What is the preferred initial treatment regimen from the CDC for tuberculosis?
The preferred initial treatment regimen is INH, rifampin (RIF), and ethambutol (EMB) daily for 2 months, followed by INH and RIF daily, or twice weekly for 7 months (for a total of 9 months of treatment).
What is the initial treatment for TB?
Drug therapy For initial empiric treatment of TB, start patients on a 4-drug regimen: isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin. Once the TB isolate is known to be fully susceptible, ethambutol (or streptomycin, if it is used as a fourth drug) can be discontinued.
What is the most common treatment for active TB?
The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol. You may begin to feel better only a few weeks after starting to take the drugs but treating TB takes much longer than other bacterial infections.
What are the 4 first line drugs for the treatment of TB?
TB can be treated effectively by using first line drugs (FLD) isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), ethambutol (EMB) and streptomycin (SM).
What is the treatment of pulmonary tuberculosis?
Pulmonary TB The usual treatment is: 2 antibiotics (isoniazid and rifampicin) for 6 months. 2 additional antibiotics (pyrazinamide and ethambutol) for the first 2 months of the 6-month treatment period.
WHO TB drug regimen?
For treatment of new cases of pulmonary or extrapulmonary TB, WHO recommends a standardized regimen consisting of two phases. The initial (intensive) phase uses four drugs (rifampicin, isoniazid, pyrazinamide and ethambutol) administered for two months.
What pharmacologic therapies and dosing strategies are available for the treatment of active pulmonary tuberculosis?
Dosing recommendations for capreomycin, streptomycin, kanamycin, and amikacin are the same. These agents are administered 5–7 days each week at a dose of 15 mg/kg/day (maximum 1 g/day) for the first 2–4 months of therapy in patients with normal renal function.
Which of the following is first-line drug used in tuberculosis?
First-line agents for treatment of active TB consist of isoniazid, a rifamycin (rifampin or [less frequently] either rifapentine or rifabutin), pyrazinamide, and ethambutol; in addition, moxifloxacin is a first-line agent when administered in combination with isoniazid, rifapentine, and pyrazinamide [6].
What is active pulmonary tuberculosis?
Active tuberculosis is a condition in which Mycobacterium tuberculosis causes infection; typically in the lungs, although many systems can be involved. The World Health Organization estimates that, annually, around 8 million people develop active tuberculosis globally, and nearly 2 million people die from the disease.
What are the first-line and second line drugs for treatment of tuberculosis?
Grouping of drugsDrugs line categoryFirst-line anti-tuberculosis drugsGroup 1Isoniazid, rifampicin, ethambutol, pyrazinamideSecond-line anti-tuberculosis drugsGroup 2Moxifloxacin, high dose levofloxacin (fluoroquinolones)4 more rows•Oct 14, 2016