Can Zometa be used to treat cancer patients?
Zometa is FDA-approved to treat hypercalcemia due to cancer. This is a high level of calcium in your blood that’s caused by cancer. It’s not known if Zometa is safe or effective for treating hypercalcemia caused by hyperparathyroidism.
How does Zometa work to prevent bone resorption?
Zometa contains the bisphosphonate drug zoledronic acid. It prevents bone resorption by osteoclasts. Zometa binds to mineralized bone, thereby blocking the action of osteoclasts on the bone. Zometa is also absorbed by the osteoclasts.
What is the typical Zometa dosage for hypercalcemia from cancer?
The typical Zometa dosage for adults with hypercalcemia from cancer is 4 mg, given as a single dose. This should be infused over at least 15 minutes. This should be infused over at least 15 minutes.
What is the efficacy of Zometa and pamidronate?
The primary endpoint of the studies was the number of patients whose calcium levels became normal after ten days of treatment. The two studies indicated that 88% of the zometa treated patients had normal calcium levels within ten days, compared to 70% of those treated with pamidronate.
What are side effects of Zometa?
Common side effects of Zometa include:dizziness,headache, or.flu-like symptoms (such as fever, chills, muscle/joint aches),cough,vision problems,diarrhea,constipation,tired feeling,More items...
What is the most common side effect of zoledronic acid?
Fever is the most common adverse effect associated with zoledronic acid infusion. Flu-like syndromes including fever, chills, bone pain, and/or arthralgias and myalgias have also occasionally been reported. These symptoms generally did not require treatment and resolved within 24 to 48 hours.
Is Zometa a form of chemotherapy?
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates.
What are the long term side effects of Zometa?
Blurred vision or other change in vision.decreased frequency or amount of urine.decreased vision.eye pain.eye tenderness.heavy jaw feeling.increased blood pressure.increased tearing.More items...•
How does zoledronic acid make you feel?
Vomiting. Constipation. Flu-like symptoms; mild fever sometimes accompanied by malaise, chills, fatigue and flushing. Usually occurs with first treatment with zoledronic acid only.
Who should not take zoledronic acid?
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, dehydration, aspirin-sensitive asthma. Some people using zoledronic acid may have serious jawbone problems. Your doctor should check your mouth before you start this medication.
Does Zometa cause hair loss?
Hair loss can occur with Zometa use. Hair loss can also occur with cancer treatments that you may have with Zometa.
How often do you get Zometa infusion?
Both Zometa and Aredia are given intravenously, usually every 4 weeks. A study suggests that after being treated with the regular dose of Zometa and/or Aredia for a year, women with bone metastases can get Zometa every 12 weeks and still get the same benefits from the medicine while reducing their risk of side effects.
Does Zometa affect your kidneys?
Zoledronic acid is associated with reports of renal impairment and renal failure, especially in patients with pre-existing renal dysfunction or other risk factors. The product information for Zometa already contains strong warnings and precautions regarding renal impairment and renal failure.
What is the cost of Zometa?
The cost for Zometa intravenous solution (4 mg/100 mL) is around $973 for a supply of 100 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. A generic version of Zometa is available, see zoledronic acid prices.
Can Zometa cause liver damage?
The most common adverse effects of ZOL treatment are post-dose symptoms [4, 5]. BP-induced liver injury is rare. Only a few cases [6–15] have been reported including two cases of ZOL [13, 14].
Does Zometa affect your immune system?
In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].
Before Taking This Medicine
You should not be treated with Zometa if you are allergic to zoledronic acid.You should not be treated with Zometa if are currently using any other...
Zometa Dosing Information
Usual Adult Dose for Osteolytic Bone Lesions of Multiple Myeloma:Zometa:4 mg IV over no less than 15 minutes, every 3 to 4 weeksComments: Oral calc...
What Should I Avoid While Receiving Zometa?
Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.Avoid drinking large amounts of alcohol....
What Other Drugs Will Affect Zometa?
Zoledronic acid can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, inj...
Will Zometa cure my condition?
Zometa can’t cure cancer. But the drug can help protect your bones from damage caused by having cancer in your bones. Keep in mind that cancer does...
Is Zometa chemotherapy?
No, Zometa isn’t chemotherapy. Zometa belongs to a class of drugs called bisphosphonates. (A class of drugs is a group of medications that work in...
If I have asthma, can I use Zometa?
You may be able to have Zometa treatment if you have asthma, but you should check with your doctor. Zometa is a type of drug called a bisphosphonat...
Can I use Zometa with Reclast?
No, you shouldn’t have Zometa treatment if you’re using Reclast. These medications contain the same active drug, zoledronic acid. Taking these medi...
If I have kidney problems, can I use Zometa?
You may be able to have Zometa treatment if you have kidney problems. It depends how severe your kidney problems are and what Zometa is treating. F...
Can I have dental work done while taking Zometa?
No, it’s best not to have dental work during Zometa treatment. Doing so can raise your risk for a serious side effect called osteonecrosis of the j...
What is the FDA's approval for Zometa?
The Food and Drug Administration (FDA) approves prescription drugs such as Zometa to treat certain conditions. Zometa may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.
What is the active ingredient in Zometa?
Zometa contains the active drug zoledronic acid. It belongs to a class of drugs called bisphosphonates. A class of drugs is a group of medications that work in a similar way. Bisphosphonates help to prevent the breakdown of bone.
How long does it take for Zometa to go away?
The symptoms typically ease in a few days. However, for some people, it may take up to 2 weeks or longer for these symptoms to go away. Most other side effects of Zometa tend to go away either on their own or with treatment. This usually takes a few days to a couple of weeks.
How many milligrams of Zometa are in a bottle?
