Medication
Drugs that can cause Stevens-Johnson syndrome include:
- Anti-gout medications, such as allopurinol
- Medications to treat seizures and mental illness (anticonvulsants and antipsychotics), with added risk if you also undergo radiation therapy;
- Pain relievers, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve)
Therapy
When distinguishing patients by severity, the mortality rate at 1 year was 24% for SJS, 43% for SJS/TEN overlap, and 49% for TEN. Several other factors were associated with a high impact on mortality, including recent malignancy and recent infection.
Self-care
Subdivisions of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
- Stevens-Johnson syndrome (SJS)
- SJS/TEN-overlap
- toxic epidermal necrolysis (TEN)
Which drugs are most associated with Stevens-Johnson syndrome?
You're more likely to get SJS if you have:
- HIV or other problems with your immune system
- Had SJS before
- Certain genes you inherit from your parents
- Radiation treatments
What is the survival rate for Steven Johnson syndrome?
What are the stages of Steven Johnson syndrome?
How do you get Stevens Johnson syndrome?
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Can you survive Steven Johnson Syndrome?
About 10 percent of people with Stevens-Johnson syndrome die from the disease, while the condition is fatal in up to 50 percent of those with toxic epidermal necrolysis.
How do you deal with a patient with Steven Johnson Syndrome?
How is Stevens-Johnson syndrome treated?Stopping the medication that has caused the problem.Replacing electrolytes with intravenous (IV) fluids.Using non-adhesive dressings on the affected skin.Using high-calorie food, possibly by tube-feeding, to promote healing.Using antibiotics when needed to prevent infection.More items...•
How quickly does Steven Johnson syndrome spread?
Within about 1 to 3 days, a red or purplish rash forms, and then the skin begins to blister and peel, leading to "raw" areas of skin that are painful. This often starts on the face and then spreads to other parts of the body.
Does Steven Johnson syndrome go away?
Stevens-Johnson syndrome is a medical emergency that usually requires hospitalization. Treatment focuses on removing the cause, caring for wounds, controlling pain and minimizing complications as skin regrows. It can take weeks to months to recover.
What antibiotic causes Steven Johnson Syndrome?
Antibiotics are the most common cause of Stevens-Johnson syndrome, followed by analgesics, cough and cold medication, NSAIDs, psycho-epileptics, and antigout drugs. Of antibiotics, penicillins and sulfa drugs are prominent culprits; ciprofloxacin has also been reported.
Is there a blood test for Stevens-Johnson syndrome?
A complete blood count (CBC) may reveal a normal white blood cell (WBC) count or a nonspecific leukocytosis. A severely elevated WBC count indicates the possibility of a superimposed bacterial infection. Electrolytes and other chemistries may be needed to help manage related problems.
Is Steven Johnson syndrome an autoimmune disease?
Stevens-Johnson syndrome, named after the two doctors who first described the disease in 1922, is an autoimmune disorder that manifests as a painful rash on the skin, mucous membranes, and genitals. The disease is often caused by an allergic reaction to certain medications.
How does Steven Johnson Syndrome affect the eyes?
It is more common in children and younger adults, but can develop at any age. Typical ocular problems associated with SJS can include conjunctivitis, scarring of the conjunctiva, inflammation inside the eye (iritis), corneal blisters and perforation, which can potentially lead to permanent vision loss.
How does Steven Johnson Syndrome affect the eyes?
It is more common in children and younger adults, but can develop at any age. Typical ocular problems associated with SJS can include conjunctivitis, scarring of the conjunctiva, inflammation inside the eye (iritis), corneal blisters and perforation, which can potentially lead to permanent vision loss.
Can Tylenol Cause Steven Johnson Syndrome?
Rarely, acetaminophen can cause serious, potentially fatal skin reactions, such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN).
What is Stevens Johnson syndrome?
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin conditions that cause your skin to develop rashes, blisters, and then peel. Your mucus membranes, including your eyes, genitalia and mouth, are also affected. If you get this condition, you’ll likely be admitted to a hospital.
How long does it take for Stevens Johnson syndrome to heal?
Each person’s experience with Stevens-Johnson syndrome can be different. Skin can regrow in a matter of weeks, but recovery can take months if symptoms are severe. Some long-term reactions may develop, including: Skin: dryness, itching, change in skin color.
Why does SJS redevelop?
Difficulties with your sense of taste. SJS may redevelop if you are exposed to the same medication known to have triggered the condition the first time . In such cases, the second episode is usually more severe than the first episode.
What are the factors that cause SJS?
A combination of factors is likely involved in developing these disorders, including a genetic bias. Environmental factors might cause the gene to be triggered. One of these genetic factors include specific human leukocyte antigens (HLAs) that may increase one’s risk of developing SJS or TEN.
What is the most severe complication of Stevens-Johnson syndrome?
What are the complications of Stevens-Johnson syndrome (SJS)? The most severe complication of SJS and TEN is death. Death happens in about 10% of cases of SJS, and about 50% of TEN.
Can SJS occur in older people?
Many cases of SJS happen in children and adults younger than 30 years old, but also occur in others, especially the elderly. More cases of SJS occur in females than males. Infections, like pneumonia, are the most likely cause of SJS in children, whereas medications are the most likely cause of SJS/TEN in adults.
