What are antituberculosis agents?
What are Antituberculosis agents? Antituberculosis agents are drugs used to treat tuberculosis, an infectious disease caused by Mycobacterium tuberculosis. This infection mainly affects the lungs but can also affect many other organ systems. Many classes of drugs, with different mechanism of action have activity against Mycobacterium tuberculosis.
How often do anti-tuberculosis drugs induce hepato-toxicity?
Conclusions: Anti-tuberculosis drugs induced hepatotoxicity occurs less frequently. All patients put on anti-tuberculous therapy must be followed up for at least the initial 4 weeks, and the patient and caregivers should be told how to recognize signs of anti-tuberculous induced hepato-toxicity.
What causes discrepancy in drug susceptibility testing for tuberculosis (TB) (TB)?
Mei Z, Sun Z, Bai D, Xu Y, Li Z, Huang H, et al. Discrepancies in drug susceptibility test for TB patients resulted from the mixed infection and the testing system. Biomed Res Int. 2015; 2105 :651980. [ PMC free article] [ PubMed] [ Google Scholar] [ Ref list] 13.
What are the second-line anti-tuberculosis drugs?
Second-line anti-tuberculosis drugs are clinically much less effective than first-line agents and elicit severe reactions much more frequently. These drugs include para-aminosalicylic acid (PAS), ethionamide, cycloserine, amikacin and capreomycin.
What are anti Tuberculars?
Antitubercular medications: rifampin, isoniazid, pyrazinamide, and ethambutol are FDA approved to treat Mycobacterium tuberculosis infections. Antitubercular medications are a group of drugs used to treat tuberculosis.
Which test is done for susceptibility to tuberculosis?
Beacon Assays. Beacon assays detect M. tuberculosis complex and associated rifampicin resistance directly from sputum samples using ultra sensitive PCR. The Genexpert TB assay is an automated real time based system that has a number of advantages including the fact that it is a closed tube system.
What is the test for tuberculosis?
The tuberculosis (TB) blood test, also called an Interferon Gamma Release Assay or IGRA, is a way to find out if you have TB germs in your body. The TB blood test can be done instead of a TB skin test (Mantoux). There are two kinds of TB blood tests: QuantiFERON®-TB.
What is the most common adverse effect of first line drug therapy for tuberculosis?
The most common serious adverse event was rash and/or drug fever.
What does drug susceptibility testing determine?
Susceptibility tests determine a microbe's vulnerability to antimicrobial drugs by exposing a standardized concentration of organism to specific concentrations of antimicrobial drugs. Susceptibility testing can be done for bacteria, fungi, and viruses.
Why are drug susceptibility tests done for TB?
The rapid and accurate diagnosis of tuberculosis (TB) and determination of drug susceptibility is critical for patient treatment and to prevent the emergence and spread of resistant strains.
Will you test positive for TB after treatment?
Yes, this is true. Even after you finish taking all of your TB medicine, your TB skin test or TB blood test will still be positive. Ask your healthcare provider to give you a written record that says your test was positive and that you finished treatment.
How many types of TB tests are there?
There are two types of tests used to diagnose TB: a blood test and a skin test. Your results from either test won't reveal whether you have latent or active TB. Instead, they're used to determine if you should be treated and with what type of medication.
What is the gold standard for TB diagnosis?
Nucleic Acid Amplification (NAA) Test Culture remains the gold standard for laboratory confirmation of TB disease, and growing bacteria are required to perform drug-susceptibility testing and genotyping.
What are the most common adverse drug reactions to anti tuberculosis drugs?
The most common ADR is the gastrointestinal symptom such as nausea/vomiting (18.6%), abdominal pain (2.3%) and diarrhea (1%). Other adverse events include 23 skin rashes (7.4%), 21 hepatitis (6.7%), 18 cases of pruritus (5.8%), 6 patients with arthralgia (2%), 3 dizziness (1%) and 2 optic neuropathies (0.7%).
What are the side effects of anti tuberculosis?
Common side effectsfeeling sick or dizzy.skin rashes.pins and needles.flu like symptoms.In very few cases people may experience jaundice, which is the yellowing of skin or eyes. If this happens, stop taking your medication and tell your doctor straight away.
What are common adverse reactions to TB treatment?
Adverse EventsUnexplained loss of appetite, nausea or vomiting, brown urine*, or jaundice (yellowing of skin or eyes)Persistent tingling, numbness, or burning of hands or feet.Persistent weakness, fatigue, fever, or abdominal tenderness.Easy bruising or bleeding.Blurred vision or changed vision.