In having discussions with many men who have advanced prostate cancer it seems that the most common pattern of drug treatment sequencing for men with advanced, castration resistant prostate cancer after they have failed either of the second-line treatments of abiraterone (Zytiga) or enzalutamide (Xtandi) is either chemotherapy with docetaxel This medication is used to treat cancer.Docetaxel
Full Answer
What is Zytiga used to treat?
ZYTIGA ® (abiraterone acetate) is a prescription medicine that is used along with prednisone. ZYTIGA ® is used to treat men with prostate cancer that has spread to other parts of the body.
Does Zytiga help lower PSA?
Did Xtandi for 4 months this year and also Provenge but PSA still rising and tumors still growing. On Zytiga now and does not appear to be lowering PSA but prednisone helps with the pain quite a bit, as does Xgeva.
Should men take Zytiga before or after chemotherapy?
For men who have elected to use Zytiga prior to their use of chemotherapy (an increasingly common “off label” occurrence) there is no real road map to make this decision. A discussion with your doctor prior to starting Zytiga about when to discontinue should be made as you begin taking the drug.
What should I do with leftover Zytiga?
Store Zytiga pills at room temperature (68°F to 77°F/20°C to 25°C) away from the reach of children. If you no longer need to take Zytiga and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident.
What comes after Zytiga?
“Our data suggest that using a sequencing strategy of [Zytiga] followed by [Xtandi] provides the greatest clinical benefit,” they said.
What is the newest treatment for recurrent prostate cancer?
Newer hormonal medications that inhibit the synthesis of androgen (abiraterone) and block androgen receptor signaling (enzalutamide) are FDA-approved for the treatment of advanced prostate cancer.
What is the best treatment for prostate cancer that has spread?
If your cancer has spread beyond your prostate to other areas of your body, your doctor may recommend: Chemotherapy. Chemotherapy can slow the growth of cancer cells, relieve signs and symptoms of cancer, and prolong the lives of men with advanced prostate cancer.
What if hormone therapy stops working?
After some months or years the hormone treatment usually stops working and the cancer starts to grow again. Your doctor might recommend stopping or changing hormone treatment at this stage. If you're having anti androgens and your PSA level has started to rise again your doctor might get you to stop taking them.
Can metastatic prostate cancer go into remission?
When first treated with hormonal therapy, metastatic prostate cancer usually responds to hormone treatments and goes into remission.
Are there any new treatments for metastatic prostate cancer?
FDA Approves Promising Therapy for Advanced Prostate Cancer: Targets a Protein Called PSMA. In 2019, Michael Rosenblum received an experimental new prostate cancer treatment after the disease spread to his bones. Since then, he has been symptom-free. The treatment is now FDA-approved.
Can you live 10 years with metastatic prostate cancer?
Of the 794 evaluable patients, 77% lived < 5 years, 16% lived 5 up to 10 years, and 7% lived > or = 10 years. Factors predicting a statistical significant association with longer survival (P < 0.05) included minimal disease, better PS, no bone pain, lower Gleason score, and lower PSA level.
How long is Zytiga effective?
After a median follow-up of 51.8 months and a final analysis the overall survival has been confirmed to be significantly longer for patients receiving Zytiga/ADT/prednisone. Zytiga treated patients survived on average 53 months compared to 36.5 months for ADT alone.
What is the life expectancy of someone with metastatic prostate cancer?
A decade ago, a man with metastatic prostate cancer would typically have a life expectancy of two to three years. Today, life expectancy for men with the same advanced disease is likely to be five to six years.
How do you know if Zytiga is working?
PSA Levels Your doctor will use your PSA level, along with other tests, to determine if your therapy is effective. Changes in PSA levels may be seen but have not been shown to correlate with clinical benefit in individual patients.
What should PSA levels be after hormone therapy?
Recent studies have shown that for optimal results, PSA levels should be lower than 1 ng/ml, and even lower than 0.5 ng/ml.
What is the success rate of hormone therapy?
Hormone replacement therapy users had a 100% survival rate at 6 years as opposed to 87% in nonusers. Both groups of tumors were detected by screening mammography, thus detected "early" by current convention. Yet, we observed a survival benefit for those women who had received HRT.
Can I use Zytiga after using Xtandi?
Yes. You can take Zytiga after taking Xtandi. According to current treatment guidelines, Zytiga is a treatment option for people whose cancer got w...
Can I take Zytiga without prednisone?
It’s recommended that you take Zytiga with the corticosteroid prednisone to reduce some of the side effects that happen because of low hormone leve...
Is Zytiga a form of chemotherapy?
No. Zytiga isn’t a form of chemotherapy. Zytiga is a type of hormone therapy that helps fight prostate cancer. It works by reducing the amount of m...
How long will I need to be treated with Zytiga?
You and your doctor will discuss how effective and safe Zytiga is for you. You will likely take Zytiga for as long as it helps prevent cancer from...
Does Zytiga affect my testosterone levels?
Yes. Zytiga helps slow or stop the growth of prostate cancer by decreasing the amount of testosterone and other male hormones in your body. Zytiga...
What is the life expectancy for someone taking Zytiga?
Life expectancy (the number of years you will likely live) is based on several factors. These include your age, overall health status, the stage (h...
What does it feel like to be on Zytiga?
