What kind of cancer can be treated with cisplatin?
Use in Cancer. Cisplatin is approved to be used alone or with other drugs to treat: Bladder cancer that cannot be treated with surgery or radiation therapy. Ovarian cancer that has metastasized (spread to other parts of the body). It is used with other drugs in patients who have already had surgery or radiation therapy.
What should I know about cisplatin before taking it?
You should not receive cisplatin if you have kidney disease, bone marrow suppression, or hearing loss. Cisplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive cisplatin, tell your doctor about all other medications you use.
What medications should I avoid while taking cisplatin?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with cisplatin, especially: 1 altretamine; 2 vitamin B6 ( pyridoxine ); or. 3 seizure medication.
How many rounds of cisplatin can you have?
You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.
How long does cisplatin take to work?
You have chemotherapy as a course of several sessions (or cycles) of treatment over a few months. Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have.
Does chemo get stronger with each treatment?
The effects of chemo are cumulative. They get worse with each cycle. My doctors warned me: Each infusion will get harder. Each cycle, expect to feel weaker.
How do you feel after second round of chemo?
Here's a list of many of the common side effects, but it's unlikely you'll have all of these.Tiredness. Tiredness (fatigue) is one of the most common side effects of chemotherapy. ... Feeling and being sick. ... Hair loss. ... Infections. ... Anaemia. ... Bruising and bleeding. ... Sore mouth. ... Loss of appetite.More items...
Is cisplatin a strong chemo?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].
What is the most common side effect of cisplatin?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
What happens after 2nd chemo treatment?
Nausea, vomiting, and taste changes You may experience nausea (feeling like you might throw up) and vomiting (throwing up) after your last chemotherapy treatment. It should go away in 2 to 3 weeks. Your appetite may continue to be affected due to taste changes you may have experienced during your treatment.
Is the second chemo treatment worse than the first?
For most people the side effects were worst in the first few days after treatment, then they gradually felt better until the next treatment. Some said the effects were worse with each successive treatment. Most side effects don't persist and disappear within a few weeks after the end of treatment.
What are the signs that chemo is working?
Complete response - all of the cancer or tumor disappears; there is no evidence of disease. A tumor marker (if applicable) may fall within the normal range. Partial response - the cancer has shrunk by a percentage but disease remains. A tumor marker (if applicable) may have fallen but evidence of disease remains.
Do chemo side effects get worse with more treatments?
Q: Do chemo side effects get worse with each treatment? A: Some people undergoing chemotherapy report that they feel more fatigue the further along they get in their regimen. Nerve damage can occur with chemotherapy, and this may get worse with each dose. Sometimes, treatment has to be stopped because of this.
What are the signs that chemo is not working?
Here are some signs that chemotherapy may not be working as well as expected: tumors aren't shrinking. new tumors keep forming. cancer is spreading to new areas.
How many days after chemo do you feel better?
Many people feel fine for the first few hours following chemotherapy. Usually, some reaction occurs about four to six hours later. However, some people don't react until 12 or even 24 to 48 hours after treatment. Some people experience almost all of the side effects described below, while others experience almost none.
How to reconstitute Cisplatin?
Reconstitute 50 mg vials with 50 mL of Sterile Water for Injection , USP. Each mL of the resulting solution will contain 1 mg of Cisplatin for injection. Reconstitution results in a clear or colorless to slight yellow solution. Do not refrigerate the reconstituted solution. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The reconstituted solution is stable for 20 hours at controlled room temperature [20°C to 25°C (68°F to 77°F)]. Solution removed from the amber vial should be protected from light if it is not to be used within six hours.
What is Cisplatin injection?
Cisplatin for injection is indicated for the treatment of advanced testicular cancer.
What is plasmapheresis used for?
Plasmapheresis has been used to treat cases of Cisplatin for injection overdosage , but the optimal treatment regimen has not been established. For current information on the management of poisoning or overdosage, contact the National Poison Control Center at 1-800-222-1222 or www.poison.org.
How long does it take for cisplatin to cause neuropathy?
Neurologic symptoms have been reported to occur after a single dose. Neuropathy can also have a delayed onset from 3 to 8 weeks after the last dose of Cisplatin for injection.
What is the mechanism of action of Cisplatin?
Mechanism of Action. The main mechanism of the cytotoxic action involves the binding of Cisplatin to genomic DNA in the cell nucleus to form interstrand and intrastrand cross-links. This interferes with normal transcription and/or DNA replication mechanisms and triggers cytotoxic processes that lead to cell death.
