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what is the precription hydroxzine hcl 25mg designed treatment

by Prof. Ethan Kihn Published 2 years ago Updated 1 year ago

Hydroxyzine

Hydroxyzine Pamoate

Hydroxyzine is used to treat itching caused by allergies.

is used in the treatment of anxiety; allergic urticaria; allergies; nausea/vomiting; pain and belongs to the drug classes antihistamines, miscellaneous anxiolytics, sedatives and hypnotics. FDA has not classified the drug for risk during pregnancy.

Full Answer

What is hydroxyzine HCl 25MG used for?

HYDROXYZINE HCL 25mg. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses and in histamine-mediated pruritus. As a sedative when used as a premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates,...

What is the USP for hydroxyzine hydrochloride?

Hydroxyzine hydrochloride, USP occurs as a white, odorless powder which is very soluble in water. Each tablet for oral administration contains 10 mg, 25 mg, or 50 mg hydroxyzine hydrochloride, USP.

What is the mechanism of action of hydroxyzine?

Hydroxyzine is rapidly absorbed from the gastrointestinal tract and hydroxyzine's clinical effects are usually noted within 15 to 30 minutes after oral administration. For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.

What is hydroxyzine used to treat before surgery?

Hydroxyzine is approved to be used for sedation (a relaxed state, for relief of tension and anxiety) before surgery or another medical procedure. This is referred to as premedication. When used as premedication, drugs with sedative effects, such as hydroxyzine, can help you relax.

What is hydroxyzine HCL 25 mg prescribed for?

Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery.

What type of anxiety does hydroxyzine treat?

Hydroxyzine's unique effect on serotonin is likely why it's the only antihistamine used for anxiety. While hydroxyzine can be used to treat many different types of anxiety disorders, it is used most often for generalized anxiety disorder (GAD), especially when it is associated with insomnia.

How long is hydroxyzine prescribed for?

Hydroxyzine is for short-term use only. You should not take this medicine for longer than 4 months. Call your doctor if your anxiety symptoms do not improve, or if they get worse.

How long does it take for hydroxyzine HCL 25 mg to work?

‍ One of the benefits of taking hydroxyzine for sleep is how quickly it works. Sleep-inducing effects can be felt in as few as 15-30 minutes, and the maximum clinical effect happens 2 hours after taking it.

Is 25mg of hydroxyzine strong?

The recommended dose of Vistaril for treating itch (pruritus) is 25 mg, 3 or 4 times daily. For sedation, the recommended dose is 50 to 100 mg. The dose to treat anxiety and tension is 50 to 100 mg 4 times daily.

Is hydroxyzine the same thing as Xanax?

Hydroxyzine and Xanax belong to different drug classes. Hydroxyzine is an antihistamine with anticholinergic (drying) and sedative properties and Xanax is an anti-anxiety medication in the benzodiazepine class. A brand name for hydroxyzine is Vistaril.

Is Benadryl better than hydroxyzine?

Benadryl has an average rating of 7.2 out of 10 from a total of 63 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 20% reported a negative effect. Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1260 ratings on Drugs.com.

What drugs should not be taken with hydroxyzine?

Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation and should not be used in combination with hydroxyzine.

What are the dangers of hydroxyzine?

Hydroxyzine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:dry mouth.constipation (especially in older adults)confusion (especially in older adults)dizziness.headache.

Is hydroxyzine the same as Benadryl?

Hydroxyzine typically helps with skin-related symptoms of an allergic reaction, such as itching or hives. Benadryl, on the other hand, usually helps with red/watery eyes, sneezing, and runny noses.

Does hydroxyzine make you gain weight?

No, hydroxyzine isn't known to cause weight gain. This side effect wasn't reported by people taking the drug in clinical studies.

Does hydroxyzine lower blood pressure?

Hydroxyzine can cause abnormal heart rhythms and low blood pressure. Your risk for these side effects is higher if you already have heart problems before taking hydroxyzine. Liver or kidney problems.

How long does hydroxyzine stay in your system?

Hydroxyzine will stay in your system for about 100 hours, on average, but its clinical effect may wear off before this time. Hydroxyzine has a half...

Does hydroxyzine make you sleepy?

Yes, hydroxyzine is an antihistamine that can cause drowsiness and sedation. It can be used to treat anxiety and tension due to its sedative proper...

How long does it take for hydroxyzine to work?

Hydroxyzine starts to work in about 15 to 30 minutes but its drowsy effect may last for 4 to 6 hours. Hydroxyzine can reduce itching and redness du...

