What is the role of G-CSF in cancer treatment?
G-CSF is a type of growth factor that makes the bone marrow produce more white blood cells so it can reduce the risk of infection after some types of cancer treatment. G-CSF also makes some stem cells move from the bone marrow into the blood. Stem cells are very early cells that develop into red blood cells, white cells and platelets.
What is GTG CSF used to treat?
Mar 18, 2021 · Granulocyte colony stimulating factor (G-CSF) is a type of drug that doctors prescribe to manage neutropenia, which is the term for a lower-than-normal white blood cell count. People with...
What is the role of G-CSF in the treatment of neutropenia?
Granulocyte colony-stimulating factor (G-CSF) administered subcutaneously daily is effective treatment of cyclic neutropenia. G-CSF is thought to affect intracellular signaling as well as stimulate production.
What is granulocyte colony stimulating factor G-CSF?
Granulocyte - colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim. Drug type: Filgrastim is a biologic response modifier.
What is G-CSF injection for?
Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.
How quickly does G-CSF work?
This usually takes 5 to 7 days, although it can be longer. If you are having G-CSF before a stem cell transplant, you usually have your first dose 4 to 6 days before your stem cells are going to be collected.
What are the side effects of G-CSF injections?
What side effects may I notice from receiving this medicine?allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.back pain.dizziness or feeling faint.fever.pain, redness, or irritation at site where injected.pinpoint red spots on the skin.shortness of breath or breathing problems.More items...
Why is G-CSF given?
G-CSF is a type of growth factor that makes the bone marrow produce more white blood cells so it can reduce the risk of infection after some types of cancer treatment.
Is G-CSF injection painful?
The most relevant adverse event of G-CSF administration is bone pain. Approximately 20% of cancer patients experienced bone pain with the administration of prophylactic daily G-CSFs (lenograstim and filgrastim).
What is G-CSF injection in IVF?
Granulocyte-colony stimulating factor (G-CSF) seems to play an important role in the process of embryo implantation and continuation of pregnancy. It has been used during in vitro fertilisation (IVF) treatment for subfertile women with chronically thin endometrium and those with previous multiple IVF failures.Jan 24, 2020
How much does G-CSF cost?
About Filgrastim The lowest GoodRx price for the most common version of Neupogen is around $317.44, 20% off the average retail price of $400.00.
How long does G-CSF stay in your system?
You can also take ibuprofen up until 24 hours before your donation (which means on days 1-3 of G-CCSF, but not on the 4th day). You must not take aspirin; this is due to the fact it can stay in the system and affect platelet function for 7 days).
Can G-CSF cause leukemia?
Abstract. A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.
Why is G-CSF given 24 hours after chemo?
Post-chemotherapy prophylactic granulocyte colony-stimulating factor (G-CSF) is customarily started 24 hours after chemotherapy in most of the current pediatric and adult solid tumors protocols to ameliorate the myelotoxicity of cytotoxic agents and reduce neutropenia-related complications.
When do you give G-CSF after chemo?
G-CSF is usually started 24 hours or more after your chemotherapy finishes. You usually have it daily. Your doctor or pharmacist will tell you how many injections you need. Some types of G-CSF stay in the body for longer.
Is G-CSF the same as filgrastim?
Granulocyte colony-stimulating factor (G-CSF) is a protein naturally produced by the body to increase the production of white blood cells. Filgrastim is a man-made version of G-CSF that stimulates white blood cell production, and in particular, neutrophil production.
What are the risks of G-CSF?
The manufacturers also warn of several health risks of using G-CSF drugs. These include: 1 ruptured spleen, which causes significant blood loss and can be fatal 2 acute respiratory distress syndrome, a lung condition that causes fluid to leak into the lungs 3 serious allergic reactions, which can include anaphylactic shock 4 sickle cell crisis, a condition that occurs in people with sickle cell disease, causing moderate-to-severe pain and swelling of the hands and feet 5 glomerulonephritis, or inflammation of the glomeruli of the kidneys, which reduces the function of these organs and causes fluid buildup and hypertension 6 myelodysplastic syndrome and acute myeloid leukemia, which are forms of blood cancer
Why do people have low white blood cells?
