Treatment FAQ

what is the drug of choice in the treatment of staphylococus aureus

by Mr. Patrick Cruickshank DDS Published 2 years ago Updated 2 years ago
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The treatment of choice for S. aureus infection is penicillin. In most countries, S. aureus strains have developed a resistance to penicillin due to production of an enzyme by the bacteria called penicillinase.

Medication

The glycopeptide drug vancomycin, and in some countries teicoplanin, is the most common drug used to treat severe MRSA infections. There are now other classes of antimicrobials available to treat staphylococcal infections, including several that have been approved after 2009.

Procedures

 · New antibiotics for Staphylococcus aureus or staph infections such as Linezolid and quinupristin have good antistaphylococcal activity; however, they are very expensive and should be reserved for patients who fail on or are intolerant of conventional therapy or who have highly resistant strains like heterogenous vancomycin intermediate staphylococcus aureus or …

Nutrition

 · In general, penicillin remains the drug of choice if isolates are sensitive (MSSA, or methicillin sensitive S. aureusstrains) and vancomycin for MRSA strains.[3] In some cases, alternative therapy is necessary for addition to antimicrobial therapy.[6]

What is the best antibiotic for Staphylococcus aureus?

Penicillinase-resistant penicillins (flucloxacillin, dicloxacillin) remain the antibiotics of choice for the management of serious methicillin-susceptible S. aureus (MSSA) infections, but first generation cephalosporins (cefazolin, cephalothin and cephalexin), clindamycin, lincomycin and erythromycin have important therapeutic roles in less serious MSSA infections such as skin …

What is the right antibiotic to use for staph infection?

11 rows ·  · Vancomycin is preferred for treatment in severe MRSA infections and is used only intravenously ...

How to cure Staphylococcus aureus infection naturally?

43 rows · Drugs used to treat Methicillin-Resistant Staphylococcus Aureus Infection The following list of medications are in some way related to or used in the treatment of this condition. Select drug class All drug classes miscellaneous antibiotics (2) quinolones (2) glycopeptide antibiotics (4) oxazolidinone antibiotics (2) streptogramins (2)

Does staph Aureas hate antibiotics?

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What drug kills staphylococcus?

Rifampin and ciprofloxacin have been shown to be the most effective intraphagocytic killing agents, while clindamycin and erythromycin were inactive in these in vitro assays.

How is Staphylococcus aureus treated?

Infections due to Staphylococcus aureus are treated with antibiotics. Doctors try to determine whether the bacteria are resistant to antibiotics and, if so, to which antibiotics. Infection that is acquired in a hospital is treated with antibiotics that are effective against MRSA.

Can ciprofloxacin treat Staphylococcus aureus?

Ciprofloxacin appears to be safe and effective for a wide variety of clinical infections. In-vitro and animal studies point to high cure rates for both methicillin-sensitive and methicillin-resistant Staphylococcus aureus infections.

Can amoxicillin treat Staphylococcus aureus?

The experimental and clinical values of amoxycillin/clavulanate in severe Staphylococcus aureus infections are reviewed. Experimentally, amoxycillin/clavulanate was highly effective in the treatment of acute endocarditis due to methicillin-sensitive isolates of S. aureus (MSSA) in rats.

What antibiotics are used for Staphylococcus aureus?

For managing the serious methicillin-susceptible Staphylococcus aureus or MSSA infections, Penicillinase-resistant penicillin’s, such as Flucloxacillin and dicloxacillin, remain the antibiotics of choice. Advertisement.

Is Staphylococcus aureus resistant to penicillin?

Most strains of Staphylococcus aureus are now resistant to the antibiotic penicillin, and methicillin-resistant strains of Staphylococcus aureus or MRSA are common in hospitals and are emerging in the community.

What is the cause of staph infection?

Staphylococcus aureus or staph infections may cause disease because of direct infection or due to the production of toxins by the bacteria.

How long does antistaphylococcal therapy last?

These antibiotics readily reach joint fluid, and the concentration in the joint fluid is 30% of the serum value. Therapy usually continues for at least 4 weeks. Duration of parenteral therapy is often debated. Some authors have demonstrated efficacy with 1 week of parenteral therapy followed with 3 weeks of oral therapy. Consider a switch to oral therapy based on the considerations mentioned above. Joint fluid that reaccumulates should be removed, and a sample should be cultured to assess the efficacy of therapy and to make the patient more comfortable.

