What are SIR Spheres used for?
Y-90 MicroSpheres (SIRSpheres ) for treatment of hepatocellular carcinoma Brachytherapy Device : Y-90 SIRSpheres ® Y-90 SIRSpheres ® is a radioactive implant in the form of resin microspheres. The intended use of these microspheres is …
What are TheraSphere and SIR-Spheres used for?
Jul 19, 2007 · Detailed Description: This study is a multi-institutional, non-randomized pilot study that aims to assess the safety and toxicity of hepatic arterial radioembolization using SIR-Spheres yttrium-90 microspheres (SIR-Spheres microspheres) in the treatment of patients with unresectable primary hepatocellular carcinoma (HCC).
What does sirspheres stand for?
SIR-Spheres in the treatment of liver metastases from prostate cancer Metastasis is what makes cancer dangerous. Uncontrolled cell growth disrupts normal organ function.some organs, such as lymph node, For example, they don’t matter, and when cancer spreads to them, they have minimal impact on the overall functioning of the organism.
How are SIR-Spheres® administered?
Aug 30, 2018 · Selective Internal Radiation Therapy (SIRT) is a treatment for liver cancers or tumours that delivers millions of tiny radioactive microspheres or beads called SIR-Spheres® directly to the liver tumours. SIR-Spheres® are about one third the diameter of a strand of hair in size and they release a type of radiation energy called ‘Beta’ radiation.
How effective is SIRT treatment?
In recent studies, SIRT was most effective in minimizing the risk of tumour progression in the treated lobe and had more of an effect on total liver volume, making it a more suitable modality for selected patients with substantial unilateral disease burden.
What are SIR spheres made of?
SIR-Spheres microspheres contain resin based microspheres with an average diameter between 20 and 60 micrometre. The microspheres are impregnated with 90Y, a beta radiating isotope of yttrium with a half-life of 64.1 hours.
How many times can you have Y90 treatments?
Patients are typically limited to two treatments, although doctors can take another approach — only with concentrated chemotherapy and larger particles — once radiation limits are reached.Jan 27, 2017
What is SIRT cancer treatment?
SIRT is a way of giving radiation treatment for cancer via tiny radioactive beads (called microspheres) that are injected into the artery supplying blood to the tumour via a catheter from the femoral artery. This helps to minimise the risk of radiation damage to healthy surrounding tissues.Feb 26, 2021
What are the side effects of Sirt?
The most common side effects are:Fatigue - this is the commonest side effect. ... Mild fever - can last from a few days to a week and usually does not cause concern.Abdominal pain for a few hours after the procedure and sometimes several days. ... Nausea, usually mild and easily controlled with tablets.More items...
Are you radioactive after Y-90 treatment?
After treatment with Y-90 radioactive material, you will emit a small amount of radiation. These levels are quite low. After treatment, you have no special precautions to follow to limit exposing other people to radiation. It is safe for people to be around you.
What happens after Y-90?
The most common side effect after Y-90 radiotherapy is fatigue (feeling very tired). This can be mild or severe. It can last up to a few weeks. Other side effects include: • Poor appetite • Mild abdominal pain • Slight fever • Nausea These symptoms should slowly go away over 1 to 2 weeks.
Can radiation shrink liver tumors?
Radiation therapy can shrink or kill tumor cells. At Memorial Sloan Kettering, we may recommend this approach if you have a primary liver tumor that can't be removed with surgery. It can be used alone or in combination with chemotherapy or other treatments.
Is SIRT painful?
Tummy (abdominal) pain Some people have tummy pain during SIRT. Let your doctor or nurse know about any pain you have during or after treatment. They can give you painkillers to help with this. Rarely, some beads may escape from the liver to the stomach or bowel.
What is the latest treatment for liver cancer?
FDA has approved the immunotherapy drug atezolizumab, used with bevacizumab, to treat some patients with advanced liver cancer.Jun 4, 2020
How long does a SIRT procedure take?
The procedure usually takes 60 to 90 minutes but may take longer. First you might have some sedation to help you relax. Then you have an injection of local anaesthetic to numb the area at the top of your leg (the groin) or your wrist.
