Precautions
Docetaxel 1 Docetaxel is used to treat breast cancer, lung cancer, prostate cancer,... 2 Important Information. Docetaxel can cause severe side effects including death,... 3 Before taking this medicine. Tell your doctor about your complete health history... 4 Docetaxel is given as an infusion into a vein.
What is docetaxel used for?
Patients on the Docetaxel Injection arm received Docetaxel Injection (T) 75 mg/m 2 by intravenous infusion on day 1 followed by cisplatin (P) 100 mg/m 2 administered as a 30-minute to three-hour intravenous infusion, followed by the continuous intravenous infusion of fluorouracil (F) 1000 mg/m 2 /day from day 1 to day 4.
How is docetaxel administered in the treatment of multiple myeloma?
While a 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule," the official docetaxel package insert recommends administration every three weeks. Treatment with docetaxel increases survival time in people with certain types of cancer.
How often should you take docetaxel?
Docetaxel is a cytotoxic chemotherapeutic agent. As with all chemotherapy, adverse effects are common, and many side effects have been documented. Because docetaxel is a cell-cycle-specific agent, it is cytotoxic to all dividing cells in the body.
Is Docetaxel a cytotoxic chemotherapy?
What is docetaxel used for?
What to do if you feel a burning sensation when you take docetaxel?
Does Docetaxel make you sleepy?
Can docetaxel harm a baby?
Can you take docetaxel if you have low WBC?
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How many times can you have docetaxel?
Docetaxel is normally given once every three weeks, over about one hour.
How long can you stay on docetaxel?
The median overall survival (OS) was 81 months with docetaxel plus standard of care (hormonal therapy with or without radiotherapy) versus 71 months with standard of care alone (0.78; 95% CI, 0.66-0·93;P= . 006).
What If docetaxel does not work?
Types of Chemotherapy Drugs If docetaxel does not work or stops working, cabazitaxel (Jevtana) may be used.
Does docetaxel shrink tumors?
Chemotherapy drugs, such as docetaxel, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors.
Is docetaxel a strong chemotherapy?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
Which is stronger Taxol or Taxotere?
According to an article recently published in the Annals of Oncology, longer follow-up results indicate that the chemotherapy agent Taxotere® (docetaxel) remains superior to the chemotherapy agent Taxol® (paclitaxel) in the treatment of metastatic breast cancer among patients who have received prior therapy with ...
When chemo stops working What next?
If chemotherapy stops working, discuss the other options with the oncologist, the rest of the healthcare team, and loved ones, including family members, before making a decision about treatment going forward. Getting internal radiation therapy (brachytherapy). (2017). Hormone therapy for breast cancer.
How many rounds of chemo is normal?
During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.
What is the most common side effect of docetaxel?
The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin ...
Does hair grow back on docetaxel?
Real hair may start to grow properly within 4–6 weeks. However, some people who undergo chemotherapy experience permanent hair loss, research shows. Certain drugs, such as docetaxel (Taxotere), can have this effect.
Is Stage 4 always terminal?
Stage 4 is the most severe stage of cancer, but it is not always terminal. Doctors use a wide range of factors to classify cancer's stage, including the size and locations of tumors and the person's overall health.
How long does it take for docetaxel to start working?
This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. The use of scarves, wigs, hats, and hairpieces may help. Hair generally starts to regrow soon after treatment is completed.
Docetaxel Side Effects: Common, Severe, Long Term - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 17 June 2022), Cerner Multum™ (updated 3 June 2022), ASHP (updated 16 May ...
Docetaxel - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol ...
Docetaxel - Get up-to-date information on Docetaxel side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Docetaxel
Docetaxel generic. Price of docetaxel. Uses, Dosage, Side effects
Breast Cancer: Docetaxel-Hospira in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer. Docetaxel-Hospira in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.
Help coping with Docetaxel/Taxotere .... Please. | Cancer Chat
Hi, not sure if my experiences will help you. I was diagnosed in Feb 2013 and had a rt mastectomy op in March. I was prescribed preventative FEC-T but because I was getting married and honeymooning in July, they decided to do the Taxotere first and cycle 3 was combined with my whole radiotherapy treatment.
Docetaxel: View Uses, Side Effects and Medicines | 1mg
Docetaxel is used in the treatment of Breast cancer, Non-small cell lung cancer, Prostate cancer, Cancer of head and neck. View Docetaxel’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com.
Docetaxel (Intravenous Route) Side Effects - Mayo Clinic
Side Effects. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
What is doxorubicin hydrochloride used for?
It is also used with doxorubicin hydrochloride and cyclophosphamide to treat breast cancer that is node-positive and can be removed by surgery. Non-small cell lung cancer that is locally advanced or has metastasized. It is used: Alone in patients whose cancer has not gotten better after platinum chemotherapy; or.
Why are drugs studied?
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
What is cisplatin used for?