What antibiotics are used for osteomyelitis?

Empirically, initiating a semisynthetic penicillin (eg, oxacillin [150 mg/kg/d]) and clindamycin (30-40 mg/kg/d) is a good choice for most cases of community-acquired osteomyelitis. In patients with allergy to penicillin, a first-generation cephalosporin and clindamycin (30-40 mg/kg/d) are an excellent alternative. Use vancomycin or linezolid when the other drugs mentioned are absolutely not tolerated or when resistance or the clinical course dictates. The duration of therapy is a controversial topic in the literature, but the consensus among multiple authors is that the minimum effective treatment time is 4-6 weeks. A switch to oral therapy is acceptable if the child is able to take oral antibiotics, is afebrile, and if he or she has demonstrated a good clinical response to parenteral antibiotics. [ 13]

Can rifampin be used alone?

Rifampin should never be used alone because resistance can develop. The response to therapy is usually slow, and patients may continue to have bacteremia, fever, and leukocytosis for at least a week after therapy is initiated. Some authors recommend obtaining blood cultures after the end of therapy.

What is Staphylococcus aureus?

Last Update: August 23, 2020. Continuing Education Activity. Staphylococcus aureus is a gram-positive bacteria that cause a wide variety of clinical diseases. Infections caused by this pathogen are common both in community-acquired and hospital-acquired settings. The treatment remains challenging due to the emergence of multi-drug resistant strains ...

Is Staphylococcus aureus a bacterial infection?

Staphylococcus aureusis a major bacterial human pathogen that causes a wide variety of clinical manifestations.[1] Infections are common both in community-acquired as well as hospital-acquired settings and treatment remains challenging to manage due to the emergence of multi-drug resistant strains such as MRSA ...

Is Staphylococcus aureus a human disease?

Staphylococcus aureus is a major bacterial human pathogen that causes a wide variety of clinical manifestations.[1] . Infections are common both in community-acquired as well as hospital-acquired settings and treatment remains challenging to manage due to the emergence of multi-drug resistant strains such as MRSA ...

Can S. aureus cause skin infections?

S. aureus does not normally cause infection on healthy skin, however, if it is allowed to enter the internal tissues or bloodstream, these bacteria may cause a variety of potentially serious infections.

How long should antibiotics be given?

When prescribing antibiotics, one should limit the duration to no more than 7 to 10 days for most infections. The reason is that the empirical prescription of antibiotics has led to the development of resistant strains.

Is Staphylococcus aureus resistant to penicillin?

Most strains of Staphylococcus aureus are now resistant to penicillin, and methicillin-resistant strains of S. aureus (MRSA) are common in hospitals and are emerging in the community. Penicillinase-resistant penicillins (flucloxacillin, dicloxacillin) remain the antibiotics of choice for the management of serious methicillin-susceptible S.

Is staph resistant to penicillin?

Staphylococcal infections are a common and significant clinical problem in medical practice. Most strains of Staphylococcus aureus are now resistant to penicillin , and methicillin-resistant strains of S. aureus (MRSA) are common in hospitals and are emerging in the community.

What antibiotics are used for MRSA?

Most community-acquired strains of MRSA in Australia and New Zealand are non multiresistant (nmMRSA), and lincosamides (clindamycin, lincomycin) or cotrimoxazole are the antibiotics of choice for less serious nmMRSA infections such as skin and soft tissue infections.

Why is Staphylococcus aureus a concern?

Because of high incidence, morbidity, and antimicrobial resistance, Staphylococcus aureus infections are a growing concern for family physicians. Strains of S. aureus that are resistant to vancomycin are now recognized. Increasing incidence of unrecognized community-acquired methicillin-resistant S.

Is S. aureus resistant to vancomycin?

Strains of S. aureus that are resistant to vancomycin are now recognized. Increasing incidence of unrecognized community-acquired methicillin-resistant S. aureus infections pose a high risk for morbidity and mortality. Although the incidence of complex S. aureus infections is rising, new antimicrobial agents, including daptomycin and linezolid, ...

Is S. aureus a bacterial infection?

