How to calculate Xeloda dosage?
Capecitabine dose calculator. Common Questions and Answers about Capecitabine dose calculator. xeloda. Mother (66F, colon CA IIIB) is starting her 4th round of XELOX (capecitabine+oxaliplatin) and has 4 more to go. Her neutrophils are naturally low (~1.6) without chemo (possibly related to the synthroid she has been taking since 2010?). By ...
What should I do if I overdose on Xeloda?
What happens if I overdose (Xeloda)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking capecitabine (Xeloda)? Follow your doctor's instructions about any restrictions on food, beverages, or activity.
How should I take Xeloda?
Tips to preventing infection:
- Washing hands, both yours and your visitors, is the best way to prevent the spread of infection.
- Avoid large crowds and people who are sick (i.e.: those who have a cold, fever or cough or live with someone with these symptoms).
- When working in your yard, wear protective clothing including long pants and gloves.
- Do not handle pet waste.
What conditions does Xeloda treat?
What Conditions does XELODA Treat?
- colon and rectal cancer that has spread to another area
- metastatic breast carcinoma
- cancer of the ovary
- stomach cancer
- pancreatic adenocarcinoma, a cancer that forms in the glands of the pancreas
- lymph node positive colon cancer
- cancer of pancreas islet cells
- cancer or malignancy
- metastatic HER2 positive breast cancer
Before Taking This Medicine
You should not take Xeloda if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have: 1. severe kidney disease; or 2. a metabol...
How Should I Take Xeloda?
Xeloda is usually taken twice per day. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Should I Avoid While Taking Xeloda?
Capecitabine can pass into body fluids (including urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body flu...
What Other Drugs Will Affect Xeloda?
If you take a blood thinner (warfarin, Coumadin, Jantoven), you may need to have more frequent "INR" or prothrombin time tests. Taking a blood thin...
What are the side effects of Xeloda?
Common Xeloda side effects may include: nausea, vomiting, diarrhea, stomach pain; feeling weak or tired; hand and foot syndrome; or. jaundice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How long after eating can you take Xeloda?
Swallow the tablet whole with water and do not crush, chew, or break it. Tell your doctor if you have trouble swallowing the tablet. Xeloda is given in a 3-week treatment cycle, and you may only need to take the medicine only on certain days of this cycle.
What is Xeloda used for?
Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer. Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).
How long after Xeloda can you get pregnant?
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Can you take Xeloda if you are allergic to capecitabine?
Before taking this medicine. You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have: severe kidney disease. To make sure Xeloda is safe for you, tell your doctor if you have ever had: a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency;
Can Xeloda be delayed?
You may need frequent medical tests and your cancer treatments may be delayed based on the results. Xeloda can have long lasting effects on your body. You may also need medical tests for a short time after your last dose. Store at room temperature away from moisture and heat.
Can you breastfeed while taking Xeloda?
Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.
What are the adverse reactions of Xeloda?
In 875 patients with either metastatic breast or colorectal cancer who received XELODA monotherapy, 62% of the 21 patients ≥80 years of age treated with XELODA experienced a treatment-related grade 3 or 4 adverse event: diarrhea in 6 (28.6%), nausea in 3 (14.3%), hand-and-foot syndrome in 3 (14.3%), and vomiting in 2 (9.5%) patients. Among the 10 patients 70 years of age and greater (no patients were >80 years of age) treated with XELODA in combination with docetaxel, 30% (3 out of 10) of patients experienced grade 3 or 4 diarrhea and stomatitis, and 40% (4 out of 10) experienced grade 3 hand-and-foot syndrome.
How long after eating can you take xeloda?
XELODA tablets should be swallowed whole with water within 30 minutes after a meal. XELODA is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1 If XELODA tablets must be cut or crushed, this should be done by a professional trained in safe handling of cytotoxic drugs using appropriate equipment and safety procedures. XELODA dose is calculated according to body surface area.
How long does it take for capecitabine to reach peak levels?
Following oral administration of 1255 mg/m² BID to cancer patients, capecitabine reached peak blood levels in about 1.5 hours (Tmax) with peak 5-FU levels occurring slightly later, at 2 hours. Food reduced both the rate and extent of absorption of capecitabine with mean Cmax and AUC0-∞ decreased by 60% and 35%, respectively. The Cmax and AUC0-∞ of 5-FU were also reduced by food by 43% and 21%, respectively. Food delayed Tmax of both parent and 5-FU by 1.5 hours [see WARNINGS AND PRECAUTIONS, DOSAGE AND ADMINISTRATION, and Drug-Food Interaction ].
What enzymes convert capecitabine to 5-fluorouracil?
Enzymes convert capecitabine to 5-fluorouracil (5-FU) in vivo. Both normal and tumor cells metabolize 5-FU to 5-fluoro-2’-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N 5-10 -methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2’-deoxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, so that a deficiency of this compound can inhibit cell division. Second, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis.
How long after Xeloda is it safe to use contraception?
Based on genetic toxicity findings, advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 3 months following the final dose of XELODA [see Nonclinical Toxicology ].
