| Characteristics | Total | Standard BP treatment | Intensive BP treatment | Pvalue |
| Body mass index, kg/m2 | 29.5 ± 5.4 | 29.7 ± 5.4 | 29.4 ± 5.3 | 0.38 |
| Systolic blood pressure, mm Hg | 137.8 ± 15.7 | 136.9 ± 16.2 | 138.6 ± 15.5 | 0.07 |
| Diastolic blood pressure, mm Hg | 74.1 ± 12.1 | 73.6 ± 12.0 | 74.7 ± 12.1 | 0.14 |
| Heart rate, bpm | 62.7 ± 11.1 | 63.2 ± 11.7 | 62.6 ± 10.7 | 0.34 |
Full Answer
Is intensive blood pressure lowering appropriate?
Therefore, according to guideline recommendations, it may be concluded that intensive BP lowering is only advisable in a subgroup of patients where there is a clear net benefit of targeting to lower BP goals.
What is the difference between standard and intensive treatment for hypertension?
The frequency at which participants discontinued the intervention but continued follow-up was 6.2% in the intensive treatment group vs 6.4% in the standard treatment group (P= .87). Blood Pressure Levels Throughout follow-up, the mean SBP in the intensive treatment group was 123.4 mm Hg, and it was 134.8 mm Hg in the standard treatment group.
Does intensive blood pressure lowering improve frailty in older hypertensive patients?
Common sense in clinical practice is to monitor creatinine, eGFR and urine albumin in these patients during BP lowering. In older hypertensive patients, the most important aspect is frailty. To our knowledge, no RCT assessing intensive BP lowering in older people adjusted for a multidomain evaluation of frailty has been published.
Is intensive BP lowering effective in patients with advanced CKD?
The number of CKD patients included in the SPRINT trial and the fact that most of them were in stage 3 should be considered when trying to apply intensive BP lowering to patients with advanced CKD. Common sense in clinical practice is to monitor creatinine, eGFR and urine albumin in these patients during BP lowering.
What is intensive blood pressure control?
The Systolic Blood Pressure Intervention Trial (SPRINT) was a large, randomized clinical trial that compared intensive blood pressure control (a systolic blood pressure target of less than 120 mmHg) with a standard target (less than 140 mmHg).
What is treatment for very high blood pressure?
Medicines for high blood pressure ACE inhibitors – such as enalapril, lisinopril, perindopril and ramipril. angiotensin-2 receptor blockers (ARBs) – such as candesartan, irbesartan, losartan, valsartan and olmesartan. calcium channel blockers – such as amlodipine, felodipine and nifedipine or diltiazem and verapamil.
What are three treatments for high blood pressure?
Medications used to treat high blood pressure include:Diuretics. Diuretics, sometimes called water pills, are medications that help your kidneys eliminate sodium and water from the body. ... Angiotensin-converting enzyme (ACE) inhibitors. ... Angiotensin II receptor blockers (ARBs). ... Calcium channel blockers.
What are the 5 symptoms of high blood pressure?
Symptoms of High Blood PressureBlurry or double vision.Lightheadedness/Fainting.Fatigue.Headache.Heart palpitations.Nosebleeds.Shortness of breath.Nausea and/or vomiting.
What are the 4 stages of hypertension?
The 4 stages of hypertension are:Elevated blood pressure levels between 120-129/less than 80. ... Hypertension stage 1 is 130-139/80-89 mmHg.Hypertension stage 2 is 140/90 mmHg or more.Hypertensive crisis is higher than 180/120 or higher.
What is the fastest way to cure high blood pressure?
AdvertisementLose extra pounds and watch your waistline. Blood pressure often increases as weight increases. ... Exercise regularly. ... Eat a healthy diet. ... Reduce sodium in your diet. ... Limit the amount of alcohol you drink. ... Quit smoking. ... Cut back on caffeine. ... Reduce your stress.More items...
What is the first line treatment for hypertension?
