Precautions
Apr 06, 2021 · Zometa ( zoledronic acid - sometimes called zoledronate) is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Zometa is used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy).
Is Zometa considered chemotherapy?
Oct 21, 2020 · Zometa is a brand-name prescription drug that’s FDA-approved to treat the following conditions * in adults: Hypercalcemia due to cancer. † Hypercalcemia is high level of calcium in your blood. In...
Can Zometa be taken before or after a chemotherapy?
Zoledronic acid is used as a support medication to treat symptoms of cancer such as hypercalcemia (high blood calcium levels) or to decrease complications (such as fractures or pain) produced by bone metastasis (spread of cancer to the bone).
Does Medicare cover Zometa?
Zoledronic acid is a type of drug known as a bisphosphonate. It has the brand name Zometa. It reduces the risk of fractures in cancers that affect the bones, such as: myeloma. secondary breast cancer. secondary prostate cancer. It also lowers high levels of calcium in the blood (hypercalcaemia), which can happen in secondary bone cancer.
What is the difference between Zometa and Reclast?
Zometa is a bisphosphonate indicated for the treatment of: • Hypercalcemia of malignancy (1.1) • Patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy. (1.2)
Is Zometa a form of chemotherapy?
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates.Nov 15, 2011
What does Zometa do to your body?
Zometa helps reduce bone damage and bone pain that can occur when cancer forms in your bones. The drug slows the breakdown of bone, so it can help prevent bone weakening that can lead to fractures. By slowing bone breakdown, Zometa can also make it harder for the cancer to grow in your bones.Oct 21, 2020
How long can you take Zometa?
Both Zometa and Aredia are given intravenously, usually every 4 weeks. A study suggests that after being treated with the regular dose of Zometa and/or Aredia for a year, women with bone metastases can get Zometa every 12 weeks and still get the same benefits from the medicine while reducing their risk of side effects.Feb 7, 2017
Does Zometa stop bone cancer?
If you're a postmenopausal woman, your doctor may recommend a bisphosphonate to strengthen your bones or treat osteoporosis. The studies reviewed here suggest that taking Zometa also could lower your risk of cancer recurrence when started right after surgery.Dec 10, 2011
Does Zometa cause weight gain?
For all uses of this drug: Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Very bad bone, joint, or muscle pain.
Can I drink alcohol while on Zometa?
What should I avoid while receiving Zometa? Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely. Avoid drinking large amounts of alcohol.Apr 6, 2021
How do you feel after a Zometa infusion?
What Are Side Effects of Zometa?dizziness,headache, or.flu-like symptoms (such as fever, chills, muscle/joint aches),cough,vision problems,diarrhea,constipation,tired feeling,More items...
Does Zometa affect your immune system?
3.5. Effects of ZOL on anti-cancer immunity. In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].
Can Zometa cause kidney failure?
Zoledronic acid is associated with reports of renal impairment and renal failure, especially in patients with pre-existing renal dysfunction or other risk factors. The product information for Zometa already contains strong warnings and precautions regarding renal impairment and renal failure.Dec 11, 2014
Can you drive after Zometa infusion?
If you are returning home immediately after the infusion, arrange to have someone else drive. avoiding use of mouthwash that contains alcohol. Use a mirror to check your teeth and gums regularly for any changes such as sores or bleeding gums. If you notice any problems, tell your doctor or dentist immediately.
Does Zometa heal bones?
Conclusions. Zoledronate does not prevent bone healing. However, the effect of zoledronate was characterized by accentuated stimulation of primary bone production and probably inhibition of remodeling, leading to retention of trabecular bone.Feb 19, 2010
How do you get metastatic breast cancer?
Metastatic breast cancer can develop when breast cancer cells break away from the primary tumor and enter the bloodstream or lymphatic system. These systems carry fluids around the body. The cancer cells are able to travel in the fluids far from the original tumor.
Will Zometa cure my condition?
Zometa can’t cure cancer. But the drug can help protect your bones from damage caused by having cancer in your bones. Keep in mind that cancer does...
Is Zometa chemotherapy?
No, Zometa isn’t chemotherapy. Zometa belongs to a class of drugs called bisphosphonates. (A class of drugs is a group of medications that work in...
If I have asthma, can I use Zometa?
You may be able to have Zometa treatment if you have asthma, but you should check with your doctor. Zometa is a type of drug called a bisphosphonat...
Can I use Zometa with Reclast?
No, you shouldn’t have Zometa treatment if you’re using Reclast. These medications contain the same active drug, zoledronic acid. Taking these medi...