Does capecitabine have an anticoagulant?
Patients receiving concomitant capecitabine and oral cou marin-derivative anticoagulant therapy should have their anticoagulant response (INR or prothrombin time) monitored closely with great frequency and the anticoagulant dose should be adjusted accordingly [see BOXED WARNING and DRUG INTERACTIONS ].
Is Xeloda a single agent?
XELODA is indicated as a single agent for adjuvant treatment in patients with Dukes C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred. XELODA was non-inferior to 5fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS). Physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing single-agent XELODA in the adjuvant treatment of Dukes C colon cancer.
Drug details
Xeloda is a form of chemotherapy called an antimetabolite. It contains capecitabine, which is a pro-drug. A pro-drug is an inactive drug that your body changes into an active drug. When you take Xeloda, your body changes it into the active drug fluorouracil.
Effectiveness
For information about the effectiveness of Xeloda, see the “ Xeloda uses ” section below.
Serious side effects
Serious side effects from Xeloda can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Side effect details
Here’s some detail on certain side effects this drug may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Xeloda.
Is Xeloda a chemotherapy drug?
Yes, Xeloda is a chemotherapy drug. However, it’s different from most other chemotherapy drugs. Xeloda is taken by mouth instead of being given as an injection. It’s also slightly more targeted against cancer cells than other chemotherapy drugs.
Is Xeloda used for pancreatic cancer?
Yes, Xeloda is sometimes used to treat pancreatic cancer. However, this is an off-label use of the drug. Off-label use refers to using a drug for a purpose that hasn’t been approved by the Food and Drug Administration (FDA).
Does Xeloda treat triple-negative breast cancer?
Yes, Xeloda can treat triple-negative breast cancer in certain situations. But it’s not specifically FDA-approved for this use.
How long after eating can you take capecitabine?
In all clinical trials, patients were instructed to administer capecitabine within 30 minutes after a meal. Recommended to administer with food.
Is paclitaxel monotherapy or doxorubicin?
Monotherapy. Indicated for patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel for whom further anthracycline therapy is not indicated (eg, patients who have received cumulative doses of 400 mg/m 2 of doxorubicin or doxorubicin equivalents) ...
Is 5-FU a metabolite of capecitabine?
5-FU, an active metabolite of capecitabine, is increased and its toxicity may be enhanced by leucovorin. Deaths from severe enterocolitis, diarrhea, and dehydration reported in older patients receiving weekly leucovorin and 5-FU. CYP2C9 substrates. Caution if coadministered with CYP2C9 substrates.
What is Xeloda used for?
Typically, it’s used to treat advanced-stage breast cancer that has stopped responding to certain other chemotherapy medicines. Xeloda is taken orally as a pill.
How do doctors judge the effectiveness of neoadjuvant treatment?
One way doctors judge the effectiveness of neoadjuvant treatment is to look at the tissue removed during surgery to see if any cancer cells are present. If no cancer cells are there, doctors call it a “pathologic complete response.”.
Does Xeloda cause side effects?
Like most chemotherapy medicines, Xeloda can cause side effects . In the study, 45% of the women completed all eight cycles of Xeloda. About 30% of the women had to take a lower dose of Xeloda because of side effects and 22.5% of the women stopped taking Xeloda because of side effects. The most common side effects in the study were:
Does Xeloda improve survival?
Xeloda also improved overall survival: 83.9% of the women who didn’t get chemotherapy were alive. When the researchers grouped the women by age, hormone-receptor-status, cancer grade, or type of neoadjuvant chemotherapy, they found that Xeloda still improved survival.
How long after breast cancer surgery can you take Xeloda?
Taking a low dose of the chemotherapy medicine Xeloda (chemical name: capecitabine) for one year after surgery to remove early-stage triple-negative breast cancer and standard post-surgery chemotherapy seems to reduce the risk ...
How long does Xeloda last after surgery?
Taking a low dose of the chemotherapy medicine Xeloda (chemical name: capecitabine) for one year after surgery to remove early-stage triple-negative breast cancer and standard post-surgery chemotherapy seems to reduce the risk of the cancer coming back (recurrence), according to a study. The research is part of the virtual program for ...
What is Xeloda used for?
About Xeloda. Xeloda is an antimetabolite chemotherapy . It kills cancer cells by acting as false building blocks in a cancer cell’s genes, causing the cancer cell to die as it gets ready to divide. Xeloda is a pill taken by mouth.
How many people took Xeloda?
221 people took a low-dose of Xeloda twice per day for 1 year. 213 people were monitored for any cancer recurrence. The researchers looked to see which group had better disease-free survival rates and also looked at overall survival rates. Disease-free survival is how long people live without the cancer coming back.
What are the side effects of Xeloda?
The most common side effects caused by Xeloda were: hand-foot syndrome. low white blood cell counts. liver problems. stomach pain.
Does Xeloda reduce the risk of cancer recurrence?
This difference in overall survival was not statistically significant, which means that it could have been due to chance. So a year of low-dose Xeloda reduced the risk of recurrence, but offered only slightly better overall survival.