What is severe male infertility (IMSI)?
Severe male infertility is one of the most common causes of male infertility. For example, a man has low sperm quality when the sperm count is poor, the sperms are too slow, or the sperm morphology is abnormal. As for IMSI in particular, it is indicated when sperm morphology is altered, a disorder that is known as teratozoospermia or teratospermia.
What is IMSI (intra-cytoplasmic morphologically selected sperm injection)?
What is IMSI (Intra-Cytoplasmic Morphologically Selected Sperm Injection)? Science is constantly trying to advance techniques used in IVF to improve the chances of fertilisation and a healthy pregnancy.
What is IMSI and why is it important?
In short, IMSI allows the embryologist to see the structure of spermatozoa in detail, thereby detecting potential abnormalities and defects in the head, middle-piece, and/or tail. According to the World Health Organization (WHO), for a sperm cell to have an excellent morphology, it must have the following characteristics:
What is ICSI and how can it help male infertility?
Male infertility often stems from one of these stages, problems with poor sperm motility, count, and structure all lower the chances of a successful fertilisation and pregnancy. What ICSI does is directly introduce the sperm cell to its female equivalent, the egg cell, hence removing these other factors which affect success.
Is IMSI better than ICSI?
Clinical IMSI is an effective technique for IVF-ET with positive clinical outcomes such as better implantation and pregnancy rates than conventional ICSI.
When do you use IMSI?
Your Melbourne IVF fertility specialist may recommend IMSI if:you have very low numbers of sperm, and.a high proportion of abnormally shaped sperm, or.evidence of poor outcomes with previous ICSI treatments.
Is ICSI better than IVF?
Results: In IVF group, fertilization and implantation rates were significantly higher than ICSI group (66.22% and 16.67% in IVF group versus 57.46% and 11.17% in ICSI group, respectively). Chemical and clinical pregnancy rates were statistically higher in IVF group as compared with the ICSI group (42.9% vs.
What's the difference between IVF and IUI?
Through intrauterine insemination (IUI), sperm is placed directly into the uterus using a speculum. Through In-vitro fertilization (IVF), eggs are surgically removed using a needle that goes through the back of the vagina, and those eggs are fertilized outside of the body.
How does IMSI work IVF?
IMSI uses ultra-high magnification to look for irregular features in the sperm head, while PICSI tests the ability of sperm to bind to a substance that is present on the surface of the egg. Sperm bind to a protein called Hyaluronic acid (HA) as part of normal fertilisation.
What is IMSI pregnancy?
The Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is a technique that is used as a part of the In Vitro Fertilisation treatments for infertility. The IMSI treatment involves morphologically injecting a selected sperm into the egg.
Does ICSI affect gender?
DOES ICSI AFFECT GENDER. ICSI, intracytoplasmic sperm injection, is used to interject the sperm into the center of the egg, with the goal of achieving an embryo. Since it is the sperm that determines the embryo's sex, ICSI doesn't affect the baby's gender in any way.
Is ICSI more expensive?
Cost. The ICSI procedure costs between $1,400 to $2,000. This is on top of the general IVF cost, which on average costs $12,000 to $15,000. It may cost more than this if other IVF options are being used.
Can you have twins with ICSI?
Abstract. One of the negative aspects of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) is the increased risk of multiple pregnancies. Multiples of high order (triplets and pregnancies of higher order) are obsolete to both doctors and patients and need to be avoided.
Are IUI babies normal?
Aside from the conception process and risks associated with combining the procedure with fertility medications, an IUI pregnancy is virtually indistinguishable from a traditional pregnancy.
Who is a good candidate for IUI?
IUI is recommended for people who have had trouble conceiving a child through natural means. For couples under 35, this means having unprotected sex for up to one year. For couples over 35, you may be a candidate for IUI if you've been having unprotected sex for six months.
Can you request twins with IUI?
IUI brings sperm close to a woman's eggs so that fertilization is easier, but it does not alter any other part of ovulation or conception. The chance of twins is just the same for a couple undergoing straight IUI treatment as it is for a couple who is conceiving naturally.
Why perform an IMSI?
An IMSI treatment increases the chances of embryo fertilisation as well as normal development of the embryo, especially among men who have had poor previous outcome of the IVF with Intracytoplasmic Sperm Injection (ICSI) treatment as well as among men with high numbers of abnormal sperm.
How much does an IMSI cost?
At Apollo Fertility, we aim to provide you with the best treatment at the most affordable rates. The Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) at Apollo Spectra costs between Rs. 183500 to Rs. 243800.
What is IMSI?