It is used: With cisplatin in patients whose cancer cannot be treated with surgery. Prostate cancer that has metastasized in men whose cancer is hormone-refractory (does not respond to hormone treatment ). Squamous cell carcinoma of the head and neck that is locally advanced. It is used with cisplatin and fluorouracil.
Is docetaxel used for cancer?
It is used in patients whose disease has not been treated with chemotherapy. Docetaxel is also being studied in the treatment of other types of cancer.
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
Can you use docetaxel alone?
Use in Cancer. Docetaxel is approved to be used alone or with other drugs to treat: Breast cancer that is locally advanced or has metastasized (spread to other parts of the body) and has not gotten better with other chemotherapy.
How many patients were treated with Docetaxel?
In the adjuvant breast cancer trial (TAX316), Docetaxel in combination with doxorubicin and cyclophosphamide was administered to 744 patients of whom 48 (6%) were 65 years of age or greater. The number of elderly patients who received this regimen was not sufficient to determine whether there were differences in safety and efficacy between elderly and younger patients.
How does docetaxel work?
Docetaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. Docetaxel binds to free tubulin and promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly. This leads to the production of microtubule bundles without normal function and to the stabilization of microtubules, which results in the inhibition of mitosis in cells. Docetaxel's binding to microtubules does not alter the number of protofilaments in the bound microtubules, a feature which differs from most spindle poisons currently in clinical use.
What are the side effects of Docetaxel injection?
unusual tiredness. muscle cramps. You may experience side effects of Docetaxel Injection that may impair your ability to drive, use tools, or operate machines. If this happens, do not drive or use any tools or machines before discussing with your healthcare provider.
What is docetaxel made of?
Docetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for Docetaxel is (2R,3S)-N-carboxy-3-phenylisoserine,N- tert -butyl ester, 13-ester with 5β-20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate. Docetaxel (anhydrous) has the following structural formula:
How long does it take to take cisplatin for gastric adenocarcinoma?
For gastric adenocarcinoma, the recommended dose of Docetaxel Injection is 75 mg/m 2 as a 1 hour intravenous infusion, followed by cisplatin 75 mg/m 2, as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the cisplatin infusion. Treatment is repeated every three weeks. Patients must receive premedication with antiemetics and appropriate hydration for cisplatin administration [ see Dosage and Administration (2.7) ].
What is docetaxel injection?
Docetaxel Injection in combination with cisplatin and fluorouracil is indicated for the treatment of patients with advanced gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for advanced disease.
How long before Docetaxel injection for prostate cancer?
For metastatic castration-resistant prostate cancer, given the concurrent use of prednisone, the recommended premedication regimen is oral dexamethasone 8 mg at 12 hours, 3 hours, and 1 hour before the Docetaxel Injection infusion [ see Warnings and Precautions ( 5.5) ].
How does docetaxel work?
Docetaxel works by disrupting the microtubular network in cells, which is essential for cell division and other normal cellular functions. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die.
What is the most common side effect of cancer treatment?
Fatigue. Fatigue is very common during cancer treatment and is an overwhelming feeling of exhaustion that is not usually relieved by rest. While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue.
Can you give a corticosteroid before a cancer infusion?
The dosage and schedule are determined by the person's size and type of cancer. It can be given alone or with other drugs. You will be given a corticosteroid prior to the infusion to prevent severe fluid retention and allergic reactions.
Can docetaxel cause liver pain?
Your labs will be closely monitored prior to each dose of docetaxel and the dose may be decreased or held if your liver function is not normal. Even when carefully and correctly administered by trained personnel, this drug may cause a feeling of burning and pain.
How is docetaxel given?
How Docetaxel Is Given: Docetaxel is given through a vein (intravenously, IV) Premedication with a corticosteroid pill starting a day prior to docetaxel infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Your doctor will prescribe the exact regimen.
What are the side effects of docetaxel?
These side effects are less common, meaning they occur in 10-29 percent of patients receiving docetaxel: Vomiting. Muscle/bone/joint pain (myalgias and arthralgias) Low platelet count (This can increase your risk of bleeding) Increases in blood tests measuring liver function.
What is the generic name for docetaxel?
Chemocare.com uses generic drug names in all descriptions of drugs. Taxotere is the trade name for docetaxel. In some cases, health care professionals may use the trade name taxotere when referring to the generic drug name docetaxel. Drug type: Docetaxel is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
Why is chemotherapy given in cycles?
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles. Chemotherapy is most effective at killing cells that are rapidly dividing.
What is the term for a drug that affects cells only when they are dividing?
They also induce cell suicide (self-death or apoptosis). Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific.
How does chemotherapy work?
Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division.
Can docetaxel cause nail fall off?
Nail changes (Color changes to your fingernails or toenails may occur while taking docetaxel. In extreme, but rare, cases nails may fall off. After you have finished docetaxel treatments, your nails will generally grow back) (see skin problems).
How does docetaxel work?
