What is the definition of first line therapy?
first-line therapy (... THAYR-uh-pee) The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When …
What is first line of therapy?
first-line treatment The initial, preferred, or best treatment for a disease. It is often the therapy that combines the best efficacy with the best safety profile and/or the lowest cost. Synonym: first-line therapy Medical Dictionary, © 2009 Farlex and Partners Want to thank TFD for its existence?
What is the best first line of treatment for hypertension?
First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible.
What is first-line chemotherapy?
Sep 01, 2017 · Oral, inhalation. Rapid heart rate, and sometimes restlessness and tremor. Anticholinergic. Relaxes muscles around the large airways. Oral, inhalation. Dry mouth. Steroid or glucocorticosteroid ...
What is the difference between first-line and second line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated.Jun 9, 2020
What does line of treatment mean?
“Lines of therapy” is the term used to describe the order in which different therapies are given to people as their disease progresses.May 5, 2021
What is a second line drug?
Second line drugs are the TB drugs that are used for the treatment of drug resistant TB. The second line drugs include levofloxacin, moxifloxacin, bedaquiline, delamanid and linezolid. There is also pretomanid which is a new second line drug recommended in 2019 for the treatment of drug resistant TB.
What is the first-line treatment for chemotherapy?
The standard first-line chemotherapy for all patients is bleomycin, etoposide, and cisplatin (BEP) using a 5-day schedule. Modifications in BEP, such as substitution of cisplatin with carboplatin to reduce toxicity or improve convenience, should be avoided because they may reduce efficacy.
What is a first-line antibiotic?
Amoxicillin or amoxicillin/clavulanate is the recommended first-line therapy. Macrolides such as azithromycin are not recommended due to high levels of Streptococcus pneumoniae antibiotic resistance (~40%).
Is adjuvant therapy first-line?
Adjuvant therapy is any type of therapy that follows the primary treatment. So, adjuvant chemotherapy takes place after you've had first-line treatment, such as surgery to remove a cancerous tumor.Mar 10, 2021
What is a third line drug?
Third line therapy is usually defined as a regimen for an individual who has developed resistance to at least one drug in all three classes of anti-HIV therapies [nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors] or has failed ...Feb 28, 2002
What is first-line and second-line drugs?
First-line antituberculosis drugs- Isoniazid (INH), rifampicin (RIF), ethambutol (EMB), pyrazinamide (PZA) and streptomycin (SM). Second-line antituberculosis drugs- Sub divided into two. Fluoroquinolones- Ofloxacin (OFX), levofloxacin (LEV), moxifloxacin (MOX) and ciprofloxacin (CIP).
What is a third line medication?
Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.
What is a line of chemo?
A PICC line (peripherally inserted central catheter line) is used to give someone chemotherapy treatment or other medicines. A PICC line is a long, thin, hollow, flexible tube called a catheter. It is put into one of the large veins of the arm, above the bend of the elbow.
How long does it take for chemo to shrink tumors?
In general, chemotherapy can take about 3 to 6 months to complete. It may take more or less time, depending on the type of chemo and the stage of your condition.Apr 13, 2021
What are the signs that chemo is working?
Complete response - all of the cancer or tumor disappears; there is no evidence of disease. A tumor marker (if applicable) may fall within the normal range. Partial response - the cancer has shrunk by a percentage but disease remains. A tumor marker (if applicable) may have fallen but evidence of disease remains.
Why is DTG used in HIV treatment?
NOTE OF CAUTION The organisation says it is updating its HIV therapy guidelines to strengthen its recommendation for dolutegravir (DTG) drug as the first-line treatment because of its efficacy, tolerability and a high genetic barrier to resistance. WHO recommends once feared drug to treat HIV.
Is Palbociclib a first line treatment?
Pfizer's NDA for palbociclib, in combination with letrozole, has been accepted for filing and granted Priority Review by the FDA as a first-line treatment for postmenopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer who have not received previous treatment.
What is the first line of treatment?
First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
What is the intent of first line therapy?
The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
What is second line therapy?
Second-line therapies are those tried when the first ones do not work adequately. The management of a cancer case requires regular evaluation of treatment and adjustment as needed. A break with the primary treatment and an adoption of a new regimen signals “second-line treatment.”.
Is salvage therapy considered third line therapy?
The terms “third-line therapy ” and even “fourth-line therapy” are occasionally used for subsequent treatment, but salvage therapy is also used. Written guidelines rarely specify anything beyond second-line therapy. The same treatments can be used for subsequent treatment.
