Treatment FAQ

what treatment is advisable for late stage pancreatic cancer

by Marielle Treutel Published 2 years ago Updated 2 years ago

Erlotinib (Tarceva).
This drug is approved by the FDA for people with advanced pancreatic cancer in combination with the chemotherapy drug gemcitabine. Erlotinib blocks the effect of the epidermal growth factor receptor (EGFR), a protein that can become abnormal and help cancer grow and spread.

Medication

Depending on the type and stage of the cancer and other factors, treatment options for people with pancreatic cancer can include: Surgery for Pancreatic Cancer. Ablation or Embolization Treatments for Pancreatic Cancer. Radiation Therapy for Pancreatic Cancer. Chemotherapy for Pancreatic Cancer. Targeted Therapy for Pancreatic Cancer.

Procedures

The staging could be (T1, N2, M0), (T2, N2, M0), (T3, N2, M0) or (T4, ANY N, M0) The treatment options for pancreatic cancer depend on the stage of cancer, the spreading of the tumour and the location of cancer along with the patient’s symptoms and response to treatment.

Therapy

Stage IV treatment is typically chemotherapy. More choices may also be available through clinical trials. Seeing pancreatic cancer specialists, physicians who diagnose and treat a high volume of pancreatic cancer patients, improves outcomes.

Nutrition

Stage I Treatment. At this stage, many tumors are resectable, or able to be removed through surgery. About 15 to 20 percent of patients with pancreatic adenocarcinoma have surgically resectable tumors. For eligible patients, surgery is the best option for long-term survival of pancreatic cancer.

What is the best treatment for pancreatic cancer?

What are the staging options for pancreatic cancer?

How is stage IV pancreatic cancer treated?

Is Stage 1 pancreatic cancer curable?

Can you survive late stage pancreatic cancer?

Stage IV Prognosis Stage IV pancreatic cancer has a five-year survival rate of 1 percent. The average patient diagnosed with late-stage pancreatic cancer will live for about 1 year after diagnosis.

What is the best treatment for metastatic pancreatic cancer?

Treating Metastatic Pancreatic Cancer Gemcitabine has been the most widely used chemotherapy drug for treating metastatic pancreas cancer. Other drug combinations include gemcitabine with erlotinib (Tarceva), gemcitabine with capecitabine, gemcitabine with cisplatin, and gemcitabine with nab-paclitaxel.

Is chemo Worth it for stage 4 pancreatic cancer?

Chemotherapy (popularly called chemo) could be effective for pancreatic cancer because it may prolong lifespan. Pancreatic cancer is fast progressing. While chemotherapy may not cure cancer, it along with radiation therapy may improve the chances of survival and result in an improved quality of life.

What is the standard treatment for stage 4 pancreatic cancer?

Stage IV patients usually get a treatment that travels through the bloodstream to reach cancer cells that are in many places throughout the body. Stage IV treatment is usually chemotherapy. Clinical trials may also give you more choices. The cancer cannot be removed by surgery (unresectable) at this stage.

What happens in the last stages of pancreatic cancer?

If you are approaching the end of life, the cancer may cause symptoms such as pain, fatigue (extreme tiredness), sickness, weight loss and bowel problems.

How long can you live with pancreatic cancer that has spread to the liver?

However, the median survival time for patients with pancreatic cancer liver metastases has been reported to be <6 months, regardless of whether the patients were treated with hepatic resection or palliative bypass procedures alone. Liver metastases are not resectable in most cases.

What is the longest you can live with Stage 4 pancreatic cancer?

Life expectancy for pancreatic cancer is often expressed in 5-year survival rates, that is, how many people will be alive 5 years after diagnosis. The life expectancy for stage 4 pancreatic cancer is very low, estimated to be about three to five months.

How long does end stage pancreatic cancer last?

The median overall survival of metastatic pancreatic cancer is 8–11 months and the median overall survival of locally advanced (but not metastatic) inoperable pancreatic cancer is 12–14 months [3, 4].

Can you go into remission with stage 4 pancreatic cancer?

Stage IVB pancreatic cancer is also called metastatic. The goal of treatment for patients with localized IVA disease is to induce a remission, or a disease-free period that may last months or years. Management of patients with Stage IVB disease is often aimed at controlling symptoms and pain from the cancer.

Does immunotherapy work for stage 4 pancreatic cancer?

Doctors and scientists around the world are actively investigating immunotherapy for treating a variety of cancers, including pancreatic cancer. “Based on previous and ongoing research, immunotherapy has promising potential for helping doctors treat pancreatic cancer of all stages and severity,” says Zheng.

