Treatment FAQ

what test do you order after treating a patient for h pylori to see if treatment worked?

by Rocky Erdman Published 2 years ago Updated 2 years ago

Stool antigen tests are very often a preferred choice for both diagnosing H pylori and confirming that the treatment has been successful. Although some people would be embarrassed about providing a stool sample, this particular test has a high rate of accuracy. Yet all of these tests have good and bad points.

Stool PCR test.
A lab test called a stool polymerase chain reaction (PCR) test can detect H. pylori infection in stool. The test can also identify mutations that may be resistant to antibiotics used to treat H. pylori .
May 5, 2022

Full Answer

Why would I need an H pylori test?

There are different ways to test for H. pylori. Your health care provider may order one or more of the following types of tests. Blood test. Checks for antibodies (infection-fighting cells) to H. pylori; Test procedure: A health care professional will take …

What are the different types of H pylori tests?

The stool antigen test and urea breath test are recommended for the diagnosis of an H. pylori infection and for the evaluation of the effectiveness of treatment. These tests are the most frequently performed because they are fast and noninvasive. (The urea breath test is not typically recommended for young children.

When should I get tested for Helicobacter pylori after treatment?

The H. pylori breath test involves breathing into a balloon-like bag. It's a safe and easy way to detect H. pylori bacteria, diagnosis H. pylori infection, and determine if treatment cured the infection. H. pylori infection is a major cause of peptic ulcer disease. Its presence also increases your risk of gastritis and stomach cancer.

Do doctors run H pylori retesting?

Jan 15, 2018 · Testing for H. pylori is indicated in certain patients. Any patient who tests positive for H. pylori infection should be treated. All patients with active or …

How do you recheck H. pylori after treatment?

Serology for H. pylori can remain positive for months to years, and therefore, it cannot be used to confirm post-treatment eradication. There are two noninvasive tests that can be used as alternatives to endoscopy and biopsy: the urea breath test and the stool antigen test.Jun 3, 2008

Do you need to retest for H. pylori after treatment?

If treatment has failed to eradicate the infection, we recommend repeat therapy. H pylori infection treatment is sought only by patients who have up- per intestinal symptoms. These symptoms are often the result of gastritis, ulcer, or esophageal reflux disease.

What testing of H. pylori may stay positive after HP eradication?

The American College of Gastroenterology (ACG) endorses the carbon 13-labeled urea breath test (13C-UBT) as the most reliable test to confirm H pylori eradication.

Which tests are potential diagnostic tests for H. pylori?

The stool antigen test and urea breath test are recommended for the diagnosis of an H. pylori infection and for the evaluation of the effectiveness of treatment. These tests are the most frequently performed because they are fast and noninvasive.Nov 9, 2021

What is the second treatment for H. pylori?

The Maastricht V/Florence Consensus Report recommends bismuth quadruple therapy, or fluoroquinolone-amoxicillin triple/quadruple therapy as the second-line therapy for H. pylori infection.Oct 28, 2018

How long does H. pylori stay positive after treatment?

Conclusion: We conclude that a 20% decline in IgG concentration has an overall sensitivity of 93% for determining H. pylori eradication 12-21 months after H. pylori treatment. Serology is an attractive alternative to endoscopy or urea breath tests in monitoring patients after H.

What is H. pylori IgG test?

This blood test is used to detect a Helicobacter pylori (H. pylori) infection in the upper part of the small intestine (duodenum) and stomach.

Can you test for H. pylori with a blood test?

Blood tests are used to measure antibodies to H pylori. Antibodies are proteins made by the body's immune system when it detects harmful substances such as bacteria. Blood tests for H pylori can only tell if your body has H pylori antibodies. It cannot tell if you have a current infection or how long you have had it.Jul 1, 2021

What is H. pylori serology test?

This test is used to diagnose bacterial infections that cause stomach ulcers. Helicobacter pylori are bacteria that are very common in the general population and the most frequent cause of stomach ulcers.

How does H. pylori test work?

H. pylori bacteria (if present) breaks down the urea in the solution you drank, releasing carbon dioxide in the breath you exhale. So if the amount of carbon dioxide in your second sample is higher than the amount in your first sample, you have a positive test for the presence of H. pylori.Nov 20, 2020

What does H. pylori IgM positive mean?

Circulating antibodies to H pylori are predominantly of the IgG class. A systemic response of the IgA type is usually less pronounced but, if significant, may indicate a more severe inflammation. A few patients develop only antibodies to IgA. Antibodies to IgM, although rare, may indicate an early infection.

How do you read H. pylori test results?

