Hence when two drugs are combined, the probability of resistance will be about 1 in 10^12 or less. The remaining organisms can be easily removed by the immune systems. This is the rationale for multi-drug therapy in tuberculosis.
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Should the client double the dose of the drug?
Based on our prior experience in treating children with metastatic osteogenic sarcoma, a multidrug regimen was developed. Nine children with evaluable osteogenic sarcoma were treated with vincristine 1.5 mg/m2 on day 1, highdose methotrexate 200-300 mg/kg i.v. on day 2, with p.o. citrovorum factor "rescue" 9 mg every 6 hours x 12, followed in 2 ...
What is drug treatment and how does it work?
Rationale for multi-drug therapy in tuberculosis. If a single drug is given for the treatment of tuberculosis, there is increased chance of development of resistance to the drug. The incidence of resistant strain in an individual will be about 1 in 10^6 to 10^8. But an indiviual be infected with 10^10 to 10^12 organisms.
What are the different types of drug treatment?
Nov 08, 2019 · Many drugs potentiate (or inhibit) the actions of other drugs; however, this is not the rationale for using multiple drugs to treat tuberculosis. Treatment with multiple drugs does not reduce adverse effects and may expose the client to more adverse effects. Combination therapy may allow some medications (e.g.,
What is the rationale that supports multidrug treatment for clients with tuberculosis?
Individuals progress through drug addiction treatment at various rates, so there is no predetermined length of treatment. However, research has shown unequivocally that good outcomes are contingent on adequate treatment length. Generally, for residential or outpatient treatment, participation for less than 90 days is of limited effectiveness ...
Why multiple drug therapy is used in treatment of tuberculosis?
What is the duration of multi drug therapy *?
What is multiple drug regimen?
How is multiple drug resistance treated?
- Polymyxins. Polymyxins acts as detergents of the outer membrane of GNB, exerting bactericidal activity. ...
- Aminoglycosides. ...
- Tigecycline. ...
- Carbapenems. ...
- Fosfomycin. ...
- Ceftazidime/Avibactam. ...
- Meropenem/Vaborbactam. ...
- Ceftolozane/Tazobactam.
What is the duration of multi bacillary leprosy treatment?
For adults the standard regimen is: Rifampicin: 600 mg once a month Dapsone: 100 mg daily Clofazimine: 300 mg once a month and 50 mg daily Duration= 12 months.
What is the recommended duration of treatment for Paucibacillary leprosy?
Why the drugs are administered in multiple doses?
What is the principle of superposition in pharmacokinetics?
What is multiple dosing?
What is the meaning of multi drug resistance?
What causes multidrug resistance?
Which mechanism is most likely to be involved in multiple drug resistance transfer from one cell to another?
What is the highest priority in a client with tuberculosis?
2. Ensuring that the client is well educated about tuberculosis is the highest priority. Education of the client and family is essential to help the client understand the need for completing the prescribed drug therapy to cure the disease. Offering the client emotional support, coordinating various agency services, and assessing the environment may be part of the care for the client with tuberculosis; however, these interventions are of less importance than education about the disease process and its treatment.
Is combination therapy effective for tuberculosis?
Use of a combination of antituberculosis drugs slows the rate at which organisms develop drug resistance. Combination therapy also appears to be more effective than single-drug therapy. Many drugs potentiate (or inhibit) the actions of other drugs; however, this is not the rationale for using multiple drugs to treat tuberculosis. Treatment with multiple drugs does not reduce adverse effects and may expose the client to more adverse effects. Combination therapy may allow some medications (e.g., antihypertensives) to be given in reduced dosages; however, reduced dosages are not prescribed for antibiotics and antituberculosis drugs.
Can you double the dose of Tyramine?
The client should not double the dose of the drug because of potential toxicity. The client taking the drug should avoid foods that are rich in tyramine, such as cheese and dairy products, or he may develop hypertension. A client who has been diagnosed with tuberculosis has been placed on drug therapy.
Can you give antihypertensives in combination therapy?
Combination therapy may allow some medications (e.g., antihypertensives) to be given in reduced dosages; however, reduced dosages are not prescribed for antibiotics and antituberculosis drugs. The client with tuberculosis is to be discharged home with community health nursing follow-up.
What is exam 2 CH 47?
Exam 2--Ch 47: Management of Patients With Intesti…
What does a nurse administer to a patient with HIV?
The nurse administers maraviroc (Selzentry) to a patient with HIV infection. It is most important for the nurse to monitor which of the following?
Is Tamiflu a prophylaxis?
Rationale: Oseltamivir (Tami flu) is the only one indicated for prophylaxis of influenza infection. Both oseltamivir and zanamivir can be used to treat active influenza illness. Treatment with oseltamivir and zanamivir ideally should begin with 2 days of symptom onset.