Medication
The Clinician’s Guide to Prevention and Treatment of Osteoporosis was developed by an expert committee of the National Osteoporosis Foundation (NOF) in collaboration with a multispecialty council of medical experts in the field of bone health convened by NOF.
Nutrition
(Bisphosphonates, calcitonin & estrogen agonist/antagonist all prevent bone resporption. Increases in bone density are also seen; however, their main efficacy lies in preventing further bone loss) Success of all osteoporosis medications requires ______.
What is the clinician’s Guide to prevention and treatment of osteoporosis?
What is osteoporosis? Osteoporosis is a common disease of the bones & is often silent until a fracture occurs, making screening important. Characterized by low bone mass & increased bone fragility. Pateints are susceptible to fractures from minor traumatic events such as coughing, rolling over in bed, walking, or falling.
Which osteoporosis medications prevent bone resporption?
Osteoporosis is preventable and treatable, but because there are no warning signs prior to a fracture, many people are not being diagnosed in time to receive effective therapy during the early phase of the disease. Many factors have been associated with an increased risk of osteoporosis-related fracture (Table 1).
What is osteoporosis?
Can osteoporosis be prevented?
How much does zoledronic acid reduce hip fractures?
Zoledronic acid reduces the incidence of vertebral fractures by 70 % (with significant reduction at 1 year), hip fractures by 41 % , and nonvertebral fractures by 25 % over 3 years in patients with osteoporosis defined by prevalent vertebral fractures and osteoporosis by BMD of the hip [66]. Drug administration .
What is the FDA approved treatment for osteoporosis?
Denosumab, brand name Prolia® . Denosumab is approved by the FDA for the treatment of osteoporosis in postmenopausal women at high risk of fracture. Denosumab reduces the incidence of vertebral fractures by about 68 %, hip fractures by about 40 %, and nonvertebral fractures by about 20 % over 3 years [56].
Why is calcium important for bone health?
Lifelong adequate calcium intake is necessary for the acquisition of peak bone mass and subsequent maintenance of bone health. The skeleton contains 99 % of the body’s calcium stores; when the exogenous supply is inadequate, bone tissue is resorbed from the skeleton to maintain serum calcium at a constant level.
Does Denosumab cause ONJ?
Denosumab has been rarely associated with the development of ONJ, both when used to treat osteoporosis and to treat patients with cancer (at much higher doses), although it is much more common in the latter setting. Denosumab has also been associated rarely with the development of atypical femur fractures.
Is teriparatide safe for men?
Teriparatide is approved by the FDA for the treatment of osteoporosis in postmenopausal women and men at high risk for fracture. It is also approved for treatment in men and women at high risk of fracture with osteoporosis associated with sustained systemic glucocorticoid therapy [91].
Is raloxifene safe for postmenopausal women?
Raloxifene is approved by the FDA for both prevention and treatment of osteoporosis in postmenopausal women. Raloxifene reduces the risk of vertebral fractures by about 30 % in patients with a prior vertebral fracture and by about 55 % in patients without a prior vertebral fracture over 3 years [55].
How many fractures are attributed to osteoporosis?
Economic toll. Annually, two million fractures are attributed to osteoporosis, causing more than 432,000 hospital admissions, almost 2.5 million medical office visits, and about 180,000 nursing home admissions in the USA [1].
What is the endogenous chain of teriparatide?
Recombinant human parathyroid hormone (PTH). Endogenous PTH is a chain of 84 amino acids. Teriparatide is a chain of the first 34 amino acids. Intermittent administration of exogenous 1-34 PTH results in preferential BONE FORMATION.
What hormone is produced by the thyroid gland in response to high levels of plasma calcium?
Calcitonin is a hormone produced by the thyroid gland in response to high levels of plasma calcium. Explain the major functions of Calcitonin. 1) Inhibits the resorption of calcium from bone (inhibits Ca++ removal from bone) 2) Increases renal exretion of calcium.
What is the function of Vit D?
1) Inhibits renal excretion (loss) of Ca++. 2) Increases calcium absorption from the intestine.
Is osteoporosis silent?
Osteoporosis is a common disease of the bones & is often silent until a fracture occurs, making screening important. Characterized by low bone mass & increased bone fragility. Pateints are susceptible to fractures from minor traumatic events such as coughing, rolling over in bed, walking, or falling.
Does raloxifene help with osteoporosis?
Treatment & prevention of osteoporosis in post-menopausal women AND also FDA approved to prevent breast cancer in women with estrogen sensitive breast cancer. Raloxifene will NOT treat menopausal symptoms - it is not a simple estrogen alternative - there are differences.
Is Ca++ better than placebo?
There are few head to head trials comparing one prescription drug to another. Ca++ alone reduces risk of fractures & increases bone density better than placebo but not as well as prescription options. Ca++ plus a prescription drug is more effective than Ca++ alone & more effective than a prescription drug along.