Medication
May 29, 2012 · What are the treatments for osteogenesis imperfecta (OI)? Fracture Care. Casting, splinting, and bracing fractured bones can help them heal properly. However, bones may weaken if... Physical Therapy. Physical therapy aims to maintain functioning in as many aspects of life as possible. A usual ...
Procedures
Specific treatment for osteogenesis imperfecta will be determined by your physician based on: Your age, overall health, and medical history Extent of the disease Your tolerance for specific medications, procedures, or therapies Expectations for …
Therapy
Treatment of Osteogenesis Imperfecta There is no cure for OI. The goal of treatment, depending on the type of OI, is to prevent or control symptoms, increase bone mass and muscle strength, and maximize a person’s ability to be independent. These treatments include: Physical or Occupational Therapy
Self-care
Feb 11, 2020 · Bisphosphonates are the most widely used agents for the treatment of osteogenesis imperfecta. In the present review, I will review the results that have been reported with individual bisphosphonates followed by an overall summary of the effects of bisphosphonates at the end of this section. Pamidronate
Nutrition
Mar 03, 2022 · Approach Considerations Because osteogenesis imperfecta (OI) is a genetic condition, it has no cure. For many years, surgical correction of deformities, physiotherapy, and the use of orthotic...
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What is the treatment for Osteogenesis Imperfecta? Some treatment strategies for this condition are: Devices: Using devices such as splint and orthopedic cast to support the bones and prevent them from any fracture. Medication: Patients with osteogenesis imperfecta are often prescribed with medications for bone health and dietary supplements.
How is osteogenesis imperfecta (OI) treated?
Treatments, including capping teeth, braces, and surgery may be needed. Physical and occupational therapy. Both are very important in babies and children with OI. Assistive devices. Wheelchairs and other custom-made equipment may be needed as babies get older. What are the possible complications of osteogenesis imperfecta in a child?
What is osteogenesis imperfecta in children?
94 rows · Mar 26, 2021 · Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the development of the bones. People with this condition have bones that break easily, often from little or no trauma. However, the severity is different from person to person. Multiple fractures are common, and in severe cases, can even occur before birth.
What is the role of the orthopedic surgeon in osteogenesis imperfecta management?
Aug 21, 2019 · Treatment for osteogenesis imperfecta is done to manage the symptoms of this disease as there is no cure for it. The main objective of all treatment for this disease is minimizing fractures, pain reduction, enhancing independent …
What causes osteogenesis imperfecta (OI)?
There is no cure for OI. Treatment can include physical or occupational therapy, medications, surgery, and aids to help you move around safely. You can do things to help you stay healthy and prevent broken bones. What is osteogenesis imperfecta? Osteogenesis imperfecta (OI) is a disease that causes your bones to break (fracture) easily.
What treatments are used for osteogenesis imperfecta?
Treatment for OI and its related symptoms may include: Fracture care. Physical therapy. Bracing....Treatments for Related ConditionsHearing aids for hearing loss.Crowns and similar dental devices for brittle teeth.Oxygen administration for people with lung problems.Dec 20, 2021
How do you treat osteogenesis imperfecta in children?
How is osteogenesis imperfecta treated in a child?Bisphosphonate medicines. These are medicines that help to strengthen bones and prevent fractures. ... Care of fractures. ... Orthopedic treatment. ... Rodding. ... Dental procedures. ... Physical and occupational therapy. ... Assistive devices.
How long can a child live with osteogenesis imperfecta?
Life expectancy for males with OI was 9.5 years shorter than that for the general population (72.4 years vs 81.9 years), and for females, was 7.1 years shorter than that for the general population (77.4 years vs 84.5 years).
What causes blue sclera in babies?
Blue sclera is associated with systemic connective tissue disorders, most commonly osteogenesis imperfecta, which presents at approximately 1 in every 20,000 live births.
Can brittle bone disease be cured?
There is no cure for brittle bone disease, but treatment can relieve symptoms, prevent breakage of bones, and maximize movement. Severe forms of the disease can affect the shape of the rib cage and spine, which can lead to life-threatening breathing problems.Jun 13, 2020
Does osteogenesis imperfecta affect the brain?