Possible results are as follows: Positive: H pylori antigen detected. Equivocal: See Interpretation. Negative: H pylori antigen not detected.
...
Blood test (normal findings)
  1. ≤30 U/mL: Negative.
  2. 30.01-39.99 U/mL: Equivocal.
  3. ≥40 U/mL: Positive.
Nov 20, 2019

What tests are done for H pylori?

There are different ways to test for an H. pylori infection. They include blood, stool, and breath tests.

What is helicobacter pylori?

What are helicobacter pylori (H. pylori) tests? Helicobacter pylori (H. pylori) is a type of bacteria that infects the digestive system. Many people with H. pylori will never have symptoms of infection. But for others, the bacteria can cause a variety of digestive disorders.

What is the name of the bacteria that infects the digestive system?

Helicobacter pylori (H. pylori) is a type of bacteria that infects the digestive system. Many people with H. pylori will never have symptoms of infection. But for others, the bacteria can cause a variety of digestive disorders. These include gastritis (inflammation of the stomach), peptic ulcers (sores in the stomach, small intestine, ...

Can H pylori cause gastritis?

Many people with H. pylori will never have symptoms of infection. But for others, the bacteria can cause a variety of digestive disorders. These include gastritis (inflammation of the stomach), peptic ulcers (sores in the stomach, small intestine, or esophagus), and certain types of stomach cancer.

How to get blood sample from arm?

A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. Breath test, also known as a urea breath test. You will provide a sample of your breath by breathing into a collection bag.

What is breath test?

Breath test, also known as a urea breath test. Checks for infection by measuring certain substances in your breath. Test procedure: You will provide a sample of your breath by breathing into a collection bag. After that, you will swallow a pill or liquid containing a harmless radioactive material.

How to check for infection?

Checks for infection by measuring certain substances in your breath. Test procedure: You will provide a sample of your breath by breathing into a collection bag. After that, you will swallow a pill or liquid containing a harmless radioactive material. You will provide another sample of your breath.

How to tell if you have H pylori?

This test can be used to diagnose the infection and confirm that it has been cured after treatment. A tissue sample , called a biopsy, is taken from the stomach lining. This is the most accurate way to tell if you have an H pylori infection.

How long does it take for H pylori to show up in your breath?

If H pylori are present, the bacteria convert the urea into carbon dioxide, which is detected and recorded in your exhaled breath after 10 minutes. This test can identify almost all people who have H pylori. It can also be used to check that the infection has been fully treated.

Where is a biopsy done?

The procedure is done in the hospital or outpatient center. Usually, a biopsy is done if endoscopy is needed for other reasons. Reasons include diagnosing the ulcer, treating bleeding, or making sure there is no cancer.

Why do you need a biopsy?

Usually, a biopsy is done if endoscopy is needed for other reasons. Reasons include diagnosing the ulcer, treating bleeding, or making sure there is no cancer.

What is the cause of ulcers?

Helicobacter pylori is a type of bacteria that is known to be a major cause of peptic ulcers. H. pylori testing detects an infection of the digestive tract caused by the bacteria to help diagnose the cause of symptoms and/or ulcers. H. pylori infections of the digestive tract are very common, with as many as half of the world's population infected.

Does H pylori cause ulcers?

However, most people with H. pylori never have any symptoms. Still, H. pylori infection increases the risk of developing ulcers (peptic ulcer disease), persistent stomach inflammation (gastritis), and gastric (stomach) cancer. The bacteria decrease the stomach's ability to produce mucus, making the stomach prone to damage from digestive acid ...

How does a breath test work?

For the urea breath test, a healthcare professional collects an initial sample of your breath by having you breathe into a bag. You are given a liquid to drink containing a substance called urea. Another breath sample is collected after a specific amount of time has elapsed.

What is the purpose of H pylori test?

H. pylori testing is used to detect the bacteria in the digestive tract, diagnose the infection, and to evaluate whether treatment has cured the infection. There are several different types of H. pylori testing that can be performed. The following tables summarize these tests:

How long does it take to get a urea test?

You will be instructed to drink a liquid containing a substance called urea, which is specially 'labeled' and then wait about 15 minutes.

How long does it take for a bacterial test to show results?

The bacteria are grown on/in a nutrient media; results can take several weeks. This test is necessary if the healthcare practitioner wants to evaluate which antibiotic will likely cure the infection. (See also Antibiotic Susceptibility Testing .) PCR (polymerase chain reaction) Fragments of H. pylori DNA are amplified and used to detect ...

