Treatment FAQ

what is the best treatment for infantile spasms?

by Francis Weber Published 2 years ago Updated 2 years ago
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How do you stop infantile spasms?

Infantile spasms usually are treated with seizure medicines or steroids. If medicines don't control the spasms, a special diet, such as the ketogenic diet, might help. Sometimes, doctors may recommend surgery.

Can infantile spasm be cured?

Many children with infantile spasms develop other kinds of epilepsy. (Watch examples of infantile spasms.) “Some of these children can be cured, but successful treatment often depends on prompt diagnosis,” said Hussain.Dec 4, 2016

What is the first line treatment for infantile spasms?

Treatment of infantile spasms has little class I data, but adrenocorticotropic hormone (ACTH), prednisolone and vigabatrin have the best evidence as first-line medications. Other therapies including the ketogenic diet and other anti-epileptics medications may also prove useful in the treatment of infantile spasms.Aug 28, 2015

What can trigger infantile spasms?

What causes infantile spasms?Brain injuries or infections: Almost any type of brain injury can cause infantile spasms. ... Issues with brain development: Several central nervous system (brain and spinal cord) malformations that occur while your baby is developing in the womb can cause infantile spasms.More items...•Mar 9, 2022

Do infantile spasms cause brain damage?

Infantile spasms is a complex and rare disorder that can have very serious consequences. It can lead to death in some babies, and cause intellectual disabilities and developmental problems in others. Even once the seizures are gone, the damaging brain effects can remain.

Can babies grow out of infantile spasms?

Infantile spasms usually stop by age five, but may be replaced by other seizure types. Many underlying disorders, such as birth injury, metabolic disorders, and genetic disorders can give rise to IS, making it important to identify the underlying cause. In some children, no cause can be found.May 6, 2019

Can infantile spasms come back?

The spasms will have disappeared by the age of 14 months in about three quarters of infants with this disorder. After this age the spasms can still come back but this is not common. infantile spasms can continue through to school age if they do not respond to treatment but eventually they do stop on their own.Feb 15, 2006

Why is ACTH used in infantile spasms?

ACTH stimulates part of the brain to release other hormones. In infantile spasms, the ACTH is injected into a muscle with an IV needle. Moderate evidence shows short-term use of ACTH may help treat infantile spasms. Moderate evidence shows that a low dose of ACTH can be as effective as higher doses.

Do babies with infantile spasms sleep more?

It is common for babies who have infantile spasms to become irritable and to go off their feeds. Their sleep pattern also changes in that they may sleep more during the day and less during the night.

Can a baby with infantile spasms live a normal life?

An etiologic diagnosis is very important because it can lead to initiation of a specific therapy that may markedly improve the long-term developmental outcome. In fact, some children with infantile spasms may ultimately lead normal lives, but only if they are diagnosed and treated correctly.

Are infantile spasms painful?

They may have many series of spasms per day. This type of seizure is usually only seen in young children. After a spasm, the baby may cry or laugh. The spasms do not cause pain, but the baby may cry because the quick jerking movement surprises them.Nov 19, 2013

What is the best treatment for infantile spasms?

Treatments that should be tried first before other therapies for children with infantile spasms include. Steroid therapy with either prednisone/predni solone or adrenocorticotropic hormone (AC TH) ACTH is given by injection into a muscle and prednisone or prednisolone is given by mouth to swallow.

Who first described infantile spasms?

The first description of infantile spasms was by English physician Dr. W. J. West, more than 170 years ago. His description is as accurate today as it was then and is very poignant since he was describing his son.

Can a baby have a spasm?

Metabolic causes can also lead to changes in brain function and can cause spasms. Other babies have had no apparent injury and have been developing normally. There is no evidence that family history, the baby's sex, or factors such as immunizations are related to infantile spasms.

What is the ISAN?

Infantile Spasms Action Network (ISAN), convened by the Child Neurology Foundation (CNF), is a collaborative network of 26 national and international entities focused on raising awareness for infantile spasms. Find videos and more information at infantilespasms.org.

Does Vigabatrin cause vision loss?

Vigabatrin is a particularly effective option for children whose spasms are due to tuberous sclerosis complex. Vigabatrin has rarely been associated with permanent loss of peripheral vision, but this side effect is of more concern when the drug is used for many months.

Is ketogenic diet safe for infantile spasms?