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by disruption of normal collagen formation resulting in varying degrees of skeletal vulnerability, ligamentous laxity, and scleral discoloration. Children with OI may suffer from complex neurosurgical problems affecting the brain and spine.
Is brittle bone disease painful?
Does brittle bone disease cause pain? The defective brittle bones themselves are not painful, but chronic pain may develop in some people with osteogenesis imperfecta due to repeated fractures and skeletal changes. Pain may also result from acute injuries such as fractures.Oct 15, 2019
Why is sclera blue in osteogenesis imperfecta?
Blue sclera is the most commonly known ocular sign for osteogenesis imperfecta and it is caused by thin scleral collagen allowing the underlying darker choroid vasculature to be seen. Patients with OI have shown a reduction in thickness of the corneal and scleral collagen fibers which can result in low ocular rigidity.
What is the management of OI?
Management of the disease includes focusing on preventing or minimizing deformities, and maximizing the individual's functional ability at home and in the community. Management of OI is either non-surgical or surgical.
What is OI in medical terms?
Osteogenesis imperfecta (OI) is a progressive condition that needs life-long management to prevent deformity and complications. The interdisciplinary healthcare team helps the family to improve the functional outcomes and to provide support.
What are non surgical interventions?
Non-surgical interventions may include one or more of the following: 1 Physical therapy 2 Positioning aids (to help sit, lie, or stand) 3 Braces and splints (to prevent deformity and promote support or protection) 4 Medications 5 Psychological counseling
Can osteogenesis imperfecta be treated?
To date, there is no known treatment, medicine, or surgery that will cure osteogenesis imperfecta (OI). The goal of treatment is to prevent deformities and fractures and allow the child to function as independently as possible. Treatments for preventing or correcting symptoms may include: Care of fractures. Surgery.
What is the best treatment for OI?
Surgery remains a pillar of treatment for patients with OI, [ 8] but it should be performed only if it is likely to improve function and only if the treatment goals are clear. Surgical interventions include intramedullary rod placement, surgery to manage basilar impression, and correction of scoliosis.
What is the best treatment for basilar invagination?
It is best treated with decompression and stabilization of the craniocervical junction. A team of orthopedic surgeons and neurosurgeons is required.
Does bisphosphonate help with bone pain?
Good evidence suggests that bisphosphonate therapy may significantly improve the natural history of type III and type IV disease, particularly by decreasing the rate of fracture, increasing BMD, decreasing bone pain, and significantly increasing height (especially with prolonged cyclic therapy up to 4 years). [ 32] .
What is soft tissue surgery?
Soft-tissue surgery is used in specific circumstances ( eg, lower-limb contractures, particularly those of the Achilles tendon). Skilled administration of anesthetics and awareness of the limitations of surgery are essential prerequisites. [ 28] .
Is a saline solution safe for children?
It has been approved by the US Food and Drug Administration (FDA) for use in osteoporosis, but because of the potential risk of osteosarcoma induction (as seen in preclinical studies in rats), it has not been approved by the FDA for use in children and adolescents.
What is the effect of bisphosphonates on osteoblasts?
As a result, unopposed osteoblastic new bone formation on the periosteal surface results in an increase in cortical thickness.
Is osteogenesis imperfecta a cure?
Because osteogenesis imperfecta (OI) is a genetic condition, it has no cure. For many years, surgical correction of deformities, physiotherapy, and the use of orthotic support and devices to assist mobility (eg, wheelchairs) were the primary means of treatment. [ 27] . Subsequently, as a consequence of improved understanding ...
How is Osteogenesis Imperfecta prevented?
Since this is a genetic disorder, there isn’t much an individual can do to prevent osteogenesis imperfecta. However, light exercise and low impact physical activity are suggested.
What is the treatment for Osteogenesis Imperfecta?
Devices: Using devices such as splint and orthopedic cast to support the bones and prevent them from any fracture.
What are the symptoms of osteogenesis imperfecta?
A curved spine. A triangle-shaped face. Loose joints. Muscle weakness. Skin that easily bruises. Hearing loss in early adulthood. Soft, discolored teeth. The symptoms of osteogenesis imperfecta may look like other medical conditions. Always see your child's healthcare provider for a diagnosis.
