Treatment FAQ

what is peyronie's disease treatment

by Virgil Bruen Published 3 years ago Updated 2 years ago
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Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie's disease. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function.

Medication

Unlike the other treatments listed above, Verapamil is not a tablet or pill. Rather, it is Peyronie’s disease treatment that is applied as a topical cream, but also can be injected directly into the penis. Verapamil is a calcium inhibitor that is often used to treat hypertension. It is thought that the this medication may alter fibroblast function.

Procedures

There are three surgical approaches for the treatment of Peyronie’s Disease. Penile Plication for Peyronie's: This is the most straightforward surgical approach. Most often under a general anesthesia, the surgeon makes an incision around the crown of the penis, usually along the man’s circumcision line, if he was circumcised, and pulls down the skin to expose the fibrous coating …

Nutrition

In men with Peyronie’s disease who also have some erectile dysfunction, drugs to treat ED may help. Injections Your doctor might suggest injecting …

Are there any ways to cure Peyronies disease?

Injections are a more common Peyronie’s disease medical treatment. Providers will inject your penis with lidocaine to numb it before we inject medications. After the injection, your provider will wrap your penis in a pressure bandage to prevent swelling and bruising. You can remove the bandage three hours after your procedure.

What treatment do you recomend for Peyronies disease?

The pain of Peyronie’s disease is usually mild and often does not require treatment, but medications like ibuprofen can be used if needed. In most cases, the pain decreases over time, but the bend in the penis related to the scar can remain a problem. If the bend is bad enough, such as greater than 30 degrees, the curve can interfere with sex.

What can be done to help with Peyronie's disease?

Nov 19, 2021 · In most men with Peyronie's disease, the condition will remain as is or worsen. Early treatment soon after developing the condition may keep it from getting worse or even improve symptoms. Even if you've had the condition for some time, treatment may help improve bothersome symptoms, such as pain, curvature and penile shortening.

What does it mean to "cure" Peyronie's disease?

Aug 15, 2021 · Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie’s disease. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function. What can you take over the counter for Peyronie’s disease?

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Apr 13, 2022 · Interferon decreases the rate of plaque proliferation and the production of extracellular collagen. The first reported use of verapamil, another intralesional option for Peyronie's disease, was first described by Laurence Levine, MD, in 1994. Verapamilworks by inhibiting fibroblast proliferation of Peyronie's plaques.

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What is the most common treatment for Peyronie's disease?

Surgery. Surgery has been shown to be the most effective treatment for Peyronie's disease to correct the curvature of the penis. However, it is usually only recommended in severe cases for patients who fail to respond to non-surgical therapy and have curvature for longer than 12 months.

What causes Peyronie disease?

Peyronie's disease is likely caused by minor injury to the penis. (See penile trauma.) This type of damage is most often caused by vigorous sex (such as bending the penis during penetration or pressure from a partner's pubic bone), though it can also be caused by sports or other accidents.

What happens if Peyronie's disease is left untreated?

If left untreated, Peyronie's disease may cause fibrotic, nonexpansile thickening of relatively discrete areas of the corpora tunica, typically resulting in focal bend, pain or other functional or structural abnormalities of the erect penis. Many cases resolve without treatment.Aug 1, 1999

Can you self cure Peyronie's disease?

Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months. There is no cure for Peyronie disease. A wide variety of medicines may be tried. Most are taken by mouth, but some are injected into the plaque.

Is Peyronie's disease serious?

Although Peyronie's disease is serious, it is not fatal. Many studies point to the condition as being a contributing factor in the development of depression and anxiety in affected men.Apr 24, 2020

How much vitamin E should I take for Peyronie's?

More recently, a 2014 study reported treatment outcomes of patients with PD using 50 mg sildenafil daily or 400 IU vitamin E for 3 months. After 12 weeks, both groups showed similar reduction in plaque volume and penile curvature that was statistically significant.

How can I improve my peyronies?