If I have kidney problems, can I use Zometa?
You may be able to have Zometa treatment if you have kidney problems. It depends how severe your kidney problems are and what Zometa is treating. F...
Can I have dental work done while taking Zometa?
No, it’s best not to have dental work during Zometa treatment. Doing so can raise your risk for a serious side effect called osteonecrosis of the j...
What is the FDA's approval for Zometa?
The Food and Drug Administration (FDA) approves prescription drugs such as Zometa to treat certain conditions. Zometa may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.
How often should I give Zometa?
The typical Zometa dosage for adults with multiple myeloma or bone metastases from solid tumors is 4 mg, given every 3 to 4 weeks. Each infusion should be given over at least 15 minutes.
What is the active ingredient in Zometa?
Zometa contains the active drug zoledronic acid. It belongs to a class of drugs called bisphosphonates. A class of drugs is a group of medications that work in a similar way. Bisphosphonates help to prevent the breakdown of bone.
How long does it take for Zometa to go away?
The symptoms typically ease in a few days. However, for some people, it may take up to 2 weeks or longer for these symptoms to go away. Most other side effects of Zometa tend to go away either on their own or with treatment. This usually takes a few days to a couple of weeks.
How many milligrams of Zometa are in a bottle?
Zometa comes as a liquid that’s available in two different forms: a single-dose, ready-to-use bottle containing 4 milligrams (mg) of drug in 100 milliliters (mL) of solution. a single-dose vial containing 4 mg of drug in 5 mL of solution. Zometa is given as an intravenous (IV) infusion by a healthcare provider.
Where can I get Xgeva?
Xgeva comes as a liquid solution in a single-dose vial. The drug is given as a subcutaneous injection (an injection just under your skin). You’ll receive Xgeva in your upper arm, upper thigh, or abdomen. This is typically done in doctor’s office or clinic. But in some cases, you can receive the injections from a healthcare provider at home or be trained how to give yourself injections.
How many people have a reaction to Zometa?
32% to 44% of people who had treatment with Zometa. 31% to 33% of people who had treatment with a similar drug called pamidronate. 20% of people who had a placebo (a treatment containing no active drug) Fever may be part of a short-term reaction that can develop in the first few days after having Zometa.
What is the trade name for Zometa?
Trade names: Zometa®. Zoledronic acid is the generic name for the trade name drug Zometa®. In some cases, health care professionals may use the trade name Zometa® when referring to the generic drug name zoledronic acid. Drug type: Zoledronic acid is a supportive care drug in the category of bisphosphonates. (For more detail, see "How this drug ...
How does osteoclast work?
How This Drug Works: Cancer cells that spread to the bone can secrete substances that can cause cells found in the bone called osteoclasts to dissolve or "eat away" a portion of the bone. These tumors or lesions weaken the bone and can lead to complications.
What is the effect of zoledronic acid on bone?
Some of the complications resulting from this bone breakdown are bone pain, fractures and less commonly, hypercalcemia (increased levels of calcium in the blood). Zoledronic acid is a bisphosphonate. Bisphosphonate medications are used to slow down the osteoclast's effects on the bone.
What are the side effects of Zolendronic Acid?
The following side effects are common (occurring in greater than 30%) for patients taking zoledronic acid: Ostealgia. Nausea. Fever usually mild and short lived.
Does Zolendronic acid cause constipation?
Constipation. Flu-like symptoms; mild fever sometimes accompanied by malaise, chills, fatigue and flushing. Usually occurs with first treatment with zoledronic acid only. These are less common side effects (occurring in 10-29%) for patients receiving zoledronic acid: Shortness of breath.
Is zoledronic acid a side effect of hypercalcemia?
Presence of these symptoms while a person is receiving treatment with zo ledronic acid may not be drug- related side effects, but related to hypercalcemia. Osteonecrosis of the jaw has been reported rarely in patients with cancer receiving treatment regimens including bisphosphonates.
Is Zolendronic acid a pill?
There is no pill form of this medication. The amount of zoledronic acid that you will receive depends on many factors, including, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
How long does zoledronic acid last?
Zoledronic acid is a clear liquid. You have it as a drip into your bloodstream (intravenously). The drip usually lasts about 15 minutes, but you might have it over a longer period.
What is the name of the drug that reduces the risk of fractures in cancers that affect the bones?
