Precautions
Why is Synagis given?
SYNAGIS gives babies who are born prematurely (at or before 35 weeks, and who are 6 months of age or less at the beginning of RSV season) the infection-fighting antibodies they lack, helping protect their vulnerable lungs from RSV.
What are the side effects of Synagis?
Common side effects of Synagis include:diarrhea,vomiting,fever,cough,earache,runny or stuffy nose,sneezing,other cold symptoms,More items...
What months do you give Synagis?
Synagis is given once a month during the RSV season, which is usually November through April but may be different where you live. To best help prevent RSV infection, your child's first injection should be given before RSV season begins.
How long do you give Synagis?
SYNAGIS is needed every 28-30 days during the RSV season. Each injection of SYNAGIS helps protect your child from severe RSV disease for about 1 month.
Is Synagis vaccine safe?
Synagis (palivizumab) has been used safely in many children. There have been cases of serious allergic reactions in children receiving injections. If this occurs, the clinic staff will provide supportive care for your child and the child should not receive any more doses of Synagis (palivizumab).
How much does Synagis cost?
under the brand name Synagis, can cost up to $6,000 for five treatments, given to at-risk children in monthly intramuscular injections during RSV season. The company is pushing for wider use, but researchers are divided over its benefits and over when and to whom it should be administered.
How effective is Synagis?
Palivizumab is an RSV-specific monoclonal antibody licensed for the prevention of serious lower respiratory tract infection (LRTI) caused by RSV in high-risk children. Several prospective clinical trials have demonstrated an efficacy of 45%–82% against RSV-related hospitalizations in high-risk infants.
What kind of drug is Synagis?
Synagis is a prescription medicine used as a prophylaxis for Respiratory Syncytial Virus (RSV) in children. Synagis may be used alone or with other medications. Synagis belongs to a class of drugs called RSV Agents.
Where do you give a Synagis injection?
Synagis should be administered in a dose of 15 mg per kg intramuscularly using aseptic technique, preferably in the anterolateral aspect of the thigh. The gluteal muscle should not be used routinely as an injection site because of the risk of damage to the sciatic nerve.
How many Synagis are in a season?
For patients undergoing cardiopulmonary bypass, administer a dose of SYNAGIS as soon as possible after the procedure, even if sooner than a month from the previous dose. Thereafter, doses should be administered every 28 to 30 days throughout the RSV season.
How many doses of Synagis are given?
The recommended dose of SYNAGIS® (palivizumab) is 15 mg/kg of body weight given monthly by IM injection. The first dose of SYNAGIS should be administered prior to commencement of the RSV season and the remaining doses should be administered monthly throughout the RSV season.
How is Synagis administered?
Synagis® (palivizumab) should be administered in a dose of 15 mg/kg intramuscularly using aseptic technique, preferably in the anterolateral aspect of the thigh. The gluteal muscle should not be used routinely as an injection site because of the risk of damage to the sciatic nerve.
Is Synagis (palivizumab) a live vaccine?
Synagis (palivizumab) is not any type of vaccine, but is a monoclonal antibody which is a different medication class. Vaccines usually inject a sma...
What is Synagis (palivizumab) used to treat?
Synagis (palivizumab) is not currently used to treat anything. The once-a-month injection is used to prevent serious infections caused by RSV in yo...
Who gets Synagis (palivizumab)?
Synagis (palivizumab) is typically used for children aged 2 and younger who are at a high risk of having a serious infection caused by RSV. High ri...
Is Synagis (palivizumab) safe?
Synagis (palivizumab) has been used safely in many children. There have been cases of serious allergic reactions in children receiving injections....
How many doses of Synagis (palivizumab) are given?
Synagis (palivizumab) should be given every month for the duration of the RSV season, which can vary based on where you live. If your child is 24 m...
Indications and Usage For Synagis
Palivizumab is used in certain infants and young children to prevent serious lung infections (such as pneumonia) that are caused by a certain virus (respiratory syncytial virus-RSV).
May Treat: Respiratory syncytial virus pneumonia
Drug Class: Antiviral Monoclonal Antibodies - Respiratory Syncytial Virus (RSV)
Availability: Prescription Required
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
May Treat: Respiratory syncytial virus pneumonia
Drug Class: Antiviral Monoclonal Antibodies - Respiratory Syncytial Virus (RSV)
Availability: Prescription Required
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: MEDIMMUNE/SOBI- · SOBI-SWEDISH OR
- If available, read the patient package insert
- Drug is given by a nurse or a doctor.
- Usually injected into a large muscle
- If available, read the patient package insert
- Drug is given by a nurse or a doctor.
- Usually injected into a large muscle
- Get medicine monthly during RSV season.
- Do not miss any doses
- Causes pain at injection site
- Call Dr now if swelling, rash or breathing problem
- Tell doctor your complete medical history
Synagis Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
- Dosing Information
The recommended dose of Synagis is 15 mg per kg of body weight given monthly by intramuscular injection. The first dose of Synagis should be administered prior to commencement of the RSV season and the remaining doses should be administered monthly throughout the RS… - Administration Instructions
1. DO NOT DILUTE THE PRODUCT. 2. DO NOT SHAKE OR VIGOROUSLY AGITATE THE VIAL. 3. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use any vials exhibiting particulate matter or discoloration. 4. Usi…
Use in Specific Populations
- Synagis is contraindicated in children who have had a previous significant hypersensitivity reaction to Synagis [see Warnings and Precautions (5.1)].
Overdosage
- Hypersensitivity Reactions
Cases of anaphylaxis and anaphylactic shock, including fatal cases, have been reported following initial exposure or re-exposure to Synagis. Other acute hypersensitivity reactions, which may be severe, have also been reported on initial exposure or re-exposure to Synagis. Signs and sympto… - Coagulation Disorders
Synagis is for intramuscular use only. As with any intramuscular injection, Synagis should be given with caution to children with thrombocytopenia or any coagulation disorder.
Synagis Description
- The most serious adverse reactions occurring with Synagis are anaphylaxis and other acute hypersensitivity reactions [see Warnings and Precautions (5.1)].
Synagis - Clinical Pharmacology
- No formal drug-drug interaction studies were conducted. In Trial 1, the proportions of children in the placebo and Synagis groups who received routine childhood vaccines, influenza vaccine, bronchodilators, or corticosteroids were similar and no incremental increase in adverse reactions was observed among children receiving these agents.