How do you get rid of SKS on the skin?
The topical formulation is an aqueous solution containing nitric acid, zinc and copper salts, and organic acids (acetic, lactic, and oxalic acid). Treatment consisted of the topical application to obtain a whitening or yellowish reaction on top of SKs.
What support is available for Smith-Kingsmore syndrome (SKS)?
Work is underway to try to clarify the types of clinical problems associated with SKS. Support for Smith-Kingsmore Syndrome is currently focussed on treatment of the individual symptoms as they occur, overseen by an appropriate specialist.
What is SKS and what are the symptoms?
Individuals affected with SKS have a range of different medical problems but, common to most people, are intellectual disability (ranging from mild to severe) and macrocephaly (enlarged head). Other SKS associations include autistic spectrum disorder and seizures.
Can I take rapamycin/sirolimus If I have SKS?
Some people with SKS have found benefits from taking rapamycin / sirolimus. Groundbreaking research is in progress to learn the differences between each MTOR variant, and how to optimize how each reacts to treatment. To learn more, check out our research updates.
What is the best treatment for seborrheic keratosis?
Freezing a growth with liquid nitrogen (cryotherapy) can be an effective way to remove a seborrheic keratosis. It doesn't always work on raised, thicker growths. This method carries the risk of permanent loss of pigment, especially on Black or brown skin. Scraping (curettage) or shaving the skin's surface.
Can you remove seborrheic keratosis at home?
There are no proven home remedies for seborrheic keratosis. Lemon juice or vinegar may cause irritation, possibly causing the lesion to dry and crumble, but there is no evidence that this is safe or effective.
What causes seborrheic keratosis to flare up?
Hormonal changes – pregnancy, menopause, and other hormonal shifts will increase the likelihood of developing seborrheic keratoses. Sun exposure – while growths can develop on just about any part of the body, they are the most common in areas that are regularly exposed to sunlight.
Is there an over the counter treatment for seborrheic keratosis?
The FDA has recently approved a topical solution of 40% hydrogen peroxide to treat seborrheic keratosis. (Over-the-counter hydrogen peroxide is a 1% solution.) The solution comes in an applicator pen, which your healthcare provider will apply to your seborrheic keratosis several times in one visit.
What is the best cream for actinic keratosis?
If you have several actinic keratoses, your doctor might prescribe a medicated cream or gel to remove them, such as fluorouracil (Carac, Fluoroplex, others), imiquimod (Aldara, Zyclara), ingenol mebutate or diclofenac (Solaraze). These products might cause redness, scaling or a burning sensation for a few weeks.
Can a seborrheic keratosis become cancerous?
Malignant tumour development within a seborrheic keratosis (SK) is extremely rare. Though the most commonly developed malignant tumour is the basal cell carcinoma (BCC), other tumour types have also been reported in literature.
Does seborrheic keratosis spread?
Causes of seborrheic keratosis The growths are not contagious and do not spread from contact with others. Some people notice that the growths tend to spread on their skin over time. The primary risk factor for seborrheic keratoses is age.
How long does it take for seborrheic keratosis to heal?
Seborrhoeic keratosis removal is usually quite a straight forward procedure. The wound that results is very superficial and will take about 7 days to heal if it is on face and about 14 days to heal if it is on the body.
How long does it take for actinic keratosis to become cancerous?
The length of time for an AK to progress to an SCC was determined to be 24.6 months (95% confidence interval, 21.04-28.16 months).
What cream is good for seborrheic keratosis?
Eskata, a 40% hydrogen peroxide topical solution, is the first FDA-approved drug for treatment of seborrheic keratoses.
What is the best lotion for seborrheic keratosis?
Self-Care for Seborrheic Keratoses Over-the-counter hydrocortisone creams may help relieve symptoms such as itching and redness. In addition, certain lotions with alpha hydroxyl acids (such as, Amlactin® lotion) may be help make these lesions feel smoother with regular use but will not remove them.
How does hydrogen peroxide cure seborrheic keratosis?