How long does it take for platinum to be excreted?
Over a dose range of 40 mg to 140 mg Cisplatin per m 2 given as a bolus injection or as infusions varying in length from 1 hour to 24 hours, from 10% to about 40% of the administered platinum is excreted in the urine in 24 hours. Over 5 days following administration of 40 mg/m 2 to 100 mg/m 2 doses given as rapid, 2‑ to 3‑hour or 6‑ to 8‑hour infusions, a mean of 35% to 51% of the dosed platinum is excreted in the urine. Similar mean urinary recoveries of platinum of about 14% to 30% of the dose are found following 5 daily administrations of 20 mg/m 2 per day, 30 mg/m 2 per day, or 40 mg/m 2 per day. Only a small percentage of the administered platinum is excreted beyond 24 hours post-infusion and most of the platinum excreted in the urine in 24 hours is excreted within the first few hours.
How long does platinum stay in your system after Cisplatin?
Following Cisplatin doses of 20 mg/m 2 to 120 mg/m 2, platinum is present in tissues for as long as 180 days after the last administration.
Is Cisplatin used for cancer?
Testicular cancer that has metastasized. It is used with other drugs in patients who have already had surgery or radiation therapy. Cisplatin is also being studied in the treatment of other types of cancer.
Can Cisplatin be used for bladder cancer?
Use in Cancer. Cisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced disease that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has metastasized (spread to other parts of the body).
Proper Use
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Missed Dose
This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
How is cisplatin administered?
How Cisplatin Is Given: Cisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If cisplatin escapes from the vein it can cause tissue damage.
Where is Cisplatin used?
Cisplatin also has been used as an infusion into the abdominal cavity ( contains the abdominal organs).
How long does nausea last after cisplatin?
The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy.
What is the trade name for SIS pla tin?
Cisplatin. (SIS pla tin) Trade Names: Platinol®, Platinol®-AQ. Other Name: CDDP. Cisplatin is the generic name for the trade name drug Platinol® and Platinol®-AQ. In some cases, health care professionals may use the trade name Platinol® and Platinol®-AQ, or other names such as CDDP, when referring to the generic drug name cisplatin. Drug Type:
Is cisplatin an anti-cancer drug?
Cisplatin is an anti-cancer (" antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent." (For more detail, see "How Cisplatin Works" section below).
Is cisplatin safe for allergic reactions?
Cisplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, carboplatin, other platinum-containing formulations or mannitol.
Does cisplatin have side effects?
Cisplatin side effects are often predictable in terms of their onset, duration, and severity. Cisplatin side effects will improve after therapy is complete. Cisplatin side effects may be quite manageable. There are many options to help minimize or prevent the side effects of cisplatin.
How long does it take for a symtom to show after taking Cisplatin?
These symptoms may occur 3 to 8 weeks after the last dose of this medicine. Cisplatin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting.
What happens if you take cisplatin out of your vein?
If cisplatin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.
Can you take other medicines?
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Does Cisplatin cause kidney problems?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
What are the side effects of Cisplatin?
Common side effects of Cisplatin include: 1 nausea and vomiting (may be severe), 2 diarrhea, 3 temporary hair loss, 4 loss in ability to taste food, 5 hiccups, 6 dry mouth, 7 dark urine, 8 decreased sweating, 9 dry skin, and 10 other signs of dehydration.
What are the reactions to cisplatin?
The reactions consist of facial edema, wheezing, tachycardia, and hypotension within a few minutes of drug administration. Reactions may be controlled by intravenous epinephrine with corticosteriods and/or antihistamines as indicated. Patients receiving cisplatin (cisplatin injection) should be observed carefully for possible anaphylactic-like reactions and supportive equipment and medication should be available to treat such a complication.
How long does it take for neuropathy to develop after cisplatin?
Although symptoms and signs of cis-platin neuropathy usually develop during treatment, symptoms of neuropathy may begin 3 to 8 weeks after the last dose of cisplatin (cisplatin injection) , although this is rare. Cisplatin (cisplatin injection) therapy should be discontinued when the symptoms are first observed.
What is cisplatin used for?
What Is Cisplatin? Cisplatin is an anti-cancer ( antineoplastic) medication used to treat cancers of the testicles, ovaries, or bladder. Cisplatin is available in generic form.