IMSI, Intracytoplasmic Morphologically Selected Sperm Injection is a technique used along with IVF treatment, to help a couple in conceiving. In IMSI fertility treatment, a single sperm is selected with the help of a high-magnification digital imaging microscope and is morphologically injected into the egg.
Why perform IMSI?
The microscope which is used to select the sperm magnifies it by almost 6,000 times. This enables the doctor to determine the structure of the sperm and eliminate the sperm that exhibits abnormalities, which is not possible in ICSI treatment.
Why is IMSI IVF treatment done?
There are certain reasons why your doctor might recommend you to get IMSI treatment done. They are-
What are the risks involved in IMSI treatment?
A male child born with the help of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is more prone to fertility issues in the future. This happens due to the passing of infertility genetics from the father to the baby.
IMSI treatment cost in India
All the centers in India aim to provide the best IMSI IVF treatment at an economic cost, to ensure that a common man can afford it. The cost of ART technique- IVF increases when advanced fertility treatments like IMSI are added. The average cost of IMSI IVF treatment in India is between 1,80,000 to 2,50,0000 INR.
The success rate of IMSI treatment in India
The success rate of IMSI treatment in India is high as compared to other developed countries. Here the success rate of IMSI treatment is around 70 to 80%. This is the reason why India has people coming from all over the world to get their infertility treatments done every year.
What is IMSI in sperm?
IMSI or Intracytoplasmic Morphologically-selected Sperm Injection, also known as Super-ICSI is a sperm selection technique based on spermatozoa morphology. To do IMSI, we use specific microscopes that help us magnify the head of spermatozoa up to 16,000 times, instead of standard microscopes that magnify only up to 400 times. This way, we select the best spermatozoa, one by one, to perform ICSI and inseminate oocytes, also, one by one.
What is IMSI in biology?
IMSI is a technique that is very similar to ICSI. ICSI is the acronym for intracytoplasmic injection of the sperm. That means what the biologists do in the lab, in the sperm sample, they look for the sperm that looks and moves the best and, then, they select those sperm to inject inside the eggs to try to fertilize them. When we use IMSI, what the biologists do, they use another kind of microscope with bigger potency and, then, they also select the sperm according to its morphology. Some small studies are saying that maybe in patients who have low morphology, or patients who have teratozoospermia in the sample, IMSI might help to have better results and to diminish the risk of miscarriage or the risk of having embryos that do not implant.
What is intracytoplasmic sperm injection?
Intracytoplasmic sperm injection is used for the majority of cases of patients with low sperm motility. There are severe cases of teratozoospermia where the number of good-looking, healthy sperm cells is low, and then, there is a need for intracytoplasmic sperm injection after magnification of sperm at least 6-8 million times to secure the best results. Eventually, in IVF-Spain intracytoplasmic sperm injection is used, but the goal is to develop a genetically normal healthy embryo, and the fertilization at this moment is not that important.
What is IMSI and how is it different from ICSI?
To properly explain IMSI we should take a quick look at ICSI. As amazing as IVF is, the chances of success have always been a bit of a cause for concern, not so much in recent years as some clinics can boast extremely high success rates, but it remains something that doctors and scientists are constantly trying to improve.
What exactly is involved in IMSI?
A high powered microscope is used to pick out and the best sperm cells which are then used in a traditional ICSI protocol.
Why should I have IMSI? Is it suitable for me?
IMSI is a good choice for anyone who has failed IVF cycles in the past, and for couples who have a component of male infertility. Unfortunately further reports need to be made to show the benefits of using IMSI and evaluate the costs.
What is IMSI?
Intracytoplasmic Sperm Injection is also known as IMSI is another procedure used during the time of IVF. It enables the doctors to differentiate between the structure of the sperm and exclude the suspected variations. Doctors perform this procedure using a high magnification digital imaging microscope during the time of injecting into the egg.
Why perform IMSI?
ICSI is performed where doctors find severe male infertility. It is performed parallel to IVF for a better result. But sometimes the process fails. To enhance a positive outcome doctors use a digital high magnification sperm to improve the process of fertilization and embryo development.
Who is IMSI suitable for?
Intracytoplasmic Sperm Injection is for the ones who have repeatedly failed in IVF cycles. Even if a couple failed in the ICSI-IVF cycle in the past they can opt for this advanced technique.
How does IMSI work?
IMSI works most uniquely. In the traditional method, embryologists used to select the most normal looking sperm using a microscope. Those microscopes magnify the sperm up to 400 times.
How is IMSI treatment performed?