What is the best treatment for fractured bones?
To prevent further problems, it is recommended that a child begin moving or using the affected area as soon as possible. Orthopedic treatment. May include bracing and splinting. Surgery may also be needed. Rodding.
What is brittle bone disease?
It is also known as brittle bone disease. A child born with OI may have soft bones that break (fracture) easily, bones that are not formed normally, and other problems. Signs and symptoms may range from mild to severe. The main goal of treatment is to prevent deformities and fractures. OI is a lifelong condition.
What is an OI?
Osteogenesis imperfecta (OI) is an inherited (genetic) bone disorder that is present at birth. It is also known as brittle bone disease. A child born with OI may have soft bones that break (fracture) easily, bones that are not formed normally, and other problems. Signs and symptoms may range from mild to severe. ...
How many bones did Natalie Brosh break?
By the age of 10, Natalie Brosh had already broken 19 bones and undergone seven surgeries. Born with osteogenesis imperfecta, Natalie’s bones are weaker than usual and more prone to fractures.
What are the different types of OI?
These include findings on X-rays and other imaging tests. The OI types are as follows: Type I. Mildest and most common type. About 50% of all affected children have this type. There are few fractures and deformities. Type II. Most severe type.
What are the symptoms of OI?
Symptoms of OI include: Easily broken bones. Bone deformities, such as bowing of the legs. Discoloration of the white of the eye (sclera), may be blue or gray in color. A barrel-shaped chest.
What is osteogenesis imperfecta?
Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the development of the bones. People with this condition have bones that break easily, often from little or no trauma. However, the severity is different from person to person. Multiple fractures are common, and in severe cases, can even occur before birth. Milder cases may involve only a few fractures over a person's lifetime. People with OI may also have dental problems ( dentinogenesis imperfecta) and hearing loss in adulthood. Other features may include muscle weakness, loose joints, and skeletal malformations. [1] [2] There are various recognized forms of OI which are distinguished by their features and genetic causes. [3] Depending on the genetic cause, OI may be inherited in an autosomal dominant (more commonly) or autosomal recessive pattern. Diagnosis is based on the symptoms, clinical exam, imaging studies, and may be confirmed by the results of genetic testing. Treatment is focused on managing the symptoms and aims to decrease the number of fractures and disabilities. [1] [2]
What are the symptoms of OI?
Milder cases may involve only a few fractures over a person's lifetime. People with OI may also have dental problems ( dentinogenesis imperfecta) and hearing loss in adulthood. Other features may include muscle weakness, loose joints, and skeletal malformations.
What is brittle bone disorder?
The Brittle Bone Disorders Consortium (BBD) is an integrated group of academic medical centers, patient support organizations, and clinical research resources dedicated to conducting clinical research on Osteogenesis Imperfecta (OI). The goal of the consortium is to learn more about the disease, develop therapies, and to inform the public about the latest research and information about OI. The BBD has a contact registry for patients who wish to be contacted about clinical research opportunities and updates on the progress of the research projects.#N#For more information on the registry see: https://www.rarediseasesnetwork.org/registry/index.htm
What is MedlinePlus?
MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic. Genetics Home Reference (GHR) contains information on Osteogenesis imperfecta. This website is maintained by the National Library of Medicine.
Why is research important?
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Is OI inherited?
Depending on the genetic cause, OI may be inherited in an autosomal dominant (more commonly) or autosomal recessive pattern. Diagnosis is based on the symptoms, clinical exam, imaging studies, and may be confirmed by the results of genetic testing.
What is the HPO database?
People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources.
What is Osteogenesis imperfecta?
How is the treatment done? Osteogenesis imperfecta is a very rare group of genetic disorder that affects the bones. This disease makes the bones brittle and breaks easily without any cause. People who have this disease are born with either defective connective tissue or the inability to make it due to defective genes.
How to prevent fractures in bones?
Healthy lifestyle choices like exercising and avoiding smoking can help prevent fractures. Painkillers, braces and proper care for fractured bones are useful. Bone infections can be healed with the use of antibiotics and antiseptics.