What happens to the body in stage 4 pancreatic cancer?

Stage 4 cancer means that the cancer has spread to other parts of your body. It may have spread to the lungs, liver or lining of your tummy (peritoneum). This is advanced or metastatic cancer. Possible treatments: You may be able to have chemotherapy to slow down the growth of the cancer.

Treating Resectable Cancer

Surgeons usually consider pancreatic cancer to be resectable if it looks like it is still just in the pancreas or doesn’t extend far beyond the pan...

Treating Borderline Resectable Cancer

A small number of pancreatic cancers have reached nearby blood vessels but have not grown deeply into them or surrounded them. These cancers might...

Treating Locally Advanced (Unresectable) Cancer

Locally advanced cancers have grown too far into nearby blood vessels or other tissues to be removed completely by surgery, but have not spread to...

Treating Metastatic (Widespread) Cancer

Pancreatic cancers often first spread within the abdomen (belly) and to the liver. They can also spread to the lungs, bone, brain, and other organs...

Treating Pancreatic Cancer That Progresses Or Recurs

If cancer continues to grow during treatment (progresses) or comes back (recurs), your treatment options will depend on where and how much the canc...

Treating Cancer of The Ampulla of Vater

The ampulla of Vater is the area where the pancreatic duct and the common bile duct empty into the duodenum (the first part of the small intestine)...

Which Treatments Are Used For Pancreatic Cancer?

Depending on the type and stage of the cancer and other factors, treatment options for people with pancreatic cancer can include: 1. Surgery 2. Abl...

Which Doctors Treat Pancreatic Cancer?

Depending on your options, you can have different types of doctors on your treatment team. The doctors on your cancer treatment team might include:...

Making Treatment Decisions

It’s important to discuss all of your treatment options, including their goals and possible side effects, with your doctors to help make the decisi...

Help Getting Through Treatment

Your cancer care team will be your first source of information and support, but there are other resources for help when you need it. Hospital- or c...

What are the treatments for pancreatic cancer?

Depending on the type and stage of the cancer and other factors, treatment options for people with pancreatic cancer can include: Surgery for Pancreatic Cancer. Ablation or Embolization Treatments for Pancreatic Cancer. Radiation Therapy for Pancreatic Cancer. Chemotherapy for Pancreatic Cancer. Targeted Therapy for Pancreatic Cancer.

What do people with cancer need?

People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.

Why is it important to discuss all of your treatment options with your doctor?

It’s important to discuss all of your treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. Some important things to consider include:

What are the services offered by the American Cancer Society?

These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help. The American Cancer Society also has programs and services – including rides to treatment, lodging, and more – to help you get through treatment.

What kind of doctor treats cancer?

The doctors on your cancer treatment team might include: A surgical oncologist: a doctor who specializes in treating cancer with surgery. A radiation oncologist: a doctor who specializes in treating cancer with radiation therapy. A medical oncologist: a doctor who specializes in treating cancer with chemotherapy, immunotherapy, and targeted therapy.

Who are the specialists involved in cancer care?

Many other specialists may be involved in your care as well, including nurse practitioners, nurses, psychologists, social workers, rehabilitation specialists, and other health professionals. Health Professionals Associated with Cancer Care.

Can you continue cancer treatment?

Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.

What is the stage 4 pancreatic cancer?

Stage 4 pancreatic cancer means the cancer has spread to other organs, typically the liver or the lungs. Cancer can’t be cured at this point, but there are still treatment options. Treatment during this stage is focused on extending life and improving the quality of life.

What happens if you enroll in pancreatic cancer research?

When you enroll in one of these trials, you’ll have a chance to test a new treatment that isn’t yet available to the general public. The study you’re in might eventually lead to a new breakthrough therapy for pancreatic cancer.

Why is pancreatic cancer so difficult to diagnose?

Pancreatic cancer is difficult to diagnose early because the pancreas isn’t located in an area of the body where a growth could be felt during a regular exam. It also doesn’t usually cause symptoms until the cancer has spread to other areas of the body.

How long does it take to live with stage 4 pancreatic cancer?

The median survival rate for stage 4 pancreatic cancer is between two and six months. But keep in mind that an outlook for an individual depends on many factors. Your medical team can provide more accurate information based on your personal health.

What are the side effects of chemotherapy?

Some common side effects are hair loss, fatigue, and increased risk for infection.

Can stage 4 cancer stop growing?