Doctors refer to low blood cell levels as neutropenia. People usually have low levels of white blood cells as a result of cancer or chemotherapy treatment. However, doctors sometimes use G-CSF to treat low white blood cell levels with unknown causes. Having a low white blood cell count increases a person’s risk of infection.
What causes white blood cells to drop?
Neutropenia is a condition that causes a person’s white blood cell level to drop below normal. White blood cells can drop in people with some types of cancer and those taking certain medications, such as chemotherapy. — a procedure that collects stem cells from the blood — may also require G-CSF treatment.
Is G-CSF a biosimilar?
G-CSF is available as a biological medication called filgrastim (Neupogen) or as a biosimilar. There are three types of biosimilars: Biosimilars are copies of biologic drugs, similar to how generic drugs are copies of brand name drugs.
What is G-CSF treatment?
People undergoing leukapheresis. Trusted Source. — a procedure that collects stem cells from the blood — may also require G-CSF treatment. G-CSF moves hematopoietic stem cells, which will go on to form blood cells, from the bone marrow into the bloodstream.
Does chemotherapy reduce neutropenia?
decreasing the risk and duration of complications of neutropenia in people with acute mye loid leukemia who are receiving chemotherapy. reducing the duration of neutropenia and its complications in people with cancer undergoing bone marrow transplantation after chemotherapy.
What is G-CSF injection?
G-CSF drugs are a type of protein called glycoproteins.
What are the side effects of G-CSF?
Possible side effects of G-CSF 1 Mild bone pain 2 Pain/bruising at the injection site
Why do we need G-CSF?
It is a colorless liquid that is either injected under the skin or given into a vein. G-CSF helps the body make infection-fighting white blood cells, called neutrophils. Some St. Jude patients need this medicine to help build up neutrophils that have been destroyed by chemotherapy.
What are the side effects of a syringe injection?
Mild bone pain. Pain/bruising at the injection site. These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse. In case of a severe side effect or reaction, call the doctor, nurse, or pharmacist at 901-595-3300.
Does St Jude's Hospital discriminate?
St. Jude complies with health care-related federal civil rights laws and does not discrimina te on the basis of race, color, national origin, age, disability, or sex. ATTENTION: If you speak another language, assistance services, free of charge, are available to you. Call 1-866-278-5833 (TTY: 1-901-595-1040).
What is G-CSF? What are its effects?
Granulocyte colony-stimulating factor (G-CSF) administered subcutaneously daily is effective treatment of cyclic neutropenia. G-CSF is thought to affect intracellular signaling as well as stimulate production. Adverse effects associated with G-CSF include osteopenia and osteoporosis; anecdotal evidence suggests beneficial effect of bisphosphonate therapy. Although there is a substantial risk of myelodysplasia and acute myelogenous leukemia in children with severe congenital neutropenia compared with cyclic neutropenia, many experts in the field believe that with increasing survival of patients receiving G-CSF, such cases will occur in cyclic neutropenia.90 The causal role of G-CSF therapy in development of myelodysplasia and acute myelogenous leukemia versus the genetic defect is uncertain.
How long does G-CSF last?
G-CSF promotes a rapid increase in neutrophilic leukocytes, which lasts about 24 hours. Despite the multitude of patients who have received G-CSF, few side effects have been reported. Even very long-term G-CSF administration seems fairly innocuous; the most common toxicity is bone pain.
Is G-CSF effective for neutropenia?
G-CSF has revolutionized the treatment of neutropenia and its sequelae (infection). It has been used by millions of patients worldwide and is remarkably effective and virtually devoid of side effects (see Table 57-211). Some patients with solid tumors present with significantly increased leukocyte counts due to G-CSF secretion. Finally, point mutations in the gene for the G-CSF receptor have been described anecdotally in patients with AML that evolved from severe congenital neutropenia.
What is G-CSF used for?
A recombinant form of G-CSF (Neupogen) is used in certain cancer patients to accelerate recovery from neutropenia after chemotherapy [79]. G-CSF is also widely used to increase the number of HSCs in the blood of the donor before collection by leukapheresis for use in HSC transplantation [80].
