Treatment FAQ

what is over treatment of breast cancer

by Muhammad O'Kon Published 2 years ago Updated 2 years ago
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Overtreatment refers to therapies for breast cancer that may not be needed and therefore expose patients to adverse effects without reasonable expectation of benefit.

Medication

Some treatments are local, meaning they treat the tumor without affecting the rest of the body. Most women with breast cancer will have some type of surgery to remove the tumor. Depending on the type of breast cancer and how advanced it is, you might need other types of treatment as well, either before or after surgery, or sometimes both.

Procedures

In recent years, there's been an explosion of life-saving treatment advances against breast cancer, bringing new hope and excitement. Instead of only one or two options, today there's an overwhelming menu of treatment choices that fight the complex mix of cells in each individual cancer.

Therapy

People with recurrent breast cancer often experience emotions such as disbelief or fear. You are encouraged to talk with the health care team about these feelings and ask about support services to help you cope. Learn more about dealing with cancer recurrence.

Nutrition

Although the risk of getting a new cancer in that breast will be lowered, surgery to remove the other breast does not reduce the risk of the original cancer coming back. Survival is based on the prognosis of the initial cancer. In addition, more extensive surgery may be linked with a greater risk of problems.

What are the treatment options for breast cancer?

Is there more hope for breast cancer treatment?

What should I do if I have recurrent breast cancer?

Does surgery to remove one breast reduce the risk of cancer?

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Is breast cancer over treated?

SEER data suggest that a meaningful amount of both invasive and noninvasive breast cancers are likely to be overdiagnosed and overtreated. Further risk stratification is needed in the treatment of breast cancer to avoid overtreatment.

Can breast cancer spread after treatment?

Recurrent breast cancer may occur months or years after your initial treatment. The cancer may come back in the same place as the original cancer (local recurrence), or it may spread to other areas of your body (distant recurrence).

What does overdiagnosis mean?

Overdiagnosis is the diagnosis of a medical condition that would never have caused any symptoms or problems. This kind of diagnosis can be harmful if it leads to psychological stress and unnecessary treatments.

What is the hardest breast cancer to treat?

What is triple-negative breast cancer? Triple-negative breast cancer is that which tests negative for three receptors: estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2). It is also the least common form of breast cancer and the hardest to treat.

How soon can breast cancer return after treatment?

This page was reviewed on February 10, 2022. Even after initial treatment is complete and tests show no sign of disease, there is a chance breast cancer may return. When that happens, it's called recurrent breast cancer. In most cases, recurrent cancers appear within the first three years after treatment.

What are the signs that breast cancer has spread?

Symptoms if cancer has spread to the lungsa cough that doesn't go away.shortness of breath.ongoing chest infections.weight loss.chest pain.coughing up blood.a build up of fluid between the chest wall and the lung (a pleural effusion)

What is the risk of overdiagnosis?

Overdiagnosis can lead to serious harms—psychological and behavioural effects of labeling; consequences of subsequent testing (including invasive tests), treatment, and follow-up; and financial effects on the individual who is overdiagnosed and on society.

What causes overshadowing?

Diagnostic overshadowing occurs when a health professional makes the assumption that the behaviour of a person with learning disabilities is part of their disability without exploring other factors such as biological determinants.

Is overdiagnosis real?

Overdiagnosis in psychiatry occurs where patients are identified with a mental disorder when they do not have significant impairment and would not be expected to benefit from treatment.

Does breast cancer spread fast?

Speed of breast cancer growth can be influenced by these factors: Breast cancer sub-type. In general, triple-negative and HER2-positive tumors tend to grow more rapidly, while hormone receptor-positive breast cancers tend to be slower moving.

Where does breast cancer spread first?

The lymph nodes under your arm, inside your breast, and near your collarbone are among the first places breast cancer spreads. It's “metastatic” if it spreads beyond these small glands to other parts of your body.

What is the best breast cancer to have?

Rare types of invasive ductal carcinoma It occurs when cancer cells within the milk duct of the breast produce mucous, which also contains breast cancer cells. The cells and mucous combine to form a tumor. Pure mucinous ductal carcinoma tends to grow slowly, and has a better prognosis than some other types of IDCs.

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What is the treatment for stage IV breast cancer?

Treatment for stage IV breast cancer is usually a systemic (drug) therapy.

What is stage 0 breast cancer?

Stage 0 means that the cancer is limited to the inside of the milk duct and is non-invasive. Treatment for this non-invasive breast tumor is often different from the treatment of invasive breast cancer. Ductal carcinoma in situ (DCIS) is a stage 0 breast tumor. Lobular carcinoma in situ (LCIS) used to be categorized as stage 0, ...

