Medication
What Are the Treatments for Hemophilia?
- Monitoring. ...
- Acquiring a blood-borne disease: In the past, people receiving clotting factor from donated blood ran the risk of contracting a blood-borne disease.
- Changes to the immune system: Your immune system may begin to recognize the administered clotting factor as foreign and then destroy it.
Therapy
There is no cure for haemophilia A, but there are treatments to control the bleeding and decrease pain when it does occur. These include: -Take medications that help stop bleeding by increasing the number of platelets in your body.
Self-care
What are the types and levels of hemophilia?
- Mild: You have some clotting factor activity in your blood. You may only have severe bleeding after surgery or a severe injury.
- Moderate: You have a low level of clotting factor activity in your blood. You may have bleeding episodes that occur suddenly. ...
- Severe: You have very little clotting factor in your blood. ...
Nutrition
Treatment - Haemophilia
- Preventative treatment. Most cases of haemophilia are severe and need preventative treatment. ...
- On-demand treatment. In mild or moderate cases, treatment for haemophilia may only be necessary as an immediate response to bleeding.
- Complications of haemophilia. ...
How do you cure hemophilia?
Are there any cures for hemophilia?
What drugs are used for hemophilia?
What are the treatment options for hemophilia?
What is a recombinant clotting factor?
Similar products, called recombinant clotting factors, are manufactured in a laboratory and aren't made from human blood. Other therapies may include: Desmopressin. In some forms of mild hemophilia, this hormone can stimulate your body to release more clotting factor.
How to stop bleeding under the skin?
For small areas of bleeding beneath the skin, use an ice pack. Ice pops can be used to slow down minor bleeding in the mouth. Vaccinations. Although blood products are screened, it's still possible for people who rely on them to contract diseases.
How to help a child with hemophilia?
To help you and your child cope with hemophilia: Get a medical alert bracelet. This bracelet lets medical personnel know that you or your child has hemophilia, and the type of clotting factor that's best in case of an emergency. Talk with a counselor.
What is the best way to prevent clots from breaking down?
It can be injected slowly into a vein or provided as a nasal spray. Clot-preserving medications. These medications help prevent clots from breaking down. Fibrin sealants. These medications can be applied directly to wound sites to promote clotting and healing. Fibrin sealants are especially useful in dental therapy.
How to prevent hemophilia?
Lifestyle and home remedies. To avoid excessive bleeding and protect your joints: Exercise regularly. Activities such as swimming, bicycle riding and walking can build up muscles while protecting joints. Contact sports — such as football, hockey or wrestling — are not safe for people with hemophilia.
How to treat internal bleeding?
If internal bleeding has caused severe damage, you may need surgery. First aid for minor cuts. Using pressure and a bandage will generally take care of the bleeding. For small areas of bleeding beneath the skin, use an ice pack.
How to prevent tooth extractions?
Practice good dental hygiene. The goal is to prevent tooth extraction, which can lead to excessive bleeding. Protect your child from injuries that could cause bleeding. Kneepads, elbow pads, helmets and safety belts all may help prevent injuries from falls and other accidents.
Why does hemophilia occur?
The disorder occurs because certain blood clotting factors are missing or do not work properly. Because a clot does not form, extensive bleeding can be caused from a cut or wound.
How is hemophilia managed?
In most cases a child with severe hemophilia is managed at home by his parents, with the administration of factor on a prophylactic schedule. As the child gets older, he is taught how to self-administer his factor on schedule or when an acute bleed occurs.
How many people have hemophilia A?
Hemophilia A affects 1 in 5,000 to 10,000 males. Hemophilia B is less common, affecting 1 in 25,000 to 30,000 males. Around 60% to 70% of people with hemophilia A have the severe form of the disorder and about 15% have the moderate form. The rest have mild hemophilia.
What causes hemophilia in a daughter?
In about 20% of all cases of hemophilia, the disorder is caused by a spontaneous gene mutation. In such cases there is no family history of abnormal bleeding.
What is the chance that any of her sons will inherit the gene and be born with hemophilia?
There is a 50% chance that any of her sons will inherit the gene and will be born with hemophilia. There is also a 50% chance that any of her daughters will be carriers of the gene without having hemophilia themselves.
What is the cause of hemophilia?
Hemophilia is caused by mutations in either the factor VIII or factor IX genes on the X chromosome. If a woman carries the abnormal gene on one of her X chromosomes (females have a pair of X chromosomes), she will not have hemophilia herself, but she will be a carrier of the disorder.