Is Lyell's syndrome a drug?
Yes. It is also known as Lyell’s syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis, and Stevens-Johnson syndrome toxic epidermal necrolysis spectrum. It might be called drug-induced Stevens-Johnson syndrome or mycoplasma-induced Stevens-Johnson syndrome if it’s linked to a specific cause.
What is Stevens Johnson syndrome?
Stevens-Johnson syndrome, also called SJS, is a rare but serious problem. Most often, it's a severe reaction to a medicine you've taken. It causes your skin to blister and peel off. It affects your mucus membranes, too. Blisters also form inside your body, making it hard to eat, swallow, even pee. Getting treated right away helps protect your skin ...
Where to get treated for SJS?
Treatment. You'll be treated for SJS in the hospital by a special team of doctors and nurses. Some people are treated in a burn center or intensive care unit. The first thing doctors will do is to stop the medication or treat the infection that made you sick.
What drugs can cause SJS in kids?
The medicines most likely to cause problems in kids are sulfa antibiotics, Tylenol, and drugs that treat seizures, especially carbamaze pine ( Carbatrol, Tegretol ). If you're going to get SJS, it will most likely happen in the first 2 months you're taking a drug. An infection, like pneumonia or the herpes virus that causes cold sores, ...
How long does it take for SJS to show up?
Your chances are better if you're young and otherwise healthy, but you're still at greater risk for up to a year. Sometimes SJS has effects that will show up years after you heal, including: Scars where your skin peeled. Dry eyes that hurt in bright light. Trouble seeing.
What does it feel like to have SJS?
SJS usually starts with a fever and feeling like you have the flu. A few days later, other symptoms appear, including: Painful red or purple skin that looks burned and peels off. Blisters on your skin, mouth, nose, and genitals. Red, painful, watery eyes.
Why do kids get SJS?
An infection, like pneumonia or the herpes virus that causes cold sores, can also trigger SJS. This happens more often with kids than adults. You're more likely to get SJS if you have: HIV or other problems with your immune system. Had SJS before. Certain genes you inherit from your parents. Radiation treatments.
How long does it take to recover from SJS?
Your care team will clean your eyes and use special drops and creams to keep them from drying out. You could be in the hospital from 2 to 4 weeks. It takes time to recover from SJS, and most people do. Severe cases can be fatal, though, especially during the 3 months after it started.
Why do people with Stevens Johnson syndrome need to be hospitalized?
People with Stevens-Johnson syndrome require treatment in a hospital due to the life threatening complications of the condition. These include sepsis, scarring of mucosal surfaces (such as the eyes and genital region), multiple organ failure, and the risk of severe disturbances in body temperature, hydration status, and other bodily functions.
When was Stevens Johnson syndrome first described?
The first description of Stevens-Johnson syndrome occurred in 1922 when two physicians — Albert Stevens and Frank Johnson — evaluated the symptoms of an unknown condition in two young boys and published a report on the condition.
How long does it take for Stevens Johnson syndrome to show up?
These symptoms include: fever. flu-like symptoms. a cough. body aches. a general feeling of being unwell. After 1–3 days, people will notice a red or purple rash forming on the body. It often starts on the face and chest.
What is the top layer of Stevens Johnson syndrome?
The top layer of the skin, called the epidermis, detaches from the second layer of skin, called the dermis. ...
Can Stevens Johnson syndrome cause death?
Despite the many treatment options, people can die from Stevens-Johnson syndrome. Individuals with more severe forms of Stevens-Johnson syndrome have higher mortality rates. Older adults and people with other underlying medical conditions also have a higher risk of dying. Last medically reviewed on October 8, 2019.
Is Stevens Johnson syndrome a specific variation of one of the HLA genes?
a specific variation of one of the HLA genes. The incidence of Stevens-Johnson syndrome and toxic epidermal necrolysis is approximately 100 times higher among people with HIV than among those not living with this condition.
What is Stevens Johnson syndrome?
Overview. Stevens-Johnson syndrome is a serious adverse reaction of the skin and mucous membranes. Signs and symptoms include blisters, rash and skin pain. Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes.
How long does Stevens Johnson syndrome take to heal?
Treatment focuses on removing the cause, caring for wounds, controlling pain and minimizing complications as skin regrows. It can take weeks to months to recover. A more severe form of the condition is called toxic epidermal necrolysis (TEN).
What medications can cause Stevens Johnson syndrome?
Medications to treat seizures and mental illness (anticonvulsants and antipsychotics) Pain relievers, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) Infections that can cause Stevens-Johnson syndrome include pneumonia and HIV.
What are the factors that increase the risk of Stevens Johnson syndrome?
Factors that increase your risk of developing Stevens-Johnson syndrome include: An HIV infection. Among people with HIV, the incidence of Stevens-Johnson syndrome is about 100 times greater than among the general population. A weakened immune system.
What is the condition that can cause shock and organ failure?
Sepsis is a rapidly progressing, life-threatening condition that can cause shock and organ failure. Eye problems. The rash caused by Stevens-Johnson syndrome can lead to eye inflammation, dry eye and light sensitivity. In severe cases, it can lead to visual impairment and, rarely, blindness. Lung involvement.
