRH antagonists?
These drugs work in a similar way to LHRH agonists, but they lower testosterone levels much more quickly. LHRH antagonists are a form of chemical castration, and doctors use them to treat people with advanced prostate cancer.
How can hormone therapy help with prostate cancer?
For people with prostate cancer, the aim of hormone therapy is to reduce testosterone levels in the body. Male hormones, such as testosterone, encourage the growth of prostate cancer cells. Therefore, lowering testosterone levels in the body can help slow the progression of prostate cancer. Doctors typically prescribe hormone therapy ...
What is the name of the drug that doctors use to treat prostate cancer?
Alternative treatment. Outlook. Summary. Lupron is the brand name for leuprolide acetate. This drug is a type of hormone therapy that doctors typically use in combination with other treatments to treat people with prostate cancer.
What is luporn used for?
Lupron is a type of hormone therapy for prostate cancer. It works by lowering the amount of testosterone in a person’s body, which helps slow the growth of cancer cells.
What is the best treatment for prostate cancer?
Anti-androgens. These drugs prevent testosterone from working in the body. Doctors usually prescribe anti-androgens in combination with other hormone therapies. The first treatment for people with prostate cancer is often watchful waiting, where a doctor closely monitors a person to see how the disease progresses.
How long do you live with prostate cancer?
According to the ACS, the overall 5-year relative survival rate for prostate cancer is 98 percent. This statistic means that people with prostate cancer are 98 percent as likely to live for at least 5 years following diagnosis as those without the condition.
What is the survival rate of prostate cancer?
For people with cancer that has not spread beyond the prostate or has only spread to nearby tissues or lymph nodes, the 5-year relative survival rate is nearly 100 percent. If the cancer has spread to other areas of the body, such as the lungs, liver, or bones, the 5-year relative survival rate is 30 percent.
What is flutamide used for?
Flutamide is used together with a luteinizing hormone-releasing hormone agonist (LHRH; a type of hormonal injection such as leuprolide [Lupron, Eligard], goserelin [Zoladex], or triptorelin [Trelstar]) to treat certain types of prostate cancer. Flutamide is in a class of medications called nonsteroidal antiandrogens.
What to tell your doctor before taking flutamide?
Before taking flutamide, tell your doctor and pharmacist if you are allergic to flutamide or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (''blood thinners'') ...
Can flutamide cause cancer?
Although it is rare, some men taking flutamide have developed breast cancer. Talk to your doctor about the risks of taking this medication. Flutamide may cause other side effects.
Can flutamide cause liver damage?
Flutamide may cause liver damage that can be serious or life-threatening. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, loss of appetite, extreme tiredness, flu-like symptoms, muscle aches, soreness, pain in the upper right part ...
Does flutamide cause diarrhea?
Flutamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea. nausea. vomiting. loss of appetite. hot flashes. decrease in sexual ability or desire. breast enlargement in men.
Can you take flutamide with LHRH?
Take flutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take flutamide along with the LHRH agonist treatment even if you feel well. Do not stop taking either medication without talking to your doctor.
What happens when you have too much testosterone?
The release of GnRH, LH and FSH is governed by negative feedback which means that when there is too much testosterone or estrogen being produced, the body sends a signal to the pituitary gland to reduce the production of GnRH which , in turn reduces the production of LH and FSH.
What is leuprolide used for?
What is leuprolide, and how does it work (mechanism of action)? Leuprolide is an injectable, man-made hormone that is used for treating prostate cancer, endometriosis, central precocious puberty (early onset of puberty), and fibroids. It is similar to but stronger than human gonadotropin releasing hormone (GnRH).
What is the name of the drug that is used to treat prostate cancer?
Leuprolide (Lupron, Lupron Depot, Lupron Depot-Ped, Eligard) is a man-made hormone injection prescribed for the treatment of prostate cancer, endometriosis, fibroids, and central precocious puberty. Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.
Why should leuprolide not be given to pregnant women?
Leuprolide should not be administered to pregnant women because there is a high chance of harm to the fetus. The effects of leuprolide on the infant have not been studied in women who are breastfeeding.
What are the side effects of leuprolide?
The most common side effects of leuprolide are: 1 aches and pain, 2 fatigue, 3 edema, 4 headaches, 5 hot flashes, 6 chest pain, and 7 irritation at the injection site.
How often is luprolide given?
For prostate cancer, leuprolide can be given daily or Lupron Depot can be given monthly or at 3 to 4 month intervals. The daily dose of leuprolide is 1 mg. The 3.5 and 7.5 mg doses of Lupron Depot are injected monthly, the 11.25 and 22.5 mg doses every three months, ...
When was leuprolide approved?
Leuprolide is used to reduce the production of estrogen and treat both fibroids and endometriosis. The FDA approved leuprolide in April 1985.
What to know before taking leuprolide?
Before using leuprolide, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
How does leuprolide work?
It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult ...
What to tell your doctor before taking a med?
Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, heart disease (such as heart attack ), stroke, high cholesterol, mental/mood problems (such as depression ), seizures.
How often should I stop taking a syringe?
This medication is given by injection under the skin as directed by your doctor, usually once a day. In children, the dosage is based on weight and response to treatment. The doctor should consider stopping treatment before age 11 for girls and age 12 for boys. Consult the doctor for details.
How to use rubbing alcohol for injections?
Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.
How long does it take for a pituitary apoplexy to occur?
Rarely, a very serious problem with your pituitary gland (pituitary apoplexy) may occur, usually in the first hour to 2 weeks after the first injection. Get medical help right away if any of these very serious side effects occur: sudden severe headache, sudden severe mental/mood changes (such as severe confusion, difficulty concentrating), ...
Can leuprolide be taken in breast milk?
It is unknown if leuprolide passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects.
DESCRIPTION
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone.
INDICATIONS
LUPRON INJECTION (leuprolide acetate) is indicated in the palliative treatment of advanced prostatic cancer.
DOSAGE AND ADMINISTRATION
The recommended dose is 1 mg (0.2 mL or 20 unit mark) administered as a single daily subcutaneous injection. As with other drugs administered chronically by subcutaneous injection, the injection site should be varied periodically.
HOW SUPPLIED
LUPRON INJECTION (leuprolide acetate) is a sterile solution supplied in a 2.8 mL multiple-dose vial. The vial is packaged as follows: 14 Day Patient Administration Kit with 14 disposable syringes and 28 alcohol swabs, NDC 0074-3612-30 and six-vial carton, NDC 0074-3612-34.
SIDE EFFECTS
In the majority of patients testosterone levels increased above baseline during the first week, declining thereafter to baseline levels or below by the end of the second week of treatment.
WARNINGS
Initially, LUPRON, like other LH-RH agonists, causes increases in serum levels of testosterone. Transient worsening of symptoms, or the occurrence of additional signs and symptoms of prostate cancer, may occasionally develop during the first few weeks of LUPRON treatment.
PRECAUTIONS
Patients with metastatic vertebral lesions and/or with urinary tract obstruction should be closely observed during the first few weeks of therapy (see WARNINGS and ADVERSE REACTIONS ).