What is the most common type of hemophilia?
There are two main types of inherited hemophilia: Type A , the most common type, is caused by a deficiency of factor VIII, one of the proteins that helps blood to form clots. This type is known as classic hemophilia. Type B hemophilia is caused by a deficiency of factor IX. This type is also called Christmas disease.
How to treat bleeding disorders?
Treatment Options for Bleeding Disorders 1 Standard half-life therapies: Standard half-life therapies are used to treat hemophilia A and B, some types of von Willebrand disease, and some rare factor disorders. Dosing can be anywhere from three times a week to every day, depending on the person. 2 Extended half-life (EHL) therapies: EHL contains a molecule that has been modified in some way to delay the breaking down of factor in the body. This results in higher levels of factor in the body lasting for longer, resulting in less frequent infusions. How long the factor is effective in the body depends on the person. Extended half-life therapies are mostly used to treat hemophilia A and B. 3 Bypassing agents are used to treat bleeds in people with hemophilia with inhibitors. These treatments contain other factors that can stimulate the formation of a clot and stop bleeding.
What is extended half life therapy?
Extended half-life therapies are mostly used to treat hemophilia A and B. Bypassing agents are used to treat bleeds in people with hemophilia with inhibitors. These treatments contain other factors that can stimulate the formation of a clot and stop bleeding.
What is non factor replacement therapy?
Non-factor replacement therapies include: Emicizumab (Hemlibra) is a therapy used to treat hemophilia A, to prevent bleeding episodes in people both with and without inhibitors. It is known as a factor VIII (8) mimetic because it mimics, or imitates, the way factor VIII (8) works.
What is EHL therapy?
Extended half-life (EHL) therapies: EHL contains a molecule that has been modified in some way to delay the breaking down of factor in the body. This results in higher levels of factor in the body lasting for longer, resulting in less frequent infusions. How long the factor is effective in the body depends on the person.
Can you take clotting factor before dental surgery?
It is often recommended before dental procedures, and to treat nose and mouth bleeds. It is taken orally, as a tablet or liquid. MASAC recommends that a dose of clotting factor be taken first to form a clot, then aminocaproic acid, to preserve the clot and keep it from being broken down prematurely.
Is emicizumab a vasopressin?
Emicizumab was approved by the FDA to treat people with hemophilia A with inhibitors in 2017 and for people with hemophilia A without inhibitors in 2018. Read MASAC's recommendation on emicizumab. Desmopressin (DDAVP) is the synthetic version of vasopressin, a natural antidiuretic hormone that helps stop bleeding.
What is a factor replacement?
Factor replacement therapies: Often referred to as “factor,” these products use a molecule that is either similar to natural factor found in humans (recombinant) or use an actual human molecule (plasma derived.)
What is Adynovate used for?
Adynovate is used to replace clotting factor VIII to help prevent and control bleeding in adults and children with hemophilia A.
What is emicizumab KXWH?
Emicizumab -kxwh (HEMLIBRA) is a medicine that can help prevent or reduce the frequency of bleeding episodes in adults and children with hemophilia A. It works by bridging the gap in the clotting factors left by the missing factor VIII. This medication is given as a weekly, under-the-skin (subcutaneous) injection.
What is the plug in the blood called?
Normally, when bleeding begins, a complex series of chemical events produces a "plug" to stop the bleeding; this plug is called a fibrin clot. The fibrin clot is the end-product of many different "clotting factors" reacting in the blood. Hemophilia is an inherited condition in which one of these clotting factors (mainly factor VIII or IX) ...
What is factor VIII used for?
Factor VIII replacement is used to treat hemophilia A and Factor IX is used in the treatment of hemophilia B. The clotting factor is given intravenously (through a needle in your vein) to stop or prevent bleeding. Factor preparations come from two sources: Donated blood plasma. Synthetic (DNA-derived)
What is the purpose of a lab test for hemophilia?
These tests help doctors diagnose the type of hemophilia and its severity.
How to give DDAVP?
DDAVP can be given intravenously, through an injection, or in the form of nasal spray. Antifibrinolytic medicines such as tranexamic acid and aminocaproic acid are oral medicines that are sometimes used with replacement therapy in certain situations to help keep blood clots from breaking down.
How to treat a bleed in a joint?
For bleeding joints, you must get treatment with clotting factor to avoid joint damage. Your doctor may also recommend resting and icing the affected joint to decrease pain and swelling. As pain and swelling subsides, physical therapy may help you recover joint mobility and strength.
What is a HIRS study?
