Table 1
| Treatment | Administration | Frequency | Dose | Adverse effects |
| Leuprolide acetate | Intramuscular | Monthly | 7.5 mg 11.25 mg 15 mg | Local reactions; pain at injection site; ... |
| 3-monthly | 11.25 mg 30 mg | |||
| Triptorelin (available only in Europe) | Intramuscular | Monthly 3-monthly | 3.75 mg 11.25 mg | Local reactions; pain at injection site; ... |
| Histrelin implant | Subcutaneous | 1–2 years | 50 mg implants (65 mcg/day) | Discomfort at implant site; local reacti ... |
How to slow down puberty?
Apr 04, 2022 · Lewis KA, Goldyn AK, West KW, Eugster EA. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct. 163 (4):1214-6. . .
Can pimples start before puberty?
4 rows · Untreated, CPP has the potential to result in early epiphyseal fusion and a significant compromise ...
What causes early onset puberty?
Jul 25, 2021 · The optimal treatment for familial male-limited precocious puberty is not well established, but the preferred treatment is a combination of an androgen antagonist (spironolactone) and an aromatase inhibitor (anastrozole, testolactone).
When should puberty start in girls and boys?
Objective: To study the causes and prognosis of peripheral precocious puberty. Methods: The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) were detected by a simplified gonadotrophin-releasing hormone (GnRH) stimulation test. The etiologies of 125 children with peripheral precocious puberty were explored by ultrasound scans and …
What is the best treatment for precocious puberty?
For central precocious puberty, medications called GnRH analogs are the standard treatment. They work by blocking the hormones coming from the pituitary gland that trigger puberty. Most children who need treatment get these medicines as injections or implants.Jan 27, 2017
Does CPP need to be treated?
Without treatment, CPP can have lasting complications. If CPP is left untreated, your child can continue to experience puberty as a result, and that can have lasting complications beyond childhood. That's why it's important to see your child's pediatrician if you think your child is showing signs of puberty too soon.
What is CPP treatment?
If not, doctors often treat CPP by blocking the hormones that cause it. They use a drug called a GnRH. It's given as a shot once every month, or once every 3 or 6 months. Another option is a small implant that works for a year.Oct 19, 2020
How is peripheral precocious puberty treated?
Cyproterone acetate (CPA) and medroxyprogesterone acetate (MPA) are two of the first agents historically used to treat precocious puberty, including in girls with MAS. CPA is a steroidal antiandrogen that works predominantly at the androgen receptor, but also has progestin and antiestrogenic activity [7].Dec 17, 2015
What is OAS Canada?
The Old Age Security (OAS) pension is a monthly payment you can get if you are 65 and older. In some cases, Service Canada will be able to automatically enroll you for the OAS pension. In other cases, you will have to apply for the Old Age Security pension.Apr 14, 2022
What is CPP C++?
A CPP file is a source code file written in C++, a popular programming language that adds features such as object-oriented programming to C. It may be a standalone program, containing all the code, or one of many files referenced in a development project.Dec 29, 2021
Does precocious puberty need to be treated?
Most children with central precocious puberty, in which there's no underlying medical condition, can be effectively treated with medication.Feb 15, 2021
When do you stop Lupron for precocious puberty?
Interventions: Lupron Depot was administered as a single monthly subcutaneous injection to each patient. Treatment was usually discontinued by 10 to 11 years of age, at which time pubertal progression was allowed to resume.
Should I give my daughter Lupron?
LUPRON DEPOT-PED should not be taken if your child is: LUPRON DEPOT-PED can cause birth defects or loss of the baby. If your child becomes pregnant, call your child's doctor.
Can precocious puberty be reversed?
The goal of treatment for is to stop the onset of early puberty signs. In some cases, the signs can be reversed. Treatment will depend on the type of precocious puberty and the cause. Treatment may be done with synthetic gonadotropin-releasing hormone.
Is precocious puberty life threatening?
Apart from just cutting a girl's physical childhood short, early puberty is linked to consequences that can reverberate throughout her life. It's linked to greater risk for breast cancer, teen pregnancy, HPV, heart disease, diabetes, and all-cause mortality, which is the risk of dying from any cause.Jun 26, 2016
What drugs are used as puberty blockers?
Puberty blocker medications contain stable amounts of gonadotropin-releasing hormone (GnRH) analogs, which help suppress sex hormones like testosterone and estrogen. Once these hormones are “blocked,” the physical changes that would occur during puberty are paused. Goserelin (Zoladex®). Histrelin (Supprelin®LA).Jan 10, 2022
Why do children have precocious puberty?
In rare cases, central precocious puberty may be caused by: A defect in the brain present at birth, such as excess fluid buildup (hydrocephalus) or a noncancerous tumor (hamartoma)
What causes a male to have a precocious puberty?
In boys, peripheral precocious puberty may also be caused by: A tumor in the cells that make sperm (germ cells) or in the cells that make testosterone (Leydig cells).
What is McCune Albright syndrome?
McCune-Albright syndrome, a rare genetic disorder that affects the skin color and bones and causes hormonal problems. Exposure to external sources of estrogen or testosterone, such as creams or ointments. In girls, peripheral precocious puberty may also be associated with: Ovarian cysts. Ovarian tumors.
What hormones are produced during precocious puberty?
The brain starts the process with the production of a hormone called gonadotropin-releasing hormone ( GnRH).
Which hormone is responsible for the growth and development of male sexual characteristics?
Estrogen is involved in the growth and development of female sexual characteristics. Testosterone is responsible for the growth and development of male sexual characteristics. Why this process begins early in some children depends on whether they have central precocious puberty or peripheral precocious puberty.
What is the term for a defect in the brain present at birth?
Injury to the brain or spinal cord. McCune-Albright syndrome — a rare genetic disease that affects bones and skin color and causes hormonal problems.
Can estrogen cause precocious puberty?
Being exposed to sex hormones. Coming in contact with an estrogen or testosterone cream or ointment, or other substances that contain these hormones (such as an adult's medication or dietary supplements), can increase your child's risk of developing precocious puberty. Having other medical conditions.
Overview
- The primary goal of treatment is to enable your child to grow to a normal adult height. Treatment for precocious puberty depends on the cause. However, in some cases, there is no identifiable cause for precocious puberty. In this instance, your child may not need treatment depending on …
Symptoms
Causes
Risk Factors
- Precocious puberty is when a child's body begins changing into that of an adult (puberty) too soon. When puberty begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Puberty includes rapid growth of bones and muscles, changes in body shape and size, and development of the body's ability to reproduce. The cause of precocious puberty o…
Complications
- Precocious puberty signs and symptoms include development of the following before age 8 in girls and before age 9 in boys. 1. Breast growth and first period in girls 2. Enlarged testicles and penis, facial hair and deepening voice in boys 3. Pubic or underarm hair 4. Rapid growth 5. Acne 6. Adult body odor
Prevention
- To understand what causes precocious puberty in some children, it's helpful to know what causes puberty to begin. The brain starts the process with the production of a hormone called gonadotropin-releasing hormone (GnRH). When this hormone reaches the pituitary gland — a small bean-shaped gland at the base of your brain — it leads to the production of more hormone…