Treatment FAQ

what is treatment for heterotopic ossification

by Dr. Carroll Murray MD Published 2 years ago Updated 2 years ago
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In general, your healthcare provider may recommend:

  • Medications such as corticosteroids to treat HO flare-ups in people with genetic heterotopic ossification.
  • Physical therapy to increase range of motion and decrease pain.
  • Surgery to remove heterotopic ossification that causes severe pain or restrictions in your daily function. ...

The two main treatments available are radiation therapy and NSAIDs. Bisphosphonates have been used in the past, but their use has been discontinued as they only postpone ossification until treatment is stopped.

Full Answer

How is heterotopic ossification treated in hip arthroplasty?

Mar 21, 2022 · Medications such as corticosteroids to treat HO flare-ups in people with genetic heterotopic ossification. Physical therapy to increase range of motion and decrease pain. Surgery to remove heterotopic ossification that causes severe pain or restrictions in your daily function. These surgeries are often a last resort, as there is a chance that the HO can form again.

What is prophylaxis for heterotopic ossification?

May 06, 2020 · What is treatment for heterotopic ossification? The two main treatments available are radiation therapy and NSAIDs. Bisphosphonates have been used in the past, but their use has been discontinued as they only postpone ossification until treatment is stopped.

What are the benefits of post-operative rehabilitation for heterotopic ossification?

Mar 21, 2022 · What is treatment for heterotopic ossification? Patients with a high risk of developing HO are often given prophylactic treatment following primary or revision arthroplasty. All patients undergoing excision of symptomatic HO …

What is heterotopic ossification Traumatica?

Jan 27, 2021 · A preliminary investigation on the effect of extracorporeal shock wave therapy as a treatment for neurogenic heterotopic ossification following …

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How do you remove heterotopic ossification?

In the case of heterotopic ossification, the only effective treatment is excision, also called resection. Dr. Nwachukwu will often delay surgical excision for 5-6 months following the initial hip trauma and/or inciting surgery, allowing the bone growth to mature and for a distinct fibrous capsule to develop.

How long does it take to recover from heterotopic ossification surgery?

Patients must have enough time before surgical resection, however, to recover from the often numerous orthopedic injuries and trauma—either local or systemic—that cause the heterotopic ossification, and the area must be well demarcated, he said. Six months gives most patients time to resolve many of their injuries, Dr.Apr 1, 2005

What doctor treats heterotopic ossification?

When heterotopic ossification (HO) is severe or problematic and causes pain, or affects a patient's mobility and function, it should be managed by an orthopaedic surgeon. Occasionally, that involves surgery or a revision procedure to resolve the problem.Dec 14, 2016

How long does heterotopic ossification last?

Prognosis is generally good after surgery. Mean time from injury to surgery is 3.6 years. Once the surgery is performed, studies have shown that average ROM in the hip can improve from 24.3 to[5]. After surgery, improvement was maintained in follow up 6 months after surgery.

Can heterotopic ossification be reversed?

Currently, "there's no way to prevent it and once it's formed, there's no way to reverse it," says Benjamin Levi, M.D., Director of the Burn/Wound/Regeneration Medicine Laboratory and Center for Basic and Translational Research in Michigan Medicine's Department of Surgery.Feb 6, 2020

How common is heterotopic ossification?

Heterotopic ossification is a common complication of total hip arthroplasty. Its prevalence is not the same in all of the patient groups. Frequency of HO varies from 15 to 90%.

What does heterotopic ossification feel like?

The most common symptom of heterotopic ossification is stiffness of a joint. Most people who develop heterotopic ossification cannot feel the abnormal bone, but notice the bone growth getting in the way of normal movements.Jan 26, 2020

What is severe heterotopic ossification?

Heterotopic ossification (HO) is a pathological condition where extra-skeletal bone forms in soft tissues due to extreme trauma or genetic defects. Induction of ectopic bone formation is highly destructive.Jul 19, 2019

How do you diagnose heterotopic ossification?