Here are the steps to perform penile stretching:Clutch your penis and pull it vertically upwards. ... After the 10 seconds have passed, pull it to the right and hold for 10 seconds.After 10 seconds, pull it to the left this time.Repeat steps 1 to 3 twice every day.Dec 7, 2021

Can you take Viagra if you have Peyronie's?

Can you take Viagra if you have Peyronie's disease? In a word, yes. Phosphodiesterease inhibitors like Viagra (sildenafil) have been studied both alone and in conjunction with other therapies to treat erectile dysfunction and penile curvature from Peyronie's disease.Feb 18, 2021

Does Peyronie's disease ever go away?

Peyronie's disease rarely goes away on its own. In most men with Peyronie's disease, the condition will remain as is or worsen. Early treatment soon after developing the condition may keep it from getting worse or even improve symptoms.Nov 19, 2021

How to cure Peyronie's disease?

In many cases, the best Peyronie’s disease treatment is surgery. There are primarily two different types of surgery, with Dr. Gelman advising the patient to undergo either a penile plication ...

What is pentoxifylline used for?

Pentoxifylline is a medication that has been used for many years for the treatment of intermittent leg cramping (claudication). It has gained recent attention as a potentially effective Peyronie’s disease treatment. Trental is now at the Center for Reconstructive Urology what Vitamin E was 20 years ago at our Center.

Does Vitamin E help with peyronies?

For decades, Vitamin E has been commonly prescribed Peyronie’s disease treatment because it is inexpensive and can be an effective treatment for scarring (of the skin).

Is Verapamil a tablet?

Unlike the other treatments listed above, Verapamil is not a tablet or pill. Rather, it is Peyronie’s disease treatment that is applied as a topical cream, but also can be injected directly into the penis. Verapamil is a calcium inhibitor that is often used to treat hypertension. It is thought that the this medication may alter fibroblast function. Fibroblast cells are involved in wound healing after tissue injury. It is called “transdermal” as supposedly, the medication can travel through the skin into the plaque leading to a beneficial change. Certainly this medication is effective in increasing the income of those who promote and sell this drug. However, there is no clearly established proven efficacy for this medicaiton being a Peyronie’s Disease cure or effective treatment in the peer-reviewed published literature.

What is penis curvature?

Penile curvature is generally related to the development of a dense inelastic plaque within the penis. In order for creams, pills or other treatments to be effective, they need to change the affected tissue from a dense scar back to elastic, supple, and healthy tissue.

How does Potaba work?

This medication is composed of potassium p-aminobenzoate and is considered an antifibrotic medication, which means that Potaba is thought to prevent fibrosis (scarring) by increasing oxygen uptake at the tissue level. In order for the medication to be effective, patients are required to take large doses every day for months at a time. The recommended daily dose is 4 (0.5gram) tablets or 6 capsules, and the number of pills patients are asked to take discourages many from going with this Peyronie’s treatment. This medication was popular in the 1990s but is no longer in use.

Who makes Xiaflex?

The manufacturer was Auxillium (now owned by Endo Pharmaceuticals). Xiaflex is a medication that is injected into the plaque inside the penis. Prior to Xiaflex injection, a different medication is injected into the penis to produce an erection to identify the area of maximum curvature, and that is marked.

What is the treatment for Peyronie's disease?

Medical Management for Peyronie's Disease. Most Peyronie’s specialists initiate treatment with medical therapy, usually pills or topical creams to the penis. The history of pill therapy for Peyronie’s includes many drugs, most non-FDA approved. Many specialists prescribe pentoxyphyline, a drug initially used to improve blood flow to the legs ...

What is Xiaflex injection?

Xiaflex, collagenase, is a biological agent that a urologist injects directly into the plaque. The enzyme digests the abnormal collagen deposits in the plaque to decrease the abnormal force exerted on the penis.

Is Xiaflex an intralesional therapy?