The exact mechanism by which hydrogen peroxide treats seborrheic keratoses is unknown. However, topical treatment is thought to result in dissociation of the chemical into water and Reactive Oxygen Species (ROS), which results in skin cell death [11].
What is SKS in genetics?
What is SKS? Smith-Kingsmore syndrome (SKS) is a rare condition, first described by Smith et al (2013) [1]. It is caused by mutations in the MTOR gene (mechanistic target of rapamycin), found at chromosome location 1p36. The specific genetic changes may vary for individuals with SKS, so the symptoms vary too, and can cause a wide range of medical, ...
What is the purpose of cellular homeostasis in Smith-Kingsmore syndrome?
Enhancing cellular homeostasis will improve lives of people with Smith-Kingsmore syndrome, and possibly prevent future devastating diseases , such as cancer . In addition to Smith-Kingsmore syndrome, mutations in different genes in this pathway result in many other neurodevelopmental disorders.
What are the symptoms of Smith-Kingsmore syndrome?
The most common findings in Smith-Kingsmore syndrome are intellectual disability (ID), developmental delay, large brain size (megalencephaly) and seizures [2] .
What are the medical problems associated with SKS?
Individuals affected with SKS have a range of different medical problems but, common to most people, are intellectual disability (ranging from mild to severe) and macrocephaly (enlarged head). Other SKS associations include autistic spectrum disorder and seizures. Work is underway to try to clarify the types of clinical problems associated with SKS.
Why does Smith Kingsmore syndrome occur?
Why does it occur? Smith Kingsmore Syndrome is caused by an alteration in the MTOR (mammalian target of rapamycin) gene. Our genes are located on chromosomes and are present, usually in pairs, in all the cells of our body. The MTOR gene sits on chromosome 1 (more precisely chromosome location 1p36) and, in SKS, ...
What is eskata solution?
What is Eskata? Eskata is a topical solution with 40% hydrogen peroxide administered by medical professionals. It was the first and only topical treatment for raised seborrheic keratoses (SKs) approved by the Food and Drug Administration (FDA), but it has since been discontinued.
Is Eskata approved for Caucasian patients?
Eskata is approved for most skin types, but notably, 98% of patients treated during clinical trials were Caucasian, with skin types I and II on the Fitzpatrick scale.
Smith-Kingsmore Syndrome Foundation
Whether you’re a parent or family member seeking more information to help your child with Smith-Kingsmore syndrome (SKS), a supportive friend, a doctor, or a researcher, you’ve come to the right place. We hope you find the information here useful, and that you’ll join our growing community. Welcome! We’re glad you found us.
Research and Treatment
If you’ve come here to learn more about Smith-Kingsmore syndrome, “What Is SKS?” is a good place to start. We cover the basic science of the MTOR gene and common features of SKS, among other topics.
Support for Families
Many strategies on how to help someone with this condition come from the families supporting persons with SKS. Read the stories of the incredible families affected by Smith-Kingsmore syndrome. If you’d like to find families and access research and advocacy opportunities, join the Friends & Family Foundation Group.
Some Science
Smith-Kingsmore syndrome (SKS) is a rare condition, first described by Smith et al (2013) [1]. It is caused by mutations in the MTOR gene (mechanistic target of rapamycin), found at chromosome location 1p36.
MTOR Gene and the mTOR Pathway
The MTOR gene is a key regulator of cell growth, cell proliferation, protein synthesis and synaptic plasticity. MTOR is also a protein coding gene, which encodes mTOR, a serine/threonine protein kinase. The mTOR protein is a core component of two protein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).
Changes in MTOR Gene
Current research [3] shows that children with MTOR mutations have different and variable clinical outcomes. These depend largely on the type of mutation and its distribution in the body. So far, children with genetic changes in MTOR segregate into three clinical groups or disorders, including Smith-Kingsmore syndrome.
What's Next?
Researchers continue to learn more about Smith-Kingsmore syndrome and other conditions caused by MTOR mutations. By better understanding the characteristics and the differences of MTOR conditions like Smith-Kingsmore syndrome, they can design well-informed, precision treatment plans.