Signs and symptoms of heterotopic ossification A diagnosis of HO can be made clinically if localized inflammatory reaction, palpable mass, or limited range of motion (ROM) is observed. Clinically, the onset of larger masses of HO is often characteristic of any inflammatory reaction.Jan 27, 2021

Is heterotopic ossification a disease?

FOP is a severely disabling genetic disease in which bone forms at extraskeletal sites within connective tissues such as skeletal muscle, tendon, ligament, fascia and aponeuroses. Specific skeletal malformations also occur in patients with this disease.Aug 10, 2010

Where does heterotopic ossification occur?

HO occurs with the highest frequency at the elbow, followed by the shoulder, and subsequently the hip. Owing to its location around joints, those patients with burn injury–induced HO often have a restriction in the range of motion as an early manifestation of the ossification.

What is the surgical technique for HO?

The usual surgical technique used on HO occurring anteriorly at the hip is anterior wedge resection. Postoperatively, position the joint properly with foam wedges so that the surgical correction can be maintained and any strain on the incision or pressure sores can be prevented.

What are the complications of HO at the elbow?

These complications include ulnar nerve compression with HO at the elbow, vascular (predominantly venous) compression with or without associated deep venous thrombosis (DVT), and lymphatic obstruction leading to lymphedema. [ 31, 32] Prophylaxis.

Why is radiation not used for HO?

One reason that radiation therapy has not been established as a treatment for HO is a risk of local induction of malignancy. However, radiation has been used in Europe by Sautter-Bihl and colleagues as a primary treatment for early HO after SCI; no adverse effects were noted. [ 41] Extracorporeal shock wave therapy.

Why is manipulation controversial?

However, such manipulation is controversial owing to the risk of the formation of new hematoma and because of the chance that long-bone fracture will occur in patients with secondary osteoporosis. Next: Medical Issues/Complications. Medical Issues/Complications.

Can PT help with HO?

The use of physical therapy (PT) in HO has long been controversial. Rossier and co-investigators noted occasional transverse microfractures on sections of HO that they thought might be caused by spasticity or by overly aggressive PROM. [ 14] Since then, the debate between resting the joint and aggressive PROM has continued. In the literature, however, the developing consensus appears to be that aggressive PROM and continued mobilization, once acute inflammatory signs have subsided, are indicated, because they help to maintain ROM; in more extensive HO, though, they may lead to the formation of a pseudarthrosis. Resting the joint appears more likely to lead to decreased ROM or to ankylosis.

What is the best treatment for HO?

As treatment or prophylaxis for HO, either a nonsteroidal antiinflammatory drug (such as indomethacin), a diphosphonate (such as ethane-1-hydroxy-1,1-diphosphate), or local radiation therapy is recommended. Before therapy begins, bone scanning may be requested to confirm the diagnosis of HO.

What is HO in a patient?

Heterotopic ossification (HO) is the presence of bone in soft tissue where bone normally does not exist. The acquired form of HO most frequently is seen with either musculoskeletal trauma, spinal cord injury, or central nervous system injury. For example, patients who have recently undergone total hip arthroplasty or have paraplegia ...

Can HO be recurrence?

In addition, surgical resection of HO is used to preserve joint mobility; however, HO is likely to recur and possibly progress if resection is undertaken before the lesion has become mature.

What is heterotopic ossification?

Heterotopic ossification is a common complication following total hip arthroplasty and surgery following acetabular trauma. It is associated with pain and a decreased range of movement.

What is the best treatment for hip arthroplasty?

Following total hip arthroplasty, other non-steroidal anti-inflammatory drugs, including naproxen and diclofenac, are equally as effective as indometacin and can be considered as alternative first-line treatments.

Is indometacin a good prophylaxis for ossification?

It was concluded that indometacin remains the 'gold standard' for heterotopic ossification prophylaxis following total hip arthroplasty and is the only drug proven to be effective against heterotopic ossification following acetabular surgery.

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