What is the purpose of PCR for H. pylori?

pylori DNA are amplified and used to detect the bacteria; primarily used in a research setting. The stool antigen test and urea breath test are recommended for the diagnosis of an H. pylori infection and for the evaluation of the effectiveness of treatment.

What is the H. pylori breath test?

H. Pylori (Helicobacter Pylori) Breath Test / Urea Breath Test. The H. pylori breath test involves breathing into a balloon-like bag. It's a safe and easy way to detect H. pylori bacteria, diagnosis H. pylori infection, and determine if treatment cured the infection. H. pylori infection is a major cause of peptic ulcer disease.

What is H pylori?

What is H. pylori? H. pylori (Helicobacter pylori) is a bacteria that infects your stomach or duodenum (first part of the small intestine).

What is the name of the bacteria that infects the stomach?

H. pylori (Helicobacter pylori) is a bacteria that infects your stomach or duodenum (first part of the small intestine). H. pylori bacteria can increase your risk of developing: Gastritis (an inflammation or irritation of the stomach lining).

Can H pylori cause gastric ulcers?

H. pylori bacteria can increase your risk of developing: Gastritis (an inflammation or irritation of the stomach lining). Peptic ulcer disease (which is either duodenal or gastric/stomach ulcers). Stomach (gastric) cancer. H. pylori is a major cause of peptic ulcer. The bacteria decreases the stomach’s protective mucus.

What causes peptic ulcers?

Stomach (gastric) cancer. H. pylori is a major cause of peptic ulcer. The bacteria decreases the stomach’s protective mucus. This makes it easier for the stomach to be damaged from digestive acids.

What test is used to diagnose H pylori?

Ideally, tests that identify active infection, such as a urea breath test, fecal antigen test, or endoscopic biopsy, should be used in the diagnosis of H. pylori infection. However, because the pretest probability of infection is higher in patients with documented peptic ulcer disease, immunoglobulin G antibody testing is acceptable in these ...

Can you test positive for H pylori?

Any patient who tests positive for H. pylori infection should be treated. All patients with active or previous peptic ulcer disease should be tested for H. pylori infection unless there is documentation that the infection was previously cured.

Is Helicobacter pylori a chronic infection?

From the AFP Editors. Helicobacter pylori infection is one of the most common chronic bacterial infections. The American College of Gastroenterology (ACG) has updated its clinical guidelines in response to significant scientific advances in the management of this disease. Because there is a lack of randomized controlled trials in North America ...

What are the risk factors for a child with a syphilis?

Risk factors include low socioeconomic status; increased number of siblings; and having an infected parent, particularly a mother. The incidence and prevalence of the disease are generally higher among persons born outside of North America.

What is the ACG test for?

Based on low-quality evidence, the ACG also recommends testing for those initiating long-term nonsteroidal anti-inflammatory drug therapy, those with unexplained iron deficiency anemia, and adults with idiopathic thrombocytopenic purpura.

How long does Clarithromycin triple therapy last?

Clarithromycin triple therapy consists of a PPI, clarithromycin (Biaxin), and amoxicillin or metronidazole (Flagyl) for 14 days. The effect of H. pylori resistance to clarithromycin is well documented.

How long does bismuth quadruple therapy last?

Bismuth quadruple therapy consists of a PPI, bismuth, tetracycline, and a nitroimidazole for 10 to 14 days. It may be a particularly good option in patients with macrolide exposure or who are allergic to penicillin.

How to treat H pylori?

Prevent or manage an H. pylori infection: 1 Wash your hands often. Infection can happen through contact with infected bowel movement, vomit, or saliva. Use soap and warm water. Use an alcohol-based gel if soap and water are not available. Clean your hands before you eat and after you use the bathroom. Clean your hands after you change a baby's diaper. 2 #N##N# 3 Handle food properly. Infection can happen if you drink water that is not clean or eat food that is not washed or cooked properly. Rinse food well before you cook or eat it. Cook food all the way through. Proper handling will help kill any bacteria that may be on your food. 4 Drink clean water from a safe source. Only drink water that has been filtered or purified. 5 Ask about NSAIDs. NSAIDs can cause stomach bleeding and kidney problems if not taken correctly. Your healthcare provider may tell you to avoid these medicines because they can make your symptoms worse. 6 Do not smoke. Nicotine and other chemicals in cigarettes and cigars can worsen your symptoms. Ask your provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your provider before you use these products. 7 Do not drink alcohol. Alcohol may worsen your symptoms of heartburn. Alcohol also increases the risk for cancer of the esophagus or stomach. Ask your provider for information if you currently drink alcohol and need help to quit.

Can H. pylori cause cancer?

