Treatment FAQ

what is monoclonal antibody treatment vs vaccine

by Dr. Tyler Johnston Published 3 years ago Updated 2 years ago
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Common question

Will monoclonal antibodies provide immunity against COVID-19?


COVID-19 vaccines help stimulate and prepare a person's immune system to respond if they are exposed to the virus. However, monoclonal antibodies boost the immune system only after a person is already sick, speeding up their immune response to prevent COVID-19 from getting worse.

Nov 8, 2021

Can I get the COVID-19 vaccine if I was treated with monoclonal antibodies or convalescent plasma?

If you were treated for COVID-19 symptoms with monoclonal antibodies or convalescent plasma, you should wait 90 days before getting a COVID-19 vaccine.

Is there a monoclonal antibody therapy for post COVID-19 exposure?



FDA authorizes bamlanivimab and etesevimab monoclonal antibody therapy for post-exposure prophylaxis (prevention) for COVID-19 | FDA.

Sep 16, 2021

Do I need the COVID-19 vaccine if I still have antibodies?

Yes, the COVID-19 vaccines are recommended, even if you had COVID-19.

Nov 23, 2021

What is a monoclonal antibody?

Monoclonal antibodies are laboratory-produced molecules that act as substitute antibodies that can restore, enhance or mimic the immune system's attack on cells.Apr 26, 2022

How many types of monoclonal antibody COVID-19 treatments are there in the US?

In the United States, there are three anti-SARS-CoV-2 monoclonal antibody treatments with FDA Emergency Use Authorization (EUA) for the treatment of COVID-19: bamlanivimab plus etesevimab, casirivimab plus imdevimab,, and sotrovimab.

Is there an antibody cocktail for COVID-19?

The treatment, bamlanivimab and etesevimab administered together, was granted FDA emergency use authorization in February. Eli Lilly and the FDA stipulated that the antibody cocktail is authorized as a COVID-19 prophylaxis only for individuals who have been exposed to the virus.

Sep 16, 2021

Should you get the COVID-19 vaccine if you already had COVID-19 and recovered?


If I already had COVID-19 and recovered, do I still need to get a COVID-19 vaccine? You should get a COVID-19 vaccine even if you already had COVID-19. Getting a COVID-19 vaccine after you recover from COVID-19 infection provides added protection to your immune system.

How long do COVID-19 antibodies last?

At this time, it is unknown for how long antibodies persist following infection and if the presence of antibodies confers protective immunity.Jan 31, 2022

Should I get the COVID-19 vaccine after recovering from the infection?


People who have COVID-19 should wait to receive any vaccine, including a COVID-19 vaccine, until after they recover and complete their isolation period.

What is a monoclonal antibody for COVID-19?

Monoclonal antibodies are laboratory-produced molecules that act as substitute antibodies that can restore, enhance or mimic the immune system's attack on cells. Monoclonal antibodies for COVID-19 may block the virus that causes COVID-19 from attaching to human cells, making it more difficult for the virus to reproduce and cause harm. Monoclonal antibodies may also neutralize a virus.Apr 26, 2022

Will a person with COVID-19 vaccine have a positive antibody test?

A COVID-19 vaccination may also cause a positive antibody test result for some but not all antibody tests. You should not interpret the results of your SARS-CoV-2 antibody test as an indication of a specific level of immunity or protection from SARS-CoV-2 infection.Feb 24, 2022

How long do antibodies last in people who have mild COVID-19 cases?

A UCLA study shows that in people with mild cases of COVID-19, antibodies against SARS-CoV-2 — the virus that causes the disease — drop sharply over the first three months after infection, decreasing by roughly half every 36 days. If sustained at that rate, the antibodies would disappear within about a year.

What Is An Antibody?

How Do Antibody Therapeutics Work?

  • To make an antibody therapeutic, we can take blood from a person who has already survived COVID-19, extract the antibody-producing B cells, and use genetic sequencing technology to make antibodies. If we can identify the antibody that neutralizes SARS-CoV2 in a test tube, then we can produce massive quantities of that antibody to use as a drug. The antibody is injected into a pati…
See more on vumc.org

How Does A Vaccine Work?

  • A vaccine, however, is what we call “active immunity.” A vaccine can be a piece of a virus, an inactivated virus, or a live virus that no longer has the ability to cause disease. When we inject this into a human being, the immune system launches an attack as if the person were actually experiencing a genuine SARS-CoV-2 infection. Here, though, the person will not get sick, and tha…
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So, What’s The difference? and Why Do We Need Both?

  • While an antibody can immediately treat an existing SARS-CoV-2 infection, a vaccine will train the immune system to battle future infections. We must develop a vaccine in order to afford the general population immunity to SARS-CoV-2, but must also have an antibody therapeutic to treat those who are already infected, or persons who have a medical co...
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