Any advice of possible treatment options for Gleason 4+3=7 (details below)? Apparently most docs are split on radiation therapy and surgery. But there are also other options I have read about: hormone therapy, radiation, surgery or chemotherapy.
Full Answer
What does it mean to have a Gleason score of 6?
What does it mean to have a Gleason Score of 6 or 7 or 8-10? The lowest Gleason Score of a cancer found on a prostate biopsy is 6. These cancers may be called well-differentiated or low-grade and are likely to be less aggressive - they tend to grow and spread slowly.
What is the Gleason score for Grade 3 cancer?
For instance, if the Gleason Score is written as 3+4=7, it means most of the tumor is grade 3 and the next largest section of the tumor is grade 4, together they make up the total Gleason Score.
What is the percentage difference between Gleason 3 and Gleason 4?
- Gleason 4+3=7, Grade III, Gleason "4" - 90%, Gleason '3' - 10%, 5mm, 62% from total mass. - Gleason 3+4=7, Grade II, Gleason "3"- 95%, Gleason "4" - 5%, 4mm, 50% from total mass.
What is the Gleason score on a prostate biopsy?
Because prostate biopsies are tissue samples from different areas of the prostate, the Gleason score on biopsy usually reflects your cancers true grade. However, in about 1 out of 5 cases the biopsy grade is lower than the true grade because the biopsy misses a higher grade area of the cancer.
Should Gleason 3/4 Be treated?
Current American Society of Clinical Oncology (ASCO)/Cancer Care Ontario (CCO) guidelines recommend treatment for most men with intermediate-risk disease, but state that men with low-volume Gleason 3+4 prostate cancer may be considered for active surveillance.
What does a Gleason score of 3 4 mean?
Gleason score 3+4=7 tumors still have a good prognosis (outlook), although not as good as a Gleason score 6 tumor. A Gleason score 4+3=7 tumor is more likely to grow and spread than a 3+4=7 tumor, yet not as likely as a Gleason score 8 tumor.
What stage cancer is Gleason 3 4?
Prostate cancer stages at a glanceStageGleason scoreGroup grade2A6 or less22B7 (3 + 4)22C7 (4 + 3) or 83 or 43A8 or less1–45 more rows•Feb 9, 2021
What is the most common Gleason score?
Currently the lowest score assigned to a tumor is grade 3. Grades below 3 show normal to near normal cells. Most cancers have a Gleason score (the sum of the two most common grades) between 6 (Gleason scores of 3+3) and 7 (Gleason scores of 3+4 or 4+3).
Can a Gleason score go down?
The decrease in proportion of high Gleason score cancers, however, was due to higher rates of low-grade disease diagnosis as a result of PSA screening. The researchers show that the shift in Gleason score proportions over time is not likely due to changes in the age at diagnosis.
What is the difference between a 3/4 and 4/3 Gleason score?
A Gleason score of 4+3 versus 3+4 was predictive of metastatic disease (P = 0.002) but not local recurrence. Conclusions: Gleason score 7 tumors are heterogeneous in their biologic behavior. The differences in prognosis for patients with Gleason scores 3+4 and 4+3 tumors at radical prostatectomy are significant.
What is the PSA number at Stage 4 cancer?
Stage 4 prostate cancer has spread to nearby lymph nodes, tissues near the prostate, or even distant parts of the body, such as the bones or distant organs. Similar to stage 3, stage 4 prostate cancer can involve any PSA levels and Gleason scores that range between two and 10.
What is the best treatment for stage 1 prostate cancer?
Radiation therapy is a good choice for many men with early-stage prostate cancer. It is also the best treatment for older men or those who have other health problems. There are different types of radiation therapy: External beam radiation.
What is a good Gleason score for prostate cancer?
The scores are added together to come up with an overall score between 6 and 10. Gleason scores of 5 or lower are not used. The lowest Gleason score is 6, which is a low-grade cancer. A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer.
Is Gleason score same as PSA?
The PSA level at the time of diagnosis. The Grade Group (based on the Gleason score), which is a measure of how likely the cancer is to grow and spread quickly. This is determined by the results of the prostate biopsy (or surgery).
What is the success rate of robotic prostatectomy?
The positive margin rate was 9.4% for all patients; i.e. 2.5% for T2 tumours, 23% for T3a and 53% for T4. The overall biochemical recurrence free (PSA level<0.1 ng/mL) survival was 95% at mean follow-up of 9.7 months. There was complete continence at 3 and 6 months in 89% and 95% of patients, respectively.
What is a high PSA level?
PSA levels under 4 ng/ml are generally considered normal, while levels over 4 ng/ml are considered abnormal. PSA levels between 4 and 10 ng/ml indicate a risk of prostate cancer higher than normal. When the PSA level is above 10 ng/ml, risk of prostate cancer is much higher.
Key definitions
The respected urology and pathology departments at Johns Hopkins have established many of today’s diagnostic and treatment criteria for PCa. Here are the definitions they used for this report:
Study findings
The team’s analysis revealed the following rates of adverse pathology for each risk level:
Important takeaway message about AS
From our viewpoint at the Sperling Prostate Center, AS is a good thing for the right patient. This Johns Hopkins study shows the diagnostic inadequacy of the TRUS biopsy to determine who those men are.
About Dr. Dan Sperling
Dan Sperling, MD, DABR, is a board certified radiologist who is globally recognized as a leader in multiparametric MRI for the detection and diagnosis of a range of disease conditions.
What is the Gleason score?
The Gleason Score is the grading system used to determine the aggressiveness of prostate cancer. This grading system can be used to choose appropriate treatment options.#N#The Gleason Score ranges from 1-5 and describes how much the cancer from a biopsy looks like healthy tissue (lower score) or abnormal tissue (higher score). Most cancers score a grade of 3 or higher.