What is a Y-90 microsphere?
About SIR-Spheres microspheres. SIR-Spheres ® Y-90 resin microspheres are tiny radioactive ‘beads’ used in selective internal radiation therapy (SIRT), sometimes referred to as Y-90 radioembolization, and are used for the treatment of stage IV colon cancer that has spread to the liver and can’t be surgically removed.
How long does it take for Y-90 to go away?
SIR-Spheres Y-90 resin microspheres emit radiation to kill the tumor. The radiation decreases over time and after 2 weeks most of the radiation is gone and the microspheres harmlessly remain in the liver.
Where are microspheres injected?
The microspheres are injected by the millions directly to the liver tumors via the tumor’s main blood supply, where they become stuck in the small blood vessels that are in and around the tumors. The microspheres emit high doses of radiation to the tumor cells to destroy them.
What to do if there is a code or emergency situation?
If there is a code or emergency situation, Nuclear Medicine will wrap the box up in the chux and sheet and remove it from the table. Try to keep the number of people coming in for the code to a minimum. (If you can) During and after the code NO ONE LEAVES THE ROOM
What is Y-90 microsphere?
Y-90 SIRSpheres®is a radioactive implant in the form of resin microspheres. The intended use of these microspheres is for implant into hepatic metastases from colorectal cancer via catheter placed in the hepatic artery, distributing non- uniformly throughout the liver.
How do sir spheres work?
During the angiogram a small amount of dye (or contrast medium) is injected through a catheter (a thin plastic tube) inserted into an artery. The dye travels down the catheter into the liver and highlights the vessels.
What is the first step in SIRT?
The first procedure for SIRT is the preparation phase for the treatment commonly known as the work-up that includes a radiology procedure known as an angiogram (see Angiography ). The purpose of the angiogram or mapping is to prepare your liver for SIRT.
What is SIRT treatment?
What is SIRT? Selective Internal Radiation Therapy (SIRT) is a treatment for liver cancers or tumours that delivers millions of tiny radioactive microspheres or beads called SIR-Spheres® directly to the liver tumours. SIR-Spheres® are about one third the diameter of a strand of hair in size and they release a type of radiation energy called ‘Beta’ ...
What are the side effects of sir spheres?
You should not have any serious after effects when SIR-Spheres® are correctly administered. You may experience some of the following side-effects or you may not experience any side effects at all: 1 Pain in the abdomen that may last for a few hours: This can be well controlled with pain medication. 2 Nausea may be caused by the angiography contrast medium that is injected into the vessels or as a result of the SIR-Spheres® infusion into the liver: This is a short term effect (several days) which can be well controlled with anti nausea medication. 3 Reduced appetite: Some patients may feel a loss of appetite for several days. 4 Tiredness: This may be caused by the effect of the radiation on the liver tumours and may last several days. 5 Fever: The destruction of the liver tumours and the by products of this destruction may cause a short term fever (up to a week). This can be well controlled with paracetamol or a similar over the counter analgesic. 6 Radiation in the body: Your treating doctor will advise you on the effects of radiation and will advise that contact with other people should be minimised for at least the first week after treatment. This means that prolonged, close physical contact should be avoided, such as, sitting/sleeping next to children or pregnant women. Please feel free to discuss this with your radiologist.
Why is SIRT not recommended?
Patients who are considered at risk of this would not be recommended to undergo SIRT due to the poor liver function of the patient as a result of their liver tumours. Inadvertent delivery of SIR-Spheres® to the gall bladder may result in inflammation of the gall bladder.
What is a referring doctor?
A referring doctor is usually a specialist and can be a medical oncologist, surgeon, gastroenterologist or other specialist doctor . If your referring doctor thinks you are suitable for SIRT they will send a fax or letter to the interventional radiologist for you to be assessed for suitability to undertake SIRT.
Where is the SIRT catheter placed?
To perform SIRT, a small puncture or incision is made in the groin and a small thin tube called a catheter is placed in the artery and guided into the liver using X-ray pictures or images. SIR-Spheres® are delivered through the catheter and are then carried by the bloodstream directly to the tumours in the liver where they only lodge in ...