EEGs are less likely to have a typical hypsarrhythmia pattern and may show more focal discharges. The ketogenic diet has been reported to be safe, well tolerated and possibly effective for treating children with infantile spasms who do not respond to AC TH or steroid and vigabatrin.

Can infantile spasms cause autism?

Some children with infantile spasms develop autism. Treating seizures early and appropriately is critical to maximizing the child’s developmental potential. Even if the infantile spasms stop, most children later develop other kinds of epilepsy, including Lennox-Gastaut syndrome and focal or multifocal epilepsy.

What is the goal of infantile spasms?

The goals of treatment for infants with infantile spasms are the best quality of life (with no seizures), the fewest adverse effects from treatment, and the lowest number of medications.

Can a ketogenic diet help with seizures?

In some patients, resection of a localized region can lead to freedom from seizures. The ketogenic diet has been used successfully to treat a variety of seizure types. Studies have shown that it can be considered for the medical management of infantile spasms.

How do you know if your baby has spasms?

Soon after the spasms begin, parents may notice a number of changes in their baby: 1 Loss of developmental milestones​ previously learned (e.g., rolling over, sitting, crawling, babbling)​​ 2 Loss of social interactions and smiles 3 Increased fussiness or silence

Why is watching a baby's movements important?

​​​​​​​​Watching your baby's every movement typically brings parents so much joy. But when a baby shows signs and symptoms of a serious neurological condition such as infantile spasms (IS), that joy can quickly turn into concern.

What is infantile spasm?

Infantile spasms are little seizures with big consequences. Early recognition leads to better outcomes; waiting to seek treatment can increase your baby's risk of permanent brain injury.

Who is Kelly Cervantes' daughter?

Above, epilepsy advocate Kelly Cervantes with daughter Adelaide , son Jacks​​on and husband Miguel Cervantes. Adelaide was diagnosed with infantile spasms when their family moved to Chicago where Miguel starred in "Hamilton: An American Musical.".

What is the best treatment for infantile spasms?

The American Academy of Neurology and the Child Neurology Society recommend adrenocorticotropic hormone (ACTH) as the first line of therapy for infantile spasms. This medication is given as a shot. The first doses are given in the hospital so your child can be closely watched for any side effects.

Can a baby have a spasm?

If you can, try to video any episodes of your baby having a spasm and show this to your child's doctors. You may be told to go to the emergency room so a pediatric neurologist can examine your child. Your child may have to be admitted to the hospital to have a test called video-electroencephalogram (EEG) monitoring.

Why do babies have spasms?

a birth injury. brain infection. a problem with brain development while a baby is still in the womb. While doctors don’t fully understand the reason for the connection, these things can cause chaotic brain wave activity resulting in the frequent spasms.

What are the symptoms of infantile spasms?

According to the American Epilepsy Society, they more commonly involve a series of sudden, jerking movements of the legs and arms, with a bending at the waist or a fast drop of the head.

How many babies have epilepsy?

Infantile spasms can be described as short and sometimes subtle seizures that occur in babies. These seizures are actually a rare form of epilepsy. Only about 2,500 babies each year will be diagnosed with the disease in the United States. These seizures or spasms generally occur before a child is 1 year old, with most cases occurring ...

When do seizures occur in children?

These seizures or spasms generally occur before a child is 1 year old, with most cases occurring when babies are about four months old. According to a review article published in the Iranian Journal of Child Neurology, only 8 percent. Trusted Source. of cases are diagnosed in babies over a year old.

Do infantile spasms cause mental problems?

Babies with infantile spasms frequently have mental and developmental problems. In research published in the Annals of Indian Academy Neurology#N#Trusted Source#N#, at three years after diagnosis, roughly 88 percent of the children studied had problems in some or all of the following:

What is the best medicine for infantile spasms?

Treatment for infantile spasms. One of the major drugs used to treat infantile spasms is adrenocorticotropic hormone (ACTH). ACTH is a hormone that is naturally produced in the body. It’s injected into a child’s muscles and has been shown to be very effective in stopping spasms.

How long does a brain wave test last?

A doctor, usually a pediatric neurologist, will watch the brain wave activity during and in between spasms. These tests usually last from one to several hours, and may be done in a doctor’s office, lab, or hospital. They may also need to be repeated after several days. Most children with infantile spasms will have disorganized brain wave activity.

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