Which stage of breast cancer is larger?

Stage II: These breast cancers are larger than stage I cancers and/or have spread to a few nearby lymph nodes.

Is lobular carcinoma in situ a stage 0 tumor?

Ductal carcinoma in situ (DCIS) is a stage 0 breast tumor. Lobular carcinoma in situ (LCIS) used to be categorized as stage 0, but this has been changed because it is not cancer. Still, it does indicate a higher risk of breast cancer. See Lobular Carcinoma in Situ (LCIS) for more information.

What are the different types of doctors who treat breast cancer?

Doctors from different specialties often work together to treat breast cancer. Surgeons are doctors who perform operations. Medical oncologists are doctors who treat cancer with medicine. Radiation oncologists are doctors who treat cancer with radiation.

What is complementary medicine?

Complementary and alternative medicine are medicines and health practices that are not standard cancer treatments. Complementary medicine is used in addition to standard treatments, and alternative medicine is used instead of standard treatments. Meditation, yoga, and supplements like vitamins and herbs are some examples.

How is breast cancer treated?

Breast cancer is treated in several ways. It depends on the kind of breast cancer and how far it has spread. People with breast cancer often get more than one kind of treatment. Surgery.

What is biological therapy?

Biological therapy. Works with your body’s immune system to help it fight cancer cells or to control side effects from other cancer treatments.

How to choose the right cancer treatment?

Choosing the treatment that is right for you may be hard. Talk to your cancer doctor about the treatment options available for your type and stage of cancer. Your doctor can explain the risks and benefits of each treatment and their side effects . Side effects are how your body reacts to drugs or other treatments.

What is the treatment for cancer?

Chemotherapy. Using special medicines to shrink or kill the cancer cells. The drugs can be pills you take or medicines given in your veins, or sometimes both.

What is the second opinion on cancer?

Side effects are how your body reacts to drugs or other treatments. Sometimes people get an opinion from more than one cancer doctor. This is called a “second opinion.”. Getting a second opinion. external icon. may help you choose the treatment that is right for you.

How does cancer spread?

Cancer can spread through tissue, the lymph system, and the blood:

Why do breasts feel warm?

The redness and warmth occur because the cancer cells block the lymph vessels in the skin. The skin of the breast may also show the dimpled appearance called peau d’orange (like the skin of an orange). There may not be any lumps in the breast that can be felt. Inflammatory breast cancer may be stage IIIB, stage IIIC, or stage IV.

What are the risk factors for breast cancer?

Risk factors for breast cancer include the following: A personal history of invasive breast cancer, ductal carcinoma in situ (DCIS), or lobular carcinoma in situ (LCIS). A personal history of benign (noncancer) breast disease.

What is the most common type of breast cancer?

The most common type of breast cancer is ductal carcinoma, which begins in the cells of the ducts. Cancer that begins in the lobes or lobules is called lobular carcinoma and is more often found in both breasts than are other types of breast cancer.

Why do cancer tests have to be repeated?

Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.

How much of breast cancer is hereditary?

The genes in cells carry the hereditary information that is received from a person’s parents. Hereditary breast cancer makes up about 5% to 10% of all breast cancer. Some mutated genes related to breast cancer are more common in certain ethnic groups.

What is the name of the disease where malignant cells form in the tissues of the breast?

Breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. The breast is made up of lobes and ducts. Each breast has 15 to 20 sections called lobes. Each lobe has many smaller sections called lobules. Lobules end in dozens of tiny bulbs that can make milk.

How does chemotherapy work?

Chemotherapy is the use of drugs to destroy cancer cells, usually by keeping the cancer cells from growing, dividing, and making more cells . It may be given before surgery to shrink a large tumor, make surgery easier, and/or reduce the risk of recurrence, called neoadjuvant chemotherapy. It may also be given after surgery to reduce the risk of recurrence, called adjuvant chemotherapy.

How long does radiation therapy last after a lumpectomy?

After a lumpectomy. Radiation therapy after a lumpectomy is external-beam radiation therapy given Monday through Friday for 3 to 4 weeks if the cancer is not in the lymph nodes. If the cancer is in the lymph nodes, radiation therapy is given for 5 to 6 weeks. However, this duration is changing, as there is a preference for a shorter duration to be given in women who meet the criteria for shorter treatment. This often starts with radiation therapy to the whole breast, followed by a more focused treatment to where the tumor was located in the breast for the remaining treatments.

How long does it take for breast cancer to recur?