H. pylori may lead to changes in the cells of your esophagus or stomach. The cells are changed into intestine cells. This is a condition called intestinal metaplasia that increases your risk for cancer of the esophagus or stomach.

Can you take 2 antibiotics at the same time?

Your healthcare provider will prescribe 2 antibiotics at the same time. Antiulcer medicines help decrease the amount of acid that is normally made by the stomach. These help heal or prevent ulcers. Bismuth is a liquid or tablet that may be used to decrease heartburn, upset stomach, or diarrhea.

Does bismuth help with ulcers?

These help heal or prevent ulcers. Bismuth is a liquid or tablet that may be used to decrease heartburn, upset stomach, or diarrhea. It may also decrease swelling in your stomach and help kill the bacteria if other medicines do not work. It also protects ulcers from stomach acid so they can heal.

What is Bismuth used for?

Bismuth is a liquid or tablet that may be used to decrease heartburn, upset stomach, or diarrhea. It may also decrease swelling in your stomach and help kill the bacteria if other medicines do not work. It also protects ulcers from stomach acid so they can heal. Take your medicine as directed.

How to get rid of a swollen bowel?

Infection can happen through contact with infected bowel movement, vomit, or saliva. Use soap and warm water. Use an alcohol-based gel if soap and water are not available. Clean your hands before you eat and after you use the bathroom. Clean your hands after you change a baby's diaper.

Can NSAIDs cause kidney problems?

NSAIDs can cause stomach bleeding and kidney problems if not taken correctly. Your healthcare provider may tell you to avoid these medicines because they can make your symptoms worse. Do not smoke. Nicotine and other chemicals in cigarettes and cigars can worsen your symptoms.

Can H pylori be in your stomach?

Even if your symptoms improve, H pylori can still be hanging around in your stomach after you’re completed your treatment. Unfortunately, doctors may not always want to run a retest, so it’s important to understand your options. This short video and article will provide you with guidance on exactly what to do when it comes to H pylori retesting.

How long does it take for H pylori to work?

Alas, some docs believe that H pylori treatment works – you take your triple or quadruple therapy for 7-14 days and that’s it, you’re done. But as you know if you’ve read the statistics I present on this website, H pylori treatment is only successful 65-70% of the time.

How long does it take to get rid of H pylori?

Alas, some docs believe that H pylori treatment works – you take your triple or quadruple therapy for 7-14 days and that’s it, you’re done.

What are the symptoms of H pylori?

H pylori symptoms return (or never go away) because of: 1 Collateral damage caused by H pylori and other things 2 Ongoing food sensitivities 3 Eating and lifestyle habits 4 Other bad bugs like Candida, SIBO and intestinal parasites 5 Low stomach acid and other digestive problems 6 Reinfection from family members or sexual partners

Does H pylori go away?

Why some people’s H pylori symptoms never go away in the first place. Doctors rightly treat H pylori when they find it. But they generally don’t consider three important factors that can prevent symptoms from clearing.

Can antibiotics kill H pylori?

Alas, as you know, the medical system is only intent on giving you the antibiotics you need to kill H pylori. Docs rarely offer any advice on what to do to accelerate digestive healing. If they did, they’d suggest avoiding certain foods and using specific herbs and nutrients.

Can H pylori cause nausea?

Well, the main H pylori symptoms – heartburn, tummy pain, reflux, bloating, burping, nausea and so on – can all be caused by other things.

Can antibiotics cause SIBO?

Third, research indicates that antibiotics can increase your susceptibility to other bacterial problems including SIBO and Clostridium difficile.

Definition

How The Test Is Performed

  • There are several methods to test for H pyloriinfection. Breath Test (Carbon Isotope-urea Breath Test, or UBT) 1. Up to 2 weeks before the test, you need to stop taking antibiotics, bismuth medicines such as Pepto-Bismol, and proton pump inhibitors (PPIs). 2. During the test, you swallow a special substance that has urea. Urea is a waste product th...
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Why The Test Is Performed

  • Testing is most often done to diagnose H pyloriinfection: 1. If you currently have a stomach or duodenal ulcer 2. If you had a stomach or duodenal ulcer in the past, and were never tested for H pylori 3. After treatment for H pyloriinfection, to make sure there are no more bacteria Testing may also be done if you need to take long-term ibuprofen or other NSAID medicines. Your healt…
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What Abnormal Results Mean

  • Abnormal results mean that you have an H pyloriinfection. Your provider will discuss treatment with you.
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References

  • Cover TL, Blaser MJ. Helicobacter pylori and other gastric Helicobacter species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 217. Morgan DR, Crowe SE. Heliobacter pylori infection. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastroint…
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