Interferon injections have also been used with similar success. Neither of these therapies is FDA approved. However, as of 2013, Xiaflex received FDA approval as an intralesional therapy. Xiaflex, collagenase, is a biological agent that a urologist injects directly into the plaque. The enzyme digests the abnormal collagen deposits in the plaque to decrease the abnormal force exerted on the penis. Men in clinical studies had a roughly 40% improvement in their curvature and reported improvements in their distress suffered from the disease. Side effects of this therapy were usually mild and included temporary pain, bruising and swelling. A few men in the clinical trials had a penile injury severe enough to need surgical correction. All of these men regained sexual function post surgery. Dr. Mills at The Men's Clinic at UCLA is a national leader in using Xiaflex, the first drug to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of Peyronie's Disease.

What are the symptoms of Peyronie's disease?

Peyronie's Disease Symptoms. Common symptoms of PD, which are visible during an erection, include: A curve or bend in the penis, Narrowing of the penis ( also referred to as “hour-glassing”), Erectile difficulties or dysfunction, and/or. Painful erections or pain during sex.

What percentage of men have Peyronie's disease?

Approximately three and a half percent to nine percent of men have Peyronie’s disease, depending on age.*. Some men experience pain with erections, which causes problems with having sex and can result in stress and anxiety.

What is a PD?

Penile Plication. Grafting Surgery. Peyronie’s disease (PD) is a common issue that occurs in many men as they get older. The disease causes a condition that men describe as bent penis or curved penis. Experts believe Peyronie’s disease is caused by an abnormal healing process when an injury occurs in a man’s penis.

How to stretch your penis?

Using the target plaque as a bending point, bend your penis in the opposite direction of the plaque and your curve. Hold this stretch for 30 seconds, then release. Rest for 30 seconds, then repeat this exercise twice more for a total of three times.

Is a penile implant covered by Medicare?

Implants are ideal for those patients because both PD and ED are corrected at the same time. Penile implants are usually covered by insurance, including Medicare.

How long does it take for a peyronie to heal?

Peyronie’s disease has two stages: acute and chronic. Acute phase: This stage lasts between six and 12 months. During this period the scar forms under the skin of your penis, causing a curvature or other change in its shape. You may feel pain when your penis is erect or when it is soft.

What is the penile curvature?

Some men can be born with penile curvature and this is called congenital curvature or chordee. It is not caused by scar tissue, and the condition does not change over time. It might not be noticeable until after puberty when a man begins having more regular erections.

Why is sex so hard?

Sex is difficult because of the bend. Symptoms of Peyronie’s disease may develop slowly or can seem to appear overnight. The pain of Peyronie’s disease is usually mild and often does not require treatment, but medications like ibuprofen can be used if needed.

What causes a man's penis to curve?

Peyronie's Disease. Peyronie’s disease is a condition where scar tissue causes the penis to curve or lose length or girth. In some cases, it can cause pain and prevent the man from having sex. There are surgical and nonsurgical treatments that can manage it and it doesn’t cause any harm to the rest of the body.

What is the process of ejaculation?

When you’re having intercourse, the blood flowing to your penis makes it straight, stiff and hard, and able to penetrate. Semen then exits through the urethra after orgasm. This process is called ejaculation. Peyronie’s disease affects the shape and size of the penis, but not urination or ejaculation.

Does Peyronie's disease go away?

Peyronie’s disease is usually a permanent condition. True Peyronie’s disease rarely goes away on its own, but can occasionally change even years after diagnosis in response to further injuries. The changes in the penis can always be improved using a variety of treatments.

Is there a cure for Peyronie's disease?

There is no cure for Peyronie’s disease, but there are always ways that the changes in the penis can be improved. Many different treatments exist including stretch therapy (traction), medications and even surgeries.

How to tell if you have Peyronie's disease?

The most common signs and symptoms include: Scar tissue. The scar tissue associated with Peyronie's disease — called plaque but different from plaque that can build up in blood vessels — can be felt under the skin of the penis as flat lumps or a band of hard tissue. A significant bend to the penis.

What are the complications of Peyronie's disease?