Feel faint or lightheaded. Headache. Confusion. Muscle weakness. Pain in your legs. Swelling in your legs or feet. Severe liver problems. You may develop changes in liver function blood tests. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA ® and during treatment with ZYTIGA ®.
Can you have low blood sugar with zytiga?
Severe low blood sugar with ZYTIGA ® can happen in people who have diabetes and take certain antidiabetic medicines. You and/or your healthcare provider should check your blood sugar levels regularly during treatment with ZYTIGA ® and after you stop treatment.
Xtandi failed suggested Zytiga
a better option because it would hit all the spots. He also mentioned that there is a trial I could...
Starting Zytiga after Xtandi failed
success going on to Zytiga after Xatandi? I was on Xtandi for 4 months and it did not work from day...
Zytiga failed, starting Xtandi. What to expect for my dad
be switched to Xtandi. My dad has been feeling amazing and I’m so scared that the Xtandi wll change...
Next steps after Xtandi and Zytiga
Docetaxel, Lupron, Xtandi, Zometa, and now Zytiga. My PSA initially decreased with Xtandi in...
Zytiga failed, starting Xtandi. What to expect for my dad
be switched to Xtandi. My dad has been feeling amazing and I’m so scared that the Xtandi wll change...
What is the drug used in Zytiga?
Zytiga contains the drug abiraterone acetate. It’s a type of medication used in hormone therapy, which is a treatment that lowers the level of male hormones in the body. Reduced levels of male hormones, such as testosterone, help slow or stop the growth of prostate cancer cells.
How does Zytiga work?
Zytiga contains the drug abiraterone acetate, which is used to treat two types of metastatic prostate cancer: Metastatic castration-resistant prostate cancer .*. This is prostate cancer that has metastasized (spread) from the prostate to another area in the body.
What is Zytiga used for?
Zytiga is a brand-name prescription medication. It’s used to treat two types of prostate cancer: metastatic castration-resistant prostate cancer (CRPC) metastatic high-risk castration-sensitive prostate cancer (CSPC) Metastatic means the cancer has spread to other parts of the body. Both of these cancers are considered advanced.
How long does Zytiga last?
When you get Zytiga from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically one year from the date they dispensed the medication.
How long before or after meal can you take zytiga?
Take Zytiga on an empty stomach, either one hour before a meal or two hours after a meal. Taking Zytiga on an empty stomach helps decrease your risk for side effects.
What is the FDA's approval for Zytiga?
The Food and Drug Administration (FDA) approves prescription drugs such as Zytiga to treat certain conditions. Zytiga may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.
Is Zytiga the same as Yonsa?
Zytiga and Yonsa contain the same drug: abiraterone acetate. But Yonsa was created as a much smaller particle of abiraterone acetate so your bloodstream can better absorb the drug. You can take Yonsa with or without food because of its smaller particle size.
What to do if you miss zytiga?
If you miss a dose of ZYTIGA ® or prednisone, take your prescribed dose the following day. If you miss more than 1 dose, tell your healthcare provider right away. Your healthcare provider will do blood tests to check for side effects.
How to report side effects of zytiga?
THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA®. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Please see the full Prescribing Information and Patient Information for ZYTIGA ® and discuss any questions you have with your doctor.
What happens if you take Zytiga with prednisone?
Yellowing of the skin or eyes. Darkening of the urine. Severe nausea or vomiting. Increased risk of bone fracture and death when ZYTIGA ® and prednisone or prednisolone is used in combination with a type of radiation called radium Ra 223 dichloride.
How long after eating can you take zytiga?
Take ZYTIGA ® on an empty stomach, at least 1 hour before or at least 2 hours after a meal. Do not take ZYTIGA® with food.
How long after Zytiga can you breastfeed?
Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with ZYTIGA ® and for 3 weeks after the last dose of ZYTIGA ®. Are breastfeeding or plan to breastfeed. It is not known if ZYTIGA ® passes into your breast milk.
Can zytiga be taken with breast milk?
It is not known if ZYTIGA ® passes into your breast milk. Tell your healthcare provider about all the medicines you take or treatments you receive including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZYTIGA ® can interact with many other medicines.
Is zytiga safe for men?
ZYTIGA ® is used to treat men with prostate cancer that has spread to other parts of the body. It is not known if ZYTIGA ® is safe and effective in females or children. Before taking ZYTIGA ®, tell your healthcare provider about all of your medical conditions, including if you: Are pregnant or plan to become pregnant.
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Prostate cancer Drugs after Zytiga begins to fail
I have been on Zytiga for over 2 years now and my PSA is climbing I am still getting lupron every 4 months I I have already had Provenge. Anyone out there in the same situation. Where do you go after Zytiga?
Does Zytia have testosterone?
There are no testosterone targets for Zytia. It operates by limiting the production of androgens from three sources, from the testes, adrenal gland and the tumor itself. Once the cancer has become castrate resistant it only takes a miniscule level of testosterone to feed the tumors.
Is Zytiga discontinued?
Zytiga was only discontinued when all threeof the criteria were experienced, not because of any one of the items. For men who have elected to use Zytiga prior to their use of chemotherapy (an increasingly common “off label” occurrence) there is no real road map to make this decision.
Does Zytiga stop working?
Zytiga goes after all three of the production points, but it does not work for all men and it will stop working at some point of the disease progression. I suspect that as you mentioned the zytiga has slowed down your disease progression, but it has not stopped it.