Can hydroxyzine be taken long-term?

Hydroxyzine is intended for short-term use only (less than 4 months) when used to treat anxiety. Using hydroxyzine long-term would be considered an...

How long does it take for hydroxyzine to work?

Hydroxyzine is rapidly absorbed from the gastrointestinal tract and hydroxyzine's clinical effects are usually noted within 15 to 30 minutes after oral administration. For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.

What are the symptoms of overdosage with hydroxyzine?

The most common manifestation of hydroxyzine overdosage is hypersedation. Other reported signs and symptoms were convulsions, stupor, nausea and vomiting. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken.

Can hydroxyzine cause QT prolongation?

Do not use epinephrine as hydroxyzine counteracts its pressor action. Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose.

How much sedative is used for anesthesia?

As a sedative when used as a premedication and following general anesthesia: 50 to 100 mg for adults and 0.6 mg/kg of body weight in children. When treatment is initiated by the intramuscular route of administration, subsequent doses may be administered orally.

Is hydroxyzine hydrochloride a mild or severe side effect?

Side effects reported with the administration of hydroxyzine hydrochloride are usually mild and transitory in nature. Anticholinergic: Dry mouth. Central Nervous System: Drowsiness is usually transitory and may disappear in a few days of continued therapy or upon reduction of dose.

Can hydroxyzine be used for AGEP?

If signs or symptoms suggest AGEP, use of hydro xyzine should not be resumed and alternative therapy should be considered. Avoid cetirizine or levocetirizine in patients who have experienced AGEP or other hypersensitivity reactions with hydroxyzine, due to the risk of cross-sensitivity. Geriatric Use.

Is hydroxyzine a cortical depressant?

Hydroxyzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate or the benzodiazepines. Hydroxyzine is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system.

How often should I take hydrozine?

How to use. Take this medication by mouth with or without food as directed by your doctor, usually three or four times daily.

What is the name of the antihistamine that is used to treat itching caused by allergies?

Brand name (s) Atarax. Uses. Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

What are the side effects of a saline solution?

Side effects. Drowsiness, dizziness, blurred vision, constipation, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Can hydroxyzine cause allergies?

Precautions. Before taking hydroxyzine, tell your doctor or pharmacist if you are allergic to it; or to cetirizine; or to levocetirizine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Can hydroxzine cause a fast heartbeat?

QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Can hydroxyzine make you dizzy?

Talk to your doctor about taking hydroxyzine safely. This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages.

What are the symptoms of overdosage of hydrozine pamoate?

The most common manifestation of overdosage of Hydroxyzine pamoate is hypersedation. Other reported signs and symptoms were convulsions, stupor, nausea and vomiting. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken.

How much sedative is used for general anesthesia?

As a sedative when used as a premedication and following general anesthesia: 50 to 100 mg in adults, and 0.6 mg/kg in children. When treatment is initiated by the intramuscular route of administration, subsequent doses may be administered orally.

Can Hydroxyzine be used as a sedative?

As a sedative when used as premedication and following general anesthesia, Hydroxyzine may potentiate meperidine (Demerol®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug.

Can Hydroxyzine interfere with Digitalis?

Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent. The effectiveness of Hydroxyzine as an antianxiety agent for long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies.

Is hydroxyzine a cortical depressant?

Hydroxyzine pamoate is unrelated chemically to the phenothiazines, reserpine, meprobamate, or the benzodiazepines. Hydroxyzine pamoate is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system.

Does hydroxyzine increase gastric secretion?

Pharmacological and clinical studies indicate that Hydroxyzine in therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity.

Is hydrozine a depressant?

Therefore, when central nervous system depressants are administered concomitantly with Hydroxyzi ne, their dosage should be reduced. Since drowsiness may occur with use of the drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Hydroxyzine pamoate. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased.

What are the symptoms of overdosage with hydroxyzine?

The most common manifestation of hydroxyzine overdosage is hypersedation. Other reported signs and symptoms were convulsions, stupor, nausea and vomiting. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken.

Why should elderly patients be on hydroxyzine?

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selections. Sedating drugs may cause confusion and over sedation in the elderly; elderly patients generally should be started on low doses of hydroxyzine and observed closely.

Can hydroxyzine cause QT prolongation?

Do not use epinephrine as hydroxyzine counteracts its pressor action. Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose.

Is hydroxyzine a barbiturates?