In fact, with modern surgery and radiation therapy, recurrence rates in the breast are now less than 5% in the 10 years after treatment or 6% to 7% at 20 years. Survival is the same with lumpectomy or mastectomy.

What is a treatment plan for cancer?

A treatment plan is a summary of your cancer and the planned cancer treatment. It is meant to give basic information about your medical history to any doctors who will care for you during your lifetime. Before treatment begins, ask your doctor for a copy of your treatment plan. You can also provide your doctor with a copy of the ASCO Treatment Plan form to fill out.

How often is chemo given?

It may be given once a week, once every 2 weeks, once every 3 weeks, or even once every 4 weeks. There are many types of chemotherapy used to treat breast cancer. Common drugs include:

What is cancer treatment?

In cancer care, doctors specializing in different areas of cancer treatment—such as surgery, radiation oncology, and medical oncology—work together with radiologists and pathologists to create a patient’s overall treatment plan that combines different types of treatments.

What is standard of care for breast cancer?

This section explains the types of treatments that are the standard of care for early-stage and locally advanced breast cancer. “Standard of care” means the best treatments known. When making treatment plan decisions, you are strongly encouraged to consider clinical trials as an option.

What is the best treatment for breast cancer?

Hormone therapy uses drugs to prevent hormones, especially estrogen, from fueling the growth of breast cancer cells. Medicines include tamoxifen ( Nolvadex) for women before and after menopause and aromatase inhibitors including anastrozole ( Arimidex ), exemestane ( Aromasin ), and letrozole ( Femara) for postmenopausal women.

How does chemotherapy work?

Chemotherapy uses drugs to kill cancer cells. You take the medicines as pills or through an IV. Most people get it after surgery to kill any cancer cells left behind. Doctors also prescribe it before surgery to make tumors smaller. Chemo works well against cancer, but it also can harm healthy cells.

What is the name of the drug that targets HER2?

These medicines target breast cancer cells that have high levels of a protein called HER2. T-DM1, or ado-trastuzumab emtansine (Kadcyla), is a medicine that combines Herceptin and the chemotherapy medicine emtansine to target HER2-positive cancer cells.

How does breast cancer affect emotions?

The experience of breast cancer will have an effect on your emotions. You may feel tired, frustrated, angry, and sad at different times. Depression is a normal part of the breast cancer experience. Chemotherapy, hormonal therapy, and some pain medications can help cause these feelings or make them worse.

What do doctors think about before they recommend a treatment for breast cancer?

Your doctor will think about a few things before they recommend a treatment for you: The type of breast cancer you have. The size of your tumor and how far the cancer has spread in your body, called the stage of your disease.

How long does it take to get a breast prosthesis fitted?

Make an appointment with a breast prosthesis consultant and allow yourself about an hour to get fitted.

How to remove breast cancer?

These include: Surgery. For most people, the first step is to take out the tumor. An operation called lumpectomy removes only the part of your breast that has cancer. It’s sometimes called breast-conserving surgery.

Why is it important to change the name of a tumour?

There is a clear precedent for changing the names of tumours to reflect increasing knowledge about benign disease behaviour to provide useful and reassuring guidance to clinicians and patients. In 1998, the WHO classification of urothelial tumours was revised, reclassifying papilloma and grade 1 carcinoma as papillary urothelial neoplasia of low malignant potential, taking the lowest grades of tumour and removing the word carcinoma.73The reasoning behind the change was that a disorder that is almost never associated with invasion and disease progression should not be called a carcinoma at all.73Similarly, designation of cervical intraepithelial neoplasia as a low-grade lesion, not a malignancy, has resulted in a substantial decrease in procedures and a switch to observation for patients with this disorder, without a concomitant increase in cancer diagnoses.

How to reduce overdiagnosis?

Strategies to reduce overdiagnosis include changing thresholds for when to undertake a biopsy, reducing the frequency of screening, focusing attention on elimination of consequential tumours, and developing more risk-based screening approaches.46 Most lesions recommended for biopsy are benign. If low-grade and intermediate-grade ductal carcinoma in situ were not a focus of screening, far fewer biopsies would be done.46Screening every other year as recommended by the US Preventive Services Task Force, and most countries outside the USA, would lower the number of false-positive biopsies, without increasing the risk of late-stage cancers.47Concentration of screening in high-volume mammography centres, which have access to tests with better sensitivity and specificity, will further improve the process.48Risk-based screening should be developed, and recommendations should be based on the type of breast cancer for which women are at risk.47–50Over time, people might be identified for whom little or no screening is the best strategy, as has been shown in lung cancer.20

How has breast cancer risen since 1983?

