TIP 49: Incorporating Alcohol Pharmacotherapies Into Medical Practice Download only This manual provides clinical practice guidelines for using medications in the medication-assisted treatment of alcohol use disorder. It offers guidance on prescribing acamprosate, disulfiram, oral naltrexone, and extended-release injectable naltrexone.
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Advisory: Prescribing Pharmacotherapies for Patients With Alcohol Use Disorder
This Advisory, based on TIP 49, Incorporating Alcohol Pharmacotherapies Into Medical Practice, focuses on medication and related treatment decisions made after screening and assessment for AUD, and medically supervised withdrawal, if necessary.
Incorporating Alcohol Pharmacotherapies Into Medical Practice
This manual guides counselors in the use of medications to help clients achieve abstinence from alcohol. It describes how the medications work and whom may benefit. It also presents the side effects of three FDA-approved medications: acamprosate, disulfiram, and naltrexone.
Identifying Mental Health and Substance Use Problems of Children and Adolescents: A Guide for Child-Serving Organizations
This manual offers guidance and tools for identifying mental illness or substance use issues early in children and adolescents in various setting, such as in schools, the juvenile justice and child welfare system, and when receiving primary care.
2020 Talk. They Hear You. Partner Toolkit Flash Drive
This partner toolkit flash drive for the "Talk. They Hear You." Parent-Oriented National Media Campaign includes the full suite of products and supporting materials for use in communities.
Medication for the Treatment of Alcohol Use Disorder: A Brief Guide
This manual provides guidance on the use of medication-assisted treatment for alcohol use misuse. It summarizes approved medications, screening and assessment, treatment planning, and patient monitoring.
Medication for the Treatment of Alcohol Use Disorder: Pocket Guide
This pocket guide is designed as a quick reference for information about medication-assisted treatment for alcohol use disorder. It offers a checklist for prescribing medications to patients and provides a list of approved medications for treatment.
Abstract
Pontin (Pont), also known as Tip49, encodes a member of the AAA+ ( A TPases A ssociated with Diverse Cellular A ctivities) superfamily and plays pivotal roles in cell proliferation and growth, yet its function in cell death has remained poorly understood.
Introduction
Pontin (Pont), also known as Tip49, Tip49a, NMP238, TAP54α, Ruvbl1, Rvb1, pontin52 1, 2, 3, 4, 5, belongs to the superfamily of AAA+ ATPases ( A TPases Associated with Diverse Cellular Activities), which is the extension of the known AAA family 6, 7.
Results and discussion
Ectopic expression of Egr in the developing eye driven by GMR -Gal4 triggers JNK-mediated cell death 38, 39 and produces dosage-dependent eye phenotypes—a rough eye from weak Egr expression ( GMR >Egr W, Fig. 1b–m) and a small eye from strong Egr expression ( GMR >Egr S, Fig. 5b–i ).
Conclusion
In the present work, we have identified ATPase Pontin as a crucial modulator of the conserved Egr-JNK signaling during the development of Drosophila. Our genetic evidence revealed that Pontin is a negative regulator of Egr-JNK cascade.
Materials and methods
All stocks were raised on standard Drosophila media and crosses were performed at 25 °C unless otherwise indicated. UAS - pont -IR #1 and UAS - pont -IR #2 were obtained from NIG stock center. bsk1/+, bsk2/+, fos1/+, UAS -LacZ, UAS - GFP -IR and en -Gal4 were obtained from the Bloomington Drosophila Stock Center.
Change history
Due to a technical error, content intended for publication in Volume 4 (2018) published in Volume 5 (2019). The content has been moved into the correct volume, and the citation information was updated accordingly.
Acknowledgements
We thank Dr. Peter Gallant, the NIG and the Bloomington Drosophila Stock Center for fly stocks. This research was supported by the Fundamental Research Funds for the Central Universities (2000219125) to X.W.
