
Treatment-resistant depression has been discussed widely for years, but treatment resistance in PTSD-another common, serious, disabling condition-has been less frequently addressed in the literature. While 70% of the world’s population has been exposed to a traumatic event, only 5.6% meet DSM-5 criteria for PTSD. 1 Moreover, 44% of patients with a PTSD diagnosis recover even without specific treatment. 2
What is the best medication for PTSD?
Medications have two names: a brand name (for example, Zoloft) and a generic name (for example, sertraline). There are four SSRIs/SNRIs that are recommended for PTSD: There are other types of antidepressant medications, but these four medications listed above are the ones that are most effective for PTSD. SSRI/SNRI: How do meds help?
What are SSRIs/SNRIs for PTSD?
SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors) are types of antidepressant medication. There are four SSRIs/SNRIs that are recommended for PTSD:
What is posttraumatic stress disorder (PTSD)?
Posttraumatic stress disorder (PTSD) is a widespread and often devastating psychiatric condition. Core symptoms include intrusive and distressing thoughts, heightened reactivity, mood changes, cognitive impairments, and consequent avoidance of trauma-related stimuli.
Can my doctor prescribe antidepressants for PTSD?
Many different types of providers, including your family provider and even some nurses and physician assistants, can prescribe antidepressant medications for PTSD. You and your provider can work together to decide which antidepressant medication may be best for you.

What percentage of PTSD is treatment resistant?
It has been suggested that about 33% of people in the general population who have PTSD are resistant to treatment; the non-response rates for cognitive behavioral therapy may be as high as 50% and for selective serotonin reuptake inhibitors about 20–40% (Green, 2013).
What are some of the barriers to treatment of the PTSD?
Barriers for effective trauma treatmentsAcknowledgment of survivors. Across many cultures trauma survivors may experience stigmatization, and a lack of acknowledgment. ... Avoidance and trauma disclosure. One of the core PTSD symptoms is avoidance. ... Limited resources. ... Ongoing conflicts and disasters.
Why is PTSD difficult to treat?
PTSD is difficult to treat because it is stored throughout the brain.
What is the most successful form of treatment for PTSD?
Psychotherapy. Cognitive Behavior Therapy (CBT): CBT is a type of psychotherapy that has consistently been found to be the most effective treatment of PTSD both in the short term and the long term. CBT for PTSD is trauma-focused, meaning the trauma event(s) are the center of the treatment.
What are the limitations of trauma-informed care?
Challenges to implementing a trauma-informed approach to care include: a lack of clearly articulated definitions (e.g. of trauma-specific interventions vs the concept and principles of trauma-informed care); translating trauma-informed care to specific practice and service settings; consistency across service settings ...
What is the barrier of trauma?
Six common barriers to trauma inquiry were selected based on published research (see introduction) and discussions with SUD stakeholders: 'Feeling uncomfortable when asking about traumatic events', 'Fear of offending the client when asking about traumatic events', 'Fear of retraumatizing the client when asking about ...
Can PTSD be treatment-resistant?
An individual who, despite adequate treatment with antidepressants and cognitive behavioral therapy, still meets the criteria for PTSD is considered treatment-resistant.
How does PTSD limit ability to work?
Now, symptoms of PTSD can interfere with the individual's ability to work in numerous ways. These include memory problems, lack of concentration, poor relationships with coworkers, trouble staying awake, fear, anxiety, panic attacks, emotional outbursts while at work, flashbacks, and absenteeism.
Can complex PTSD be cured?
But is complex PTSD curable? Despite its own inherent barriers to healing, complex post-traumatic stress disorder is treatable. With a knowledgeable and compassionate guide, someone can approach their all-too-familiar barriers and triggers and begin to reshape their experiences.
What is the gold standard treatment for PTSD?
behavior therapy, or TF-CBT, is considered the gold standard treatment for children and adolescents with PTSD.
Is medication or therapy better for PTSD?
“PTSD is one diagnosis for which the psychotherapy modalities, which are evidence-based, are shown to be far more effective than any medication,” Dr. Hunter says. Those modalities include therapies like prolonged exposure therapy, cognitive processing therapy, and eye movement desensitization (all described later).
What is the most effective therapy for trauma?
What is the 'best' therapy for trauma?Cognitive behavioral therapy (CBT) CBT is often considered the first line of defense against trauma. ... Prolonged exposure (PE) therapy. ... Eye movement desensitization and reprocessing (EMDR)
Review of First-Line Treatments For PTSD
An Approach to Treatment Resistance
- For the 70% of patients who do not achieve full remission despite use of first-line treatments, a number of important factors should be considered before determining the best next-step—please see the algorithm in Fig. 1which summarizes a practical approach. The first is to review the diagnosis and clarify problematic target symptoms. While the characteristic trauma and well-def…
Next-Step and Augmentation Strategies For Treatment Resistance
- Managing TRPTSD requires balancing the desire to reduce the symptom burden and functional impairment endured by sufferers with a degree of uncertainty about the best treatment due to the relatively limited evidence base [8••, 27••]. A rational approach should involve detailed assessment as already described, followed by an individualized treatment plan. The intervention choices in a…
Novel and Emerging Treatments
- Complementary and alternative medicine
Alongside conventional treatment, there is some evidence that complementary and alternative medicine (CAM) may be valuable in PTSD [74, 75]. While there are important criticisms of this evidence base, in particular the weak methodologies of many of the studies [76], the potential be… - Emerging pharmacological options
Based on increasing understanding of the neurobiology of PTSD, several novel pharmacological treatments are being investigated [16•, 22]. Initially used for treatment-resistant depression [83], the glutamate NMDA receptor antagonist ketamine given as a single infusion produced rapid an…