Since 1983, the incidence of invasive breast cancer has risen substantially, especially the incidence of cancers with less aggressive characteristics.1,38Although overdiagnosis of indolent lesions has been recognised to be a result of screening,39the extent is under-appreciated.40Of screening-detected invasive breast cancers, up to 30% might be ultra-low risk on the basis of their molecular profile.40If validated, this proportion of low-risk cancers presents an opportunity for an IDLE classification.1Molecular classifiers are used to avoid chemotherapy,41,42but could also classify tumours that have a very low or no risk of metastatic progression after simple excision, supporting the safe elimination of radiation therapy after lumpectomy in postmenopausal women, benefiting many women.43–45

How much does a helical CT reduce lung cancer?

The National Lung Screening Trial34reported a 20% relative reduction in lung cancer death with low-dose helical CT (LDCT) screening compared with chest radiograph; however, this finding was seen only in high-risk populations assessed at institutions with cancer expertise.34Furthermore, the increase in early-stage disease was substantially greater than the reduction in more advanced cancers20and results of an analysis suggest that the probability of overdiagnosis for any lung cancer is 18·5% (95% CI 5·4–30·6) with LDCT, varying on the basis of subtype.35Importantly, in the LDCT group, 39% had at least one positive screen, of which 96% were false positives. Nodules under 1 cm in diameter had only a 1·5% chance of being cancer. Thus, the US Preventive Services Task Force concluded that the balance of benefits versus harms of LDCT screening justified screening, but only for the highest risk populations at experienced centres; and recommended that patients be informed of benefits and harms (including complications of diagnostic procedures, radiation exposure, and effect on quality of life) of identification of low-risk lesions.20,36Development of diagnostic tests to distinguish between indolent (IDLE) and aggressive tumours will mitigate overtreatment.37

Why should the terminology for other precancerous lesions change?

Terminology for other precancerous lesions should change to reduce urgency of intervention and enable assessment of new strategies for screening and treatment. Fuelled by fear of missing the chance for early detection, an aggressive strategy of undertaking biopsies has evolved.

What is the assumption of screening for cancer?

Screening is based on the assumption that cancer has an orderly and gradual progression (figure 1A). Good survival outcomes for patients with the earliest stages of disease led to the conclusion that detection of cancer at an early stage would dramatically reduce cancer mortality.

Do cancers have unrelenting capacity for progression?

Many physicians think so as well, and act or advise their patients accordingly. However, since many tumours do not have the unrelenting capacity for progression and death, new guidance is needed to describe and label the heterogeneous diseases currently referred to as cancer.

What is neoadjuvant therapy?

Neoadjuvant therapy is treatment given before surgery. Treatment can be chemotherapy, HER2-targeted therapy or hormone therapy. Neoadjuvant therapy may also be called preoperative therapy. Some women with early breast cancer may have neoadjuvant therapy as a first treatment. Neoadjuvant therapy may shrink a tumor enough so a lumpectomy becomes an ...

What is the first step in treating breast cancer?

Surgery. Surgery is usually the first step in treating early breast cancer. You may have a mastectomy (the entire breast is removed) or a lumpectomy (only the tumor and some surrounding tissue are removed). With either type of surgery, some lymph nodes in the underarm area (axillary lymph nodes) may be removed to find out if they contain cancer.

How to treat breast cancer locally?

Treatment for locally advanced breast cancer usually begins with neoadjuvant therapy. Neoadjuvant therapy helps shrink the tumor (s) in the breast and lymph nodes so surgery can more easily remove all the cancer. Learn more about neoadjuvant therapy.

What is a locally advanced breast cancer?

Locally advanced breast cancer. Locally advanced breast cancer has spread beyond the breast to the chest wall or the skin of the breast. Or, it has spread to many axillary lymph nodes. Locally advanced breast cancer can also refer to a large tumor.

Why are lymph nodes removed?

With either type of surgery, some lymph nodes in the underarm area (axillary lymph nodes) may be removed to find out if they contain cancer.

What is tumor profiling?

Tumor profiling may also be called genomic testing or molecular profiling . Learn more about factors that affect treatment options. For a summary of research studies on chemotherapy and early breast cancer, visit the Breast Cancer Research Studies section.

How long do women live with breast cancer?

Women diagnosed with breast cancer that had spread to nearby lymph nodes, but not to other parts of the body were 86 percent as likely to live 5 years beyond diagnosis as women in the general population. With recent improvements in treatment, survival for women diagnosed today may be even higher. However, prognosis for breast cancer depends on each ...

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