As a sedative when used as a premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug.

Is hydroxyzine hydrochloride a mild or severe side effect?

Side effects reported with the administration of hydroxyzine hydrochloride are usually mild and transitory in nature. Anticholinergic: Dry mouth. Central Nervous System: Drowsiness is usually transitory and may disappear in a few days of continued therapy or upon reduction of dose.

Can hydroxyzine be used for AGEP?

If signs or symptoms suggest AGEP, use of hydro xyzine should not be resumed and alternative therapy should be considered. Avoid cetirizine or levocetirizine in patients who have experienced AGEP or other hypersensitivity reactions with hydroxyzine, due to the risk of cross-sensitivity. Geriatric Use.

Does hydroxyzine increase gastric secretion?

Pharmacological and clinical studies indicate that hydroxyzine in therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity.

What are the side effects of hydroxyzine?

Serious side effects of hydroxyzine oral tablets that have been reported include: abnormal heart rhythm, such as long QT syndrome and torsades de pointes. skin reactions*.

How long does hydroxyzine stay in your system?

Typically, it takes about five half-lives for a drug to completely leave your system. For hydroxyzine, this means the drug will stay in your system for about 70 hours after your last dose.

What are the interactions with hydroxyzine?

Interactions. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions. Before taking hydroxyzine oral tablet, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types.

Can hydroxyzine cause breathing problems?

They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. Call your doctor right away if you have an allergic reaction to hydroxyzine oral tablets.

Can hydroxyzine cause skin reactions?

You may have serious skin reactions while you’re taking hydroxyzine oral tablets. Skin reactions weren’t reported in studies of the drug. But these side effects have been reported since the drug’s initial studies.

Can hydroxyzine cause low blood pressure?

Instead, low blood pressure from hydroxyzine was reported after the drug’s initial studies. Keep in mind, though, that low blood pressure is also a possible side effect with overdose of hydroxyzine oral tablets. Your risk for low blood pressure from hydroxyzine is higher if you have heart problems.

Is hydroxyzine a generic drug?

Hydroxyzine oral tablet is a generic drug, which means it’s an exact copy of the active drug in a brand-name medication. The brand-name medication that hydroxyzine oral tablet is based on was called Atarax. But brand-name Atarax is no longer available.

What is hydroxyzine?

Generally speaking, hydroxyzine is an antihistamine related to over-the-counter (OTC) medications like Benadryl and Zyrtec that are used to treat symptoms of allergies and colds such as runny nose and itchy or watery eyes.

How does hydroxyzine work for anxiety?

Researchers don’t know exactly how hydroxyzine works in the human body and mind to treat anxiety, but most healthcare providers agree that it affects 2 chemicals in our bodies: histamine and serotonin.

Hydroxyzine for anxiety dosage

If you’ve read some of our other articles, you may have seen that there are some anxiety medications that need to be taken regularly to be effective, and others — like hydroxyzine — that can be taken as needed.

How long does it take for hydroxyzine to start working?

Hydroxyzine starts working very quickly. Most people will start to feel it kick in within 30 minutes and will feel its maximum effect at around 2 hours. While it’s great that it gets to work quickly, keep in mind that you can also expect to feel many of its potential side effects quickly, as well.

Is hydroxyzine safe to take during pregnancy?

Hydroxyzine is not safe to take during early pregnancy as it may cause harm to a developing fetus. Talk to your provider if you think you may be pregnant or are planning to be pregnant. There may be other options that are safer while you are pregnant.

Hydroxyzine side effects

Side effects with hydroxyzine are generally mild and will likely wear off as you get used to the medication.

Hydroxyzine interactions

If you currently take opioids (such as Vicodin or OxyContin), benzodiazepines (such as Xanax or Klonopin ), or sleep medications (such as Ambien or Lunesta ), let your provider know because taking these medications with hydroxyzine may affect how both drugs work.

Most voted positive review

THIS MEDICATION IS VERY GOOD FOR ALLERGIC REACTIONS. IT STOPS THE ITCHING IN ABOUT 15 MINUTES. THIS DRUG ALS0 HELPS WITH SLEEPING...I RECOMMEND IT TO ANYONE WHO HAS FREQUENT REACTIONS WHICH RESULT IN HIVES OR DIFFICULTY BREATHING AND THE REACTIONS ARE UNKNOWN.....

Most voted negative review

Once I saw it could cause heart disturbances I refused to take this drug. I am using benedryl instead. The risks seem to be very high with this drug with what I see as a low effectiveness for the risks at hand.

