Treatment FAQ

what test used to determine whither treatment is better than control group

by Earnestine Heller Published 3 years ago Updated 2 years ago

Paired t-test will tell you if training is effective or not. You need to compare the data after training with the control group using unpaired t test. If more than two groups you can use ANOVA.

1. Standard ttest
ttest
One-sample t-test

In testing the null hypothesis that the sample mean is equal to a specified value μ0, one uses the statistic. where is the sample mean, s is the sample standard deviation and n is the sample size. The degrees of freedom used in this test are n − 1.
https://en.wikipedia.org › wiki › Student's_t-test
– The most basic type of statistical test, for use when you are comparing the means from exactly TWO Groups, such as the Control Group versus the Experimental Group. 2. Paired ttest – An extremely powerful test for detecting differences (it is, in fact, the most “sensitive” of all our five tests).

Full Answer

What do statistical tests of the treatment/control difference tell us?

The statistical tests of the treatment/control difference in mean values of a set of variables will indicate whether such problems exist for any given site.

Should we compare the treatment and control groups at baseline?

If our analysis of comparability of the two groups using screen data indicates no differences between the treatment and control groups, then comparisons of their data at baseline can be conducted to assess the issues of nonresponse and measurement bias described above.

Why is comparability of treatment and control groups important?

The comparability of the treatment and control groups at randomization is also important because it is the first stage in our investigation of a set of methodological problems that could result in biased estimates of channeling's impact.

What is a control group in a test group?

To ensure the accuracy of any test, the test group should always contain what’s known as a control group. What is a Control Group? A control group is a group of users for whom content and interactions remain unchanged throughout a test.

What method could be used to test whether this difference between the experimental and control groups is statistically significant?

Statistical hypothesis testing - last but not least, probably the most common way to do statistical inference is to use a statistical hypothesis testing. This is a method of making statistical decisions using experimental data and these decisions are almost always made using so-called “null-hypothesis” tests.

How do you compare a control group and a treatment?

The treatment group (also called the experimental group) receives the treatment whose effect the researcher is interested in. The control group receives either no treatment, a standard treatment whose effect is already known, or a placebo (a fake treatment).

What kind of statistical test should I use to compare two groups?

The two most widely used statistical techniques for comparing two groups, where the measurements of the groups are normally distributed, are the Independent Group t-test and the Paired t-test.

What is the t-test used for?

A t-test is a statistical test that is used to compare the means of two groups. It is often used in hypothesis testing to determine whether a process or treatment actually has an effect on the population of interest, or whether two groups are different from one another.

When do you use the t-test to compare for differences between groups?

The between groups t-test is used when we have a continuous dependent variable and we are interested in comparing two groups. An example might be if there is experiment with an experimental and control group, or perhaps a comparison between two non-experimental groups like women and men.

What t-test would you run to compare the means of the treatment and control group?

Paired t-test will tell you if training is effective or not. You need to compare the data after training with the control group using unpaired t test.

When do you use an ANOVA test?

Use a one-way ANOVA when you have collected data about one categorical independent variable and one quantitative dependent variable. The independent variable should have at least three levels (i.e. at least three different groups or categories).

When do you use the Mann Whitney U test?

The Mann-Whitney U test is used to compare whether there is a difference in the dependent variable for two independent groups. It compares whether the distribution of the dependent variable is the same for the two groups and therefore from the same population.

How do you compare two groups of data statistically?

Use an unpaired test to compare groups when the individual values are not paired or matched with one another. Select a paired or repeated-measures test when values represent repeated measurements on one subject (before and after an intervention) or measurements on matched subjects.

What is at test and z-test?

Content: T-test Vs Z-test T-test refers to a type of parametric test that is applied to identify, how the means of two sets of data differ from one another when variance is not given. Z-test implies a hypothesis test which ascertains if the means of two datasets are different from each other when variance is given.

When do you use independent t-test?

The independent t-test is used when you have two separate groups of individuals or cases in a between-participants design (for example: male vs female; experimental vs control group).

Is adjustment for pretreatment differences a desperate strategy?

I disagree! Adjusting for pre-treatment differences is not a “desperate” strategy. It’s standard statistics (for example in chapter 19 of Regression and Other Stories, but it’s an old, old method; we didn’t come up with it, I’m just referring to our book as a textbook presentation of this standard method), nothing desperate at all. Also, no need to “wring significance” out of anything. The point is to summarize the evidence in the study. The adjusted analysis should indeed “move our needle” to the extent that it resolves concerns about imbalance. In this case the data are simple enough that you could just show a table of outcomes for each category treatment or control and high or low blood pressure. I guess I’d prefer to use blood pressure as a continuous predictor but that’s probably not such a big deal here.

Is the pre-existing group difference in blood pressure dramatic?