The available treatments for stage 4 cancer generally won’t stop your cancer from growing . But don’t give up hope if your doctor says there are no other treatments left to try. Researchers are testing new cancer therapies in clinical trials.

Can cancer be treated with pain medicine?

Your doctor might give you an injection of pain medicine, or they might cut the nerves that are causing the pain sensation. This treatment doesn’t cure the cancer, but it can make you feel more comfortable.

What stage of pancreatic cancer is the most likely to recur?

Staging is an important factor to decide the course of treatment of this cancer. Stage III is an advanced stage and is more likely to recur or relapse even ...

How long does pancreatic cancer last?

The treatment primarily aims at improving the patient’s chances and prolonging survival. The five year survival rate which reflects how many patients out of 100 diagnosed with a certain cancer live beyond five years is about 3%.

What does TNM stand for in pancreatic cancer?

Pancreatic cancer is staged primarily using the TNM method of staging cancers, T stands for Tumour , N stands for node and M for Metastasis. Tumour shows the size of the primary tumour, Node shows the presence of cancer in the lymph nodes and Metastasis is the spreading of cancer from the primary tissue to the other tissues and organs.

What is targeted therapy for cancer?

When the tumour cannot entirely be removed by the surgery or has already spread to different parts of the body, targeted therapy is used. This treatment uses drugs that interfere with specific tissues that cancer cell growth and survival unlike in chemotherapy where the drugs target the rapidly dividing cells itself.

What is the treatment for cancer?

Chemoradiation is the combination of chemotherapy and radiation therapy that can be given before or after surgery aimed to remove cancer tumours. The chemotherapy drugs make the cells more sensitive and susceptible to radiation, though the side effects are worse too and is opted when the cancer has spread too much.

What is radiation therapy?

Radiation therapy use s high dosage of radiation to kill cancer cells and shrink the cancerous tumours. It is not typically used to treat cancer that has already spread to the other parts of the body and is mainly used post surgery as a part of adjuvant therapy.

Can a stent be placed on a cancer patient?

If it is not possible to open the duct through a stent, a bypass procedure may be done too.

What is the treatment for cancer before surgery?

Treatment before surgery is called neoadjuvant therapy. If surgery is not possible, other standard treatment choices include chemotherapy, radiation or both.

What is it called when pancreatic cancer returns?

Treating Recurrent Pancreatic Cancer. When the disease returns after treatment, it is called a recurrence . The cancer may come back to the pancreas or to another place or organ in the body, such as the liver.

How many surgeries per year for pancreatic cancer?

The Pancreatic Cancer Action Network strongly recommends you have a high volume pancreatic surgeon (more than 15 surgeries per year) perform the surgery. Your tumor’s location determines the type of surgery you have. The most common pancreatic surgery is the Whipple procedure. This is used for cancer in the head of the pancreas.

What is the Pancreatic Cancer Action Network?

The Pancreatic Cancer Action Network strongly recommends that you discuss your treatment goals with your healthcare team and know all of your options at every stage of your disease. Pancreatic cancer treatment depends on the patient’s general health and the disease stage. Staging is the process doctors use ...

How many patients are ineligible for pancreatic surgery?

About 30 to 50 percent of patients who are eligible for surgery are told they are ineligible. The Pancreatic Cancer Action Network strongly recommends you see a surgeon who performs a high volume of pancreatic surgeries (more than 15 per year) to determine eligibility.

What is the most common form of pancreatic cancer?

Please note: This information applies specifically to adenocarcinoma, the most common form of pancreatic cancer. Pancreatic neuroendocrine tumors (PNETs) and other rare pancreatic cancer types have different treatments.

What is stage IV treatment?

Stage IV treatment is typically chemotherapy. More choices may also be available through clinical trials.

Chemotherapy for early-stage pancreatic cancer

The primary treatment for early-stage pancreatic is surgery. Chemotherapy is often used before or after surgery to increase the chance of completely removing the cancer cells. If chemotherapy is combined with radiation therapy, it’s called chemoradiation therapy.

Chemotherapy for late-stage pancreatic cancer

Cancer that has spread to multiple organs is known as stage 4 cancer. Typically, stage 4 pancreatic cancer is not considered curable.

What to do when you can't eat or drink?

If you do not feel hungry and thirsty or uncomfortable you do not need any artificial food and fluids. If you don’t fancy eating and drinking anything but are getting a dry mouth then you may be able to use mouthwash, take sips of fluids or use a sponge to freshen your mouth. Sucking on boiled sweets may also help. Lip balm can help prevent your lips from drying out, especially if you are breathing through your mouth. Family and friends can also help with this if you feel as though you are finding it difficult.