Shared reviews and ratings

I was given hydroxyzine hcl 25mg to treat anxiety. I am very leary using meds so I cut pill in half. about half an hour later a extreme low hit me a little later I became extremely tired. Could not function take or take care my 3yr old grandchild. The anxiety went away, but not something I want to take again.

What is the most common manifestation of hydroxyzine hydrochloride overdose?

The most common manifestation of hydroxyzine hydrochloride overdosage is hypersedation. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken.

How much sedative is used for general anesthesia?

As a sedative when used as a premedication and following general anesthesia: 50-100 mg in adults, and 0.6 mg/kg of body weight in children. When treatment is initiated by the intramuscular route of administration, subsequent doses may be administered orally.

What is Atarax used for?

What is Atarax and how is it used? Atarax is a prescription medicine used to treat the symptoms of itching caused by allergies and anxiety. Atarax may be used alone or with other medications. Atarax belongs to a class of drugs called Antihistamines, 1st Generation, Antiemetic Agents, Antihistamines, Piperazine Derivatives.

Is hydroxyzine hydrochloride a transitory drug?

Side effects reported with the administration of hydroxyzine hydrochloride are usually mild and transitory in nature. Anticholinergic: Dry mouth. Central Nervous System: Drowsiness is usually transitory and may disappear in a few days of continued therapy or upon reduction of the dose.

Is hydroxyzine safe for pregnant women?

Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range. Clinical data in human beings are inadequate to establish safety in early pregnancy. Until such data are available, hydroxyzine is contraindicated in early pregnancy.

Does hydroxyzine interfere with digitalis?

Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent. The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies.

Is hydroxyzine a barbiturates?

As a sedative when used as premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates, so their use in pre- anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug.

Hydroxyzine Description

Image
Hydroxyzine pamoate is designated chemically as 1-(p-chlorobenzhydryl) 4- [2-(2-hydroxyethoxy) ethyl] diethylenediamine salt of 1,1′-methylene bis (2 hydroxy- 3-naphthalene carboxylic acid). Inert ingredients for the capsule formulations are: hard gelatin capsules (which may contain Yellow 10, Green 3, Yellow 6, Red 33, an…
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Hydroxyzine - Clinical Pharmacology

  • Hydroxyzine pamoate is unrelated chemically to the phenothiazines, reserpine, meprobamate, or the benzodiazepines. Hydroxyzine pamoate is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. Primary skeletal muscle relaxation has been demonstrated experimentally. Bronchodila…
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Indications

  • For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus. As a sedative when used as premedication and following general a…
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Contraindications

  • Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range. Clinical data in human beings are inadequate to establish safety in early pregnancy. Until such data are available, Hydroxyzine is contraindicated in early pregnancy. Hydroxyzine is contraindic…
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Warnings

  • Nursing Mothers
    It is not known whether this drug is excreted in human milk. Since many drugs are so excreted, Hydroxyzine should not be given to nursing mothers.
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Precautions

  • THE POTENTIATING ACTION OF Hydroxyzine MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore, when central nervous system depressants are administered concomitantly with Hydroxyzine, their dosage should be reduced. …
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Adverse Reactions

  • Side effects reported with the administration of Hydroxyzine pamoate are usually mild and transitory in nature. Skin and Appendages:Oral Hydroxyzine hydrochloride is associated with Acute Generalized Exanthematous Pustulosis (AGEP) and fixed drug eruptions in postmarketing reports. Anticholinergic:Dry mouth. Central Nervous System:Drowsiness is usually transitory an…
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Overdosage

  • The most common manifestation of overdosage of Hydroxyzine pamoate is hypersedation. Other reported signs and symptoms were convulsions, stupor, nausea and vomiting. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken. If vomiting has not occurred spontaneously, it should be induced. Immediate g…
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Dosage

  • For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: in adults, 50 to 100 mg 4 times daily; children under 6 years, 50 mg daily in divided doses; and over 6 years, 50 to 100 mg daily in divided doses. For use in the management of pruritus due to allergic conditions such as chronic …
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How Is Hydroxyzine Supplied

  • Hydroxyzine pamoate capsules (Hydroxyzine pamoate equivalent to Hydroxyzine hydrochloride) Store below 30°C (86°F). Dispense in tight, light-resistant containers (USP). This product's label may have been updated. For full prescribing information, please visit www.greenstonellc.com. LAB-1402-1.0 Revised: February 2020
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