There are three main classes of medication that are usually in the first line of treatment for hypertension: 1. Calcium Channel Blockers (CCB) 2. Angiotensin Converting Enzyme inhibitors (ACE inhibitors or ACE-I) and Angiotensin Receptor Blockers (ARBs) 3. Diuretics.
What are the top 5 blood pressure medications?
In terms of dollar sales, there are 5 top high blood pressure medications.the angiotensin II receptor blocker valsartan (Diovan) in the lead for high blood pressure medications,the beta-blocker metoprolol,the generic combination of valsartan and HCTZ,olmesartan (Benicar), and.olmesartan and HCTZ (Benicar HCT).
What is the fastest way to cure high blood pressure?
AdvertisementLose extra pounds and watch your waistline. Blood pressure often increases as weight increases. ... Exercise regularly. ... Eat a healthy diet. ... Reduce sodium in your diet. ... Limit the amount of alcohol you drink. ... Quit smoking. ... Cut back on caffeine. ... Reduce your stress.More items...
Why is my blood pressure still high on medication?
You're taking a diuretic and at least two other blood pressure medicines. But your blood pressure still isn't budging. This is called resistant hypertension. Simply put, it means that your high blood pressure (HBP or hypertension) is hard to treat and may also have an underlying (secondary) cause.
When is blood pressure high enough to go to the hospital?
High blood pressure, caused by lifestyle issues like obesity and not getting enough exercise, among other causes, is a serious disease. If it gets too high, specifically 180/120 or higher, and you have the symptoms listed here, you need to call 911 or go to the emergency room.
What is the first line treatment for hypertension?
There are three main classes of medication that are usually in the first line of treatment for hypertension: 1. Calcium Channel Blockers (CCB) 2. Angiotensin Converting Enzyme inhibitors (ACE inhibitors or ACE-I) and Angiotensin Receptor Blockers (ARBs) 3. Diuretics.
Introduction
- See Editorial Commentary, pp 299–300 Hypertension is a public health concern with high prevalence reported worldwide.1,2 It increases the risk of several cardiovascular events, such as coronary heart disease, stroke, and heart failure,3,4 and lowering blood pressure (BP) results in significantly decreased risk of developing such cardiovascular events.5 Nonpharmacologic ther…
Methods
- The anonymized data from the SPRINT study have been made publicly available at the National Heart, Lung, and Blood Institute and can be accessed at https://biolincc.nhlbi.nih.gov/studies/sprint_pop/?q=SPRINT.
Results
- Patient Characteristics
Baseline characteristics are shown in Table 1. The present study included patients with (n=1397) and without (n=7698) resistant hypertension. In patients with and without resistant hypertension, the baseline characteristics did not significantly differ between the intensive and standard treat… - Primary and Secondary Outcomes in Patients With and Without Resistant Hypertension
The overall mean (±SD) follow-up period was 3.1 (±0.9) years. MACE was confirmed in 381 patients. Kaplan-Meier survival curves and cumulative event rates for cardiovascular events and death in patients with resistant hypertension are shown in Figure 2 and Table 2, respectively. Th…
Discussion
- The present study demonstrated that intensive BP treatment resulted in a decreased incidence of cardiovascular events and death in patients with resistant hypertension. Similar associations between intensive BP treatment and decreased risk of cardiovascular events and death were observed in the relevant subgroups with resistant hypertension. Resist...
Perspectives
- Resistant hypertension is a common clinical problem faced by both specialists and primary care clinicians. Although the management of resistant hypertension is important, evidence about the BP target in patients with resistant hypertension is currently limited. The present study demonstrated that intensive BP treatment resulted in a decreased incidence of cardiovascular e…
Acknowledgments
- The study concept, design, and data acquisition was done by T. Tsujimoto; analysis and data interpretation was done by T. Tsujimoto and H. Kajio; drafting the article was done by T. Tsujimoto; statistical analysis was done by T. Tsujimoto. T. Tsujimoto had full access to all data in the study and takes responsibility for the integrity and accuracy of the data analysis.