Docetaxel works by damaging the structure or the “skeleton” that supports cancer cells. Docetaxel (Taxotere) is a type of human-made taxane chemotherapy medicine. It was first made from yew tree needles.
How long before docetaxel can I take it?
Usually you will start taking these medicines the day before each treatment and continue for 3 days. In some cases, you get the medicines with your docetaxel treatment instead.
What is docetaxel made of?
Docetaxel(Taxotere) is a type of human-made taxanechemotherapymedicine. It was first made from yew tree needles. Docetaxel is used with other medicines to treat some types of breast cancer. How Docetaxel Works. Docetaxelworks by damaging the structure or the “skeleton” that supports cancer cells.
What is the best combination for breast cancer?
Docetaxelis often given in combination to help treat breast cancer and prevent recurrence. Combinations include: TC (Taxotere and Cyclophosphamide) TAC (Taxotere, Adriamycin and Cyclophosphamide) Docetaxel is given by vein, usually in several cycles, with a day (or days) of treatment followed by a period of “off” days.
Does docetaxel cause numbness in feet?
Neuropathy(numbness or tingling in the hands and feet) Neutropenia(a low number of a type of white blood cell) Rash. Nail changes. Because docetaxel can decrease your blood cellcounts, called bone marrow suppression, your doctors will test your blood counts regularly.
Can docetaxel be used for breast cancer?
Docetaxelmay be used in chemotherapy treatment regimens for most types of invasive breast cancer, including triple- negative breast cancer. It can be used with targeted therapy, such as trastuzumab(Herceptin), in treating HER2-positive breast cancers.
Can you take Docetaxel with chemotherapy?
It can also be given with the chemotherapy medicines doxorubicin(Adriamycin) and cyclophosphamide(Cytoxan) after surgeryas adjuvant treatment or as neoadjuvant (before surgery) treatment for breast cancers that require chemotherapy. Docetaxel is sometimes given alone for metastatic breast cancer. How Docetaxel Is Given.
How does Docetaxel work?
It works by disrupting the normal function of microtubules and thereby stopping cell division. Docetaxel was patented in 1986 and approved for medical use in 1995. It is on the World Health Organization's List of Essential Medicines. Docetaxel is available as a generic medication.
What is the active ingredient in docetaxel?
Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80. The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL. 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL sterile pyrogen-free anhydrous polysorbate 80, and a single dose Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose for administration. 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to give a solution of 10 mg/mL and the required dose is drawn from this solution. Vials have an overfill to compensate for liquid loss during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months below 25 °C away from light and 80 mg vials for 26 months in the same conditions.
What is the name of the drug that is used to treat cancer?
Docetaxel. Docetaxel ( DTX or DXL ), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer.
What is the best medicine for breast cancer?
Other medications will often be given to aid pain management and other symptoms. The treatment of breast cancer with doxorubicin and cyclophosphamide is enhanced by adjuvant treatment with docetaxel. Docetaxel is also used in combination with capecitabine, a DNA synthesis inhibitor.
What is DTX used for?
Docetaxel ( DTX or DXL ), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer. It may be used by itself or along with other chemotherapy medication.
Where is docetaxel metabolized?
Docetaxel is mainly metabolised in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes. Metabolism is principally oxidative and at the tert-butylpropionate side chain, resulting first in an alcohol docetaxel (M2), which is then cyclised to three further metabolites (M1, M3 and M4). M1 and M3 are two diastereomeric hydroxyoxazolidinones and M4 is an oxazolidinedione. Phase II trials of 577 patients showed docetaxel clearance is related to body surface area and to hepatic enzyme and alpha1 acid glycoprotein plasma levels. The following model represents docetaxel clearance in humans:
What are the drugs that interact with Docetaxel?
Drug interactions may be the result of altered pharmacokinetics or pharmacodynamics due to one of the drugs involved. Cisplatin, dexamethasone, doxorubicin, etoposide, and vinblastine are all potentially co-administered with docetaxel and did not modify docetaxel plasma binding in phase II studies.
What is docetaxel used for?
Docetaxel is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer. Docetaxel may also be used for purposes not listed in this medication guide.
What to do if you feel a burning sensation when you take docetaxel?
If this happens, wash right away with soap and water. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when docetaxel is injected. You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.
Does Docetaxel make you sleepy?
Docetaxel contains alcohol. Using other drugs that can make you sleepy can worsen the feeling of being drunk. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Can docetaxel harm a baby?
Docetaxel can harm an unborn baby or cause birth defects if the mother or the father is using this medicine. If you are a woman, do not use docetaxel if you are pregnant. You may need to have a negative pregnancy test before starting this treatment.
Can you take docetaxel if you have low WBC?
You should not receive docetaxel if you have: a low white blood cell (WBC) count; or. a history of severe allergic reaction to docetaxel or to any medicine that contains polysorbate 80. Tell your doctor about your complete health history and all medications you have used. Docetaxel can cause severe side effects including death, especially: ...