What is a G-CSF?
G-CSF. A biosimilar is a biologic medical product that is almost an identical copy of an original medication that is manufactured by a different pharmaceutical company. Other Names: G-CSF, granulocyte-colony stimulating factor. Chemocare.com uses generic names in all descriptions of drugs.
How often should I take filgrastim?
Filgrastim is generally given on a daily basis. The number of days you receive filgrastim will be prescribed by your doctor. Filgrastim should be refrigerated.
Where are blood cells made?
Blood cells are made in the body's bone marrow (the soft, sponge-like material found inside bones). There are three major types of blood cells; white blood cells, which fight infection; red blood cells, which carry oxygen and remove waste products from organs and tissues; and platelets, which enable the blood to clot.
Does Tylenol cause pain?
You may experience bone or joint pain as a result of this medication. Ask your healthcare provider if you may take a mild pain medicine to relieve this. Acetaminophen (Tylenol®) may help. Apply a warm compress if you have any pain, redness or swelling at the injection site, and notify your doctor.
What is the generic name for filgrastim?
In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim. Drug type: Filgrastim is a biologic response modifier. It is classified as a colony stimulating factor and a hematopoietic agent.
How to know if you have a fever?
When to contact your doctor or health care provider: Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of 100.4° F (38° C) or higher, chills (possible signs of infection) Shortness of breath. Rapid heart beat.
Does filgrastim have CBC?
Periodic blood work to monitor your complete blood count (CBC) will be ordered by your doctor.
What are the side effects of G-CSF?
Administration of G-CSF may result in a dramatic increase in the numbers of neutrophils in the blood and is without a doubt, the most effective therapy in treating SCN. Some SCN patients receiving G-CSF report bone or muscle pain and splenomegaly (enlargement of spleen). Other side effects are infrequent but few patients have experienced some of the following: 1 Thrombocytopenia (Low platelet levels) 2 Injection site reactions such as rash 3 Hepatomegaly (liver enlargement) 4 Arthralgia (joint pain) 5 Osteoporosis (reduced bone density) 6 Cutaneous vasculitis (renal disease) 7 Haematuria/ proteinuria (blood or serum in urine) 8 Alopecia (hair loss) 9 Exacerbation of some pre-existing skin disorders (e.g. psoriasis).
What is G-CSF used for?
G-CSF stimulates the production and enhances the activity of mature neutrophils to improve their bacteria-killing function.
How much does a G-CSF injection cost?
G-CSF treatments can be expensive, up to $4000 a month. However, it might be possible to get financial help with G-CSF supplies.
Where is G-CSF administered?
G-CSF is usually administered by an injection just under the skin in areas such as the abdomen below the naval, upper outer arms, and upper outer thighs. It is possible to self-administer G-CSF depending on the age of the patient.
Does G-CSF cause muscle pain?
Some SCN patients receiving G-CSF report bone or muscle pain and splenomegaly (enlargement of spleen).
How do steroids affect neutrophils?
Steroids work by encouraging neutrophils to leave the bone marrow and enter the blood stream. However, they do not induce the production of new neutrophils in the bone marrow.
Is BMT a first choice treatment?
BMT is a very intensive procedure, carrying serious risks and therefore it is not recommended as first choice treatment.
How to use G-CSF?
G-CSF is used in two ways. It is given: 1 During treatment with chemotherapy to stimulate the bone marrow to make white blood cells, called neutrophils. These blood cells help to fight infection. 2 Before a stem cell transplant to encourage stem cells to be released from the bone marrow into the blood. The stem cells can then be collected for use in a stem cell transplant. Stem cells are blood cells at their earliest stage.
What to do if you need to get G-CSF?
If you need medical treatment for any reason, always tell the doctors and nurses that you are having G-CSF. Give them the contact details for your cancer doctor so they can ask for advice.
What is G-CSF used for?
It increases the number of some types of blood cells in the blood. It can be used with chemotherapy. It can also be used before and after a stem cell transplant. Different types of G-CSF can be used.
How does G-CSF work?
