Ultimately, 81/91 (89%) patients proceeded to high dose chemotherapy and ASCT [82% in HyperCVAD versus 96% in non-HyperCVAD (p=0.06)]. Four of the remaining 10 patients with mobilization failure (all from HyperCVAD arm) proceeded to Allogeneic HCT, the remaining 6 patients did not receive any further treatment.
Full Answer
What is the treatment for Hyper-CVAD?
Treatment consisted of four cycles of Hyper-CVAD alternating with four cycles of high-dose methotrexate (MTX) and cytarabine therapy, together with intrathecal CNS prophylaxis and supportive care with antibiotic prophylaxis and granulocyte colony-stimulating factor therapy.
What is the starting dose of hyper CVAD?
Click here for common hyper cvad starting doses, or click on the clinical study references at the bottom of this page. HyperCVAD Part A usually requires a 4 - 5 day stay in a hospital. Typically, cyclophosphamide, doxorubicin, vincristine, and dexamethasone are all given in the hospital on Days 1 - 4 of each cycle.
What should I expect after hyper-CVAD treatment?
Your doctor or nurse can tell you what to expect. If your skin feels dry, try using an unperfumed moisturising cream every day. Hyper-CVAD can cause a rash, which may be itchy. During, and for some months after treatment, you will be more sensitive to the sun.
Should I talk to my doctor about my hyper-CVAD symptoms?
Other conditions can cause these symptoms, but it is important to get them checked by a doctor. If you cannot get through to your doctor, call the NHS urgent advice number on 111 . Rarely, hyper-CVAD can affect the nervous system. Tell your doctor or nurse straight away if you notice that you feel:
Is Hyper-CVAD effective?
The MD Anderson Cancer Center (MDACC) study reported a complete response (CR) rate of 92%, 5‐year overall survival of 38% and progression‐free survival (PFS) of 66% for adult patients with ALL 7, 8. The hyper‐CVAD regimen is made up of three curative steps: induction, consolidation, and subsequent maintenance therapy.
What is Hyper-CVAD protocol?
An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.
What is in Hyper-CVAD?
Hyper-CVAD includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone. It also includes the drugs methotrexate and cytarabine.
What is Hyper-CVAD Part B?
HyperCVAD (Part B) is a Chemotherapy Regimen for Acute Lymphoid Leukemia (ALL)
What is modified hyper-CVAD?
The modified hyper-CVAD regimen is a combination of chemotherapy drugs including cyclophosphamide, vincristine, Adriamycin, dexamethasone and pegylated asparaginase given together for one "course" of treatment.
How often is hyper-CVAD given?
HyperCVAD Part A is alternated with HyperCVAD Part B every 21 days. This sometimes takes longer if waiting for normal blood counts recover after the previous cycle. When both Part A and Part B are completed, this is known as one Cycle.
How does Hyper-CVAD work?
Hyper-CVAD chemotherapy consists of two combinations of drugs (courses A and B) given in an alternating fashion. The term 'hyper' refers to the hyperfractionated nature of the chemotherapy, which is given in smaller doses, more frequently, to minimize side effects.
How is Hyper-CVAD administered?
Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.
How long is a cycle of Hyper-CVAD?
Your course of chemotherapy You usually have a course of several cycles of treatment over a few months Each cycle of hyper-CVAD lasts 21 days.
What is the Nordic regimen?
Maxi-CHOP, also known as the “Nordic Regimen,” consists of 5 phases of treatment, including 1) Induction, 2) Stem cell mobilization, 3) Stem cell purging, 4) Consolidation, 5) High-dose therapy, and 6) Preemptive treatment at molecular relapse.
What is HiDAC consolidation?
The phrase HiDAC (high dose cytarabine) is usually used to refer to the administration of high doses of cytarabine as a single agent (monotherapy) as part of consolidation treatment. This is where disease remission has already been achieved following induction therapy.
What cyclophosphamide is used for?
Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).