Complications of Peyronie's disease might include: Inability to have sexual intercourse. Difficulty achieving or maintaining an erection (erectile dysfunction) Anxiety or stress about sexual abilities or the appearance of your penis. Stress on your relationship with your sexual partner.

What causes the fingers to pull inward?

Men who have certain connective tissue disorders appear to have an increased risk of developing Peyronie' s disease. For example, a number of men who have Peyronie's disease also have a cordlike thickening across the palm that causes the fingers to pull inward (Dupuytren's contracture). Age.

Does Peyronie's disease cause erectile dysfunction?

Peyronie's disease might cause problems getting or maintaining an erection (erectile dysfunction). But, often men report erectile dysfunction before the beginning of Peyronie's disease symptoms. Shortening of the penis. Your penis might become shorter as a result of Peyronie's disease. Pain.

What is the best treatment for Peyronie's disease?

Image:ShutterStock. One of the best herbs for the natural treatment of Peyronie’s Disease traction and plaque is the Gotu Kola herb which is an ancient remedy for the cure of pain during penis erection.

How to cure Peyronie's disease?

Add a tablespoon of fresh, dried, and crushed leaves of the Gotu Kola herb in hot water. Take the saucepan off the flame after about 7-10 minutes of boiling. Add a teaspoon of honey to the tea and then drink it while it’s hot. Do this twice or thrice a day to cure Peyronie’s Disease traction and plaque.

What is Ylang Ylang essential oil?

Ylang-Ylang. Image: Shutterstock. Ylang-ylang essential oil ( 2) is a powerful natural remedy for Peyronie’s Disease . It can also get used for the cure of Peyronie’s Disease cancer.

How long does it take for Peyronie's disease to cure?

In most cases, Peyronie’s disease gets cured on its own with time. However, doctors suggest a waiting period of 1-2 years before they can correct it. Mild cases however, rarely need any treatment.

Is almond milk good for the penis?

Almond-milk mixture is an incredibly effective aphrodisiac. Almonds are richly packed vitamin E that aids in healthy blood and promote regular flow to the penis. Eating almonds that a steeped with minerals like copper, manganese, and zinc, can cut down on stress and anxiety and there by providing relief from mental issues associated with Peyronie’s Disease.

Does apple cider vinegar help with peyronies?

Drinking diluted apple cider vinegar solution on a daily basis helps in the natural cure of Peyronie’s Disease . Apple cider vinegar works by reducing the size of Peyronie’s Disease plaque and reducing the pain and curvature of the penis.

What is the benefit of acupuncture?

Benefits of acupuncture treatment. Acupuncture helps in the establishment of a healthy flow of blood and energy to the penis. It aids in the alleviation of pain, swelling, and the development of scar tissue in the penis.

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Diagnosis

Clinical Trials

Coping and Support

Preparing For Your Appointment

Your provider will work with you to develop a care plan that may include one or more of these treatment options.
Initially the condition is monitored and if there is no improvement, then it is treated by medication or surgery based on the severity.
Medication

Hemorrheologic agents: Improve blood flow and reduce the amount of scar tissue.

Pentoxifylline


Enzymes: Used to improve the curvature and problems associated with the condition.

Collagenase clostridium histolyticum


Anti hypertensive drugs: Used to treat high blood pressure.

Verapamil


Proteins: It disrupts the production of scar tissues and breaks it down.

Interferon

Procedures

Plication: Suturing (plicating) the unaffected side results in a straightening of the penis.

Incision and grafting: Cuts are made in scar tissue to stretch out the sheath and allow the penis to straighten.

Iontophoresis: Verapamil and a steroid are administered noninvasively to improve the penile curvature and erectile function.

Penile implant surgery: Used to replace the spongy tissue that fills with blood during an erection.

Nutrition

Foods to eat:

  • NA

Foods to avoid:

  • NA

Specialist to consult

Primary care physician
Specializes in the acute and chronic illnesses and provides preventive care and health.

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