Zometa comes as a liquid that’s available in two different forms: a single-dose, ready-to-use bottle containing 4 milligrams (mg) of drug in 100 milliliters (mL) of solution. a single-dose vial containing 4 mg of drug in 5 mL of solution. Zometa is given as an intravenous (IV) infusion by a healthcare provider.
How often should I give Zometa?
The typical Zometa dosage for adults with multiple myeloma or bone metastases from solid tumors is 4 mg, given every 3 to 4 weeks. Each infusion should be given over at least 15 minutes.
What is the difference between a bone metastasis and a multiple myeloma?
Multiple myeloma and bone metastases of solid tumors. Multiple myeloma is a form of cancer that affects the tissue inside your bones. Bone metastases of solid tumors are cancers that have spread from their original site to your bones. Solid tumors are cancerous lumps, such as breast and prostate cancers.
What is a solid tumor?
Solid tumors are cancerous lumps, such as breast and prostate cancers. * To learn more about the specific uses of Zometa, see the “ Zometa uses ” section below. † Zometa has certain limitations of use. For more information, see the “ Zometa uses ” section below.
What is the trade name for Zometa?
Trade names: Zometa®. Zoledronic acid is the generic name for the trade name drug Zometa®. In some cases, health care professionals may use the trade name Zometa® when referring to the generic drug name zoledronic acid. Drug type: Zoledronic acid is a supportive care drug in the category of bisphosphonates. (For more detail, see "How this drug ...
What is the effect of zoledronic acid on bone?
Some of the complications resulting from this bone breakdown are bone pain, fractures and less commonly, hypercalcemia (increased levels of calcium in the blood). Zoledronic acid is a bisphosphonate. Bisphosphonate medications are used to slow down the osteoclast's effects on the bone.
How does osteoclast work?
How This Drug Works: Cancer cells that spread to the bone can secrete substances that can cause cells found in the bone called osteoclasts to dissolve or "eat away" a portion of the bone. These tumors or lesions weaken the bone and can lead to complications.
Is zoledronic acid a side effect of hypercalcemia?
Presence of these symptoms while a person is receiving treatment with zo ledronic acid may not be drug- related side effects, but related to hypercalcemia. Osteonecrosis of the jaw has been reported rarely in patients with cancer receiving treatment regimens including bisphosphonates.
Is Zolendronic acid a pill?
There is no pill form of this medication. The amount of zoledronic acid that you will receive depends on many factors, including, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
Can osteonecrosis of the jaw be treated with bisphosphonates?
Osteonecrosis of the jaw has been reported rarely in patients with cancer receiving treatment regimens including bis phosphonates. Many of the reported cases were associated with dental procedures such as removal of a tooth. Many had signs of local infection including infection in the bone.
Does Zoledronic Acid go away?
Important things to remember about the side effects of zoledronic acid: Most people do not experience all of the side effects listed. Side effects are often predictable in terms of their onset and duration. Side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize ...
What is the name of the drug that reduces the risk of fractures in cancers that affect the bones?
Zoledronic acid (Zometa) Zoledronic acid is a type of drug known as a bisphosphonate. It has the brand name Zometa. It reduces the risk of fractures in cancers that affect the bones, such as: It also lowers high levels of calcium in the blood (hypercalcaemia), which can happen in secondary bone cancer.
How long does zoledronic acid last?
Zoledronic acid is a clear liquid. You have it as a drip into your bloodstream (intravenously). The drip usually lasts about 15 minutes, but you might have it over a longer period.
Can cancer drugs interact with other drugs?
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
How to use Zometa Vial
Read the Patient Information Leaflet if available from your pharmacist before you start receiving zoledronic acid and each time you get a treatment. If you have any questions, ask your doctor or pharmacist.
Are you currently using Zometa Vial?
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What is Zometa used for?
Zometa belongs to a group of medicines known as bisphosphonates. 2. Upsides. Zometa is used for the treatment of high calcium levels (hypercalcemia) associated with cancer. It is given as a single IV dose of 4mg and retreatment may be considered after 7 days if serum calcium levels do not return to normal.
How does Zometa work?
Zoledronic acid strengthens bones and may be used for the treatment or prevention of osteoporosis. It works by inhibiting osteoclasts which are responsible for breaking down and reabsorbing bone (by a process known as bone resorption).
How long does Zometa take to be administered?
It must be administered over no less than 15 minutes.
What are some medications that interact with Zometa?
Common medications that may interact with Zometa include: aminoglycoside antibiotics, such as amikacin, gentamicin, kanamycin, neomycin, paromomycin, or tobramycin. angiogenesis inhibitors, such as bevacizumab or everolimus. aspirin. calcitonin.
What are the drugs that are used for cancer?
calcitonin. deferasirox. diuretics, such as bumetanide, ethacrynic acid, or furosemide. digoxin. chemotherapy agents for cancer. NSAIDs, such as ibuprofen, diclofenac, and naproxen. oral steroids, such as dexamethasone, prednisone and methylprednisone. proton pump inhibitors, such as omeprazole. thalidomide.
Is Zometa a generic?
Zometa is available as a generic under the name zoledronic acid. 3. Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
Can you give Zometa at the same time as Reclast?
Zometa should never be given at the same time as other bisphosphonates, such as Reclast. Zometa must be administered over no faster than 15 minutes because shorter infusion times have been associated with an increased risk of renal toxicity which may progress to kidney failure.
Use in Cancer
Zoledronic acid is approved to be used alone or with other drugs to treat:
More About Zoledronic Acid
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
Clinical Trials Accepting Patients
Find Clinical Trials for Zoledronic Acid - Check for trials from NCI's list of cancer clinical trials now accepting patients.