S. aureus is a common pathogen in skin, soft-tissue, catheter-related, bone, joint, pulmonary, and central nervous system infections. S. aureus bacteremias are particularly problematic because of the high incidence of associated complicated infections, including infective endocarditis. Adherence to precautions recommended by ...

Can you use vancomycin for staph infection?

Vancomycin (Vancocin) should not be used for known methicillin- susceptible Staphylococcus aureus infections unless there is a betalactam allergy. Physicians should be aware of the regional prevalence of community- acquired MRSA and plan empiric therapy for S. aureus infections accordingly.

Is S. aureus a common pathogen?

Increasing incidence of unrecognized community-acquired methicillin-resistant S. aureus infections pose a high risk for morbidity and mortality. Although the incidence of complex S. aureus infections is rising, new antimicrobial agents, including daptomycin and linezolid, are available as treatment. S. aureus is a common pathogen in skin, ...

Why is vancomycin used for MRSA?

Vancomycin is preferred for treatment in severe MRSA infections and is used only intravenously because the oral formulation is not readily absorbed from the gastrointestinal tract. Vancomycin-intermediate susceptible and vancomycin-resistant strains of S. aureus have been reported.

What are the complications of S. aureus?

S. aureus bacteremia may lead to several complications including infective endocarditis, sepsis, or metastatic foci of infection. About 12 percent of patients with S. aureus bacteremia have infective endocarditis. 16 Transesophageal echocardiography is superior to transthoracic echocardiography in diagnosis of perivalvular abscess, prosthetic valve involvement, and recognizing smaller vegetations. Transthoracic echocardiography helps secure the diagnosis of infective endocarditis and predict serious intracardiac complications. 17 A cost-effectiveness study 18 suggested that in clinically uncomplicated catheter-associated S. aureus bacteremia, the use of transesophageal echocardiography was cost-effective compared with two or four weeks of empiric antimicrobial therapy, although this issue remains controversial. Consultation with an infectious diseases sub-specialist may be beneficial. 19 An algorithm for the management of S. aureus bacteremia is provided in Figure 1.

Drugs used to treat Methicillin-Resistant Staphylococcus Aureus Infection

The following list of medications are in some way related to, or used in the treatment of this condition.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

What antibiotics are prescribed for staph infection?

Commonly prescribed Staph infection antibiotics can include (but are not limited to): B-lactams: Such as Oxacillin, Flucloxacillin. First generation Cephalosporins: Such as Cefazolin, Cephalothin and Cephalexin. Lincosamides: Such as Clindamycin and Lincomycin. Macrolides: Such as Erythromycin. Tetracyclines: Such as Doxycycline, Minocycline.

What antibiotics are used for MRSA?

Vancomycin (IV) and Linezolid (for severe or resistant MRSA strains) Most of the above antibiotics are for less severe Staph infections. MRSA is resistant to the B-lactams listed above. Fortunately, Staph is generally easy to treat and antibiotics prescribed will generally work. If you have a mild Staph infection, antibiotics may not be required, ...

Can you get MRSA from a staph infection?

Unfortunately, Staph infections can sometimes turns into MRSA, which is a type of Staph that has become immune to common antibiotics. If MRSA does develop, special antibiotics for MRSA are the best conventional treatment option. Also consider alternative remedies for Staph, which are often just as effective as antibiotics, ...

What are the side effects of antibiotics?

Most antibiotic drugs have significant negative side effects, which can include: diarrhea, hives, yeast infections, upset stomach, nausea, vomiting, depressed white blood cell counts ...

Can you take antibiotics while pregnant?

Consult your physician if you are pregnant or breast feeding. Many people can not take antibiotics because of the severe side effects. RxISK.org is a free, independent drug safety website where you can research your antibiotic for ALL of the side effects that actual people are experiencing. You can also report your side-effects.

Is antibiotic resistance a problem?

Antibiotics are the medical treatment of choice for Staph, however, growing antibiotic resistance is a serious issue. The overuse of antibiotics over many years has resulted in the ever growing population of antibiotic resistant bacteria, such as MRSA. Antibiotics have become less and less effective with each passing year.

Can antibiotics cause diarrhea?

Most antibiotic drugs have significant negative side effects, which can include: diarrhea, hives, yeast infections, upset stomach, nausea, vomiting, depressed white blood cell counts (immune cells), rashes, and more. Consult your physician if you are pregnant or breast feeding.

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