G-CSF stimulates the bone marrow to make more stem cells. These then move (mobilise) from the bone marrow into the bloodstream , where they can be collected to be used in a transplant. G-CSF may also be used after a stem cell transplant to help speed up the recovery of the new stem cells in the bone marrow.
Does chemotherapy lower white blood cells?
Chemotherapy can lower the number of white blood cells in your blood. The main white blood cells that fight infection are called neutrophils. When they are low you are neutropenic. If you have a low number of white blood cells, you are more likely to get an infection.
What is the purpose of neutrophils in chemo?
During treatment with chemotherapy to stimulate the bone marrow to make white blood cells, called neutrophils. These blood cells help to fight infection. Before a stem cell transplant to encourage stem cells to be released from the bone marrow into the blood. The stem cells can then be collected for use in a stem cell transplant.
How long does it take to get a G-CSF injection?
Some people may have G-CSF as a drip into a vein, which takes about 30 minutes. You will have this at the hospital or clinic. The levels of white blood cells in your body will be tested regularly with a blood test while you are having G-CSF injections.
What is the G-CSF?
Granulocyte colony-stimulating factor ( G-CSF or GCSF ), also known as colony-stimulating factor 3 ( CSF 3 ), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, ...
When was G-CSF first used?
Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983 , and the human form was cloned by groups from Japan and Germany / United States in 1986.
What is the function of G-CSF?
Neurons. G-CSF can also act on neuronal cells as a neurotrophic factor. Indeed, its receptor is expressed by neurons in the brain and spinal cord. The action of G-CSF in the central nervous system is to induce neurogenesis, to increase the neuroplasticity and to counteract apoptosis.
What is G-CSF used for?
In oncology and hematology, a recombinant form of G-CSF is used with certain cancer patients to accelerate recovery and reduce mortality from neutropenia after chemotherapy, allowing higher-intensity treatment regimens. It is administered to oncology patients via subcutaneous or intravenous routes.
How many amino acids are in a glycoprotein?
The natural human glycoprotein exists in two forms, a 174- and 177- amino-acid -long protein of molecular weight 19,600 grams per mole. The more-abundant and more-active 174-amino acid form has been used in the development of pharmaceutical products by recombinant DNA (rDNA) technology. White blood cells.
Where is the G-CSF receptor located?
The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. G-CSF stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.
Does G-CSF affect HSC?
G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the bloodstream, although it has been shown that it does not directly affect the hematopoietic progenitors that are mobilized.
What Is G-CSF?
- Granulocyte colony stimulating factor, also called G-CSF or Filgrastim, is a man-made form of a natural human hormone. It is a colorless liquid that is either injected under the skin or given into a vein. G-CSF helps the body make infection-fighting white blood cells, called neutrophils. Some St. Judepatients need this medicine to help build up neu...
How to Give G-CSF
- Inject just below the skin
1. If your G-CSF is injected under the skin (subcutaneous injection), a nurse will teach you how to give the injection (refer to “Do you know… How to give subcutaneous injections” or “Do you know… Subcutaneous tissue infusion set”). 2. Your subcutaneous injection dose is __________ microgra… - By IV
If your G-CSF is given into a vein, a nurse will give the G-CSF dose.
Possible Side Effects of G-CSF
- Mild bone pain
- Pain/bruising at the injection site
Special Instructions For G-CSF
- Until you are ready to use it, keep the G-CSF refrigerated but not frozen.G-CSF may be kept at room temperature for up to 24 hours if needed.
- Before giving a dose of G-CSF, take it out of the refrigerator about an hour before and let it warm to room temperature.
- G-CSF should always be a clear, colorless liquid. Do not use G-CSF if the liquid looks cloudy, …
- Until you are ready to use it, keep the G-CSF refrigerated but not frozen.G-CSF may be kept at room temperature for up to 24 hours if needed.
- Before giving a dose of G-CSF, take it out of the refrigerator about an hour before and let it warm to room temperature.
- G-CSF should always be a clear, colorless liquid. Do not use G-CSF if the liquid looks cloudy, changes color, or has flakes or specks in it.
- Do not use G-CSF if the date on the vial has expired. If you receive G-CSF in syringes from the pharmacy, do not use them after the expiration date listed on the syringe. For safety, throw away the...