Can you get pressure ulcers if you have cancer?

If you become unwell and have lost weight in combination with moving around less, you can become at risk of pressure ulcers. Anyone can get a pressure ulcer, but the chances increase if you are unwell with pancreatic cancer.

Can you take pain medication at the end of life?

You may have experienced pain throughout your disease. This does not necessarily get worse at the end of life, but you may not be able to take medication orally, if you are too sleepy for example. Medication can be given via a number of routes and if you require regular pain relief, you may be given a constant dose of medication using a syringe.

What does it mean when you have pancreatic cancer?

You may have told that you have advanced pancreatic cancer, this means that your cancer cannot be cured and will likely lead to your death.

What is palliative care?

Palliative care acknowledges that death is a part of life and a natural process. It does not aim to speed up or slow down your death, instead it acts to support you and the people who care about you throughout your disease. Palliative care can be provided wherever you are and by a number of different professionals.

What is end of life care?

End of life care is palliative care for when someone is approaching the end of their life. It focuses specifically on making sure this time is comfortable and meets your wishes. Palliative and end of life care can help you make decisions about the level of treatment you receive, the places where you receive treatment and what your priorities are ...

Can you have palliative care with other people?

You can have palliative care alongside other treatments and with your current medical team. Palliative care aims to support you with any physical, emotional, social, relationship issues that arise over the course of your illness.

Can pancreatic cancer spread to distant organs?

Often, because the symptoms of pancreatic cancer can be vague, the disease is difficult to diagnose. Therefore, your tumour may have spread to nearby organs and blood vessels (locally advanced) or to distant organs (metastatic) and it is not possible to operate and remove the disease. It is important to realise that this does not necessarily mean that you are dying immediately. It means instead that treatment will focus on your quality of life and managing your symptoms.

How to treat cancer pain?

Treating the cancer with chemotherapy and/or radiation therapy can also sometimes relieve pain by shrinking the size of the cancer.

What to do if you have pain?

If you are having any pain, please be sure to tell your doctor or nurse. Pain is easier to control if the treatment is started when you first have it. You and your doctor or nurse can talk about the best ways to treat your pain. A pain specialist can also help develop a treatment plan.

Can pancreatic cancer cause pain in the abdomen?

Pain can be a major problem for people with pancreatic cancer. These cancers can invade and press on nerves near the pancreas, which can cause pain in the abdomen (belly) or back.

Can alcohol help with pancreas pain?

Sometimes certain procedures might be needed to treat pain. For example, cutting or injecting alcohol into some of the nerves (that carry pain sensations) near the pancreas can often improve pain and may allow you to use lower doses of pain medicines. If you are having surgery for some reason (such as to remove the cancer or relieve bile duct blockage), this can usually be done as part of the same operation.

Living as a Cancer Survivor

For many people, cancer treatment often raises questions about next steps as a survivor.

Cancer Concerns After Treatment

Treatment may remove or destroy the cancer, but it's very common to worry about the risk of developing another cancer.

All Stages

Treatment by Stage

Stage I Treatment

Stage II (Locally Advanced) Treatment

Medically reviewed by
Dr. Rakshith Bharadwaj
Your provider will work with you to develop a care plan that may include one or more of these treatment options.
Treatment depends on the location of tumor, age and general health. Treatment includes surgery, chemotherapy and radiation.
Medication

Chemotherapy: Drugs, either taken orally or through injection, kills the cancer cells. In advanced stages, it only helps control growth of cancer cells.

5-Fluorouracil . Capecitabine . Irinotecan . Oxaliplatin

Procedures

Tumor excision: Surgery to remove tumor in the pancreatic head.

Distal pancreatectomy: Surgery to remove the tumor on left side (body and tail) of the pancreas.

Total pancreatectomy: Surgery to remove entire pancreas. Insulin will be administered lifelong after this surgery.

Therapy

Radiation therapy:High energy beams are used to kill the cancerous cells. A combination of therapies may be needed to recover completely.

Nutrition

Foods to eat:

  • NA

Foods to avoid:

  • NA

Specialist to consult

Endocrinologist
Specializes in the function and disorders of the endocrine system of the body.
Oncologist
Specializes in the diagnosis and treatment of cancer.

Stage III (Locally Advanced) Treatment

Stage IV (Metastatic) Treatment

Treating Recurrent Pancreatic Cancer

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