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What is the best medicine for morphea?
The prognosis for morphea is good when proper treatment is taken. There is no absolute cure for the Morphea. The symptoms of Morphea subside on its own within 3 to 5 years of time. The treatment of Morphea includes only symptom management and itch control.
What is the prognosis for morphea?
These include:
- Fatigue, lethargy
- Non-specific joint pain and/or inflammation ( arthralgia, arthritis)
- Muscle pain
- Reflux/heartburn
- Raynaud phenomenon (cold hands with red/white/blue colour changes)
- Eye dryness, irritation or blurred vision due to ocular involvement (most commonly episcleritis, anterior uveitis, keratitis) – related or unrelated to the site of morphoea
How to treat localized morphea?
Phototherapy
- UVA1 penetrates most deeply and is hence useful when deeper subcutaneous tissues are involved, but is rarely available.
- Topical or systemic photochemotherapy (PUVA, ie, psoralen + UVA) may be helpful.
- Narrowband UVB is less effective, as it only penetrates superficially.
How is morphea treated?
How do you treat linear morphea?
TreatmentMedicated creams. Your doctor may prescribe a vitamin D cream, such as calcipotriene, to help soften the skin patches. ... Light therapy. For severe or widespread morphea, treatment may include the use of ultraviolet light (phototherapy).Oral medications. ... Physical therapy.
Does linear morphea go away?
Although morphea eventually goes away on its own over time, treatment usually is recommended to decrease symptoms. Treatment works best when the condition is in its early stages, so the sooner a lesion is treated, the better.
How do you get rid of morphea naturally?
5 Ways to Relieve Morphea ItchMoisturize your skin. The main morphea symptoms are tight, hard, and dry discolored patches on the skin. ... Get out in the sun. Another inexpensive morphea treatment includes getting more sunlight. ... Try phototherapy. ... Use a medicated cream. ... Avoid itchy situations.
How is linear scleroderma treated?
Treatment may include: Medication — Your child's medical team may recommend medications such as nonsteroidal, anti-inflammatory medications (NSAIDs) or corticosteroids to relieve pain; penicillamine to slow the thickening process and delay damage to internal organs; or immunosuppressive medications.
What causes linear morphea?
The cause of morphea is unknown. It may be caused by an unusual reaction of your immune system. In people at increased risk of morphea, it could be triggered by injury to the affected area, medications, chemical toxins, an infection or radiation therapy. The condition isn't contagious.
What is the difference between morphea and linear scleroderma?
The distinction between morphea and linear morphea is that morphea does not involve the underlying structures of the skin. The treatment of localized scleroderma remains unsatisfactory. Fortunately it is generally self-limiting and if it is an easily hidden area may require no treatment at all.
What foods are good for morphea?
Low FODMAP food guide:FODMAP CategoryFoods to chooseMonosaccharides: containing excess Fructoseblueberry, blackberry, boysenberry, cranberry, raspberry, strawberry, loganberry kumquat, grapefruit, lemon, lime, mandarin, orange, tangelo ripe banana, jackfruit, kiwi fruit, passion fruit, pineapple, rhubarbPolyolsNone2 more rows
Is sunlight good for morphea?
Sun exposure may be helpful for morphea lesions, but do not over do it. Ten to 15 minutes of exposure to midday sunlight two to three times per week may improve the morphea lesions.
What medications can cause morphea?
Agents that may cause drug-induced scleroderma-like skin lesion....Introduction.AgentsClinical characteristicsReferences1. ChemotherapeuticsPemetrexedScleroderma-like lesion, morphea-like plaques28, 29, 30, 31Uracil-tegafurScleroderma-like lesion462. Immune checkpoint inhibitors25 more rows
Does steroid cream help morphea?
Systemic corticosteroids can be helpful in the inflammatory phases of morphea, but they have little benefit for established sclerosis and are not recommended for long-term monotherapy given their risk of adverse effects and tendency for relapse with discontinuation.
Is linear scleroderma fatal?
In general, patients with limited scleroderma have a normal life expectancy. Some have problems with their GI tract, especially heartburn; severe Raynaud's and musculoskeletal pain; and a small subset can develop pulmonary hypertension that can be life-threatening.
How common is linear scleroderma?
Linear scleroderma is often observed in children and adolescents, and is the most frequent form of scleroderma in childhood, affecting 40-70% of the children studied. Approximately 67% of patients with linear scleroderma are diagnosed before age 18 years.
How to treat morphea?
There is no cure for morphea. Type of treatment depends on the type of morphea and how severe it is. Current treatment is aimed at controlling symptoms until the morphea goes away on its own, typically within five years. For more limited morphea , treatment is considered optional and may include: 1 phototherapy (light therapy using artificial ultraviolet light) 2 a vitamin D cream called calcipotriene (Dovonex)
What doctor treats morphea?
How is morphea diagnosed? If you have unexplained hard or discolored patches of skin, your doctor may refer you to a dermatologist (a doctor who specializes in skin problems) or a rheumatologist (a doctor who specializes in diseases of the joints, bones, and muscles).
What is morphea on the face?
What is morphea? Morphea is a skin condition that involves a patch or patches of discolored or hardened skin on the face, neck, hands, torso, or feet. The condition is rare and thought to affect less than 3 out of 100,000 people.