Although the pre-existing group difference in blood pressure was dramatic, their results were several orders of magnitude more dramatic. The paper Pachter is criticizing does a regression to determine whether the results are still significant even controlling for blood pressure, and finds that they are. I can’t see any problem with their math, but it should be remembered that this is a pretty desperate attempt to wring significance out of a small study, and it shouldn’t move our needle by very much either way.

Did the randomization of the study in Cordoba Hospital have malfeasance?

Or to put it another way – perhaps correcting for multiple comparisons proves that nobody screwed up the randomization of this study; there wasn’t malfeasance involved. But that’s only of interest to the Cordoba Hospital HR department when deciding whether to fire the investigators. If you care about whether Vitamin D treats COVID-19, it matters a lot that the competently randomized, non-screwed up study still coincidentally happened to end up with a big difference between the two groups. It could have caused the difference in outcome.

Why is it important to compare treatment and control groups?

The comparability of the treatment and control groups at randomization is also important because it is the first stage in our investigation of a set of methodological problems that could result in biased estimates of channeling's impact. Differences between treatment and control groups in the types of individuals who fail to respond to interviews could result in noncomparable groups in the sample being analyzed, even if the full samples were comparable. Differences in the way baseline data were collected for treatments and controls could lead to differential measurement error, which could cause regression estimates of program impacts to -be biased. In order to assess these other potential sources of bias, it is important to first determine whether the two groups were comparable before the baseline interview.

Why is treatment/control difference statistically tested?

However, because of the relatively small number of observations at each site, most of the analysis of channeling will be based on treatment/control differences at the model level, to ensure a high level of precision (i.e., the ability to distinguish between fairly small impacts of channeling and differences between treatment and control groups arising simply by chance).

What are the factors that lead to differences in the mean values of the pre-application characteristics of the treatment and control groups?

Only two factors can lead to differences in the true mean values of the pre-application characteristics of the treatment and control groups: deviation from the randomization procedures and normal sampling variability. Deviations from the carefully developed randomization procedures could be either deliberate (e.g., site staff purposely misrecording as treatments some applicants who are randomly assigned to the control group, but who have especially pressing needs for assistance) or accidental (e.g., misrecording of a sample member's status). The dedication and professionalism of this site staff and the safeguards built into the assignment procedure make either occurrence very unlikely. Site staff were extremely cooperative in faithfully executing the procedures. Sampling variability, on the other hand, is the difference between the two groups that occurs simply by chance. For the sample sizes available at the model level, such differences between the two groups should be very small, and statistically insignificant.

Why was the screening instrument used in the Channeling project?

The screening instrument was designed for a short telephone interview, to be administered in a uniform manner by each of the 10 demonstration projects. The telephone screening process was intended to reduce the cost of determining appropriateness for channeling compared to using a comprehensive in-person assessment for that purpose. Channeling project staff who conducted the screening interviews were in a separate administrative unit from assessment and case management staff. This was required chiefly to preserve the integrity of the experimental design--the potential for influencing the behavior of persons assigned to the control groups through contact with channeling staff was minimized by this administrative separation.

What is a screening instrument for nursing home placement?

The screening instrument was developed to identify those elderly individuals who were at high risk of nursing home placement ( those who in the absence of channeling would be in an institution). A set of objective criteria were established that were felt would distinguish such individuals. Data collected from the screen were used to establish whether a given applicant satisfied these criteria and should therefore be classified as eligible. The criteria incorporated the following dimensions: severe functional impairment; expected unmet need in two service categories (e.g., meal preparation, housework, administration of medication or medical treatment, etc.) for six months or more, or expected lack of sufficient help from family and friends in the coming months; residence in the community or, if institutionalized, certified as likely to be discharged into a noninstitutional setting within three months; residence within the project's geographical boundaries; age; and (for financial control sites only) Medicare Part A eligibility. 1

How many statistically significant differences are there between treatments and controls?

Out of over 250 comparisons at the five basic sites, we find 15 statistically significant differences between treatments and controls. (at the 90 percent or greater confidence level). This is substantially less than the 25 that might be expected to occur simply by chance. As shown in Table 4, the significant differences were more prevalent in Kentucky than in other sites, but tended to be scattered rather than concentrated in specific variables. Thus, there is no indication of systematic tampering with the random assignment process.

How are treatments different from controls?

Demographics and living arrangements show no significant differences between treatments and controls for the financial control model. Slightly more treatments than controls are male; slightly more controls than treatments are black. The proportion of treatments with income in excess of 1,000 dollars per month was significantly lower for treatments than controls (5.7 versus 7.3 percent, respectively); however, the difference is not large in absolute terms and the average incomes of the two groups do not differ significantly. Just over 2 percent of both treatments and controls lived in long term care institutions at the time the screen.