How long does nausea last after cisplatin?
Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours.
Can cisplatin cause hearing loss?
Deafness after the initial dose of cisplatin (cisplatin injection) has been reported rarely. Ototoxic effects may be more severe in children receiving cisplatin (cisplatin injection) . Hearing loss can be unilateral or bilateral and tends to become more frequent and severe with repeated doses.
Is cisplatin ototoxic?
Ototoxicity -Ototoxicity has been observed in up to 31% of patients treated with a single dose of cisplatin (cisplatin injection) 50 mg/m 2, and is manifested by tinnitus and/or hearing loss in the high frequency range (4,000 to 8,000 Hz). Decreased ability to hear normal conversational tones may occur occasionally. Deafness after the initial dose of cisplatin (cisplatin injection) has been reported rarely. Ototoxic effects may be more severe in children receiving cisplatin (cisplatin injection) . Hearing loss can be unilateral or bilateral and tends to become more frequent and severe with repeated doses. Ototoxicity may be enhanced with prior or simultaneous cranial irradiation. It is unclear whether cisplatin (cisplatin injection) induced ototoxicity is reversible. Ototoxic effects may be related to the peak plasma concentration of cisplatin (cisplatin injection) . Careful monitoring of audiometry should be performed prior to initiation of therapy and prior to subsequent doses of cisplatin (cisplatin injection) .
Indications and Usage For Cisplatin
Cisplatin Dosage and Administration
- Hydration and Anti-Emetic Treatment
Patients treated with Cisplatin for injection must receive appropriate pre-treatment hydration. Maintain adequate hydration and urinary output for 24 hours after Cisplatin for injection administration [see Warnings and Precautions (5.1)]. Administer pre-treatment and post-treatme… - Advanced Testicular Cancer
Cisplatin for injection has been administered at 20 mg/m2intravenously daily for 5 days per cycle. Other doses and combination regimens have been used.
Dosage Forms and Strengths
- Cisplatin for injection, USP: single-dose vials containing 50 mg of Cisplatin as white to light yellow lyophilized powder for reconstitution.
Contraindications
- Cisplatin for injection is contraindicated in patients with severe hypersensitivity to Cisplatin [see Warnings and Precautions (5.4)].
Warnings and Precautions
- Nephrotoxicity
Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. Renal toxicity typically begins during the second week after a dose ofCisplatin for injection. Patients with baseline rena… - Peripheral Neuropathy
Cisplatin for injectioncan cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms have been reported to occur after a single dose. Neuropathy can also have a delayed onset from 3 to 8 weeks after the last dose of …
Adverse Reactions
- The following adverse reactions are described in greater detail, in other sections: • 1. Nephrotoxicity [see Warnings and Precautions (5.1)] • 1. Peripheral Neuropathy [see Warnings and Precautions (5.2)] • 1. Nausea and vomiting [see Warnings and Precautions (5.3)] • 1. Myelosuppression [see Warnings and Precautions (5.4)] • 1. Hypersensitivity reactions [see War…
Drug Interactions
- The following drug interactions are described in other sections: • 1. Nephrotoxic drugs [see Warnings and Precautions (5.1)] • 1. Ototoxic drugs [see Warnings and Precautions (5.6)]
Use in Specific Populations
- Pregnancy
Risk Summary Based on human data from published literature, Cisplatin for injection can cause fetal harm when administered to pregnant women. Advise pregnant women and females of reproductive potential of the potential risk to a fetus. Data demonstrates transplacental transfer … - Lactation
Risk Summary Limited data from published literature report the presence of Cisplatin in human milk in low amounts. Because of the potential for serious adverse reactions from Cisplatin for injection in a breastfed child and because of the potential for tumorigenicity shown for Cisplatin …
Overdosage
- Acute overdosage with Cisplatin for injection may result in renal failure, hepatic failure, hearing loss, ocular toxicity, myelosuppression, nausea and vomiting, and neuritis. In addition, death can occur following overdosage. Management of overdosage should include general supportive measures to sustain the patient through any period of toxicity that may occur. Important measur…
Cisplatin Description
- Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP contains 50 mg Cisplatin, 450 mg Sodium Chloride, USP, and 500 mg Mannitol, USP. Cisplatin for Injection, USP may contain hydrochloric acid for pH adjustment. Cisplatin, the active ingredient in Cisplatin for injection, US…