Zoledronic acid (Zometa) Zoledronic acid is a type of drug known as a bisphosphonate. It has the brand name Zometa. It reduces the risk of fractures in cancers that affect the bones, such as: It also lowers high levels of calcium in the blood (hypercalcaemia), which can happen in secondary bone cancer.
What do they check before and during a chemo treatment?
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
What is the chemical name of Zometa?
Zometa contains zoledronic acid , a bisphosphonic acid which is an inhibitor of osteoclastic bone resorption. Zoledronic acid is designated chemically as (1-Hydroxy-2-imidazol-1-yl-phosphonoethyl) phosphonic acid monohydrate and its structural formula is:
How often should I take Zometa?
The recommended dose of Zometa in patients with multiple myeloma and metastatic bone lesions from solid tumors for patients with creatinine clearance (CrCl) greater than 60 mL/min is 4 mg infused over no less than 15 minutes every 3 to 4 weeks. The optimal duration of therapy is not known.
How long does it take for a reaction to resolve after taking Zometa?
Within three days after Zometa administration, an acute phase reaction has been reported, with symptoms including pyrexia, fatigue, bone pain and/or arthralgias, myalgias, chills, influenza-like illness and arthritis with subsequent joint swelling; these symptoms usually resolve within three days of onset, but resolution could take up to 7 to 14 days. However, some of these symptoms have been reported to persist for a longer duration. Musculoskeletal Pain Severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported with bisphosphonate use [see Warnings and Precautions (5.5)].
How long should I take Zometa 4 mg?
The incidence of renal toxicity and renal failure has been shown to be reduced when Zometa 4 mg is given as a 15-minute intravenous infusion. Zometa should be administered by intravenous infusion over no less than 15 minutes [see Warnings and Precautions (5.3), Dosage and Administration (2.4)].
How long should Zometa be infused?
Due to the risk of clinically significant deterioration in renal function, which may progress to renal failure, single doses of Zometa should not exceed 4 mg and the duration of infusion should be no less than 15 minutes [see Warnings and Precautions (5.3)]. In the trials and in postmarketing experience, renal deterioration, progression to renal failure and dialysis, have occurred in patients, including those treated with the approved dose of 4 mg infused over 15 minutes. There have been instances of this occurring after the initial Zometa dose.
How much Zometa should I take for hypercalcemia?
The maximum recommended dose of Zometa in hypercalcemia of malignancy (albumin-corrected serum calcium greater than or equal to 12 mg/dL [3.0 mmol/L]) is 4 mg. The 4 mg dose must be given as a single-dose intravenous infusion over no less than 15 minutes. Patients who receive Zometa should have serum creatinine assessed prior to each treatment.
What is the formula for cCa in zometa?
Zometa is indicated for the treatment of hypercalcemia of malignancy defined as an albumin-corrected calcium (cCa) of greater than or equal to 12 mg/dL [3.0 mmol/L] using the formula: cCa in mg/dL = Ca in mg/dL + 0.8
What is Zometa used for?
Zometa belongs to a group of medicines known as bisphosphonates. 2. Upsides. Zometa is used for the treatment of high calcium levels (hypercalcemia) associated with cancer. It is given as a single IV dose of 4mg and retreatment may be considered after 7 days if serum calcium levels do not return to normal.
How does Zometa work?
Zoledronic acid strengthens bones and may be used for the treatment or prevention of osteoporosis. It works by inhibiting osteoclasts which are responsible for breaking down and reabsorbing bone (by a process known as bone resorption).
How long does Zometa take to be administered?
It must be administered over no less than 15 minutes.
What are some medications that interact with Zometa?
Common medications that may interact with Zometa include: aminoglycoside antibiotics, such as amikacin, gentamicin, kanamycin, neomycin, paromomycin, or tobramycin. angiogenesis inhibitors, such as bevacizumab or everolimus. aspirin. calcitonin.
What are the drugs that are used for cancer?
calcitonin. deferasirox. diuretics, such as bumetanide, ethacrynic acid, or furosemide. digoxin. chemotherapy agents for cancer. NSAIDs, such as ibuprofen, diclofenac, and naproxen. oral steroids, such as dexamethasone, prednisone and methylprednisone. proton pump inhibitors, such as omeprazole. thalidomide.
Is Zometa a generic?
Zometa is available as a generic under the name zoledronic acid. 3. Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
Can you give Zometa at the same time as Reclast?
Zometa should never be given at the same time as other bisphosphonates, such as Reclast. Zometa must be administered over no faster than 15 minutes because shorter infusion times have been associated with an increased risk of renal toxicity which may progress to kidney failure.