When testing period ends and results are analyz ed, what is a control group?

When the testing period ends and results are analyz ed, a control group can be used to establish how users would have behaved had no changes been implemented. By comparing these results against the results of the different variables, marketers will easily see what impact their changes have had.

What is a test group?

A test group is the name given to the entire group of users who will be analyzed as part of a study. So, if you’re running a mobile A/B test and the variables are being sent to a set proportion of users, your test group will be the total number of users being sent either variable.

Why do marketers use test groups?

Marketers use test groups to study how users interact with their campaigns, and control groups too have an important role to play . Read on to find out more about how these groups differ and learn how they can be used to ensure the accuracy of test results.

What is a control group?

A control group is a group of users for whom content and interactions remain unchanged throughout a test. By creating such a group and measuring the interactions of this group throughout the study, marketers can start to understand how different variables may have changed their results. Without a control group, ...

Why is thorough testing important?

Thorough testing and analysis is key to gaining a greater understanding of users’ behavior. It’s this understanding that helps to pave the way for improvements in marketing campaigns, enabling marketing professionals to learn from users’ past behavior and tweak interactions to appeal to the specific preferences of target audiences.

Why are control groups important?

Control groups are particularly important in A/B testing and multivariate testing, as they help to ensure the results of such tests are as accurate as they can possibly be. Take a look at some of the main uses of control groups for marketing professionals below.

How do control groups work?

Control groups are used in many different areas of research. Take drug trials, for example. In every drug trial, there will be a group of people who do not receive any of the drugs being tested. Instead, they’ll be given a placebo. This allows researchers to study the results of any drugs that were tested, and compare them to a scenario in which participants received no treatment. A control group works in exactly the same way.

What should you do if you have 3 groups?

If you have three groups you should do an ANOVA (after checking assumptions of normality etc of course) which will test if the three groups differ overall. If that is the case you can then either do contrasts or post-hoc tests to test your hypotheses directly, e.g. does group 1 differ from group 2.

Why do we use ANOVA in textbooks?

Textbooks say 3 groups or more, use ANOVA to avoid type-1 errors.

Can you run two t-tests instead of ANOVA?

You can also run two t-tests instead of either an ANOVA or Dunnett's test, but if you want to control for type I error inflation, you will need to use the Bonferroni correction as your tests would not be independent.

All Answers (9)

Your case sounds a lot like the situation in AIDS Research. Prof Marie Davidian has done a lot of work in that area. I am attaching a document from her that you may find helpful describing methods used there and in similar situations. Hope this helps. Best wishes, David Booth

Similar questions and discussions

What statistical test should I use if I have control and experimental groups to show pre to post treatment significant changes?

Which test is used for analysis of two groups?

T-test is used for the analysis of two groups and ANOVA is used for more than two groups. Is that right?

Why do you conduct Levene's test?

I also recommend conducting Levene's test to determine if the groups have similar error variances. This will give you at least some confidence that the groups are similar.

What is an alternate design for the groups comparison?

An alternate design for the groups comparison would be one-way ancova ; such that randomly occurring differences between groups at baseline would be controlled for, and the group/condition comparison would be on post scores adjusted for pre/baseline differences.

What does paired t-test tell you?

Paired t-test will tell you if training is effective or not. You need to compare the data after training with the control group using unpaired t test. If more than two groups you can use ANOVA.

Why is precision medicine important?

As autoimmunologists we truly believe there is a strong need for Precision Medicine approaches that can improve the care of individuals with autoimmune diseases, or even lead to disease prevention.

Does Mauchley's test apply to repeated measures?

For repeated measures factors, Mauchley's test is applicable only if there are more than two measurements/levels of the factor. You have two (pre, post), so it does not apply.

Is repeated measures ANOVA better than t-tests?

Yes, a repeated-measures ANOVA is better than conducting multiple t-tests since you increase the risk of committing a Type-I error with each test. In this case, a repeated-measures ANOVA including 'training' as a between-subjects factor with two levels (training, control) and 'time' as a within-subjects factor with two levels (pre, post).

Control Groups in Experiments

  • Control groups are essential to experimental design. When researchers are interested in the impact of a new treatment, they randomly divide their study participants into at least two groups: 1. The treatment group (also called the experimental group) receives the treatment whose effect the researcher is interested in. 2. The control groupreceives e...
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Control Groups in Non-Experimental Research

  • Although control groups are more common in experimental research, they can be used in other types of research too. Researchers generally rely on non-experimental control groups in two cases: quasi-experimental or matching design.
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Importance of Control Groups

  • Control groups help ensure the internal validityof your research. You might see a difference over time in your dependent variable in your treatment group. However, without a control group, it is difficult to know whether the change has arisen from the treatment. It is possible that the change is due to some other variables. If you use a control group that is identical in every other way to t…
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