Can a first line therapy be approved for second line therapy?
Sometimes first-line therapies show progress for a period of time followed by a stalling or continued growth of the cancer. Often the FDA will specifically approve a new drug for second-line therapy. This labeling is common for new drugs that treat cancers which already have accepted treatments.
Is there a law on first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, ...
Is there a law that states that doctors must use first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, although when they do they “cover their backsides” to some extent and reduce their exposure to malpractice suits. Second-line therapies are those tried when the first ones do not work adequately.
What is the purpose of bronchodilators?
Bronchodilators help your bronchial muscles relax and open wider. This clears your airways, making it easier for you to breath. Bronchodilators are normally either short-acting or long-acting. Many different medications are bronchodilators, and most fall into these categories: Upset stomach.
Why are antibiotics important for COPD?
Antibiotics. Antibiotics are important in treating COPD, because symptoms are often triggered or made worse by bacterial infections such as sinusitis or pneumonia. Also, when you have a viral infection or flu, secondary bacterial infections may follow.
Is there a cure for COPD?
The most important consideration will be the severity of your disease. COPD often shows no symptoms until it has progressed to later stages. There’s no cure for COPD, but beginning treatment as early as possible can help ease its symptoms and possibly slow it down.
What makes a drug first line?
What makes a drug first-line? These are the medicines doctors first resort to for a given disease (the doctors first choice try). They are the most commonly prescribed medicines for a particular disease. These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar.
Is corticosteroids a first line treatment for COPD?
So, it remains a first-line treatment for COPD. Likewise, because it may help some asthmatics, it remains a second-line option here. Researchers learn more. Back in the 1970s, doctors were leary that inhaled corticosteroids (ICS) may cause the same side effects as systemic corticosteroids.
Is Atrovent a first line asthma medicine?
Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent studies did not show it benefited most asthmatics. Studies do show, however, that it does help most COPDers. So, it remains a first-line treatment for COPD.
What is the first line of treatment for type 2 diabetes?
Keywords: first-line therapy, metformin, type 2 diabetes. Introduction. Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.
What is metformin used for?
Within a year, metformin was prescribed in Europe for the treatment of type 2 diabetes mellitus, and Sterne dubbed the drug “glucophage” for its perceived ability to devour blood glucose.3.
Is metformin a monotherapy?
Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications. It is generally well-tolerated with minimal side effects and is affordable.
What is the first line of treatment for acne vulgaris?
First-line treatment for severe acne vulgaris includes an oral antibiotic, benzoyl peroxide, and a topical antibiotic (erythromycin or clarithromycin), topical retinoid, or both. Oral isotretinoin can also be considered as a first-line option. Alternative treatment options to consider include changing the oral antibiotic;
What is the best treatment for acne?
Azelaic acid (Finacea) can be used to manage dyspigmentation that occurs with inflammatory acne. For acne in children who have not reached adolescence, topical adapalene (Differin), tretinoin (Retin-A), and benzoyl peroxide are safe to use.
What is the AAD for acne vulgaris?
In addition, knowledge about its pathogenesis is constantly evolving. The American Academy of Dermatology (AAD) has released guidelines for managing acne vulgaris in adolescents and adults.
What antibiotics are used for acne?
Moderate to severe acne, as well as inflammatory acne in which topical medications have been ineffective, can be treated with systemic antibiotics. Data are limited regarding the use of antibiotics that are not tetracyclines or macrolides; therefore, their use should be avoided. Doxycycline and minocycline (Minocin) have been shown to be more effective than tetracycline. Oral erythromycin and azithromycin (Zithromax) should be used only in patients in whom tetracyclines are contraindicated (e.g., pregnant women, children younger than eight years), but erythromycin use should be limited given its associated drug resistance. Trimethoprim/sulfamethoxazole or trimethoprim should be used only in patients who cannot take tetracyclines or in whom tetracyclines have been ineffective.
Understanding First-Line Treatment
Questions to Ask
- When you and your healthcare provider consider a first-line treatment or first-line treatments, think through these questions. 1. Clarify the type and stage and molecular profile of your tumor. Is there any further testing that should be done? (If you've been diagnosed with advanced cancer, ask about the molecular profile of your tumor, and if this hasn't been done, ask why not). 2. What is y…
Alternative and Complementary Treatments
- It's important when talking about treatment to clarify what is meant by "alternative treatments." Most people now use the phrase alternative treatments to refer to complementary treatments that are offered by some cancer centers. In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with tradition…