IMSI is performed to differentiate between the normal sperms and the abnormal sperms before microinjecting. It is performed using a high powered microscope with 600 times digital imaging. The ultrastructure of the sperm is analyzed through this procedure.
What does IMSI treatment cost?
The average cost of IMSI in India is Rs.1,50,000 – Rs.2,76,000 in addition to the ICSI treatment. The IMSI treatment is performed at a very low cost in India than in any other country in the world. It is performed using a high digital magnifying lens which is 6000 times.
Treatment Options For Infertility
Couples at a certain point in time have the desire to conceive. Many studies have found that almost 85% of the couples successfully conceive within one year of trying.
About IMSI
IMSI is based on a method of high magnification motile sperm organelle morphology examination (MSOME). It requires an inverted light microscope equipped with high power Nomarski optics enhanced with digital imaging. Such examination helps to identify spermatozoa with a normal nucleus and nuclear content.
Success or failure factors
Several comparative studies have indicated that the use of high-magnification sperm selection was associated with both higher pregnancy and delivery rates, whereas also lower miscarriage rates were observed. However, still to date randomized, well-powered studies to confirm these findings are scarce and show conflicting results.
Complications
IMSI is a time-consuming procedure at the expense of oocyte ageing. The lack of proof and understanding of its benefit does not justify its routine clinical application at present.
Prognosis
As the technique seems not effective for any unselected ART patient, relevant indications for the use of IMSI need to be defined. For severe male factor patients, evidence suggests a higher clinical pregnancy rate with IMSI. The benefit for repeated ICSI failure patients, however, remains unproven.
Why do ICSI treatments help with IVF?
If you haven't had success with IVF due to problems fertilizing eggs, adding ICSI to your next treatment can improve the chance of fertilization because an embryologist handles the process in a lab.
What is ICSI in a sperm injection?
With ICSI, a single sperm is injected directly into an egg. ICSI is used with in vitro fertilization (IVF) ...
How many babies are born in the US each year from ICSI?
ICSI is used with in vitro fertilization (IVF) and is performed in more than 65 percent of IVF procedures. As a result of IVF with ICSI, more than 17,000 babies are born in the United States each year.
What to do if microsurgery doesn't work?
Tissue sample (if needed). If microsurgery doesn't work, the doctor takes a tissue sample from inside your testicle, which could contain sperm. (If no sperm is found, your doctor may suggest that you consider using donor sperm to conceive a child.) Gathering the eggs.
How many eggs does IVF release?
(She usually releases only one egg a month.)
What is the risk of having multiples during IVF?
Risk of multiples. Because more than one embryo may be placed in your partner's uterus during IVF treatment, your chance of having twins or more is about 20 percent. Some may consider this a blessing, but carrying multiples increases the risk of miscarriage and other complications such as preterm labor.
Who collects sperm from a sample?
An embryologist (a scientist who specializes in sperm, eggs, and embryos) obtains sperm from the sample. The doctor may time sperm collection with your partner's egg retrieval, or the doctor can collect the sperm in advance and freeze it until your partner's eggs are ready to be fertilized. Microsurgery (if needed).
IMSI vs. ICSI
When Is It used?
- Severe male infertility is one of the most common causes of male infertility. For example, a man has low sperm quality when the sperm count is poor, the sperms are too slow, or the sperm morphologyis abnormal. As for IMSI in particular, it is indicated when sperm morphology is altered, a disorder that is known as teratozoospermia or teratospermia. Moreover, IMSI can be u…
Benefits of IMSI
- The main benefit of IMSI is that it allows for an accurate visualization of sperm cells, that is, an increase greater than 6300-fold of spermatozoa. To sum up, IMSI is 15 times more powerful than conventional microscopes used in IVF/ICSI cycles. With IMSI, live sperms can be selected in real time. Thanks to it, dye tests that could damage the sperm cells become unnecessary to check s…
Disadvantages
- In spite of all the advantages that IMSI can add to your fertility treatment, it also has some cons that one should consider, including: 1. It adds a considerable amount of extra timeto the IVF procedure: about 1.5 to 5 hours. 2. Due to its elevated cost, it is not available in most IVF laboratories. For all these reasons, IMSI is used only when sperm quality is too low or in cases o…
Suggested For You
- We have mentioned teratozoospermia as the main indication for IMSI to be used. To get a much deeper insight on this sperm disorder, we recommend that you visit the following post: What Is Teratozoospermia? – Causes, Pregnancy Rate & Treatment. According to the WHO, a semen analysis is the most useful tool when it comes to evaluate male fertility, as it is used to detect p…