Center for Disease Control and Prevention (CDC) website, including results of the CDC’s 6-year, Hemophilia Inhibitor Research Study (HIRS), which tested the feasibility of conducting national monitoring for inhibitors amongst people with hemophilia in the United States.
What is the CDC's Flickr album?
CDC’s National Center on Birth Defects and Developmental Disabilities (NCBDDD) hosts a Flickr Album featuring the stories of people with hemophilia who have also experienced the added challenge of an inhibitor. This Flickr Album provides powerful, personal testimonials on what it’s like to live with hemophilia and an inhibitor. It is aimed at raising awareness of this serious bleeding disorder complication, the need for continued inhibitor research, and the importance of routine inhibitor screening.
What is plasma derived product?
A plasma-derived product is a factor concentrate made from carefully-screened, donated blood plasma. During the manufacturing process, the proteins extracted from the plasma go through a series of extensive sterilization procedures to eliminate viruses and other contaminants.
What is a broviac catheter?
BROVIAC® catheters and HICKMAN® catheters (often referred to as “broviacs”) are similar to a PICC line. However, A BROVIAC® catheter is placed directly into a central vein and threaded to a position just above the heart. It is tunneled under the skin and brought out away from the site where it enters the vein to theoretically prevent bacteria from gaining access to the central portion of the catheter. BROVIAC® catheters contain a “cuff” that is under the skin. As the skin grows into this “cuff,” the catheter becomes more stable, reducing the chance of it becoming pulled out. Like the PICC line, his device is easy to use and does not require sticks into the person’s skin. The difference is that these catheters can last for a prolonged period of time. The most common long-term complications of this type of central line are infection, movement that takes the catheter out of the proper position, and damage to the catheter.
What is port in medical terms?
A port is a device that is surgically implanted under the skin. It has tubing that is inserted into a central vein. In most cases, it is placed on the chest. Below are some considerations regarding this type of access:
How long do PIC lines last?
This device is easy to use and does not require a stick through the skin. A sterile dressing is applied over the site where the PICC comes out of the skin, and that dressing must be kept clean and drive. It is generally changed weekly. However, PICC lines only last a few weeks or months.
What is a butterfly needle used for?
Peripheral venous access, where a butterfly needle is inserted directly into a vein and is used to infuse FVIII into the bloodstream, is commonly used by those who infuse at home but do not have a venous access device , such as a port, PICC line, or BROVIAC®. Below are some considerations regarding this type of access:
Why are blood products safer for people with hemophilia?
Blood products became safer after the mid-1980s due to screening of donated blood for hepatitis and HIV. Adverse reaction to clotting factor treatment.
What are the symptoms of hemophilia?
Signs or symptoms of bleeding into the brain. An injury in which the bleeding won't stop. Swollen joints that are hot to the touch and painful to bend. If you have a family history of hemophilia, you may want to undergo genetic testing to see if you're a carrier of the disease before you start a family.
What happens when the immune system is affected by hemophilia?
When this happens, the immune system develops proteins (known as inhibitors) that inactivate the clotting factors, making treatment less effective. By Mayo Clinic Staff. Hemophilia care at Mayo Clinic.
What is acquired hemophilia?
Acquired hemophilia is a rare variety of the condition that occurs when a person's immune system attacks clotting factors in the blood. It can be associated with:
How does hemophilia happen in boys?
This means that hemophilia almost always occurs in boys and is passed from mother to son through one of the mother's genes. Most women with the defective gene are simply carriers and experience no signs or symptoms of hemophilia.
Where is the faulty gene located in hemophilia?
Hemophilia inheritance. In the most common types of hemophilia, the faulty gene is located on the X chromosome. Everyone has two sex chromosomes, one from each parent. A female inherits an X chromosome from her mother and an X chromosome from her father.
Is hemophilia inherited?
Hemophilia occurs when you have a deficiency in one of these clotting factors. There are several types of hemophilia, and most forms are inherited. However, about 30% of people with hemophilia have no family history of the disorder. In these people, an unexpected change occurs in one of the genes associated with hemophilia.
Diagnosis
Treatment
Clinical Trials
Lifestyle and Home Remedies
Specialist to consult
Coping and Support
Preparing For Your Appointment
- The main treatment for severe hemophilia involves replacing the clotting factor you need through a tube in a vein. This replacement therapy can be given to treat a bleeding episode in progress. It can also be given on a regular schedule at home to help prevent bleeding episodes. Some people receive continuous replacement therapy. Replacement clotti...