How long does morphea last?
Most cases of morphea slowly go away on their own over time and don’t alter a person’s life expectancy. On average, a lesion lasts three to five years, but discoloration might persist for a few more years. Occasionally, people will develop new lesions later on.
Why does my skin have morphea?
The exact cause of morphea isn’t yet known. It’s thought to be an immune disorder , meaning that the immune system is attacking the skin. The collagen-producing cells might become overactive and overproduce collagen. Collagen is a protein normally found in skin that helps provide structural support.
How long does it take for morphea to go away?
Current treatment is aimed at controlling symptoms until the morphea goes away on its own, typically within five years. For more limited morphea , treatment is considered optional and may include:
What is the color of morphea?
The outer edge of the lesion may be lilac, and the patch itself is usually reddish in color. It gradually becomes white or yellow in color toward the center of the oval. The exact symptoms and the severity of those symptoms depends on the type of morphea:
How long does it take for morphea to respond to hydroxychloroquine?
However, in 2019, a retrospective study of 84 adults with morphea treated with at least 6 months of hydroxychloroquine showed 43% of patients had a complete response, with only 7.1% having no response. [ 78]
What is UVA based phototherapy?
UVA-based phototherapy modalities (broadband UVA, UVA1, PUVA—both oral and bath) have all been shown to improve morphea lesions in multiple case series and a randomized controlled trial.
How long does MTX last?
[ 66, 67, 68, 69, 70] To minimize the risk of relapse, the recommended treatment duration of MTX is at least 2 years. [ 71]
Is calcipotriene good for nightly occlusion?
Topical calcipotriene may also be beneficial, especially when nightly occlusion (eg, with plastic wrap) is used to increase penetration of the medication. [ 59] . The combination of topical calcipotriol with betamethasone dipropionate has also been reported effective. [ 60]
Is reducing inflammation in early disease more successful than sclerosis?
[ 55] In general, therapy aimed at reducing inflammatory activity in early disease is more successful than attempts to decrease sclerosis in well-established lesions. [ 56]
Is UVA1 more effective than UVB?
In a randomized trial comparing the efficacy of different forms of phototherapy for morphea, medium dose UVA1 (50 J/cm 2) was found to be significantly more effective than narrowband UVB.
What is linear morphea?
Scleroderma is characterized by the appearance of circumscribed or diffuse, hard, smooth, ivory-colored areas that are immobile and give the appearance of hidebound skin ( Andrews’ Diseases of the Skin ). There are many forms, which Linear Morphea is one…which often develops in children, usually in the first decade of life. In the inflammatory phase the lesions may appear pink, purple or bruise-like. Once sclerosis sets in the skin becomes hard, thickened, bound down, shiny, ivory white and may have a purple border of surrounding inflammation.
When does linear morphhea develop?
There are many forms, which Linear Morphea is one…which often develops in children, usually in the first decade of life. In the inflammatory phase the lesions may appear pink, purple or bruise-like. Once sclerosis sets in the skin becomes hard, thickened, bound down, shiny, ivory white and may have a purple border of surrounding inflammation.
What is morphea in the body?
Morphea is a rare fibrosing disorder of the skin that may also involve the underlying muscle, connective tissue, bone and brain. The pathogenesis of morphea is incompletely understood, but results in an increase of collagen production and decrease in collagen destruction. Morphea typically goes through two stages: an active (inflammatory) ...
Is morphea a life threatening disease?
It is important for patients to enter into therapy knowing that morphea is not life-threatening and does not progress to systemic sclerosis. Patients with linear morphea are at risk for facial deformity, limb length discrepancy and contractures. Patients need to balance the risks of systemic therapy with the risk of untreated disease. Patients with plaque morphea and superficial generalized variants will generally be left with hyperpigmentation as the only sign of prior disease. Patient′s expectations should also be managed. Patients need to recognize that the involved skin will never look completely normal. They must be counseled that treatment is aimed at active disease in the hopes of preventing enlargement of already-present lesions and the development of new lesions. Burnt-out disease is unlikely to improve with immunosuppression and, therefore, the risks of these medications are not warranted in burnt-out disease.
Why is morphea important?
Since, morphea has a potential to run a severe course, especially in linear and pansclerotic types, it is important to initiate a suitable treatment promptly to avoid morbidity and deformity of the joints causing permanent disability.
What is morphea in clinical terms?
The clinical presentation of morphea or localized scleroderma is diverse depending on the subdivision of the disease, localization of the condition and the depth of involvement. Broadly it can be classified as circumscribed, linear, generalized, pansclerotic and mixed. The disease process includes the involvement of the skin in circumscribed subtype localized to one to three lesions, while in generalized subtype spread over a wider area of the skin, linear subtype involves a linear streak in the skin or involving the deeper tissue and sometimes bone too. Pansclerotic subtype involves the skin, fascia, muscles and bone too. Mixed lesions include one or more subtype occurring in an individual at the same time. Since, morphea has a potential to run a severe course, especially in linear and pansclerotic types, it is important to initiate a suitable treatment promptly to avoid morbidity and deformity of the joints causing permanent disability.
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