Why is Gleason score important?
The Gleason Score is very important in predicting the behavior of a prostate cancer. Still, other factors are also important such as: The PSA Level. Findings on a rectal exam. How much of each core is made up of cancer. The number of cores that contain cancer. Whether cancer was found in both sides of the prostate.
What does a 7 mean in cancer?
A score of 7 suggests and intermediate risk for aggressive cancer. Scoring a 7 means that the primary score (largest section of the tumor) scored a 3 or 4. Tumors with a primary score of 3 and a secondary score ...
How many grades are there for prostate cancer?
Since prostate tumors are often made up of cancerous cells that have different grades, two grades are assigned for each patient. A primary grade is given to describe the cells that make up the largest area of the tumor and a secondary grade is given to describe the cells of the next largest area. For instance, if the Gleason Score is written as ...
Is the Gleason score higher or lower than the grade?
The Gleason Score on a biopsy usually reflects the cancer's true grade. However, it is possible that the Gleason Score from your biopsy is lower or higher than the true grade. To reduce the risk of over-or-under scoring, multiple biopsies are usually taken from different areas within the prostate.
Close to divorce after prostatectomy
I am in shock and am grieving what I think is coming soon. My husband had a radical prostatectomy a year ago, one nerve spared, the cancer had left the capsule. He is young (52), and so far, his PSA has been 0 (checked four times a year). When he had the surgery, he developed an infection and had a terrible reaction to cipro.
Is there any chance of a sex life when taking Lupron
Hi All, It looks like I will be going on a six month course of Lupron and I am wondering what this does to your sex life. I believe your libido no longer exists so you have no desire, but what happens if you try to have an orgasm whilst on this drug.
Orgasm after prostatectomy - time for honesty!
Hey guys, I've been thinking about writing this post for quite some time now. In fact about 29 months since my nerve-sparing robotic surgery. It seems the thing that no one wants to talk about honestly- so here goes. Yes we all know that, despite no ejaculation, some of us (maybe nearly all of us) can still get an orgasm.
ANY thoughts: use of Ivermectin for prostate cancer in the lungs?
Prostate cancer nodules just in the lungs. PSA controlled by Bicalutamide at 0.6 BUT, would like to see the cancer gone! Are there any thoughts on use of Ivermectin (Stromectol) tablets? 12mg per day till cancer is gone? Thanks for your thoughts. Sign up to continue reading
Close to divorce after prostatectomy
I am in shock and am grieving what I think is coming soon. My husband had a radical prostatectomy a year ago, one nerve spared, the cancer had left the capsule. He is young (52), and so far, his PSA has been 0 (checked four times a year). When he had the surgery, he developed an infection and had a terrible reaction to cipro.
Is there any chance of a sex life when taking Lupron
Hi All, It looks like I will be going on a six month course of Lupron and I am wondering what this does to your sex life. I believe your libido no longer exists so you have no desire, but what happens if you try to have an orgasm whilst on this drug.
Orgasm after prostatectomy - time for honesty!
Hey guys, I've been thinking about writing this post for quite some time now. In fact about 29 months since my nerve-sparing robotic surgery. It seems the thing that no one wants to talk about honestly- so here goes. Yes we all know that, despite no ejaculation, some of us (maybe nearly all of us) can still get an orgasm.
ANY thoughts: use of Ivermectin for prostate cancer in the lungs?
Prostate cancer nodules just in the lungs. PSA controlled by Bicalutamide at 0.6 BUT, would like to see the cancer gone! Are there any thoughts on use of Ivermectin (Stromectol) tablets? 12mg per day till cancer is gone? Thanks for your thoughts. Sign up to continue reading
Can The Gleason Score On My Biopsy Really Tell What The Cancer Grade Is In The Entire Prostate
Because prostate biopsies are tissue samples from different areas of the prostate, the Gleason score on biopsy usually reflects your cancers true grade. However, in about 1 out of 5 cases the biopsy grade is lower than the true grade because the biopsy misses a higher grade area of the cancer.
Technique Of Focal Therapy
A variety of techniques have been described, all involving the use of directed energy and image guidance. These include high intensity focused ultrasound , MR guided ultrasound, laser ablation, cryosurgical ablation, focal photodynamic therapy, electroporation, various forms of radiation.
The Ajcc Tnm Staging System
A staging system is a standard way for the cancer care team to describe how far a cancer has spread. The most widely used staging system for prostate cancer is the AJCC TNM system, which was most recently updated in 2018.
La Classification Clinique Tnm
TX La tumeur na pu être évaluéeT0 Absence de tumeur dans la prostateT1 La tumeur est de petite taille, se limite à la prostate et est non-palpable au toucher rectal. Il sagit dun cancer de la prostate localisé.
How Is The Gleason Score Derived
The pathologist looking at the biopsy sample will assign one Gleason grade to the most predominant pattern in your biopsy and a second Gleason grade to the second most predominant pattern. For example: 3 + 4. The two grades will then be added together to determine your Gleason score. Theoretically, Gleason scores range from 2-10. However, since Dr.
Relationship Of Gleason Grade To Pathologic And Clinical End Points
Increasing Gleason grade is directly related to a number of histopathological end points, including lymphvascular space invasion by carcinoma, tumor size, positive surgical margins, and pathological stage, including risk of extraprostatic extension and metastasis .
What Is A Normal Gleason Score For Prostate Cancer
Your Gleason score doesn’t rank potential ranges like ranges set for elevated PSA tests. Instead, providers break Gleason scores into three categories: